Chromatin organization and remodeling of interstitial telomeric sites during meiosis in the Mongolian gerbil (Meriones unguiculatus).

abstract：:The T-complex protein 1, TCP1, gene codes for the CCT-alpha subunit of the group II chaperonins. The gene was first described in the house mouse, in which it is closely linked to the T locus at a distance of approximately 11 cM from the Mhc. In the zebrafish, Danio rerio, in which the T homolog is linked to the class ...

journal_title：Genetics

authors： Takami K,Figueroa F,Mayer WE,Klein J

更新日期：2000-01-01 00:00:00

abstract：:Motile and immotile (or primary) cilia are microtubule-based structures that mediate multiple cellular functions, including the transduction of environmental cues, developmental signaling, cellular motility, and modulation of fluid flow. Although their core architectures are similar, motile and primary cilia exhibit m...

journal_title：Genetics

authors： Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE

更新日期：2017-12-01 00:00:00

abstract：:We have isolated a new class of deletion mutants of phage lambda that extend from the prophage attachment site, att, into the gam and cIII genes. In this respect they are similar to certain of the lambda pbio transducing phage, but they differ in having a low burst size and in forming minute plaques. Lytically grown s...

journal_title：Genetics

authors： Henderson D,Weil J

更新日期：1975-02-01 00:00:00

abstract：:Very few mutations derived from Mutator maize lines have been studied at the molecular level. The variety of Mu elements that can induce mutations, the relative frequency of mutant induction by insertion of a given class of Mu elements or by a Mu-induced genomic rearrangement, a possible intragenic insertion site spec...

journal_title：Genetics

authors： Brown WE,Robertson DS,Bennetzen JL

更新日期：1989-06-01 00:00:00

abstract：:The nucleotide sequences encoding the mature portion of 31 ribulose 1.5-bisphosphate carboxylase small subunit (SSU) genes from 17 genera of plants, green algae and cyanobacteria were examined. Among the 465 pairwise sequence comparisons, SSU multigene family members within the same species were more similar to each o...

journal_title：Genetics

authors： Meagher RB,Berry-Lowe S,Rice K

更新日期：1989-12-01 00:00:00

abstract：:Fisher's geometric model was originally introduced to argue that complex adaptations must occur in small steps because of pleiotropic constraints. When supplemented with the assumption of additivity of mutational effects on phenotypic traits, it provides a simple mechanism for the emergence of genotypic epistasis from...

journal_title：Genetics

authors： Hwang S,Park SC,Krug J

更新日期：2017-06-01 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae ectopic recombination has been shown to occur at high frequencies for artificially created repeats, but at relatively low frequencies for a natural family of repeated sequences, the Ty family. Little is known about the mechanism(s) that prevent recombination between repeated seque...

journal_title：Genetics

authors： Nevo-Caspi Y,Kupiec M

更新日期：1996-11-01 00:00:00

abstract：:Homothallic strains of Saccharomyes cerevisiae are able to switch efficiently from one mating genotype to another. From a single haploid spore arise both a and mating type cells, which then self-mate to produce a colony consisting almost exclusively of nonmating a/ diploid cells. We have isolated a mutant homothallic ...

journal_title：Genetics

authors： Haber JE,Garvik B

更新日期：1977-09-01 00:00:00

abstract：:Wright's method of estimating the number of genes contributing to the difference in a quantitative character between two populations involves observing the means and variances of the two parental populations and their hybrid populations. Although simple, Wright's method provides seriously biased estimates, largely due...

journal_title：Genetics

authors： Zeng ZB

更新日期：1992-08-01 00:00:00

abstract：:Natural populations of Daphnia magna have been found which are polymorphic for electrophoretic variants of supernatant malic dehydrogenase, esterase, and alkaline phosphatase. Using these enzyme variants as genetic markers it has been possible to demonstrate the absence of recombination during parthenogenetic reproduc...

journal_title：Genetics

authors： Hebert PD,Ward RD

更新日期：1972-08-01 00:00:00

abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

journal_title：Genetics

authors： Wagner M,Briza P,Pierce M,Winter E

更新日期：1999-04-01 00:00:00

abstract：:The primary structures of peptides may be adapted for efficient synthesis as well as proper function. Here, the Saccharomyces cerevisiae genome sequence, DNA microarray expression data, tRNA gene numbers, and functional categorizations of proteins are employed to determine whether the amino acid composition of peptide...

journal_title：Genetics

authors： Akashi H

更新日期：2003-08-01 00:00:00

abstract：:The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of interlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. T...

journal_title：Genetics

authors： Kelly JK

更新日期：1997-07-01 00:00:00

abstract：:Inverted DNA repeats are an at-risk motif for genetic instability that can induce both deletions and recombination in yeast. We investigated the role of the length of inverted repeats and size of the DNA separating the repeats for deletion and recombination. Stimulation of both deletion and recombination was directly ...

journal_title：Genetics

authors： Lobachev KS,Shor BM,Tran HT,Taylor W,Keen JD,Resnick MA,Gordenin DA

更新日期：1998-04-01 00:00:00

abstract：:In budding yeast, at least 10 proteins are required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Spo11 is the enzyme responsible for cleaving DNA and is found in a complex that also contains Ski8, Rec102, and Rec104. The Mre11/Rad50/Xrs2 complex is required for both DSB formati...

