Multi-trait Genome-Wide Analyses of the Brain Imaging Phenotypes in UK Biobank.

abstract：:Meiosis and spore formation in the yeast Saccharomyces cerevisiae are associated with increased expression of sporulation-specific genes. One of these genes, IME2, encodes a putative protein kinase that is a positive regulator of other sporulation-specific genes. We have isolated mutations that cause reduced expressio...

journal_title：Genetics

authors： Su SS,Mitchell AP

更新日期：1993-01-01 00:00:00

abstract：:Conditional cdc1(Ts) mutants of S. cerevisiae arrest with a phenotype similar to that exhibited by Mn(2+)-depleted cells. Sequence similarity between Cdc1p and a class of Mn(2+)-dependent phosphoesterases, as well as the observation that conditional cdc1(Ts) growth can be ameliorated by Mn(2+) supplement, suggests tha...

journal_title：Genetics

authors： Eguez L,Chung YS,Kuchibhatla A,Paidhungat M,Garrett S

更新日期：2004-05-01 00:00:00

abstract：:Very few mutations derived from Mutator maize lines have been studied at the molecular level. The variety of Mu elements that can induce mutations, the relative frequency of mutant induction by insertion of a given class of Mu elements or by a Mu-induced genomic rearrangement, a possible intragenic insertion site spec...

journal_title：Genetics

authors： Brown WE,Robertson DS,Bennetzen JL

更新日期：1989-06-01 00:00:00

abstract：:In this work we study how mutations that change physical properties of cell proteins (stability) affect population survival and growth. We present a model in which the genotype is presented as a set folding free energies of cell proteins. Mutations occur upon replication, so stabilities of some proteins in daughter ce...

journal_title：Genetics

authors： Chen P,Shakhnovich EI

更新日期：2009-10-01 00:00:00

abstract：:The evidence in support of two types of alternate disjunction in translocation heterozygotes from the German cockroach, Blattella germanica (L.), is reviewed. When unique cytomorphological features occur in the translocation figure, the two types of alternate disjunction are identifiable regardless of the angle of obs...

journal_title：Genetics

authors： Cochran DG

更新日期：1983-05-01 00:00:00

abstract：:This paper draws attention to the formal parallelism that exists between chromosomal-loss mosaicism and mutagenically induced mosaicism in Drosophila and suggests that, although the underlying processes by which these two types of genetic mosaics are generated are very different, the more refined methodology employed ...

journal_title：Genetics

authors： Nissani M

更新日期：1977-08-01 00:00:00

abstract：:An analysis of the effects of spontaneous mutations affecting age-specific mortality was conducted using 29 lines of Drosophila melanogaster that had accumulated spontaneous mutations for 19 generations. Divergence among the lines was used to estimate the mutational variance for weekly mortality rates and the covarian...

journal_title：Genetics

authors： Pletcher SD,Houle D,Curtsinger JW

更新日期：1998-01-01 00:00:00

abstract：:The external genitalia are some of the most rapidly evolving morphological structures in insects. The posterior lobe of the male genital arch shows striking differences in both size and shape among closely related species of the Drosophila melanogaster species subgroup. Here, we dissect the genetic basis of posterior ...

journal_title：Genetics

authors： Masly JP,Dalton JE,Srivastava S,Chen L,Arbeitman MN

更新日期：2011-09-01 00:00:00

abstract：:We have identified two Saccharomyces cerevisiae genes that, in high copy, confer resistance to Kluyveromyces lactis zymocin, an inhibitor that blocks cells in the G(1) phase of the cell cycle prior to budding and DNA replication. One gene (GRX3) encodes a glutaredoxin and is likely to act at the level of zymocin entry...

journal_title：Genetics

authors： Jablonowski D,Butler AR,Fichtner L,Gardiner D,Schaffrath R,Stark MJ

更新日期：2001-12-01 00:00:00

abstract：:The micronutrient boron is essential in maintaining the structure of plant cell walls and is critical for high yields in crop species. Boron can move into plants by diffusion or by active and facilitated transport mechanisms. We recently showed that mutations in the maize boron efflux transporter ROTTEN EAR (RTE) caus...

