Abstract：
:As an ancient segmental tetraploid, the maize (Zea mays L.) genome contains large numbers of paralogs that are expected to have diverged by a minimum of 10% over time. Nearly identical paralogs (NIPs) are defined as paralogous genes that exhibit > or = 98% identity. Sequence analyses of the "gene space" of the maize inbred line B73 genome, coupled with wet lab validation, have revealed that, conservatively, at least approximately 1% of maize genes have a NIP, a rate substantially higher than that in Arabidopsis. In most instances, both members of maize NIP pairs are expressed and are therefore at least potentially functional. Of evolutionary significance, members of many NIP families also exhibit differential expression. The finding that some families of maize NIPs are closely linked genetically while others are genetically unlinked is consistent with multiple modes of origin. NIPs provide a mechanism for the maize genome to circumvent the inherent limitation that diploid genomes can carry at most two "alleles" per "locus." As such, NIPs may have played important roles during the evolution and domestication of maize and may contribute to the success of long-term selection experiments in this important crop species.
journal_name
Geneticsjournal_title
Geneticsauthors
Emrich SJ,Li L,Wen TJ,Yandeau-Nelson MD,Fu Y,Guo L,Chou HH,Aluru S,Ashlock DA,Schnable PSdoi
10.1534/genetics.106.064006subject
Has Abstractpub_date
2007-01-01 00:00:00pages
429-39issue
1eissn
0016-6731issn
1943-2631pii
genetics.106.064006journal_volume
175pub_type
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