journal_title：Genetics

authors： Li J,Hooker GW,Roeder GS

更新日期：2006-08-01 00:00:00

abstract：:The Drosophila gene exuperantia (exu) is a maternal effect gene which is needed for proper localization of the bcd RNA during the formation of oocytes. We have extended the characterization of the exu phenotype and find that the gene functions in the male as well as the female germline. Six of seven exu alleles are ma...

journal_title：Genetics

authors： Hazelrigg T,Watkins WS,Marcey D,Tu C,Karow M,Lin XR

更新日期：1990-11-01 00:00:00

abstract：:We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling thos...

journal_title：Genetics

authors： Roux F,Colomé-Tatché M,Edelist C,Wardenaar R,Guerche P,Hospital F,Colot V,Jansen RC,Johannes F

更新日期：2011-08-01 00:00:00

abstract：:Several hypotheses and concepts have tended to oversimplify the problem of mutagenesis and can be misleading when used for genetic risk estimation. These include: (1) the hypothesis that radiation-induced mutation frequency depends primarily on the DNA content per haploid genome, (2) the extension of this concept to c...

journal_title：Genetics

authors： Russell WL

更新日期：1979-05-01 00:00:00

abstract：:The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mu...

journal_title：Genetics

authors： Acharya SN,Many AM,Schroeder AP,Kennedy FM,Savytskyy OP,Grubb JT,Vincent JA,Friedle EA,Celerin M,Maillet DS,Palmerini HJ,Greischar MA,Moncalian G,Williams RS,Tainer JA,Zolan ME

更新日期：2008-12-01 00:00:00

abstract：:In the absence of a vg+ gene, extensive cell death occurs in third instar imaginal discs, which results in a complete loss of adult wing margin structures. Essentially all molecularly characterized vg alleles are associated with deletions or insertions of DNA into the vg locus. These alterations reduce or eliminate a ...

journal_title：Genetics

authors： Williams JA,Scott IM,Atkin AL,Brook WJ,Russell MA,Bell JB

更新日期：1990-08-01 00:00:00

abstract：:We tested the hypothesis that the time course of the evolution of antifungal drug resistance depends on the ploidy of the fungus. The experiments were designed to measure the initial response to the selection imposed by the antifungal drug fluconazole up to and including the fixation of the first resistance mutation i...

journal_title：Genetics

authors： Anderson JB,Sirjusingh C,Ricker N

更新日期：2004-12-01 00:00:00

abstract：:Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...

journal_title：Genetics

authors： Hodgkin J

更新日期：1983-01-01 00:00:00

abstract：:Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties "Misuzud...

journal_title：Genetics

authors： Watanabe S,Xia Z,Hideshima R,Tsubokura Y,Sato S,Yamanaka N,Takahashi R,Anai T,Tabata S,Kitamura K,Harada K

更新日期：2011-06-01 00:00:00

abstract：:Distributive disjunction is defined as the first division meiotic segregation of either nonhomologous chromosomes that lack homologs or homologous chromosomes that have not recombined. To determine if chromosomes from the yeast Saccharomyces cerevisiae were capable of distributive disjunction, we constructed a strain ...

journal_title：Genetics

authors： Guacci V,Kaback DB

更新日期：1991-03-01 00:00:00

abstract：:Laboratory strains of mice are thought to be derived from wild populations of Mus domesticus. Many instances of non-domesticus genetic information fixed in these strains have been described, however, and the amount of strain-to-strain genetic variation exceeds that found in wild domesticus populations. In order to est...

journal_title：Genetics

authors： Blank RD,Campbell GR,D'Eustachio P

更新日期：1986-12-01 00:00:00

abstract：:We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...

journal_title：Genetics

authors： Spiliopoulou A,Colombo M,Orchard P,Agakov F,McKeigue P

更新日期：2017-05-01 00:00:00

abstract：:The lin-31 gene is required for the proper specification of vulval cell fates in the nematode Caenorhabditis elegans and encodes a member of the winged-helix family of transcription factors. Members of this important family have been identified in many organisms and are known to bind specific DNA targets involved in a...

journal_title：Genetics

authors： Miller LM,Hess HA,Doroquez DB,Andrews NM

更新日期：2000-12-01 00:00:00

abstract：:Serrate (Ser) is an essential gene in Drosophila melanogaster best known for the Ser dominant (SerD) allele and its effects on wing development. Animals heterozygous or homozygous for SerD are viable and exhibit loss of wing margin tissue and associated bristles and hairs. The Beaded of Goldschmidt (BdG) allele of Ser...

journal_title：Genetics

authors： Hukriede NA,Fleming RJ

更新日期：1997-02-01 00:00:00

abstract：:The micronutrient boron is essential in maintaining the structure of plant cell walls and is critical for high yields in crop species. Boron can move into plants by diffusion or by active and facilitated transport mechanisms. We recently showed that mutations in the maize boron efflux transporter ROTTEN EAR (RTE) caus...

journal_title：Genetics

authors： Chatterjee M,Liu Q,Menello C,Galli M,Gallavotti A

更新日期：2017-08-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00