A Genetic Screen for Pre-mRNA Splicing Mutants of Arabidopsis thaliana Identifies Putative U1 snRNP Components RBM25 and PRP39a.

abstract：:We have identified a new locus involved in gibberellin (GA) signal transduction by screening for suppressors of the Arabidopsis thaliana GA biosynthetic mutant gal-3. The locus is named RGA for repressor of gal-3. Based on the recessive phenotype of the digenic rga/gal-3 mutant, the wild-type gene product of RGA is pr...

journal_title：Genetics

authors： Silverstone AL,Mak PY,Martínez EC,Sun TP

更新日期：1997-07-01 00:00:00

abstract：:Differential gene expression across cell types underlies development and cell physiology in multicellular organisms. Caenorhabditis elegans is a powerful, extensively used model to address these biological questions. A remaining bottleneck relates to the difficulty to obtain comprehensive tissue-specific gene transcri...

journal_title：Genetics

authors： Gómez-Saldivar G,Osuna-Luque J,Semple JI,Glauser DA,Jarriault S,Meister P

更新日期：2020-12-01 00:00:00

abstract：:Thyroid hormone has pleiotropic effects on cochlear development, and genomic variation influences the severity of associated hearing deficits. DW/J-Pou1f1dw/dw mutant mice lack pituitary thyrotropin, which causes severe thyroid hormone deficiency and profound hearing impairment. To assess the genetic complexity of pro...

journal_title：Genetics

authors： Fang Q,Longo-Guess C,Gagnon LH,Mortensen AH,Dolan DF,Camper SA,Johnson KR

更新日期：2011-10-01 00:00:00

abstract：:Much of the material taken into cells by endocytosis is rapidly returned to the plasma membrane by the endocytic recycling pathway. Although recycling is vital for the correct localization of cell membrane receptors and lipids, the molecular mechanisms that regulate recycling are only partially understood. Here we sho...

journal_title：Genetics

authors： Nilsson L,Conradt B,Ruaud AF,Chen CC,Hatzold J,Bessereau JL,Grant BD,Tuck S

更新日期：2008-05-01 00:00:00

abstract：:Hybrid matings between the sexual species Poeciliopsis monacha and Poeciliopsis lucida produced a series of diploid all-female lineages of P. monacha-lucida that inhabit the Río Fuerte of northwestern Mexico. Restriction site analyses of mitochondrial DNA (mtDNA) clearly revealed that P. monacha was the maternal ances...

journal_title：Genetics

authors： Quattro JM,Avise JC,Vrijenhoek RC

更新日期：1991-02-01 00:00:00

abstract：:While a variety of methods have been developed to deal with incomplete parental genotype information in family-based association tests, sampling design issues with incomplete parental genotype data still have not received much attention. In this article, we present simulation studies with four genetic models and vario...

journal_title：Genetics

authors： Yang Q,Xu X,Laird N

更新日期：2003-05-01 00:00:00

abstract：:In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked ...

journal_title：Genetics

authors： Weissman DB,Hallatschek O

更新日期：2014-04-01 00:00:00

abstract：:Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...

journal_title：Genetics

authors： Alcazar RM,Lin R,Fire AZ

更新日期：2008-11-01 00:00:00

abstract：:Mta is a cell surface antigen of the mouse and serves as a target for specific T killer lymphocytes. Using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including Mus molossinus, Mus castaneu...

journal_title：Genetics

authors： Lindahl KF,Hausmann B

更新日期：1983-03-01 00:00:00

abstract：:This study examines the intrinsic fitness burden associated with RNA polymerase (rpoB) mutations conferring rifampin resistance in Escherichia coli K12 (MG1655) and explores the nature of adaptation to the costs of resistance. Among 28 independent Rif(r) mutants, the per-generation fitness burden (in the absence of ri...

journal_title：Genetics

authors： Reynolds MG

更新日期：2000-12-01 00:00:00

abstract：:The pathogenic life cycle of the rice blast fungus Magnaporthe oryzae involves a series of morphogenetic changes, essential for its ability to cause disease. The smo mutation was identified > 25 years ago, and affects the shape and development of diverse cell types in M. oryzae, including conidia, appressoria, and asc...

