Ty1 copy number dynamics in Saccharomyces.

abstract：:The reproductive success of individual fire ant queens (Solenopsis invicta) previously has been shown to be strongly influenced by their genotype at a single enzyme-encoding gene, designated Pgm-3. This paper presents evidence that a second, tightly linked gene, designated Gp-9, is under similarly strong selection in ...

journal_title：Genetics

authors： Ross KG

更新日期：1997-04-01 00:00:00

abstract：:An AluI family of highly reiterated nontranscribed sequences has been found in the genome of the honeybee Apis mellifera. This repeated sequence is shown to be present at approximately 23,000 copies per haploid genome constituting about 2% of the total genomic DNA. The nucleotide sequence of 10 monomers was determined...

journal_title：Genetics

authors： Tarès S,Cornuet JM,Abad P

更新日期：1993-08-01 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae ectopic recombination has been shown to occur at high frequencies for artificially created repeats, but at relatively low frequencies for a natural family of repeated sequences, the Ty family. Little is known about the mechanism(s) that prevent recombination between repeated seque...

journal_title：Genetics

authors： Nevo-Caspi Y,Kupiec M

更新日期：1996-11-01 00:00:00

abstract：:Three previously described genes, enhancer of yellow, 1, 2 and 3, are shown to cooperate with the zeste gene in the control of white gene expression. The mutations e(y)1u1, e(y)3u1, and to a lesser extent e(y)2u1, enhance the effect of the zeste null allele zv77h. Different combinations of e(y)1u1, e(y)2u1 and e(y)3u1...

journal_title：Genetics

authors： Georgiev PG

更新日期：1994-11-01 00:00:00

abstract：:The heterochromatin of the third chromosome is the largest uncharacterized region of the Drosophila melanogaster genome, and the last major block of D. melanogaster heterochromatin to be thoroughly analyzed. In the present study, this region was genetically dissected by generating and analyzing a series of attached, d...

journal_title：Genetics

authors： Marchant GE,Holm DG

更新日期：1988-10-01 00:00:00

abstract：:Studying phage codon adaptation is important not only for understanding the process of translation elongation, but also for reengineering phages for medical and industrial purposes. To evaluate the effect of mutation and selection on phage codon usage, we developed an index to measure selection imposed by host transla...

journal_title：Genetics

authors： Chithambaram S,Prabhakaran R,Xia X

更新日期：2014-05-01 00:00:00

abstract：:Efficient haplotyping in pedigrees is important for the fine mapping of quantitative trait locus (QTL) or complex disease genes. To reconstruct haplotypes efficiently for a large pedigree with a large number of linked loci, two algorithms based on conditional probabilities and likelihood computations are presented. Th...

journal_title：Genetics

authors： Gao G,Hoeschele I,Sorensen P,Du F

更新日期：2004-08-01 00:00:00

abstract：:The Drosophila melanogaster Chd3 gene encodes a member of the CHD group of SNF2/RAD54 ATPases. CHD proteins are conserved from yeast to man and many are subunits of chromatin-remodeling complexes that facilitate transcription. Drosophila CHD3 proteins are not found in protein complexes, but as monomers that remodel ch...

journal_title：Genetics

authors： Cooper MT,Conant AW,Kennison JA

更新日期：2010-07-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences; however, mechanisms by which these deletions arise are unknown. A limitatio...

journal_title：Genetics

authors： Kalifa L,Quintana DF,Schiraldi LK,Phadnis N,Coles GL,Sia RA,Sia EA

更新日期：2012-03-01 00:00:00

abstract：:Yip1p is the first identified Rab-interacting membrane protein and the founder member of the YIP1 family, with both orthologs and paralogs found in all eukaryotic genomes. The exact role of Yip1p is unclear; YIP1 is an essential gene and defective alleles severely disrupt membrane transport and inhibit ER vesicle budd...

journal_title：Genetics

authors： Chen CZ,Calero M,DeRegis CJ,Heidtman M,Barlowe C,Collins RN

更新日期：2004-12-01 00:00:00

abstract：:Four-cutter molecular polymorphism of Adh and P6, and chromosome inversion polymorphism of chromosome II were investigated in 95 isogenic lines of an Ivory Coast population of Drosophila melanogaster, a species assumed to have recently spread throughout the world from a West African origin. The P6 gene showed little l...

journal_title：Genetics

authors： Bénassi V,Aulard S,Mazeau S,Veuille M

更新日期：1993-07-01 00:00:00

abstract：:When individuals' fitnesses depend on the genetic composition of the population in which they are found, selection is then frequency dependent. Frequency-dependent selection (FDS) is often invoked as a heuristic explanation for the maintenance of large numbers of alleles at a locus. The pairwise interaction model is a...

journal_title：Genetics

authors： Trotter MV,Spencer HG

更新日期：2007-07-01 00:00:00

abstract：:The morphogenetic pathway of bacteriophage phi X 174 was investigated in rep mutant hosts that specifically block stage III single-stranded DNA synthesis. The defects conferred by the mutant rep protein most likely affect the formation or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediat...

journal_title：Genetics

authors： Ekechukwu MC,Oberste DJ,Fane BA

更新日期：1995-08-01 00:00:00

abstract：:The change in the frequency of a rare mutant allele under constant sex-differentiated viability selection in an infinite, partial full-sib mating population is studied. The diplo-diploid and haplo-diploid polygynous models are considered with a Poisson distribution for the number of offspring produced by every mated f...

