Abstract：
:Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive early Drosophila embryogenesis. Maternal HP1a upregulates genes involved in translation, mRNA splicing, and cell division, but downregulates genes involved in neurogenesis, organogenesis, and germline development, which all occur later in development. Our study reveals the earliest contribution of HP1a during oogenesis in regulating the production of maternal transcripts that drive early Drosophila embryogenesis.
journal_name
Geneticsjournal_title
Geneticsauthors
Park AR,Liu N,Neuenkirchen N,Guo Q,Lin Hdoi
10.1534/genetics.118.301704subject
Has Abstractpub_date
2019-01-01 00:00:00pages
201-217issue
1eissn
0016-6731issn
1943-2631pii
genetics.118.301704journal_volume
211pub_type
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