journal_title：Genetics

authors： Kershaw MJ,Basiewicz M,Soanes DM,Yan X,Ryder LS,Csukai M,Oses-Ruiz M,Valent B,Talbot NJ

更新日期：2019-01-01 00:00:00

abstract：:Plant breeders make selection decisions based on multiple traits, such as yield, plant height, flowering time, and disease resistance. A commonly used approach in multi-trait genomic selection is index selection, which assigns weights to different traits relative to their economic importance. However, classical index ...

journal_title：Genetics

authors： Moeinizade S,Kusmec A,Hu G,Wang L,Schnable PS

更新日期：2020-08-01 00:00:00

abstract：:NudC encodes a protein of unknown biochemical function that is required for nuclear migration. In an attempt to define its function by identifying interacting proteins, a screen for extragenic suppressors of the temperature-sensitive nudC3 mutation was undertaken that identified nine snc genes. Here we demonstrate tha...

journal_title：Genetics

authors： Chiu YH,Morris NR

更新日期：1997-03-01 00:00:00

abstract：:The application of quantitative genetics in plant and animal breeding has largely focused on additive models, which may also capture dominance and epistatic effects. Partitioning genetic variance into its additive and nonadditive components using pedigree-based models (P-genomic best linear unbiased predictor) (P-BLUP...

journal_title：Genetics

authors： Muñoz PR,Resende MF Jr,Gezan SA,Resende MD,de Los Campos G,Kirst M,Huber D,Peter GF

更新日期：2014-12-01 00:00:00

abstract：:Drosophila adult leg development provides an ideal model system for characterizing the molecular mechanisms of hormone-triggered morphogenesis. A pulse of the steroid hormone ecdysone at the onset of metamorphosis triggers the rapid transformation of a flat leg imaginal disc into an immature adult leg, largely through...

journal_title：Genetics

authors： Ward RE,Evans J,Thummel CS

更新日期：2003-11-01 00:00:00

abstract：:In Saccharomyces cerevisiae, silencers flanking the HML and HMR loci initiate the establishment of transcriptional silencing. We demonstrate that the activity of a silencer pertaining to its potency and directionality is dependent on its genomic position. The context of the HML-E silencer is more permissive to silence...

journal_title：Genetics

authors： Zou Y,Yu Q,Chiu YH,Bi X

更新日期：2006-09-01 00:00:00

abstract：:The rate of decline in reproductive fitness in populations of Drosophila melanogaster inbred at an initial rate of approximately 1% per generation has been investigated under both competitive and noncompetitive conditions. Breeding population size was variable in the inbred lines with an estimated harmonic mean of 66....

journal_title：Genetics

authors： Latter BD,Mulley JC,Reid D,Pascoe L

更新日期：1995-01-01 00:00:00

abstract：:Florida teosinte from Honduras and Guanajuato teosinte have most of their knobs internally located and a common inversion in the short arm of chromosome 8. Teosintes from northern Guatemala, Huixta and Monajil, have all their knobs terminally located and do not have any inversions. Therefore, Florida teosinte from Hon...

journal_title：Genetics

authors： Ting YC

更新日期：1976-08-01 00:00:00

abstract：:A common theme in medical microbiology is that the amount of amino acid sequence variation in proteins that are targets of the host immune system greatly exceeds that found in metabolic enzymes or other housekeeping proteins. Twenty-four Mycobacterium tuberculosis genes coding for targets of the host immune system wer...

journal_title：Genetics

authors： Musser JM,Amin A,Ramaswamy S

更新日期：2000-05-01 00:00:00

abstract：:We leverage two complementary Drosophila melanogaster mapping panels to genetically dissect starvation resistance-an important fitness trait. Using >1600 genotypes from the multiparental Drosophila Synthetic Population Resource (DSPR), we map numerous starvation stress QTL that collectively explain a substantial fract...

