Multigene family of ribosomal DNA in Drosophila melanogaster reveals contrasting patterns of homogenization for IGS and ITS spacer regions. A possible mechanism to resolve this paradox.

abstract：:Positive selection on a new mutant allele can increase the frequencies of closely linked alleles (through hitchhiking), as well as create linkage disequilibrium between them. Because this disequilibrium is induced by the selected allele, one may be able to identify loci under selection by measuring the influence of a ...

journal_title：Genetics

authors： Grote MN,Klitz W,Thomson G

更新日期：1998-11-01 00:00:00

abstract：:Interactions with bacteria play a major role in immune responses, ecology, and evolution of all animals, but they have been neglected until recently in the case of C. elegans. We report a genetic investigation of the interaction of C. elegans with the nematode-specific pathogen Microbacterium nematophilum, which colon...

journal_title：Genetics

authors： Gravato-Nobre MJ,Nicholas HR,Nijland R,O'Rourke D,Whittington DE,Yook KJ,Hodgkin J

更新日期：2005-11-01 00:00:00

abstract：:We constructed a genetic linkage map of Gibberella zeae (Fusarium graminearum) by crossing complementary nitrate-nonutilizing (nit) mutants of G. zeae strains R-5470 (from Japan) and Z-3639 (from Kansas). We selected 99 nitrate-utilizing (recombinant) progeny and analyzed them for amplified fragment length polymorphis...

journal_title：Genetics

authors： Jurgenson JE,Bowden RL,Zeller KA,Leslie JF,Alexander NJ,Plattner RD

更新日期：2002-04-01 00:00:00

abstract：:Disease resistance to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) in the cultivated tomato, Lycopersicon esculentum, and the closely related L. pimpinellifolium is triggered by the physical interaction between plant disease resistance protein, Pto, and the pathogen avirulence protein, AvrPto. To inves...

journal_title：Genetics

authors： Rose LE,Langley CH,Bernal AJ,Michelmore RW

更新日期：2005-09-01 00:00:00

abstract：:We have mapped quantitative trait loci (QTL) for Drosophila mechanosensory bristle number in six recombinant isogenic line (RIL) mapping populations, each of which was derived from an isogenic chromosome extracted from a line selected for high or low, sternopleural or abdominal bristle number and an isogenic wild-type...

journal_title：Genetics

authors： Dilda CL,Mackay TF

更新日期：2002-12-01 00:00:00

abstract：:Extensive Monte Carlo simulations are conducted of spatial distributions of two-locus genotypes in large, continuous populations under isolation by distance models. The results show that substantial patches of double homozygotes are present in the spatial structures, even when loci are unlinked. The stochastic spread ...

journal_title：Genetics

authors： Epperson BK

更新日期：1995-05-01 00:00:00

abstract：:The St. Thomas Hospital (STH) rabbit has been previously shown to have a Mendelian form of hypertriglyceridemia, accompanied by accelerated atherosclerosis, and these animals may serve as a useful model for human dyslipoproteinemia syndromes. Here we describe the establishment of a new colony of these STH animals, and...

journal_title：Genetics

authors： Beaty TH,Prenger VL,Virgil DG,Lewis B,Kwiterovich PO,Bachorik PS

更新日期：1992-12-01 00:00:00

abstract：:The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expr...

journal_title：Genetics

authors： van der Linden AM,Wiener S,You YJ,Kim K,Avery L,Sengupta P

更新日期：2008-11-01 00:00:00

abstract：:In Drosophila and other insects egg production is related to the nutrients available. Somehow the nutritional status of the environment is translated into hormonal signs that can be "read" by each individual egg chamber, influencing the decision to either develop into an egg or die. We have shown that BR-C is a contro...

journal_title：Genetics

authors： Terashima J,Bownes M

更新日期：2004-08-01 00:00:00

abstract：:There are two naturally occurring functional alleles of the recombination hotspot cog, which is located 3.5 kb from the his-3 locus of Neurospora crassa. The presence of the cog+ allele in a cross significantly increases recombination in the his-3 region compared to a cross homozygous for the cog allele. Data obtained...

