Experimental population genetics of meiotic drive systems. I. Pseudo-Y chromosomal drive as a means of eliminating cage populations of Drosophila melanogaster.

abstract：:The genetic basis of stochastic variation within a defined environment, and the consequences of such micro-environmental variance for fitness are poorly understood . Using a multigenerational breeding design in Drosophila serrata, we demonstrated that the micro-environmental variance in a set of morphological wing tra...

journal_title：Genetics

authors： Sztepanacz JL,McGuigan K,Blows MW

更新日期：2017-08-01 00:00:00

abstract：:Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...

journal_title：Genetics

authors： Falque M,Mercier R,Mézard C,de Vienne D,Martin OC

更新日期：2007-07-01 00:00:00

abstract：:Centromere H3 proteins (CenH3's) are variants of histone H3 specialized for packaging centromere DNA. Unlike canonical H3, which is among the most conserved of eukaryotic proteins, CenH3's are rapidly evolving, raising questions about orthology and conservation of function across species. To gain insight on CenH3 evol...

journal_title：Genetics

authors： Baker RE,Rogers K

更新日期：2006-11-01 00:00:00

abstract：:Simple meiotic gene conversion tracts produced in wild-type females were compared with those from two meiotic mutants, mei-9 and mei-218. The positions and lengths of conversion tracts were determined by denaturing gradient gels and DNA sequencing. Conversion tracts in wild type averaged 885 base pairs in length, were...

journal_title：Genetics

authors： Curtis D,Bender W

更新日期：1991-04-01 00:00:00

abstract：:Nucleosome-depleted regions (NDRs) are present immediately adjacent to the transcription start site in most eukaryotic promoters. Here we show that NDRs in the upstream promoter region can profoundly affect gene regulation. Chromatin at the yeast HO promoter is highly repressive and numerous coactivators are required ...

journal_title：Genetics

authors： Yarrington RM,Goodrum JM,Stillman DJ

更新日期：2016-02-01 00:00:00

abstract：:Forty-one stocks from 30 Drosophila species were surveyed for Wolbachia infection using PCR technology. D. sechellia and two strains of D. auraria were found to be infected and were tested for the expression of cytoplasmic incompatibility, along with D. ananassae and D. melanogaster strains, which are already known to...

journal_title：Genetics

authors： Bourtzis K,Nirgianaki A,Markakis G,Savakis C

更新日期：1996-11-01 00:00:00

abstract：:Genetic study of the reproductive barriers between related species plays an essential role in understanding the process of speciation. We developed a new method for mapping all possible factors causing deviations from expected Mendelian segregation ratios in F(2) progeny, which substantially contribute to reproductive...

journal_title：Genetics

authors： Harushima Y,Nakagahra M,Yano M,Sasaki T,Kurata N

更新日期：2001-10-01 00:00:00

abstract：:Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...

journal_title：Genetics

authors： Myster SH,Wang F,Cavallo R,Christian W,Bhotika S,Anderson CT,Peifer M

更新日期：2004-02-01 00:00:00

abstract：:In plants, many major regulatory genes that control plant growth and development have been identified and characterized. Despite a detailed knowledge of the function of these genes little is known about how they contribute to the natural variation for complex traits. To determine whether major regulatory genes of maiz...

journal_title：Genetics

authors： Weber A,Clark RM,Vaughn L,Sánchez-Gonzalez Jde J,Yu J,Yandell BS,Bradbury P,Doebley J

更新日期：2007-12-01 00:00:00

abstract：:Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and encode small secreted proteins of unknown function. For both families in three Caenorhabditis species, concerted groups of ge...

journal_title：Genetics

authors： Thomas JH

更新日期：2006-04-01 00:00:00

abstract：:Accumulation of RNA was measured in adult males of two genotypes: car bb/Ybb- and car bb/YbbSuVar-5. The two genotypes have similar amounts of rDNA, which is reduced in comparison to wild type (CLARK, STRAUSBAUGH and KIEFER 1977). Although genotypically bobbed, car bb/YbbSuVar-5 flies have a wild-type phenotype; car b...

journal_title：Genetics

authors： Strausbaugh LD,Clark SH,Grainger RM

更新日期：1979-11-01 00:00:00

abstract：:In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...

journal_title：Genetics

authors： Sarot E,Payen-Groschêne G,Bucheton A,Pélisson A

更新日期：2004-03-01 00:00:00

abstract：:There is increasing evidence that certain Vacuolar protein sorting (Vps) proteins, factors that mediate vesicular protein trafficking, have additional roles in regulating transcription factors at the endosome. We found that yeast mutants lacking the phosphatidylinositol 3-phosphate [PI(3)P] kinase Vps34 or its associa...

journal_title：Genetics

authors： Gaur NA,Hasek J,Brickner DG,Qiu H,Zhang F,Wong CM,Malcova I,Vasicova P,Brickner JH,Hinnebusch AG

更新日期：2013-03-01 00:00:00

abstract：:The primary signal for Drosophila sex determination is the number of X chromosomes relative to the number of sets of autosomes. The present report shows that the numerator of this X/A signal appears to be determined by the cumulative dose of a relatively limited number of discrete X-linked genetic elements, two of whi...

journal_title：Genetics

authors： Cline TW

更新日期：1988-08-01 00:00:00

abstract：:We have examined the number of X-linked loci specifically required only during oogenesis. Complementation analyses among female-sterile (fs) mutations obtained in two mutagenesis screens--GANS' and MOHLER's--indicate that any fs locus represented by two or more mutant alleles in GANS' collection are usually present in...

journal_title：Genetics

authors： Perrimon N,Mohler D,Engstrom L,Mahowald AP

更新日期：1986-07-01 00:00:00

abstract：:Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins, siblings and parents and offspring suggest that a substantial proportion of variation in total finger pattern intensity is due ...