journal_title：Genetics

authors： Chatterjee M,Liu Q,Menello C,Galli M,Gallavotti A

更新日期：2017-08-01 00:00:00

abstract：:The fixation of a beneficial allele in a population leaves a well-characterized signature in patterns of nucleotide variation at linked sites. This signature can be used to estimate the time since fixation from patterns of polymorphism in extant individuals. I introduce a method to assess the support in polymorphism d...

journal_title：Genetics

authors： Przeworski M

更新日期：2003-08-01 00:00:00

abstract：:In fission yeast, regulation of p34cdc2 plays an important role in the checkpoint coupling mitosis to completion of DNA replication. The cdc2 mutations cdc2-3w (C67Y) and cdc2-4w (C67F) abolish checkpoint control without seriously affecting normal cell proliferation. However the molecular basis of this phenotype is no...

journal_title：Genetics

authors： Basi G,Enoch T

更新日期：1996-12-01 00:00:00

abstract：:Several human pathogens (e.g., Bacillus anthracis, Yersinia pestis, Bordetella pertussis, Plasmodium falciparum, and Mycobacterium tuberculosis) have very restricted unselected allelic variation in structural genes, which hinders study of the genetic relationships among strains and strain-trait correlations. To addres...

journal_title：Genetics

authors： Gutacker MM,Smoot JC,Migliaccio CA,Ricklefs SM,Hua S,Cousins DV,Graviss EA,Shashkina E,Kreiswirth BN,Musser JM

更新日期：2002-12-01 00:00:00

abstract：:Trans-species polymorphism, meaning the presence of alleles in different species that are more similar to each other than they are to alleles in the same species, has been found at loci associated with vegetative incompatibility in filamentous fungi. If individuals differ at one or more of these loci (termed het for h...

journal_title：Genetics

authors： Muirhead CA,Glass NL,Slatkin M

更新日期：2002-06-01 00:00:00

abstract：:Cyclic guanosine monophosphate (cGMP) is a key secondary messenger used in signal transduction in various types of sensory neurons. The importance of cGMP in the ASE gustatory receptor neurons of the nematode Caenorhabditis elegans was deduced by the observation that multiple receptor-type guanylyl cyclases (rGCs), en...

journal_title：Genetics

authors： Smith HK,Luo L,O'Halloran D,Guo D,Huang XY,Samuel AD,Hobert O

更新日期：2013-08-01 00:00:00

abstract：:Bacteriophages are the most abundant biological entities in our biosphere, characterized by their hyperplasticity, mosaic composition, and the many unknown functions (ORFans) encoded by their immense genetic repertoire. These genes are potentially maintained by the bacteriophage to allow efficient propagation on hosts...

journal_title：Genetics

authors： Ang D,Georgopoulos C

更新日期：2012-03-01 00:00:00

abstract：:BTB-zinc finger transcription factors play many important roles in metazoan development. In these proteins, the BTB domain is critical for dimerization and for recruiting cofactors to target genes. Identification of these cofactors is important for understanding how BTB-zinc finger proteins influence transcription. He...

journal_title：Genetics

authors： Howell K,Arur S,Schedl T,Sundaram MV

更新日期：2010-04-01 00:00:00

abstract：:Studying phage codon adaptation is important not only for understanding the process of translation elongation, but also for reengineering phages for medical and industrial purposes. To evaluate the effect of mutation and selection on phage codon usage, we developed an index to measure selection imposed by host transla...

journal_title：Genetics

authors： Chithambaram S,Prabhakaran R,Xia X

更新日期：2014-05-01 00:00:00

abstract：:We consider inference for demographic models and parameters based upon postprocessing the output of an MCMC method that generates samples of genealogical trees (from the posterior distribution for a specific prior distribution of the genealogy). This approach has the advantage of taking account of the uncertainty in t...