journal_title：Genetics

authors： Yeadon PJ,Bowring FJ,Catcheside DE

更新日期：2004-07-01 00:00:00

abstract：:Satellite DNA is an enigmatic component of genomic DNA with unclear function that has been regarded as "junk." Yet, persistence of these tandem highly repetitive sequences in heterochromatic regions of most eukaryotic chromosomes attests to their importance in the genome. We explored the Anopheles gambiae genome for t...

journal_title：Genetics

authors： Krzywinski J,Sangaré D,Besansky NJ

更新日期：2005-01-01 00:00:00

abstract：:On the basis of interallelic recombination frequencies measured in diallelic crosses of the 5 amylose-extender alleles in maize, ae, B1, B3, M2 and i1, it was possible to construct a unique linear genetic map ordering all 5 alleles within the locus. The reciprocal diallelic crosses each gave comparable frequency estim...

journal_title：Genetics

authors： Moore CW,Creech RG

更新日期：1972-04-01 00:00:00

abstract：:I factors in Drosophila melanogaster are non-LTR retrotransposons that transpose at very high frequencies in the germ line of females resulting from crosses between reactive females (devoid of active I factors) and inducer males (containing active I factors). Constructs containing I factor ORF1 under the control of th...

journal_title：Genetics

authors： Malinsky S,Bucheton A,Busseau I

更新日期：2000-11-01 00:00:00

abstract：:The shibire locus of Drosophila melanogaster encodes dynamin, a GTPase required for the fission of endocytic vesicles from plasma membrane. Biochemical studies indicate that mammalian dynamin is part of a complex containing multiple dynamin subunits and other polypeptides. To gain insight into sequences of dynamin cri...

journal_title：Genetics

authors： Grant D,Unadkat S,Katzen A,Krishnan KS,Ramaswami M

更新日期：1998-06-01 00:00:00

abstract：:Electrophoretic comparisons of 40S and 55S ribosomal subunit proteins from 18 strains of Drosophila melanogaster revealed the virtual absence of allelic variation. More detailed two-dimensional studies on the large subunit proteins in 6 of the strains demonstrated additional complexity but still no interstrain variati...

journal_title：Genetics

authors： Berger EM,Weber L

更新日期：1974-12-01 00:00:00

abstract：:AFLP markers are becoming one of the most popular tools for genetic analysis in the fields of evolutionary genetics and ecology and conservation of genetic resources. The technique combines a high-information content and fidelity with the possibility of carrying out genomewide scans. However, a potential problem with ...

journal_title：Genetics

authors： Caballero A,Quesada H,Rolán-Alvarez E

更新日期：2008-05-01 00:00:00

abstract：:We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the fir...

journal_title：Genetics

authors： Tomasini M,Peischl S

更新日期：2018-07-01 00:00:00

abstract：:The genetic effects of one generation of spermatogonial X-irradiation in rats, by a single dose of 600r in one experiment and by a fractionated dose of 450r in another, were measured in three generations of their descendants. Estimates of dominant lethal mutation rates--(2 to 3) X 10-4/gamete/r--from litter size diffe...

journal_title：Genetics

authors： Chambers JR,Chapman AB

更新日期：1977-02-01 00:00:00

abstract：:Meiotic recombination depends upon the tightly coordinated regulation of chromosome dynamics and is essential for the production of haploid gametes. Central to this process is the formation and repair of meiotic double-stranded breaks (DSBs), which must take place within the constraints of a specialized chromatin arch...

journal_title：Genetics

authors： Turcotte CA,Sloat SA,Rigothi JA,Rosenkranse E,Northrup AL,Andrews NP,Checchi PM

更新日期：2018-03-01 00:00:00

abstract：:This report examines five different naturally occurring alcohol dehydrogenase-1 alleles via the recombinational behavior of Adh1(-) mutants induced within them. Twenty-two biochemically characterized Adh1(-) mutants have been assessed for ability to recombine intragenically, using data generated by specifically staini...

