Satellite DNA from the Y chromosome of the malaria vector Anopheles gambiae.

abstract：:Evolution of a multigene family is studied from the standpoint of population genetics. It is assumed that the multigene family is undergoing continuous interchromosomal unequal crossing over, mutation and random frequency drift. The equilibrium properties of the probability of gene identity (clonality) are investigate...

journal_title：Genetics

authors： Ohta T

更新日期：1979-03-01 00:00:00

abstract：:The vertebrate limb serves as an experimental paradigm to study mechanisms that regulate development of the stereotypical skeletal elements. In this study, we simultaneously inactivated Sall4 using Hoxb6Cre and Plzf in mouse embryos, and found that their combined function regulates development of the proximal-anterior...

journal_title：Genetics

authors： Chen KQ,Tahara N,Anderson A,Kawakami H,Kawakami S,Nishinakamura R,Pandolfi PP,Kawakami Y

更新日期：2020-05-01 00:00:00

abstract：:We studied thorax formation in Drosophila melanogaster using a misexpression screen with EP lines and thoracic Gal4 drivers that provide a genetically sensitized background. We identified 191 interacting lines showing alterations of thoracic bristles (number and/or location), thorax and scutellum malformations, lethal...

journal_title：Genetics

authors： Peña-Rangel MT,Rodriguez I,Riesgo-Escovar JR

更新日期：2002-03-01 00:00:00

abstract：:Establishing durable disease resistance in agricultural crops, where much of the plant defense is provided through effector-R gene interactions, is complicated by the ability of pathogens to overcome R gene resistance by losing the corresponding effector gene. Many proposed methods to maintain disease resistance in th...

journal_title：Genetics

authors： Wichmann G,Bergelson J

更新日期：2004-02-01 00:00:00

abstract：:TAHRE, the least abundant of the three retrotransposons forming telomeres in Drosophila melanogaster, has high sequence similarity to the gag gene and untranslated regions of HeT-A, the most abundant telomere-specific retrotransposon. Despite TAHRE's apparent evolutionary relationship to HeT-A, we find TAHRE Gag canno...

journal_title：Genetics

authors： Fuller AM,Cook EG,Kelley KJ,Pardue ML

更新日期：2010-03-01 00:00:00

abstract：:The point mutation rate of phage PhiX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0x10(-6) substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per roun...

journal_title：Genetics

authors： Cuevas JM,Duffy S,Sanjuán R

更新日期：2009-10-01 00:00:00

abstract：:A natural population of Culex tritaeniorhynchus was sampled to test the efficacy of a proposed method to detect and measure concealed variability. Thirty-nine lethals and ten recessive visible mutations were uncovered out of a total of 125 chromosomes tested. ...

journal_title：Genetics

authors： Sakai RK,Baker RH

更新日期：1972-06-01 00:00:00

abstract：:Previous mathematical analyses of mutation-selection balance for metric traits assume that selection acts on the relevant loci only through the character(s) under study. Thus, they implicitly assume that all of the relevant mutation and selection parameters are estimable. A more realistic analysis must recognize that ...

journal_title：Genetics

authors： Turelli M

更新日期：1985-09-01 00:00:00

abstract：:The Su(f) protein of Drosophila melanogaster shares extensive homologies with proteins from yeast (RNA14) and man (77 kD subunit of cleavage stimulation factor) that are required for 3' end processing of mRNA. These homologies suggest that su(f) is involved in mRNA 3' end formation and that some aspects of this proces...

journal_title：Genetics

authors： Simonelig M,Elliott K,Mitchelson A,O'Hare K

更新日期：1996-04-01 00:00:00

abstract：:The maize r locus encodes a transcription factor that regulates the developmental expression of the plant pigment anthocyanin. In an unusual example of gene regulatory diversity, the R-sc (Sc, strong seed color) and the R-p (P, plant color) alleles of r have nonoverlapping tissue specificity and nonhomologous 5' flank...

journal_title：Genetics

authors： Li Y,Bernot JP,Illingworth C,Lison W,Bernot KM,Eggleston WB,Fogle KJ,DiPaola JE,Kermicle J,Alleman M

更新日期：2001-12-01 00:00:00

abstract：:Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...

journal_title：Genetics

authors： Turner BC

更新日期：1977-03-01 00:00:00

abstract：:The inbred mouse strain, C57BL/6J, was derived from mice of the Mus musculus complex. C57BL/6J can be crossed in the laboratory with a closely related mouse species, M. spretus to produce fertile offspring; however there has been no previous evidence of gene flow between M. spretus and M. musculus in nature. Analysis ...

journal_title：Genetics

authors： Rikke BA,Zhao Y,Daggett LP,Reyes R,Hardies SC

更新日期：1995-02-01 00:00:00

abstract：:We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...

journal_title：Genetics

authors： Kurkulos M,Weinberg JM,Roy D,Mount SM

更新日期：1994-03-01 00:00:00

abstract：:The forest tent caterpillar is polymorphic for two melanic genes affecting wing color of moths. These are the first genetically determined morphological traits reported for the genus. Dark (D) is a sex-limited, autosomal dominant with a phenotype of dark brown males. Frequencies in population samples varied from 8 to ...

journal_title：Genetics

authors： Lorimer N

更新日期：1979-06-01 00:00:00

abstract：:We present a Bayesian method for characterizing the mating system of populations reproducing through a mixture of self-fertilization and random outcrossing. Our method uses patterns of genetic variation across the genome as a basis for inference about reproduction under pure hermaphroditism, gynodioecy, and a model de...

journal_title：Genetics

authors： Redelings BD,Kumagai S,Tatarenkov A,Wang L,Sakai AK,Weller SG,Culley TM,Avise JC,Uyenoyama MK

