An exact sampling formula for the Wright-Fisher model and a solution to a conjecture about the finite-island model.

abstract：:Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spe...

journal_title：Genetics

authors： Ono BI,Fujimoto R,Ohno Y,Maeda N,Tsuchiya Y,Usui T,Ishino-Arao Y

更新日期：1988-01-01 00:00:00

abstract：:The specification of floral organ identity in the higher dicots depends on the function of a limited set of homeotic genes, many of them members of the MADS-box gene family. Two such genes, APETALA3 (AP3) and PISTILLATA (PI), are required for petal and stamen identity in Arabidopsis; their orthologs in Antirrhinum exh...

journal_title：Genetics

authors： Kramer EM,Dorit RL,Irish VF

更新日期：1998-06-01 00:00:00

abstract：:We recently described a yeast assay suitable for genetic screening in which simple religation nonhomologous end-joining (NHEJ) and single-strand annealing (SSA) compete for repair of an I-SceI-created double-strand break. Here, the required allele has been introduced into an array of 4781 MATa deletion mutants and eac...

journal_title：Genetics

authors： Wilson TE

更新日期：2002-10-01 00:00:00

abstract：:Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies of the a or alpha mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. The lack of expression of the a and alpha genes at the silent loci results from repression by trans-acting regulators encoded by SI...

journal_title：Genetics

authors： Rine J,Herskowitz I

更新日期：1987-05-01 00:00:00

abstract：:Two protocols are presented that allow the selection of mutations mapping to micronuclear chromosome 5 in Tetrahymena thermophilia. One protocol involves crossing mutagenized diploid cells directly to a strain nullisomic for chromosome 5 and screening the monosomic progeny for a mutant phenotype. The second protocol f...

journal_title：Genetics

authors： Altschuler MI,Bruns PJ

更新日期：1984-03-01 00:00:00

abstract：:As part of our investigation of disease resistance in lettuce, we generated mutants that have lost resistance to Bremia lactucae, the casual fungus of downy mildew. Using a rapid and reliable screen, we identified 16 distinct mutants of Latuca sativa that have lost activity of one of four different downy mildew resist...

journal_title：Genetics

authors： Okubara PA,Anderson PA,Ochoa OE,Michelmore RW

更新日期：1994-07-01 00:00:00

abstract：:Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabi...

journal_title：Genetics

authors： Teuscher F,Broman KW

更新日期：2007-03-01 00:00:00

abstract：:Salient features of recombination at ARG4 of Saccharomyces provoke a variation of the double-strand-break repair (DSBR) model that has the following features: (1) Holliday junction cutting is biased in favor of strands upon which DNA synthesis occurred during formation of the joint molecule (this bias ensures that cut...

journal_title：Genetics

authors： Foss HM,Hillers KJ,Stahl FW

更新日期：1999-10-01 00:00:00

abstract：:Caenorhabditis elegans' behavioral states, like those of other animals, are shaped by its immediate environment, its past experiences, and by internal factors. We here review the literature on C. elegans behavioral states and their regulation. We discuss dwelling and roaming, local and global search, mate finding, sle...

journal_title：Genetics

authors： Flavell SW,Raizen DM,You YJ

更新日期：2020-10-01 00:00:00

abstract：:As hamster scrapie cannot infect mice, due to sequence differences in their PrP proteins, we find "species barriers" to transmission of the [URE3] prion in Saccharomyces cerevisiae among Ure2 proteins of S. cerevisiae, paradoxus, bayanus, cariocanus, and mikatae on the basis of differences among their Ure2p prion doma...

journal_title：Genetics

authors： Edskes HK,McCann LM,Hebert AM,Wickner RB

更新日期：2009-03-01 00:00:00

abstract：:Twelve mutations affecting nuclear migration, a major developmental phase in Schizophyllum commune, display a complex pattern of complementation and recombination. They are expressed only when a genetic factor controlling this phase of development, the B incompatibility factor, is operative. All twelve mutations are l...

journal_title：Genetics

authors： Dubovoy C

更新日期：1976-03-01 00:00:00

abstract：:Primary cilia have essential roles in transducing signals in eukaryotes. At their core is the ciliary axoneme, a microtubule-based structure that defines cilium morphology and provides a substrate for intraflagellar transport. However, the extent to which axonemal microtubules are specialized for sensory cilium functi...

journal_title：Genetics

authors： Hurd DD,Miller RM,Núñez L,Portman DS

更新日期：2010-07-01 00:00:00

abstract：:This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performan...

journal_title：Genetics

authors： Pan W,Kim J,Zhang Y,Shen X,Wei P

更新日期：2014-08-01 00:00:00

abstract：:We consider resequencing studies of associated loci and the problem of prioritizing sequence variants for functional follow-up. Working within the multivariate linear regression framework helps us to account for the joint effects of multiple genes; and adopting a Bayesian approach leads to posterior probabilities that...

journal_title：Genetics

authors： Stell L,Sabatti C

更新日期：2016-02-01 00:00:00

abstract：:Although the role of U1 small nuclear RNAs (snRNAs) in 5' splice site recognition is well established, suppressor U1 snRNAs active in intact multicellular animals have been lacking. Here we describe suppression of a 5' splice site mutation in the Drosophila melanogaster white gene (wDR18) by compensatory changes in U1...

