Abstract：
:Obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. We hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. Comparisons of interaction networks among six bacteria that have varied genome sizes (Mycoplasma pneumoniae, Treponema pallidum, Helicobacter pylori, Campylobacter jejuni, Synechocystis sp., and Mycobacterium tuberculosis) reveal that proteins in small genomes interact with proteins from a wider range of functions than do their orthologs in larger genomes. This suggests that surviving proteins form increasingly complex functional relationships to compensate for genes that are lost.
journal_name
Geneticsjournal_title
Geneticsauthors
Kelkar YD,Ochman Hdoi
10.1534/genetics.112.145656subject
Has Abstractpub_date
2013-01-01 00:00:00pages
303-7issue
1eissn
0016-6731issn
1943-2631pii
genetics.112.145656journal_volume
193pub_type
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