Abstract:
:Mutants of Paramecium caudatum with abnormal swimming behavior or responses to cations were obtained by mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Some of the mutants, like pawn in P. tetraurelia, cannot swim backward and are called CNR. Seven independently obtained CNR mutants belonged to three complementation groups, designated as cnrA, cnrB and cnrC. Some characteristics of double homo- and heterozygotes were compared with single homo- and heterozygotes. Other behavioral mutants shown to have a genic basis included K(+)-sensitive, temperature-shock behavioral and slow swimmer. All those mutants except for slow swimmer had lesions in the membrane because Triton-extracted models of them show almost the same swimming behavior as wild type.
journal_name
Geneticsjournal_title
Geneticsauthors
Takahashi Msubject
Has Abstractpub_date
1979-03-01 00:00:00pages
393-408issue
3eissn
0016-6731issn
1943-2631journal_volume
91pub_type
杂志文章相关文献
GENETICS文献大全abstract::N6-methyladenosine (m6A), catalyzed by Mettl3 methyltransferase, is a highly conserved epigenetic modification in eukaryotic messenger RNA (mRNA). Previous studies have implicated m6A modification in multiple biological processes, but the in vivo function of m6A has been difficult to study, because mettl3 mutants are ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.300574
更新日期:2018-02-01 00:00:00
abstract::Mutations in genes of Saccharomyces cerevisiae that code for proteins that interact with beta-tubulin were sought by screening for unlinked mutations that fail to complement mutations in the single beta-tubulin-encoding gene (TUB2). Among the first three noncomplementing mutations examined, two are linked to TUB2 whil...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::Selective genotyping and phenotyping strategies are used to lower the cost of quantitative trait locus studies. Their efficiency has been studied primarily in simplified contexts--when a single locus contributes to the phenotype, and when the residual error (phenotype conditional on the genotype) is normally distribut...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.094607
更新日期:2009-04-01 00:00:00
abstract::Mutant alleles of two genetic regulatory elements, which underlie a three- to sixfold reduction in beta-glucuronidase (GUS) activity levels, distinguish mice of the H haplotype from those of the other two common GUS haplotypes, A and B. Both elements are tightly linked to the GUS structural gene over which they exert ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Selection of Gl-Sb coupling heterozygotes was carried out for more than one hundred generations commencing with six independent lines drawn from a common base population. Population sizes were eight, sixteen and forty-eight parents per generation. The effect of natural selection on recombination value was measured by ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-03-01 00:00:00
abstract::As multi-individual population-scale data become available, more complex modeling strategies are needed to quantify genome-wide patterns of nucleotide usage and associated mechanisms of evolution. Recently, the multivariate neutral Moran model was proposed. However, it was shown insufficient to explain the distributio...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302074
更新日期:2019-08-01 00:00:00
abstract::A consensus microsatellite-based linkage map of the turbot (Scophthalmus maximus) was constructed from two unrelated families. The mapping panel was derived from a gynogenetic family of 96 haploid embryos and a biparental diploid family of 85 full-sib progeny with known linkage phase. A total of 242 microsatellites we...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.075416
更新日期:2007-12-01 00:00:00
abstract::The LmR1 locus, which controls seedling resistance to the blackleg fungus Leptosphaeria maculans in the Brassica napus cultivar Shiralee, was positioned on linkage group N7. Fine genetic mapping in a population of 2500 backcross lines identified three molecular markers that cosegregated with LmR1. Additional linkage m...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.049098
更新日期:2005-12-01 00:00:00
abstract::The larval cuticle protein (Lcp) cluster in Drosophila melanogaster contains four functional genes and a closely related pseudogene. A 630-bp fragment including the larval cuticle pseudogene locus (Lcp psi) was nucleotide sequenced in 10 strains of D. melanogaster and a 458-bp Lcp psi fragment from D. simulans was als...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::In a previous study, a mitochondrial mutant expressing a specific enzymatic deficiency in co-enzyme QH2-cytochrome c reductase was described (TZAGO-LOFF, FOURY and AKAI 1976). Analysis of the mitochondrially translated proteins revealed the absence in the mutant of the mitochondrial product corresponding to cytochrome...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1980-08-01 00:00:00
abstract::Genetic drift is an important evolutionary force of strength inversely proportional to Ne , the effective population size. The impact of drift on genome diversity and evolution is known to vary among species, but quantifying this effect is a difficult task. Here we assess the magnitude of variation in drift power amon...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303622
更新日期:2020-10-01 00:00:00
abstract::The white-apricot (wa) allele differs from the wild-type white gene by the presence of the retrovirus-like transposable element copia within the transcription unit. Most RNAs derived from wa have 3' termini within this insertion, and only small amounts of structurally normal RNA are produced. The activity of wa is red...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Accounting for gene-environment (G×E) interactions in complex trait association studies can facilitate our understanding of genetic heterogeneity under different environmental exposures, improve the ability to discover susceptible genes that exhibit little marginal effect, provide insight into the biological mechanism...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.171686
