Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature.

abstract：:A Plasmodium-refractory strain of Anopheles gambiae melanotically encapsulates many species of Plasmodium, whereas wild-type mosquitoes are usually susceptible. This encapsulation trait can also be observed by studying the response of refractory and susceptible strains to intrathoracically injected CM-Sephadex beads. ...

journal_title：Genetics

authors： Gorman MJ,Severson DW,Cornel AJ,Collins FH,Paskewitz SM

更新日期：1997-07-01 00:00:00

abstract：:Individuals within a species vary in their responses to a wide range of stimuli, partly as a result of differences in their genetic makeup. Relatively little is known about the genetic and neuronal mechanisms contributing to diversity of behavior in natural populations. By studying intraspecies variation in innate avo...

journal_title：Genetics

authors： Ghosh R,Bloom JS,Mohammadi A,Schumer ME,Andolfatto P,Ryu W,Kruglyak L

更新日期：2015-08-01 00:00:00

abstract：:A model is presented showing that natural selection operating at the individual level can adequately explain the evolution of multiple mating behavior by honey bee queens. Group selection need not be invoked. The fitness of a given female genotype is a function of the number of sex alleles in the population, the numbe...

journal_title：Genetics

authors： Page RE Jr

更新日期：1980-09-01 00:00:00

abstract：:We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associa...

journal_title：Genetics

authors： Smith LA,Peixoto AA,Kramer EM,Villella A,Hall JC

更新日期：1998-07-01 00:00:00

abstract：:The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the post...

journal_title：Genetics

authors： Hayashi S,Kondo T

更新日期：2018-06-01 00:00:00

abstract：:We describe here a family of P elements that we refer to as type I repressors. These elements are identified by their repressor functions and their lack of any deletion within the first two-thirds of the canonical P sequence. Elements belonging to this repressor class were isolated from P strains and were made in vitr...

journal_title：Genetics

authors： Gloor GB,Preston CR,Johnson-Schlitz DM,Nassif NA,Phillis RW,Benz WK,Robertson HM,Engels WR

更新日期：1993-09-01 00:00:00

abstract：:IS1 is one of the smallest transposable elements found in bacteria (768 bp). It contains eight overlapping open-reading-frames (ORFs) greater than 50 codons, designated insA to insG and insB'. To determine which of the ORFs actually code for proteins involved in transposition, we have introduced amber codons into each...

journal_title：Genetics

authors： Jakowec M,Prentki P,Chandler M,Galas DJ

更新日期：1988-09-01 00:00:00

abstract：:Post-transcriptional RNA processing is an important regulatory control mechanism for determining the phenotype of eukaryotic cells. The processing of a transcribed RNA species into alternative splice isoforms yields products that can perform different functions. Each type of cell in a multi-cellular organism is presum...

journal_title：Genetics

authors： Chisa JL,Burke DT

更新日期：2007-03-01 00:00:00

abstract：:X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress and X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, a...

journal_title：Genetics

authors： Meneely PM,Nordstrom KD

更新日期：1988-06-01 00:00:00

abstract：:Demonstrating that naturally occurring enzyme polymorphisms significantly impact metabolic pathway flux is a fundamental step in examining the possible adaptive significance of such polymorphisms. In earlier studies of the glucose-6-phosphate dehydrogenase (G6PD) polymorphism in Drosophila melanogaster, we used two di...

journal_title：Genetics

authors： Labate J,Eanes WF

更新日期：1992-11-01 00:00:00

abstract：:Availability of animal protein for human consumption is very low in the developing countries mainly because of low productivity of existing livestock; ways and means to improve productivity through breeding are discussed and some basic issues requiring further research pointed out. ...

journal_title：Genetics

authors： Rendel J

更新日期：1974-09-01 00:00:00

abstract：:A genetic strategy identified Salmonella typhimurium strains carrying large (> 40 kb) Tn 10-catalyzed inversions; the inverted segments were characterized by XbaI digestion and pulsed field gel electrophoresis. Two size classes of large inversions were found. More than half of the inversions extended 40-80 kb either c...

journal_title：Genetics

authors： Krug PJ,Gileski AZ,Code RJ,Torjussen A,Schmid MB

更新日期：1994-03-01 00:00:00

abstract：:Adaptive dynamics formalism demonstrates that, in a constant environment, a continuous trait may first converge to a singular point followed by spontaneous transition from a unimodal trait distribution into a bimodal one, which is called "evolutionary branching." Most previous analyses of evolutionary branching have b...

journal_title：Genetics

authors： Wakano JY,Iwasa Y

更新日期：2013-01-01 00:00:00

abstract：:Mutations in ilvO, the operator site for operon A of the ilv region of E. coli K-12, are reported to cause a cis dominant derepression of the operon A gene products and to map between ilvC and ilvA. Studies reported here demonstrate that the F25 episome which does not carry the region between ilvC and ilvA but only il...

journal_title：Genetics

authors： Cohen BM,Jones EW

更新日期：1976-06-01 00:00:00

abstract：:A study of spontaneous mutation in Arabidopsis thaliana was initiated from a single inbred Columbia founder; 120 lines were established and advanced 17 generations by single-seed descent. Here, we report an assay of reproductive traits in a random set of 40 lines from generations 8 and 17, grown together at the same t...

journal_title：Genetics

authors： Shaw RG,Byers DL,Darmo E

更新日期：2000-05-01 00:00:00

abstract：:The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which make N. furzeri a uniqu...