journal_title：Genetics

authors： Lessard S

更新日期：2005-09-01 00:00:00

abstract：:We have examined the effects of prolonged histidine deprivation on the reversion of Salmonella typhimurium histidine auxotrophs containing either hisG46, a missense mutation (CTC----CCC), or hisG428, an ochre mutation (CAA----TAA). Both of these mutants can revert to His+ via intragenic and extragenic mechanisms. Wher...

journal_title：Genetics

authors： Prival MJ,Cebula TA

更新日期：1992-10-01 00:00:00

abstract：:Mutations in maternally transmitted symbionts can affect host fitness. In this study we investigate a mutation in an obligate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid hosts (Acyrthosiphon pisum). The heat-sensitive allele arises through a single base deletion in a ho...

journal_title：Genetics

authors： Burke GR,McLaughlin HJ,Simon JC,Moran NA

更新日期：2010-09-01 00:00:00

abstract：:Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda r...

journal_title：Genetics

authors： Hofnung M

更新日期：1974-02-01 00:00:00

abstract：:A spontaneous antimycin A-resistant mutant carrying approximately four extra copies of ADH2 on chromosome XII was isolated from yeast strain 315-1D which lacks a functional copy of ADH1 and thus is antimycin A-sensitive. The additional copies of the normally glucose-repressed ADH2 are expressed during growth on glucos...

journal_title：Genetics

authors： Paquin CE,Dorsey M,Crable S,Sprinkel K,Sondej M,Williamson VM

更新日期：1992-02-01 00:00:00

abstract：:The behavior of chromosomal inversions in Escherichia coli depends upon the region they affect. Regions flanking the replication terminus have been termed nondivisible zones (NDZ) because inversions ending in the region were either deleterious or not feasible. This regional phenomenon is further analyzed here. Thirty ...

journal_title：Genetics

authors： Guijo MI,Patte J,del Mar Campos M,Louarn JM,Rebollo JE

更新日期：2001-04-01 00:00:00

abstract：:Obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. We hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. Comparisons of i...

journal_title：Genetics

authors： Kelkar YD,Ochman H

更新日期：2013-01-01 00:00:00

abstract：:Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (...

journal_title：Genetics

authors： Funkhouser SA,Vazquez AI,Steibel JP,Ernst CW,Los Campos G

更新日期：2020-05-01 00:00:00

abstract：:Post-transcriptional RNA processing is an important regulatory control mechanism for determining the phenotype of eukaryotic cells. The processing of a transcribed RNA species into alternative splice isoforms yields products that can perform different functions. Each type of cell in a multi-cellular organism is presum...

journal_title：Genetics

authors： Chisa JL,Burke DT

更新日期：2007-03-01 00:00:00

abstract：:Inverted DNA repeats are an at-risk motif for genetic instability that can induce both deletions and recombination in yeast. We investigated the role of the length of inverted repeats and size of the DNA separating the repeats for deletion and recombination. Stimulation of both deletion and recombination was directly ...

journal_title：Genetics

authors： Lobachev KS,Shor BM,Tran HT,Taylor W,Keen JD,Resnick MA,Gordenin DA

更新日期：1998-04-01 00:00:00

abstract：:Understanding which genes contribute to evolutionary change and the nature of the alterations in them are fundamental challenges in evolution. We analyzed regulatory and enzymatic genes in the maize anthocyanin pathway as related to the evolution of anthocyanin-pigmented kernels in maize from colorless kernels of its ...

journal_title：Genetics

authors： Hanson MA,Gaut BS,Stec AO,Fuerstenberg SI,Goodman MM,Coe EH,Doebley JF

更新日期：1996-07-01 00:00:00

abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...

journal_title：Genetics

authors： Keightley PD

更新日期：1994-12-01 00:00:00

abstract：:The extent of conservation of synteny and gene order in the Lepidoptera has been investigated previously only by comparing a small subset of linkage groups between the moth Bombyx mori and the butterfly Heliconius melpomene. Here we report the mapping of 64 additional conserved genes in H. melpomene, which contributed...

journal_title：Genetics

authors： Pringle EG,Baxter SW,Webster CL,Papanicolaou A,Lee SF,Jiggins CD

更新日期：2007-09-01 00:00:00

abstract：:The HML and HMR loci carry unexpressed copies of MATa and MAT alpha information, and a replica of that information is transposed to MAT during mating-type interchange in Saccharomyces yeasts. A negative control mechanism keeps silent the information located at the HML and HMR loci. We mapped these loci by constructing...

journal_title：Genetics

authors： Klar AJ,McIndoo J,Hicks JB,Strathern JN

更新日期：1980-10-01 00:00:00

abstract：:Prions have revived interest in hereditary change that is due to change in cellular structure. How pervasive is structural inheritance and what are its mechanisms? Described here is the initial characterization of [Leu(P)], a heritable structural change of the mitochondrion of Saccharomyces cerevisiae that often but n...

journal_title：Genetics

authors： Lockshon D

更新日期：2002-08-01 00:00:00

abstract：:While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years,...

journal_title：Genetics

authors： Kato A,Kurashima K,Chae M,Sawada S,Hatakeyama S,Tanaka S,Inoue H

更新日期：2010-08-01 00:00:00

abstract：:Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcri...

journal_title：Genetics

authors： Zhang H,Emmons SW

更新日期：2002-02-01 00:00:00