更新日期:2015-03-01 00:00:00
abstract::Two strains of Drosophila melanogaster derived from different geographical localities were subjected to selection for fast and slow developmental rate. Four enzyme polymorphisms were monitored for their response to such selection. Significant changes in allele frequencies were effected for the alphaGpdh and 6Pgd polym...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract::We have investigated the order of the four genes cyc1, rad7, SUP4, and cdc8 which form a tightly linked cluster on the right arm of chromosome X in the yeast Saccharomyces cerevisiae. Crossing over and coconversion data from tetrad analysis established the gene order to be centromere-cyc1-rad7-SUP4. Also cdc8 appeared...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract::Neurospora crassa is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its capacity to produce secondary metabolites. Here, we report the role of the fungal-specific regulatory velvet complexes in development and secondary metabolism (SM) ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302277
更新日期:2019-07-01 00:00:00
abstract::The long terminal repeat retrotransposon, Magnaporthe gypsy-like element (MAGGY), has been shown to be targeted for cytosine methylation in a subset of Magnaporthe oryzae field isolates. Analysis of the F1 progeny from a genetic cross between methylation-proficient (Br48) and methylation-deficient (GFSI1-7-2) isolates...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.155978
更新日期:2013-11-01 00:00:00
abstract::The rdgB mutants depend on recombinational repair of double-strand breaks. To assess other consequences of rdgB inactivation in Escherichia coli, we isolated RdgB-dependent mutants. All transposon inserts making cells dependent on RdgB inactivate genes of double-strand break repair, indicating that chromosomal fragmen...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.051144
更新日期:2006-02-01 00:00:00
abstract::Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic data sets, which are often discovered and visualized using dimension reduction techniques such as principal component analysis (PCA). Mean relatedness is an average of the relationships across locus-s...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.118.301747
更新日期:2019-01-01 00:00:00
abstract::Some mutant strains of the filamentous fungus Podospora anserina spontaneously present a growth impairment, which has been called Crippled Growth (CG). CG is caused by a cytoplasmic and infectious factor, C. C is efficiently transmitted during mitosis but is not transmitted to the progeny after sexual crosses. C is in...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::We show that major chromosomal rearrangements can occur upon T-DNA transformation of Arabidopsis thaliana. In the ACL4 line, two T-DNA insertion loci were found; one is a tandem T-DNA insert in a head-to-head orientation, and the other is a truncated insert with only the left part of the T-region. The four flanking DN...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-02-01 00:00:00
abstract::Following transformation of a Drosophila melanogaster true M strain with an autonomous P element, six lines were established and monitored for their molecular and phenotypic properties during a 4-yr period. The number of P elements increased with time in all the lines but the rate of increase differed among lines. Fur...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
abstract::I have studied nucleotide polymorphism and linkage disequilibrium using multilocus data from 77 fragments, with an average length of fragments of 550 bp, in the deciduous tree Populus tremula (Salicaceae). The frequency spectrum across loci showed a modest excess of mutations segregating at low frequency and a marked ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.090431
更新日期:2008-09-01 00:00:00
abstract::Strains of Dictyostelium discoideum resistant to cobaltous chloride have been isolated at a frequency of approximately 10(-6). The resistant strains have one of three phenotypes, recessive to wild type, dominant to wild type and dominant to wild type but requiring the presence of cobaltous chloride to maintain resista...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::The Saccharomyces cerevisiae nuclear membrane is part of a complex nuclear envelope environment also containing chromatin, integral and peripheral membrane proteins, and large structures such as nuclear pore complexes (NPCs) and the spindle pole body. To study how properties of the nuclear membrane affect nuclear enve...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.119149
更新日期:2010-11-01 00:00:00
abstract::In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.178160
更新日期:2015-12-01 00:00:00
abstract::The transcription factors WHITE COLLAR-1 (WC-1) and WHITE COLLAR-2 (WC-2) interact to form a heterodimeric complex (WCC) that is essential for most of the light-mediated processes in Neurospora crassa. WCC also plays a distinct non-light-related role as the transcriptional activator in the FREQUENCY (FRQ)/WCC feedback...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Predicting the chromosomal location of mapped markers has been difficult because linkage maps do not reveal differences in crossover frequencies along the physical structure of chromosomes. Here we combine a physical crossover map based on the distribution of recombination nodules (RNs) on Solanum lycopersicum (tomato...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.074138
更新日期:2007-08-01 00:00:00
abstract::A study of DNA polymorphism and divergence was conducted for the cytosolic phosphoglucose isomerase (PGI:E.C.5.3.1.9) gene of five species of the mustard genus Leavenworthia: Leavenworthia stylosa, L. alabamica, L. crassa, L. uniflora, and L. torulosa. Sequences of an internal 2.3-kb PgiC gene region spanning exons 6-...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00