Linkage disequilibrium for two X-linked genes in Sardinia and its bearing on the statistical mapping of the human X chromosome.

Abstract:

:The distribution of four X-linked mutants (G6PD, Deutan, Protan and Xg) among lowland and once highly malarial populations of Sardinia discloses a clear-cut example of linkage disequiligrium between two of them (G6PD and Protan). In the same populations the distribution of G6PD-deficiency versus colorblindness of the Deutan type and the Xg blood-group is not significantly different from that expected at equilibrium. These data suggest indirectly that the loci for G6PD and Protan may be nearer to one another than those for G6PD and Deutan.

journal_name

Genetics

journal_title

Genetics

authors

Filippi G,Rinaldi A,Palmarino R,Seravalli E,Siniscalco M

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

199-212

issue

1

eissn

0016-6731

issn

1943-2631

journal_volume

86

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Estimating Linear and Nonlinear Gene Coexpression Networks by Semiparametric Neighborhood Selection.

    abstract::Whereas nonlinear relationships between genes are acknowledged, there exist only a few methods for estimating nonlinear gene coexpression networks or gene regulatory networks (GCNs/GRNs) with common deficiencies. These methods often consider only pairwise associations between genes, and are, therefore, poorly capable ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.120.303186

    authors: Kontio JAJ,Rinta-Aho MJ,Sillanpää MJ

    更新日期:2020-07-01 00:00:00

  • A map-based cloning strategy employing a residual heterozygous line reveals that the GIGANTEA gene is involved in soybean maturity and flowering.

    abstract::Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties "Misuzud...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.110.125062

    authors: Watanabe S,Xia Z,Hideshima R,Tsubokura Y,Sato S,Yamanaka N,Takahashi R,Anai T,Tabata S,Kitamura K,Harada K

    更新日期:2011-06-01 00:00:00

  • End joining at Caenorhabditis elegans telomeres.

    abstract::Critically shortened telomeres can be subjected to DNA repair events that generate end-to-end chromosome fusions. The resulting dicentric chromosomes can enter breakage-fusion-bridge cycles, thereby impeding elucidation of the structures of the initial fusion events and a mechanistic understanding of their genesis. Cu...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.089920

    authors: Lowden MR,Meier B,Lee TW,Hall J,Ahmed S

    更新日期:2008-10-01 00:00:00

  • Rapid detection of positive selection in genes and genomes through variation clusters.

    abstract::Positive selection in genes and genomes can point to the evolutionary basis for differences among species and among races within a species. The detection of positive selection can also help identify functionally important protein regions and thus guide protein engineering. Many existing tests for positive selection ar...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.074732

    authors: Wagner A

    更新日期:2007-08-01 00:00:00

  • Nonlinear tests for genomewide association studies.

    abstract::As millions of single-nucleotide polymorphisms (SNPs) have been identified and high-throughput genotyping technologies have been rapidly developed, large-scale genomewide association studies are soon within reach. However, since a genomewide association study involves a large number of SNPs it is therefore nearly impo...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.060491

    authors: Zhao J,Jin L,Xiong M

    更新日期:2006-11-01 00:00:00

  • Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans.

    abstract::Meiotic recombination depends upon the tightly coordinated regulation of chromosome dynamics and is essential for the production of haploid gametes. Central to this process is the formation and repair of meiotic double-stranded breaks (DSBs), which must take place within the constraints of a specialized chromatin arch...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.300686

    authors: Turcotte CA,Sloat SA,Rigothi JA,Rosenkranse E,Northrup AL,Andrews NP,Checchi PM

    更新日期:2018-03-01 00:00:00

  • Marker-based cloning of the region containing the UhAvr1 avirulence gene from the basidiomycete barley pathogen Ustilago hordei.

    abstract::Race-cultivar specialization during the interaction of the basidiomycete smut pathogen Ustilago hordei with its barley host was described in the 1940s. Subsequent genetic analyses revealed the presence of dominant avirulence genes in the pathogen that conform to the gene-for-gene theory. This pathosystem therefore pre...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.166.1.99

    authors: Linning R,Lin D,Lee N,Abdennadher M,Gaudet D,Thomas P,Mills D,Kronstad JW,Bakkeren G

    更新日期:2004-01-01 00:00:00

  • Extended Region of Nodulation Genes in Rhizobium meliloti 1021. II. Nucleotide Sequence, Transcription Start Sites and Protein Products.

    abstract::We have established the DNA sequence and analyzed the transcription and translation products of a series of putative nodulation (nod) genes in Rhizobium meliloti strain 1021. Four loci have been designated nodF, nodE, nodG and nodH. The correlation of transposon insertion positions with phenotypes and open reading fra...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Fisher RF,Swanson JA,Mulligan JT,Long SR

    更新日期:1987-10-01 00:00:00

  • The genetic architecture of Drosophila sensory bristle number.