journal_title：Genetics

authors： Everman ER,McNeil CL,Hackett JL,Bain CL,Macdonald SJ

更新日期：2019-04-01 00:00:00

abstract：:Laterality is believed to have genetic components, as has been deduced from family studies in humans and responses to artificial selection in mice, but these genetic components are unknown and the underlying physiological mechanisms are still a subject of dispute. We measured direction of laterality (preferential use ...

journal_title：Genetics

authors： Roubertoux PL,Le Roy I,Tordjman S,Cherfou A,Migliore-Samour D

更新日期：2003-03-01 00:00:00

abstract：:Mendelian loci that control the expression levels of transcripts are called expression quantitative trait loci (eQTL). When mapping eQTL, we often deal with thousands of expression traits simultaneously, which complicates the statistical model and data analysis. Two simple approaches may be taken in eQTL analysis: (1)...

journal_title：Genetics

authors： Jia Z,Xu S

更新日期：2007-05-01 00:00:00

abstract：:The genetic requirements for spontaneous and transcription-stimulated mitotic recombination were determined using a recombination system that employs heterochromosomal lys2 substrates that can recombine only by crossover or only by gene conversion. The substrates were fused either to a constitutive low-level promoter ...

journal_title：Genetics

authors： Freedman JA,Jinks-Robertson S

更新日期：2002-09-01 00:00:00

abstract：:The extent of conservation of synteny and gene order in the Lepidoptera has been investigated previously only by comparing a small subset of linkage groups between the moth Bombyx mori and the butterfly Heliconius melpomene. Here we report the mapping of 64 additional conserved genes in H. melpomene, which contributed...

journal_title：Genetics

authors： Pringle EG,Baxter SW,Webster CL,Papanicolaou A,Lee SF,Jiggins CD

更新日期：2007-09-01 00:00:00

abstract：:Using an insertional mutagenesis approach, a series of Neurospora crassa mutants affected in the ability to control entry into the conidiation developmental program were isolated. One such mutant, GTH16-T4, was found to lack normal vegetative hyphae and to undergo constitutive conidiation. The affected gene has been n...

journal_title：Genetics

authors： Kothe GO,Free SJ

更新日期：1998-05-01 00:00:00

abstract：:I reexamine the use of isolation by distance models as a basis for the estimation of demographic parameters from measures of population subdivision. To that aim, I first provide results for values of F-statistics in one-dimensional models and coalescence times in two-dimensional models, and make more precise earlier r...

journal_title：Genetics

authors： Rousset F

更新日期：1997-04-01 00:00:00

abstract：:Methodology for mapping quantitative trait loci (QTL) has focused primarily on treating the QTL as a fixed effect. These methods differ from the usual models of genetic variation that treat genetic effects as random. Computationally expensive methods that allow QTL to be treated as random have been explicitly develope...

journal_title：Genetics

authors： Zimmer D,Mayer M,Reinsch N

更新日期：2011-01-01 00:00:00

abstract：:Self-incompatibility (SI) is a genetic system found in some hermaphrodite plants. Recognition of pollen by pistils expressing cognate specificities at two linked genes leads to rejection of self pollen and pollen from close relatives, i.e., to avoidance of self-fertilization and inbred matings, and thus increased outc...

journal_title：Genetics

authors： Gervais CE,Castric V,Ressayre A,Billiard S

更新日期：2011-07-01 00:00:00

abstract：:Plant endo-beta-1,3-glucanases (EGases) degrade the cell wall polysaccharides of attacking pathogens and release elicitors of additional plant defenses. Isozymes EGaseA and EGaseB of soybean differ in susceptibility to a glucanase inhibitor protein (GIP1) produced by Phytophthora sojae, a major soybean pathogen. EGase...

journal_title：Genetics

authors： Bishop JG,Ripoll DR,Bashir S,Damasceno CM,Seeds JD,Rose JK

更新日期：2005-02-01 00:00:00

abstract：:Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determin...

journal_title：Genetics

authors： Koval TM,Hart RW,Myser WC,Hink WF

更新日期：1977-11-01 00:00:00