Multiplicative vs. arbitrary gene action in heterosis.

abstract：:There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models...

journal_title：Genetics

authors： Anacleto O,Garcia-Cortés LA,Lipschutz-Powell D,Woolliams JA,Doeschl-Wilson AB

更新日期：2015-11-01 00:00:00

abstract：:Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...

journal_title：Genetics

authors： Falque M,Mercier R,Mézard C,de Vienne D,Martin OC

更新日期：2007-07-01 00:00:00

abstract：:The phenomenon of heterosis describes the increased agronomic performance of heterozygous F(1) plants compared to their homozygous parental inbred plants. Heterosis is manifested during the early stages of root development in maize. The goal of this study was to identify nonadditive gene expression in primary roots of...

journal_title：Genetics

authors： Hoecker N,Keller B,Muthreich N,Chollet D,Descombes P,Piepho HP,Hochholdinger F

更新日期：2008-07-01 00:00:00

abstract：:The nonparametric bootstrap approach is known to be suitable for calculating central confidence intervals for the locations of quantitative trait loci (QTL). However, the distribution of the bootstrap QTL position estimates along the chromosome is peaked at the positions of the markers and is not tailed equally. This ...

journal_title：Genetics

authors： Bennewitz J,Reinsch N,Kalm E

更新日期：2002-04-01 00:00:00

abstract：:The Drosophila mei-S332 gene acts to maintain sister-chromatid cohesion before anaphase II of meiosis in both males and females. By isolating and analyzing seven new alleles and a deficiency uncovering the mei-S332 gene we have demonstrated that the onset of the requirement for mei-S332 is not until late anaphase I. A...

journal_title：Genetics

authors： Kerrebrock AW,Miyazaki WY,Birnby D,Orr-Weaver TL

更新日期：1992-04-01 00:00:00

abstract：:The Sex-Ratio (SR) phenomenon is associated with the X chromosome of many species of Drosophila. Males carrying SR transmit predominantly sperm bearing the X chromosome. SR, therefore, has a very significant advantage in segregation. This paper provides an experimental analysis of the role of virility selection in pre...

journal_title：Genetics

authors： Wu CI

更新日期：1983-11-01 00:00:00

abstract：:A causal link between deficiency of the cytochrome respiratory pathway and life span was previously shown in the filamentous fungus Podospora anserina. To gain more insight into the relationship between mitochondrial function and life span, we have constructed a strain carrying a thermosensitive mutation of the gene o...

journal_title：Genetics

authors： Sellem CH,Lemaire C,Lorin S,Dujardin G,Sainsard-Chanet A

更新日期：2005-03-01 00:00:00

abstract：:Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is ...

journal_title：Genetics

authors： Smith KN,Miller SC,Varani G,Calabrese JM,Magnuson T

更新日期：2019-12-01 00:00:00

abstract：:Phytochromes play an important role in light signaling and photoperiodic control of flowering time in plants. Here we propose that the red/far-red light photoreceptor HvPHYTOCHROME C (HvPHYC), carrying a mutation in a conserved region of the GAF domain, is a candidate underlying the early maturity 5 locus in barley (H...

journal_title：Genetics

authors： Pankin A,Campoli C,Dong X,Kilian B,Sharma R,Himmelbach A,Saini R,Davis SJ,Stein N,Schneeberger K,von Korff M

更新日期：2014-09-01 00:00:00

abstract：:The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have...

journal_title：Genetics

authors： Qian W,Zhang J

更新日期：2008-08-01 00:00:00

abstract：:A study of spontaneous mutation in Arabidopsis thaliana was initiated from a single inbred Columbia founder; 120 lines were established and advanced 17 generations by single-seed descent. Here, we report an assay of reproductive traits in a random set of 40 lines from generations 8 and 17, grown together at the same t...

journal_title：Genetics

authors： Shaw RG,Byers DL,Darmo E

更新日期：2000-05-01 00:00:00

abstract：:The third hypervariable (V3) region of the HIV-1 gp120 protein is responsible for many aspects of viral infectivity. The tertiary structure of the V3 loop seems to influence the coreceptor usage of the virus, which is an important determinant of HIV pathogenesis. Hence, the information about preferred conformations of...

journal_title：Genetics

authors： Watabe T,Kishino H,Okuhara Y,Kitazoe Y

更新日期：2006-03-01 00:00:00

abstract：:The neurogenic loci comprise a small group of genes which are required for proper division between the neural and epidermal pathways of differentiation within the neuroectoderm. Loss of neurogenic gene function results in the misrouting of prospective epidermal cells into neuroblasts. A molecular analysis of the neuro...

journal_title：Genetics

authors： Yedvobnick B,Smoller D,Young P,Mills D

更新日期：1988-03-01 00:00:00

abstract：:A combination of nuclear and chloroplast simple sequence repeats (SSRs) have been used to investigate the levels and pattern of variability detected in Glycine max and G. soja genotypes. Based on the analysis of 700 soybean genotypes with 115 restriction fragment length polymorphism (RFLP) probes, 12 accessions were i...

journal_title：Genetics

authors： Powell W,Morgante M,Doyle JJ,McNicol JW,Tingey SV,Rafalski AJ

更新日期：1996-10-01 00:00:00

abstract：:Using the biological species definition, yeasts of the genus Saccharomyces sensu stricto comprise six species and one natural hybrid. Previous work has shown that reproductive isolation between the species is due primarily to sequence divergence acted upon by the mismatch repair system and not due to major gene differ...