    abstract::We have mapped quantitative trait loci (QTL) for Drosophila mechanosensory bristle number in six recombinant isogenic line (RIL) mapping populations, each of which was derived from an isogenic chromosome extracted from a line selected for high or low, sternopleural or abdominal bristle number and an isogenic wild-type...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Dilda CL,Mackay TF

    更新日期:2002-12-01 00:00:00

  • VNTR allele frequency distributions under the stepwise mutation model: a computer simulation approach.

    abstract::Variable numbers of tandem repeats (VNTRs) are a class of highly informative and widely dispersed genetic markers. Despite their wide application in biological science, little is known about their mutational mechanisms or population dynamics. The objective of this work was to investigate four summary measures of VNTR ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shriver MD,Jin L,Chakraborty R,Boerwinkle E

    更新日期:1993-07-01 00:00:00

  • Does diploidy increase the rate of adaptation?

    abstract::Explanations of the evolution of diploidy have focused on the advantages gained from masking deleterious alleles. Recent theory has shown, however, that masking does not always provide an advantage to diploidy and would never favor diploidy in predominantly asexual organisms. We explore a neglected alternative theory ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Orr HA,Otto SP

    更新日期:1994-04-01 00:00:00

  • Spontaneous mutation in Escherichia coli containing the dnaE911 DNA polymerase antimutator allele.

    abstract::We have previously isolated mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants have a mutation in the dnaE gene, encoding the alpha subunit of DNA polymerase III. They were isolated in a mismatch-repair-defective mutL background, in which mutations can be considered to represen...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Oller AR,Schaaper RM

    更新日期:1994-10-01 00:00:00

  • Genetic Fine Structure Analysis of the AMYLOSE-EXTENDER Locus in ZEA MAYS L.

    abstract::On the basis of interallelic recombination frequencies measured in diallelic crosses of the 5 amylose-extender alleles in maize, ae, B1, B3, M2 and i1, it was possible to construct a unique linear genetic map ordering all 5 alleles within the locus. The reciprocal diallelic crosses each gave comparable frequency estim...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Moore CW,Creech RG

    更新日期:1972-04-01 00:00:00

  • Modes of Selection Maintaining an Inversion Polymorphism in DROSOPHILA PAULISTORUM.

    abstract::The possibility that fitness relationships associated with an inversion polymorphism in D. paulistorum were frequency dependent was investigated. Using allozymes of tetrazolium oxidase to mark inversions, the effects of genotype frequency, larval density, and culture conditions on fitness were assessed. The proportion...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Gromko MH,Richmond RC

    更新日期:1978-02-01 00:00:00

  • A penalized-likelihood method to estimate the distribution of selection coefficients from phylogenetic data.

    abstract::We develop a maximum penalized-likelihood (MPL) method to estimate the fitnesses of amino acids and the distribution of selection coefficients (S = 2Ns) in protein-coding genes from phylogenetic data. This improves on a previous maximum-likelihood method. Various penalty functions are used to penalize extreme estimate...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.114.162263

    authors: Tamuri AU,Goldman N,dos Reis M

    更新日期:2014-05-01 00:00:00

  • Insights into mutagenesis using Escherichia coli chromosomal lacZ strains that enable detection of a wide spectrum of mutational events.

    abstract::Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.127746

    authors: Seier T,Padgett DR,Zilberberg G,Sutera VA Jr,Toha N,Lovett ST

    更新日期:2011-06-01 00:00:00

  • Type I repressors of P element mobility.

    abstract::We describe here a family of P elements that we refer to as type I repressors. These elements are identified by their repressor functions and their lack of any deletion within the first two-thirds of the canonical P sequence. Elements belonging to this repressor class were isolated from P strains and were made in vitr...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Gloor GB,Preston CR,Johnson-Schlitz DM,Nassif NA,Phillis RW,Benz WK,Robertson HM,Engels WR

    更新日期:1993-09-01 00:00:00

  • A Critical Role for Dna2 at Unwound Telomeres.

    abstract::Dna2 is a nuclease and helicase that functions redundantly with other proteins in Okazaki fragment processing, double-strand break resection, and checkpoint kinase activation. Dna2 is an essential enzyme, required for yeast and mammalian cell viability. Here, we report that numerous mutations affecting the DNA damage ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.300809

    authors: Markiewicz-Potoczny M,Lisby M,Lydall D

    更新日期:2018-05-01 00:00:00

  • Regulation of sex determination in mice by a non-coding genomic region.

    abstract::To identify novel genomic regions that regulate sex determination, we utilized the powerful C57BL/6J-Y(POS) (B6-Y(POS)) model of XY sex reversal where mice with autosomes from the B6 strain and a Y chromosome from a wild-derived strain, Mus domesticus poschiavinus (Y(POS)), show complete sex reversal. In B6-Y(POS), th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.113.160259

    authors: Arboleda VA,Fleming A,Barseghyan H,Délot E,Sinsheimer JS,Vilain E

    更新日期:2014-07-01 00:00:00

  • Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes.

