Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex.

Abstract:

:Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.

journal_name

Genetics

journal_title

Genetics

authors

Zhang H,Emmons SW

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

799-803

issue

2

eissn

0016-6731

issn

1943-2631

journal_volume

160

pub_type

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