journal_title：Genetics

authors： Liti G,Barton DB,Louis EJ

更新日期：2006-10-01 00:00:00

abstract：:In order to define more precisely the most proximal portion of chromosome 3R in Drosophila melanogaster, several new chromosome aberrations involving this region have been recovered and analyzed. These new arrangements were recovered as induced reversions of two dominant mutations, ANTPNs and dsxD, located in the regi...

journal_title：Genetics

authors： Duncan IW,Kaufman TC

更新日期：1975-08-01 00:00:00

abstract：:Retrotransposons are mobile genetic elements that colonize eukaryotic genomes by replicating through an RNA intermediate. As retrotransposons can move within the host genome, defense mechanisms have evolved to repress their potential mutagenic activities. In the fission yeast Schizosaccharomyces pombe, the mRNA of Tf2...

journal_title：Genetics

authors： Mallet PL,Larochelle M,Bachand F

更新日期：2017-02-01 00:00:00

abstract：:Cytoplasmic male sterility (CMS), the maternally inherited failure to produce functional pollen, has been used in the breeding of sugar beet (Beta vulgaris ssp. vulgaris). At least three different sources of CMS can be distinguished from one another as well as from normal fertile cytoplasm by polymorphisms in their mi...

journal_title：Genetics

authors： Nishizawa S,Mikami T,Kubo T

更新日期：2007-11-01 00:00:00

abstract：:Conditional lethal mutant systems developed in T-even bacteriophages T2, T4 and T6 have been used to study the partial exclusion which characterizes mixed infections of these phages. In bacteria mixedly infected with T2 and T4, the dominant phage (T4) acts against localized exclusion sensitivity determinants in the ge...

journal_title：Genetics

authors： Russell RL,Huskey RJ

更新日期：1974-12-01 00:00:00

abstract：:The back-to-back geometry of sister kinetochores is essential in preventing loss or damage of chromosomes during mitosis. Kinetochore orientation is generated in part by a process of resolving kinetochores at the centromere (centromere resolution) prior to spindle interactions. Because few of the genes required for ce...

journal_title：Genetics

authors： Stanvitch G,Moore LL

更新日期：2008-01-01 00:00:00

abstract：:The mutation process at microsatellite loci typically occurs at high rates and with stepwise changes in allele sizes, features that may introduce bias when using classical measures of population differentiation based on allele identity (e.g., F(ST), Nei's Ds genetic distance). Allele size-based measures of differentia...

journal_title：Genetics

authors： Hardy OJ,Charbonnel N,Fréville H,Heuertz M

更新日期：2003-04-01 00:00:00

abstract：:We test models for the evolution of helical regions of RNA sequences, where the base pairing constraint leads to correlated compensatory substitutions occurring on either side of the pair. These models are of three types: 6-state models include only the four Watson-Crick pairs plus GU and UG; 7-state models include a ...

journal_title：Genetics

authors： Savill NJ,Hoyle DC,Higgs PG

更新日期：2001-01-01 00:00:00

abstract：:The DNA-binding protein encoded by the zeste gene of Drosophila activates transcription and mediates interchromosomal interactions such as transvection. The mutant protein encoded by the zeste1 (z1) allele retains the ability to support transvection, but represses white. Similar to transvection, repression requires Ze...

journal_title：Genetics

authors： Rosen C,Dorsett D,Jack J

更新日期：1998-04-01 00:00:00

abstract：:This study examines the intrinsic fitness burden associated with RNA polymerase (rpoB) mutations conferring rifampin resistance in Escherichia coli K12 (MG1655) and explores the nature of adaptation to the costs of resistance. Among 28 independent Rif(r) mutants, the per-generation fitness burden (in the absence of ri...

journal_title：Genetics

authors： Reynolds MG

更新日期：2000-12-01 00:00:00

abstract：:The Caenorhabditis elegans gene gld-1 is essential for oocyte development; in gld-1 (null) hermaphrodites, a tumor forms where oogenesis would normally occur. We use genetic epistasis analysis to demonstrate that tumor formation is dependent on the sexual fate of the germline. When the germline sex determination pathw...

journal_title：Genetics

authors： Francis R,Maine E,Schedl T

更新日期：1995-02-01 00:00:00

abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...

journal_title：Genetics

authors： Desai MM,Plotkin JB

更新日期：2008-12-01 00:00:00

abstract：:A major correlation has been found between the incidence of glucocorticoid-induced cleft palate and the chromosome 8 segment identified by N-acetyl transferase in mice. The resistant strain became fully susceptible while the susceptible strain became resistant when this chromosomal region, representing less than 0.7% ...

journal_title：Genetics

authors： Karolyi J,Erickson RP,Liu S,Killewald L

更新日期：1990-09-01 00:00:00

abstract：:In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...

journal_title：Genetics

authors： Sarot E,Payen-Groschêne G,Bucheton A,Pélisson A

更新日期：2004-03-01 00:00:00

abstract：:We subjected the genes encoding the 19.3-, 21.3c-, and 51-kDa iron-sulfur subunits of respiratory chain complex I from Neurospora crassa to site-directed mutagenesis to mimic mutations in human complex I subunits associated with mitochondrial diseases. The V135M substitution was introduced into the 19.3-kDa cDNA, the ...

journal_title：Genetics

authors： Duarte M,Schulte U,Ushakova AV,Videira A

更新日期：2005-09-01 00:00:00

abstract：:Functional analyses of the Arabidopsis genome require analysis of the gametophytic generation, since approximately 10% of the genes are expressed in the male gametophyte and approximately 9% in the female gametophyte. Here we describe the genetic and molecular characterization of 67 Ds insertion lines that show reduce...

journal_title：Genetics

authors： Boavida LC,Shuai B,Yu HJ,Pagnussat GC,Sundaresan V,McCormick S

更新日期：2009-04-01 00:00:00