journal_title：Genetics

authors： Lo PC,Roy D,Mount SM

更新日期：1994-10-01 00:00:00

abstract：:A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals....

journal_title：Genetics

authors： Fu YX

更新日期：1997-08-01 00:00:00

abstract：:To identify hypothesized missing components of the synaptic G alpha(o)-G alpha(q) signaling network, which tightly regulates neurotransmitter release, we undertook two large forward genetic screens in the model organism C. elegans and focused first on mutations that strongly rescue the paralysis of ric-8(md303) reduct...

journal_title：Genetics

authors： Schade MA,Reynolds NK,Dollins CM,Miller KG

更新日期：2005-02-01 00:00:00

abstract：:Escherichia coli K12 does not metabolize beta-glucosides such as arbutin and salicin because of lack of expression of the bglBSRC operon, which contains structural genes for transport (bglC) and hydrolysis (bglB) of phospho-beta-glucosides. Mutants carrying lesions in the cis-acting regulatory site bglR metabolize bet...

journal_title：Genetics

authors： Defez R,De Felice M

更新日期：1981-01-01 00:00:00

abstract：:Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...

journal_title：Genetics

authors： Eustice M,Pillus L

更新日期：2014-04-01 00:00:00

abstract：:The standard slipped-strand mispairing (SSM) model for the formation of variable number tandem repeats (VNTRs) proposes that a few tandem repeats, produced by chance mutations, provide the "raw material" for VNTR expansion. However, this model is unlikely to explain the formation of VNTRs with long motifs (e.g., minis...

journal_title：Genetics

authors： Taylor JS,Breden F

更新日期：2000-07-01 00:00:00

abstract：:The fission yeast DNA repair gene rad21+ is essential for cell growth. To investigate the function essential for cell proliferation, we have isolated a temperature-sensitive mutant of the rad21+ gene. The mutant, rad21-K1, showed abnormal mitosis at the nonpermissive temperature. Some cells contained abnormal nuclear ...

journal_title：Genetics

authors： Tatebayashi K,Kato J,Ikeda H

更新日期：1998-01-01 00:00:00

abstract：:We compared allele sequences of two loci near the Arabidopsis lyrata self-incompatibility (S) loci with sequences of A. thaliana orthologs and found high numbers of shared polymorphisms, even excluding singletons and sites likely to be highly mutable. This suggests maintenance of entire S-haplotypes for long evolution...

journal_title：Genetics

authors： Charlesworth D,Kamau E,Hagenblad J,Tang C

更新日期：2006-04-01 00:00:00

abstract：:We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...

journal_title：Genetics

authors： Spiliopoulou A,Colombo M,Orchard P,Agakov F,McKeigue P

更新日期：2017-05-01 00:00:00

abstract：:The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon s...

journal_title：Genetics

authors： Petersen L,Enos-Berlage J,Downs DM

更新日期：1996-05-01 00:00:00

abstract：:While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years,...

journal_title：Genetics

authors： Kato A,Kurashima K,Chae M,Sawada S,Hatakeyama S,Tanaka S,Inoue H

更新日期：2010-08-01 00:00:00

abstract：:The level of activity of the enzyme glucose-6-phosphate dehydrogenase was determinel in flies having seven different chromosomic constitutions. All those having an integral number of chromosomes [XAA, XXAA, XAAA, XXAAA, and XXXAAA (X=Xchromosome, A=set of autosomes)] were found to have similar units of enzyme activity...

journal_title：Genetics

authors： Maroni G,Plaut W

更新日期：1973-06-01 00:00:00

abstract：:Our understanding of the cellular mechanisms by which animals regulate their response to starvation is limited, despite the strong relevance of the problem to major human health issues. The L1 diapause of Caenorhabditis elegans, where first-stage larvae arrest in response to a food-less environment, is an excellent sy...

journal_title：Genetics

authors： Cui M,Wang Y,Cavaleri J,Kelson T,Teng Y,Han M

更新日期：2017-02-01 00:00:00

abstract：:Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties "Misuzud...

journal_title：Genetics

authors： Watanabe S,Xia Z,Hideshima R,Tsubokura Y,Sato S,Yamanaka N,Takahashi R,Anai T,Tabata S,Kitamura K,Harada K

更新日期：2011-06-01 00:00:00

abstract：:Differential gene expression across cell types underlies development and cell physiology in multicellular organisms. Caenorhabditis elegans is a powerful, extensively used model to address these biological questions. A remaining bottleneck relates to the difficulty to obtain comprehensive tissue-specific gene transcri...

journal_title：Genetics

authors： Gómez-Saldivar G,Osuna-Luque J,Semple JI,Glauser DA,Jarriault S,Meister P

更新日期：2020-12-01 00:00:00

abstract：:Repair of double-strand breaks (DSBs) in chromosomal DNA by nonhomologous end-joining (NHEJ) is not well characterized in the yeast Saccharomyces cerevisiae. Here we demonstrate that several genes associated with NHEJ perform essential functions in the repair of endonuclease-induced DSBs in vivo. Galactose-induced exp...

journal_title：Genetics

authors： Lewis LK,Westmoreland JW,Resnick MA

更新日期：1999-08-01 00:00:00