Abstract：
:Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.
journal_name
Geneticsjournal_title
Geneticsauthors
Ard R,Allshire RC,Marquardt Sdoi
10.1534/genetics.117.300095subject
Has Abstractpub_date
2017-10-01 00:00:00pages
357-367issue
2eissn
0016-6731issn
1943-2631pii
genetics.117.300095journal_volume
207pub_type
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