journal_title：Genetics

authors： Valenzano DR,Kirschner J,Kamber RA,Zhang E,Weber D,Cellerino A,Englert C,Platzer M,Reichwald K,Brunet A

更新日期：2009-12-01 00:00:00

abstract：:For most common diseases with heritable components, not a single or a few single-nucleotide polymorphisms (SNPs) explain most of the variance for these disorders. Instead, much of the variance may be caused by interactions (epistasis) among multiple SNPs or interactions with environmental conditions. We present a new ...

journal_title：Genetics

authors： Albrechtsen A,Castella S,Andersen G,Hansen T,Pedersen O,Nielsen R

更新日期：2007-06-01 00:00:00

abstract：:Genotype by environment interactions (GEI) play a major part in shaping the genetic architecture of quantitative traits and are confounding factors in genetic studies, for example, in attempts to associate genetic variation with disease susceptibility. It is generally not known what proportion of phenotypic variation ...

journal_title：Genetics

authors： Sambandan D,Carbone MA,Anholt RR,Mackay TF

更新日期：2008-06-01 00:00:00

abstract：:We analyzed the dynamics of transposable elements (TEs) according to Wright's island and continent-island models, assuming that selection tends to counter the deleterious effects of TEs. We showed that migration between host populations has no impact on either the existence or the stability of the TE copy number equil...

journal_title：Genetics

authors： Deceliere G,Charles S,Biémont C

更新日期：2005-01-01 00:00:00

abstract：:An association was found earlier between the Ep(1) gene locus coding for an endopeptidase and the endosperm color gene Y(1) on chromosome 6 of Zea mays. By employing primary trisomics we have unequivocally placed the Ep(1) gene on chromosome 6, closely linked to the Y(1) locus. Additionally we describe new alleles at ...

journal_title：Genetics

authors： Nielsen G,Scandalios JG

更新日期：1974-08-01 00:00:00

abstract：:In Drosophila melanogaster, the female sexual development of the soma and the germline requires the activity of the gene Sxl. The somatic cells need the function of the gene fl(2)d to follow the female developmental pathway, due to its involvement in the female-specific splicing of Sxl RNA. Here we report the analysis...

journal_title：Genetics

authors： Granadino B,San Juán A,Santamaria P,Sánchez L

更新日期：1992-03-01 00:00:00

abstract：:Intron sizes show an asymmetrical distribution in a number of organisms, with a large number of "short" introns clustered around a minimal intron length and a much broader distribution of longer introns. In Drosophila melanogaster, the short intron class is centered around 61 bp. The narrow length distribution suggest...

journal_title：Genetics

authors： Parsch J

更新日期：2003-12-01 00:00:00

abstract：:There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models...

journal_title：Genetics

authors： Anacleto O,Garcia-Cortés LA,Lipschutz-Powell D,Woolliams JA,Doeschl-Wilson AB

更新日期：2015-11-01 00:00:00

abstract：:We demonstrate that the previously described gene Androgen binding protein (Abp; Dlouhy and Karn, 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa). A study of recombinant inbred strains demonstrates that Abpa is located on chromosome 7 near Glucose phosphate isomerase...

journal_title：Genetics

authors： Dlouhy SR,Taylor BA,Karn RC

更新日期：1987-03-01 00:00:00

abstract：:The three-dimensional organization of polytene chromosomes within nuclei containing rearranged X chromosomes was examined in male Drosophila melanogaster. Salivary glands of third instar larvae containing either an inverted X chromosome (YSX.YL, In(1)EN/O) or a ring X chromosome (R(1) 2/BSYy+) were fixed, embedded, an...

journal_title：Genetics

authors： Mathog D,Sedat JW

更新日期：1989-02-01 00:00:00

abstract：:During animal development, transcription factor activities are modulated by several means, including subcellular localization. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax...

journal_title：Genetics

authors： Stevens KE,Mann RS

更新日期：2007-04-01 00:00:00

abstract：:The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expr...

journal_title：Genetics

authors： van der Linden AM,Wiener S,You YJ,Kim K,Avery L,Sengupta P

更新日期：2008-11-01 00:00:00

abstract：:The RAD54 gene, which encodes a protein in the SWI2/SNF2 family, plays an important role in recombination and DNA repair in Saccharomyces cerevisiae. The yeast genome project revealed a homologue of RAD54, RDH54/TID1. Properties of the rdh54/tid1 mutant and the rad54 rdh54/tid1 double mutant are shown for mitosis and ...

journal_title：Genetics

authors： Shinohara M,Shita-Yamaguchi E,Buerstedde JM,Shinagawa H,Ogawa H,Shinohara A

更新日期：1997-12-01 00:00:00

abstract：:Use of the CRISPR/Cas9 RNA-guided endonuclease complex has recently enabled the generation of double-strand breaks virtually anywhere in the C. elegans genome. Here, we present an improved strategy that makes all steps in the genome editing process more efficient. We have created a toolkit of template-mediated repair ...

journal_title：Genetics

authors： Norris AD,Kim HM,Colaiácovo MP,Calarco JA

更新日期：2015-10-01 00:00:00

abstract：:Signaling by the second messenger inositol 1,4,5-trisphosphate is thought to affect several developmental and physiological processes. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene of Drosophila exhibit delays in molting while stronger alleles are also larval lethal. In a freshly generated set of EM...

journal_title：Genetics

authors： Joshi R,Venkatesh K,Srinivas R,Nair S,Hasan G

更新日期：2004-01-01 00:00:00