journal_title：Genetics

authors： Freeling M

更新日期：1978-05-01 00:00:00

abstract：:Many of the transcription factors and target genes that pattern the developing adult remain unknown. In the present study, we find that an ortholog of the poorly understood transcription factor, glucose transporter (GLUT4) enhancer factor (Glut4EF, GEF) [also known as the Huntington's disease gene regulatory region-bi...

journal_title：Genetics

authors： Yazdani U,Huang Z,Terman JR

更新日期：2008-02-01 00:00:00

abstract：:We consider some practical statistical issues in QTL analysis where several crosses originate in multiple inbred parents. Our results show that ignoring background polygenic variation in different crosses may lead to biased interval mapping estimates of QTL effects or loss of efficiency. Threshold and power approximat...

journal_title：Genetics

authors： Zou F,Yandell BS,Fine JP

更新日期：2001-07-01 00:00:00

abstract：:The genetic basis underlying inbreeding depression and heterosis for three grain yield components of rice was investigated in five interrelated mapping populations using a complete RFLP linkage map, replicated phenotyping, and the mixed model approach. The populations included 254 F(10) recombinant inbred lines (RILs)...

journal_title：Genetics

authors： Luo LJ,Li ZK,Mei HW,Shu QY,Tabien R,Zhong DB,Ying CS,Stansel JW,Khush GS,Paterson AH

更新日期：2001-08-01 00:00:00

abstract：:Centric regions of eukaryotic genomes are packaged into heterochromatin, which possesses the ability to spread along the chromosome and silence gene expression. The process of spreading has been challenging to study at the molecular level due to repetitious sequences within centric regions. A heterochromatin protein 1...

journal_title：Genetics

authors： Hines KA,Cryderman DE,Flannery KM,Yang H,Vitalini MW,Hazelrigg T,Mizzen CA,Wallrath LL

更新日期：2009-08-01 00:00:00

abstract：:Temporally spaced genetic data allow for more accurate inference of population genetic parameters and hypothesis testing on the recent action of natural selection. In this work, we develop a novel likelihood-based method for jointly estimating selection coefficient and allele age from time series data of allele freque...

journal_title：Genetics

authors： He Z,Dai X,Beaumont M,Yu F

更新日期：2020-10-01 00:00:00

abstract：:Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the ...

journal_title：Genetics

authors： Yi N,Banerjee S,Pomp D,Yandell BS

更新日期：2007-07-01 00:00:00

abstract：:The challenges of breeding autotetraploid potato (Solanum tuberosum) have motivated the development of alternative breeding strategies. A common approach is to obtain uniparental dihaploids from a tetraploid of interest through pollination with S. tuberosum Andigenum Group (formerly S. phureja) cultivars. The mechanis...

journal_title：Genetics

authors： Amundson KR,Ordoñez B,Santayana M,Tan EH,Henry IM,Mihovilovich E,Bonierbale M,Comai L

更新日期：2020-02-01 00:00:00

abstract：:The Notch receptor is the central element in a cell signaling mechanism controlling a broad spectrum of cell fate choices. Genetic modifier screens in Drosophila and subsequent molecular studies have identified several Notch pathway components, but the biochemical nature of signaling is still elusive. Here, we report ...

journal_title：Genetics

authors： Go MJ,Artavanis-Tsakonas S

更新日期：1998-09-01 00:00:00

abstract：:Pathogen resistance is an ecologically important phenotype increasingly well understood at the molecular genetic level. In this article, we examine levels of avrRpt2-dependent resistance and Rps2 locus DNA sequence variability in a worldwide sample of 27 accessions of Arabidopsis thaliana. The rooted parsimony tree of...

journal_title：Genetics

authors： Mauricio R,Stahl EA,Korves T,Tian D,Kreitman M,Bergelson J

更新日期：2003-02-01 00:00:00

abstract：:Epistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus...

journal_title：Genetics

authors： Kelly JK

更新日期：2005-12-01 00:00:00