Mitotic Cell Division in Caenorhabditis elegans.

Abstract:

:Mitotic cell divisions increase cell number while faithfully distributing the replicated genome at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell division. Nearly all of the genes that regulate cell division in C. elegans are conserved across metazoan species, including humans. The C. elegans pathways tend to be streamlined, facilitating dissection of the more redundant human pathways. Here, we summarize the virtues of C. elegans as a model system and review our current understanding of centriole duplication, the acquisition of pericentriolar material by centrioles to form centrosomes, the assembly of kinetochores and the mitotic spindle, chromosome segregation, and cytokinesis.

journal_name

Genetics

journal_title

Genetics

authors

Pintard L,Bowerman B

doi

10.1534/genetics.118.301367

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

35-73

issue

1

eissn

0016-6731

issn

1943-2631

pii

genetics.118.301367

journal_volume

211

pub_type

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