journal_title：Genetics

authors： Meligkotsidou L,Fearnhead P

更新日期：2007-09-01 00:00:00

abstract：:Translocation induced in the immature oocyte, in meiotic prophase, affects division I orientation and segregation, the usual result being that the two halves of translocations are directed to opposite poles. Since interchange is usually (if not exclusively) between chromatids, this is to be expected from the creation ...

journal_title：Genetics

authors： Parker DR,Williamson JH

更新日期：1974-09-01 00:00:00

abstract：:Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous re...

journal_title：Genetics

authors： Singer JB,Hill AE,Nadeau JH,Lander ES

更新日期：2005-02-01 00:00:00

abstract：:An exact sampling formula for a Wright-Fisher population of fixed size N under the infinitely many neutral alleles model is deduced. This extends the Ewens formula for the configuration of a random sample to the case where the sample is drawn from a population of small size, that is, without the usual large-N and smal...

journal_title：Genetics

authors： Lessard S

更新日期：2007-10-01 00:00:00

abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...

journal_title：Genetics

authors： Beckwith EJ,Hernando CE,Polcowñuk S,Bertolin AP,Mancini E,Ceriani MF,Yanovsky MJ

更新日期：2017-10-01 00:00:00

abstract：:Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of ev...

journal_title：Genetics

authors： Heasley LR,Watson RA,Argueso JL

更新日期：2020-09-01 00:00:00

abstract：:In S. commune the frequency of recombination between the two subunits, alpha and beta, of the B incompatibility factor is genetically controlled. Analysis of the progeny obtained from crosses between high- and low-recombining strains indicates that the gene controlling recombination frequency in the B factor is linked...

journal_title：Genetics

authors： Koltin Y,Stamberg J

更新日期：1973-05-01 00:00:00

abstract：:Nucleosome-depleted regions (NDRs) are present immediately adjacent to the transcription start site in most eukaryotic promoters. Here we show that NDRs in the upstream promoter region can profoundly affect gene regulation. Chromatin at the yeast HO promoter is highly repressive and numerous coactivators are required ...

journal_title：Genetics

authors： Yarrington RM,Goodrum JM,Stillman DJ

更新日期：2016-02-01 00:00:00

abstract：:A mouse homolog of the Drosophila pair-rule gene Odd Oz (Odz4) maps to the critical region of the l7Rn3 locus on mouse chromosome 7. Here we show that Odz4 is an excellent candidate for this allelic series because (1) it spans the entire critical region, (2) the phenotypes correlate with embryonic expression, (3) the ...

journal_title：Genetics

authors： Lossie AC,Nakamura H,Thomas SE,Justice MJ

更新日期：2005-01-01 00:00:00

abstract：:An association was found earlier between the Ep(1) gene locus coding for an endopeptidase and the endosperm color gene Y(1) on chromosome 6 of Zea mays. By employing primary trisomics we have unequivocally placed the Ep(1) gene on chromosome 6, closely linked to the Y(1) locus. Additionally we describe new alleles at ...

journal_title：Genetics

authors： Nielsen G,Scandalios JG

更新日期：1974-08-01 00:00:00

abstract：:Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type II topoisomera...

journal_title：Genetics

authors： Hohl AM,Thompson M,Soshnev AA,Wu J,Morris J,Hsieh TS,Wu CT,Geyer PK

更新日期：2012-11-01 00:00:00

abstract：:Age-specific effects of spontaneous mutations on mortality rates in Drosophila are inferred from three large demographic experiments. Data were collected from inbred lines that were allowed to accumulate spontaneous mutations for 10, 19, and 47 generations. Estimates of age-specific mutational variance for mortality w...

journal_title：Genetics

authors： Pletcher SD,Houle D,Curtsinger JW

更新日期：1999-10-01 00:00:00