    abstract::In multigene families, variation among loci and alleles can contribute to trait evolution. We explored patterns of functional and genetic variation in six duplicated Arabidopsis thaliana trypsin inhibitor (ATTI) loci. We demonstrate significant variation in constitutive and herbivore-induced transcription among ATTI l...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.166.3.1419

    authors: Clauss MJ,Mitchell-Olds T

    更新日期:2004-03-01 00:00:00

  • Precise mapping of the homothallism genes HML and HMR in Saccharomyces cerevisiae.

    abstract::The HML and HMR loci carry unexpressed copies of MATa and MAT alpha information, and a replica of that information is transposed to MAT during mating-type interchange in Saccharomyces yeasts. A negative control mechanism keeps silent the information located at the HML and HMR loci. We mapped these loci by constructing...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Klar AJ,McIndoo J,Hicks JB,Strathern JN

    更新日期:1980-10-01 00:00:00

  • The amino terminus of the Saccharomyces cerevisiae DNA helicase Rrm3p modulates protein function altering replication and checkpoint activity.

    abstract::The Pif1 family of DNA helicases is conserved from yeast to humans. Although the helicase domains of family members are well conserved, the amino termini of these proteins are not. The Saccharomyces cerevisiae genome encodes two Pif1 family members, Rrm3p and Pif1p, that have very different functions. To determine if ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.028035

    authors: Bessler JB,Zakian VA

    更新日期:2004-11-01 00:00:00

  • Localized mutagenesis for the isolation of temperature-sensitive mutants of Escherichia coli affected in protein synthesis.

    abstract::Two variations of the method of localized mutagenesis were used to introduce mutations into the 72 min region of the Escherichia coli chromosome. Twenty temperature-sensitive mutants, with linkage to markers in this region, have been examined. Each strain showed an inhibition of growth in liquid medium at 44 degrees, ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Champney WS

    更新日期:1979-02-01 00:00:00

  • Amylase Variation in the Salt Marsh Amphipod, GAMMARUS PALUSTRIS.

    abstract::There are two common alleles at the Amylase-2 locus in populations of Gammarus palustris, the salt marsh amphipod. Intensive sampling of individuals from two localities at Jamaica Bay revealed a consistent pattern of heterozygote deficiency.-Five possible sources of heterozygote deficiency were examined in this study....

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Borowsky R,Borowsky B,Milani H,Greenberg P

    更新日期:1985-10-01 00:00:00

  • The SOS and RpoS Regulons Contribute to Bacterial Cell Robustness to Genotoxic Stress by Synergistically Regulating DNA Polymerase Pol II.

    abstract::Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stre...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.199471

    authors: Dapa T,Fleurier S,Bredeche MF,Matic I

    更新日期:2017-07-01 00:00:00

  • Yeast Mn2+ transporter, Smf1p, is regulated by ubiquitin-dependent vacuolar protein sorting.

    abstract::Conditional cdc1(Ts) mutants of S. cerevisiae arrest with a phenotype similar to that exhibited by Mn(2+)-depleted cells. Sequence similarity between Cdc1p and a class of Mn(2+)-dependent phosphoesterases, as well as the observation that conditional cdc1(Ts) growth can be ameliorated by Mn(2+) supplement, suggests tha...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.167.1.107

    authors: Eguez L,Chung YS,Kuchibhatla A,Paidhungat M,Garrett S

    更新日期:2004-05-01 00:00:00

  • Estimating differential reproductive success from nests of related individuals, with application to a study of the mottled sculpin, Cottus bairdi.

    abstract::Understanding how variation in reproductive success is related to demography is a critical component in understanding the life history of an organism. Parentage analysis using molecular markers can be used to estimate the reproductive success of different groups of individuals in natural populations. Previous models h...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.067066

    authors: Jones B,Grossman GD,Walsh DC,Porter BA,Avise JC,Fiumera AC

    更新日期:2007-08-01 00:00:00

  • The population genetics of adaptation: multiple substitutions on a smooth fitness landscape.

    abstract::Much recent work in the theoretical study of adaptation has focused on the so-called strong selection-weak mutation (SSWM) limit, wherein adaptation is due to new mutations of definite selective advantage. This work, in turn, has focused on the first step (substitution) during adaptive evolution. Here we extend this t...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.109.106757

    authors: Unckless RL,Orr HA

    更新日期:2009-11-01 00:00:00

  • Patterns of recombination and MLH1 foci density along mouse chromosomes: modeling effects of interference and obligate chiasma.

    abstract::Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.070235

    authors: Falque M,Mercier R,Mézard C,de Vienne D,Martin OC

    更新日期:2007-07-01 00:00:00

  • The genetic control of apomixis: asexual seed formation.

    abstract::Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.114.163105

    authors: Hand ML,Koltunow AM

    更新日期:2014-06-01 00:00:00