更新日期：2015-11-01 00:00:00

abstract：:The nuclear aod-1 gene of Neurospora crassa encodes the alternative oxidase and is induced when the standard cytochrome-mediated respiratory chain of mitochondria is inhibited. To study elements of the pathway responsible for alternative oxidase induction, we generated a series of mutations in the region upstream from...

journal_title：Genetics

authors： Chae MS,Lin CC,Kessler KE,Nargang CE,Tanton LL,Hahn LB,Nargang FE

更新日期：2007-04-01 00:00:00

abstract：:Four genes encoding the major egg yolk polypeptides of the Mediterranean fruit fly Ceratitis capitata, vitellogenins 1 and 2 (VG1 and VG2), were cloned, characterized and partially sequenced. The genes are located on the same region of chromosome 5 and are organized in pairs, each encoding the two polypeptides on oppo...

journal_title：Genetics

authors： Rina M,Savakis C

更新日期：1991-04-01 00:00:00

abstract：:A consensus map for loblolly pine (Pinus taeda L.) was constructed from the integration of linkage data from two unrelated three-generation outbred pedigrees. The progeny segregation data from restriction fragment length polymorphism, random amplified polymorphic DNA, and isozyme genetic markers from each pedigree wer...

journal_title：Genetics

authors： Sewell MM,Sherman BK,Neale DB

更新日期：1999-01-01 00:00:00

abstract：:Pigmentation is a rapidly evolving trait that can play important roles in mimicry, sexual selection, thermoregulation, and other adaptive processes in many groups of animals. In Drosophila, pigmentation can differ dramatically among closely related taxa, presenting a good opportunity to dissect the genetic changes und...

journal_title：Genetics

authors： Ng CS,Hamilton AM,Frank A,Barmina O,Kopp A

更新日期：2008-09-01 00:00:00

abstract：:The mutational origin and subsequent evolution of de novo genes, which are hypothesized to be genes of recent origin that are not obviously related to ancestral coding sequence, are poorly understood. However, accumulating evidence suggests that such genes may often function in male reproduction. Here we use testis-de...

journal_title：Genetics

authors： Begun DJ,Lindfors HA,Kern AD,Jones CD

更新日期：2007-06-01 00:00:00

abstract：:The Drosophila melanogaster genome contains a single region (at 83DE on the polytene chromosome map) for which both heterozygous deficiency and heterozygous duplication are inviable. Seven EMS-induced mutations have been recovered that are viable in combination with a duplication of this region. Two classes of mutatio...

journal_title：Genetics

authors： Roehrdanz RL,Lucchesi JC

更新日期：1980-06-01 00:00:00

abstract：:RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) in Drosophila cells are currently being performed and emphasize the strengths and weaknesses of the...

journal_title：Genetics

authors： Perrimon N,Mathey-Prevot B

更新日期：2007-01-01 00:00:00

abstract：:DNA repair of single-strand breaks (produced by ionizing radiation) and of base damage (produced by ultraviolet (UV) light) are two repair mechanisms that most mammalian cells possess. Genetic defects in these repair mechanisms are exemplified by cells from the human premature-aging disease, progeria, which fail to re...

journal_title：Genetics

authors： Cleaver JE,Bootsma D,Friedberg E

更新日期：1975-06-01 00:00:00

abstract：:Although most living organisms reproduce sexually, some have developed a uniparental reproduction where the embryo usually derives from the female parent. A unique case of paternal apomixis in plants has been recently reported in Cupressus dupreziana, an endangered Mediterranean conifer. This species produces unreduce...

journal_title：Genetics

authors： Pichot C,Liens B,Nava JL,Bachelier JB,El Maâtaoui M

更新日期：2008-01-01 00:00:00

abstract：:To analyze the phenotype of cells lacking the vacuolar ATPase, we inactivated the vma-1 gene, which encodes the catalytic subunit of the enzyme. Because preliminary experiments suggested the vma-1 gene was essential, we developed a method of simultaneously inactivating the gene and complementing it with a functional c...

journal_title：Genetics

authors： Ferea TL,Bowman BJ

更新日期：1996-05-01 00:00:00

abstract：:Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms. Likewise 1-naphthylamine and 2-naphthylamine are also nonmutagenic but the N-hydroxy derivatives are mutagenic in microorganisms. Apparently these compounds require metabolism to breakdown produ...

journal_title：Genetics

authors： Mayer VW

更新日期：1973-07-01 00:00:00

abstract：:Within the context of a conservation program the management of subdivided populations implies a compromise between the control of the global genetic diversity, the avoidance of high inbreeding levels, and, sometimes, the maintenance of a certain degree of differentiation between subpopulations. We present a dynamic an...

journal_title：Genetics

authors： Fernández J,Toro MA,Caballero A

更新日期：2008-05-01 00:00:00

abstract：:Double-strand DNA breaks can be repaired by any of several alternative mechanisms that differ greatly in the nature of the final repaired products. We used a reporter construct, designated "Repair reporter 3" (Rr3), to measure the relative usage of these pathways in Drosophila germ cells. The method works by creating ...

journal_title：Genetics

authors： Preston CR,Flores CC,Engels WR

更新日期：2006-02-01 00:00:00

abstract：:Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, de...

journal_title：Genetics

authors： Hartl TA,Ni J,Cao J,Suyama KL,Patchett S,Bussiere C,Gui DY,Tang S,Kaplan DD,Fish M,Johnson AW,Scott MP

更新日期：2013-05-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Despite remarkable success in uncovering many risk variants and providing novel insights into disease biology, genetic variants identified to date fail to explain the vast majority of the heri...

journal_title：Genetics

authors： Huang J,Wang K,Wei P,Liu X,Liu X,Tan K,Boerwinkle E,Potash JB,Han S

更新日期：2016-03-01 00:00:00