journal_title：Genetics

authors： Heath AC,Martin NG,Eaves LJ,Loesch D

更新日期：1984-04-01 00:00:00

abstract：:In the sensory system of C. elegans, the candidate odorant receptor gene str-2 is strongly expressed in one of the two AWC neurons and weakly in both ASI neurons. Asymmetric AWC expression results from suppression of str-2 expression by a Ca2+/MAPK signaling pathway in one of the AWC neurons early in development. Here...

journal_title：Genetics

authors： Lans H,Jansen G

更新日期：2006-07-01 00:00:00

abstract：:Sequences of Bronze2 (Bz2), a maize gene which is required for the synthesis of the purple pigment anthocyanin, have been cloned by combining the techniques of transposon tagging and differential hybridization. First, a mutable bz2 allele (bz2-mu1) was recovered from a Mutator line. The mutation was assumed to result ...

journal_title：Genetics

authors： McLaughlin M,Walbot V

更新日期：1987-12-01 00:00:00

abstract：:We found that heterozygous mutant alleles of E(Pc) and esc increased homologous recombination from an allelic template in somatic cells in a P-element-induced double-strand break repair assay. Flies heterozygous for mutant alleles of these genes showed increased genome stability and decreased levels of apoptosis in im...

journal_title：Genetics

authors： Holmes AM,Weedmark KA,Gloor GB

更新日期：2006-04-01 00:00:00

abstract：:We have established the DNA sequence and analyzed the transcription and translation products of a series of putative nodulation (nod) genes in Rhizobium meliloti strain 1021. Four loci have been designated nodF, nodE, nodG and nodH. The correlation of transposon insertion positions with phenotypes and open reading fra...

journal_title：Genetics

authors： Fisher RF,Swanson JA,Mulligan JT,Long SR

更新日期：1987-10-01 00:00:00

abstract：:Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced t...

journal_title：Genetics

authors： LaFave MC,Varshney GK,Vemulapalli M,Mullikin JC,Burgess SM

更新日期：2014-09-01 00:00:00

abstract：:In this paper we study the process of allele frequency change in finite populations with overlapping generations with the purpose of evaluating the possibility of estimating the effective size from observations of temporal frequency shifts of selectively neutral alleles. Focusing on allele frequency changes between su...

journal_title：Genetics

authors： Jorde PE,Ryman N

更新日期：1995-02-01 00:00:00

abstract：:Codon usage bias in Drosophila melanogaster genes has been attributed to negative selection of those codons whose cellular tRNA abundance restricts rates of mRNA translation. Previous studies, which involved limited numbers of genes, can now be compared against analyses of the entire gene complements of 12 Drosophila ...

journal_title：Genetics

authors： Heger A,Ponting CP

更新日期：2007-11-01 00:00:00

abstract：:Knowledge of multigenic family organization should provide insight into their mode of evolution. Accordingly, we characterized the 5S ribosomal gene family in the Drosophila melanogaster strain ry506. The 5S genes in this strain display a striking HindIII restriction difference compared to the "standard" D. melanogast...

journal_title：Genetics

authors： Samson ML,Wegnez M

更新日期：1988-04-01 00:00:00

abstract：:The existence of temporally stable frequency clines for In(2L)t in natural populations of Drosophila melanogaster suggests a role for selection in the maintenance of this polymorphism. We have collected nucleotide polymorphism data from the proximal breakpoint junction regions of In(2L)t to infer its evolutionary hist...

journal_title：Genetics

authors： Andolfatto P,Wall JD,Kreitman M

更新日期：1999-11-01 00:00:00

abstract：:Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than conventional metaanalysis based on within-study estimates. However, conducting analyses with pooled genetic data, in particular, is a daunting task that raises importan...

journal_title：Genetics

authors： Heo M,Leibel RL,Boyer BB,Chung WK,Koulu M,Karvonen MK,Pesonen U,Rissanen A,Laakso M,Uusitupa MI,Chagnon Y,Bouchard C,Donohoue PA,Burns TL,Shuldiner AR,Silver K,Andersen RE,Pedersen O,Echwald S,Sørensen TI,Behn P,

更新日期：2001-11-01 00:00:00

abstract：:The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the post...

journal_title：Genetics

authors： Hayashi S,Kondo T

更新日期：2018-06-01 00:00:00

abstract：:Interactions with bacteria play a major role in immune responses, ecology, and evolution of all animals, but they have been neglected until recently in the case of C. elegans. We report a genetic investigation of the interaction of C. elegans with the nematode-specific pathogen Microbacterium nematophilum, which colon...

journal_title：Genetics

authors： Gravato-Nobre MJ,Nicholas HR,Nijland R,O'Rourke D,Whittington DE,Yook KJ,Hodgkin J

更新日期：2005-11-01 00:00:00

abstract：:Aimed at investigating the recovery of a specific mutant allele of the mating type locus (MAT) by switching a defective MAT allele, these experiments provide information bearing on several models proposed for MAT interconversion in bakers yeast, Saccharomyces cerevisiae. Hybrids between heterothallic (ho) cells carryi...

journal_title：Genetics

authors： Klar AJ,Fogel S,Radin DN

更新日期：1979-07-01 00:00:00

abstract：:The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chrom...

journal_title：Genetics

authors： Conley EJ,Nduati V,Gonzalez-Hernandez JL,Mesfin A,Trudeau-Spanjers M,Chao S,Lazo GR,Hummel DD,Anderson OD,Qi LL,Gill BS,Echalier B,Linkiewicz AM,Dubcovsky J,Akhunov ED,Dvorák J,Peng JH,Lapitan NL,Pathan MS,Nguyen HT

更新日期：2004-10-01 00:00:00