Genetic and molecular analysis of a tRNA(Leu) missense suppressor of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.

abstract：:The segregation and random assortment of characters observed by Mendel have their basis in the behavior of chromosomes in meiosis. But showing this actually to be the case requires a correct understanding of the meiotic behavior of chromosomes. This was achieved only gradually, over several decades, with much dispute ...

journal_title：Genetics

authors： Koszul R,Meselson M,Van Doninck K,Vandenhaute J,Zickler D

更新日期：2012-06-01 00:00:00

abstract：:We examined the effect of a single variant repeat on the stability of a 51-base pair (bp) microsatellite (poly GT). We found that the insertion stabilizes the microsatellite about fivefold in wild-type strains. The stabilizing effect of the variant base was also observed in strains with mutations in the DNA mismatch r...

journal_title：Genetics

authors： Petes TD,Greenwell PW,Dominska M

更新日期：1997-06-01 00:00:00

abstract：:Epistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus...

journal_title：Genetics

authors： Kelly JK

更新日期：2005-12-01 00:00:00

abstract：:The mutation rates of specific loci and chromosome regions were estimated for two types of dysgenic hybrid males. These came from crosses between P or Q males and M females in the P-M system of hybrid dysgenesis. The M X P hybrids were the more mutable for each of the loci and chromosome regions tested. The Beadex loc...

journal_title：Genetics

authors： Simmons MJ,Raymond JD,Johnson NA,Fahey TM

更新日期：1984-01-01 00:00:00

abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...

journal_title：Genetics

authors： Rhee Y,Sekhon RS,Chopra S,Kaeppler S

更新日期：2010-11-01 00:00:00

abstract：:The genetic etiology of many complex diseases is highly heterogeneous. A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci. Although these disease-susceptibility mutations can be collectively common in the population, they are often individu...

journal_title：Genetics

authors： Li M,He Z,Tong X,Witte JS,Lu Q

更新日期：2018-10-01 00:00:00

abstract：:Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...

journal_title：Genetics

authors： Seier T,Padgett DR,Zilberberg G,Sutera VA Jr,Toha N,Lovett ST

更新日期：2011-06-01 00:00:00

abstract：:Diversity in insect pigmentation, encompassing a wide range of colors and spatial patterns, is among the most noticeable features distinguishing species, individuals, and body regions within individuals. In holometabolous species, a significant portion of such diversity can be attributed to the melanin synthesis genes...

journal_title：Genetics

authors： Liu J,Lemonds TR,Marden JH,Popadić A

更新日期：2016-05-01 00:00:00

abstract：:Protein kinases mediate much of the signal transduction in eukaryotic cells and defects in kinase function are associated with a variety of human diseases. To understand and correct these defects, we will need to identify the physiologically relevant substrates of these enzymes. The work presented here describes a nov...

journal_title：Genetics

authors： Deminoff SJ,Howard SC,Hester A,Warner S,Herman PK

更新日期：2006-08-01 00:00:00

abstract：:Allozyme and inversion data from natural populations of Drosophila melanogaster from the eastern United States were analyzed to determine whether the clines at allozyme loci are due to nonrandom associations with common cosmopolitan inversions. All inversions show strong clines. Clines were large and significant for h...

journal_title：Genetics

authors： Voelker RA,Cockerham CC,Johnson FM,Schaffer HE,Mukai T,Mettler LE

更新日期：1978-03-01 00:00:00

abstract：:Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...

journal_title：Genetics

authors： Ellis LL,Carney GE

更新日期：2011-01-01 00:00:00

abstract：:Paramutation generates heritable changes affecting regulation of specific alleles found at several Zea mays (maize) loci that encode transcriptional regulators of anthocyanin biosynthetic genes. Although the direction and extent of paramutation is influenced by poorly understood allelic interactions occurring in diplo...

journal_title：Genetics

authors： Hollick JB,Kermicle JL,Parkinson SE

更新日期：2005-10-01 00:00:00

abstract：:For multiallelic loci, standard measures of linkage disequilibrium provide an incomplete description of the correlation of variation at two loci, especially when there are different numbers of alleles at the two loci. We have developed a complementary pair of conditional asymmetric linkage disequilibrium (ALD) measure...

journal_title：Genetics

authors： Thomson G,Single RM

更新日期：2014-09-01 00:00:00

abstract：:We define a new gene, SRD1, involved in the processing of pre-rRNA to mature rRNA. The SRD1 gene was identified by selecting for second-site suppressors of the previously described rrp1-1 mutation. The rrp1-1 mutation causes temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S...

journal_title：Genetics

authors： Fabian GR,Hess SM,Hopper AK

更新日期：1990-03-01 00:00:00

abstract：:The primary structures of peptides may be adapted for efficient synthesis as well as proper function. Here, the Saccharomyces cerevisiae genome sequence, DNA microarray expression data, tRNA gene numbers, and functional categorizations of proteins are employed to determine whether the amino acid composition of peptide...

journal_title：Genetics

authors： Akashi H

更新日期：2003-08-01 00:00:00

abstract：:Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network. Two MAP kinase (MAPK) pathways are essential for communicat...

journal_title：Genetics

authors： Fischer MS,Wu VW,Lee JE,O'Malley RC,Glass NL

更新日期：2018-06-01 00:00:00

abstract：:Pseudo-homothallism is a reproductive strategy elected by some fungi producing heterokaryotic sexual spores containing genetically different but sexually compatible nuclei. This lifestyle appears as a compromise between true homothallism (self-fertility with predominant inbreeding) and complete heterothallism (with ex...

journal_title：Genetics

authors： Grognet P,Bidard F,Kuchly C,Tong LC,Coppin E,Benkhali JA,Couloux A,Wincker P,Debuchy R,Silar P

更新日期：2014-05-01 00:00:00

abstract：:Grain yield is a major goal for the improvement of durum wheat, particularly in drought-prone areas. In this study, the genetic basis of grain yield (GY), heading date (HD), and plant height (PH) was investigated in a durum wheat population of 249 recombinant inbred lines evaluated in 16 environments (10 rainfed and 6...

journal_title：Genetics

authors： Maccaferri M,Sanguineti MC,Corneti S,Ortega JL,Salem MB,Bort J,DeAmbrogio E,del Moral LF,Demontis A,El-Ahmed A,Maalouf F,Machlab H,Martos V,Moragues M,Motawaj J,Nachit M,Nserallah N,Ouabbou H,Royo C,Slama A,Tubero

更新日期：2008-01-01 00:00:00

abstract：:An analysis of mortality is undertaken in two breeds of pigs: Danish Landrace and Yorkshire. Zero-inflated and standard versions of hierarchical Poisson, binomial, and negative binomial Bayesian models were fitted using Markov chain Monte Carlo (MCMC). The objectives of the study were to investigate whether there is s...

journal_title：Genetics

authors： Varona L,Sorensen D

更新日期：2010-01-01 00:00:00

abstract：:Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...

journal_title：Genetics

authors： Matsumoto S,Bandyopadhyay A,Kwiatkowski DJ,Maitra U,Matsumoto T

更新日期：2002-07-01 00:00:00

abstract：:We have examined the in vivo requirement of two recently identified nonessential components of the budding yeast anaphase-promoting complex, Swm1p and Mnd2p, as well as that of the previously identified subunit Apc9p. swm1Delta mutants exhibit synthetic lethality or conditional synthetic lethality with other APC/C sub...

journal_title：Genetics

authors： Page AM,Aneliunas V,Lamb JR,Hieter P

更新日期：2005-07-01 00:00:00

abstract：:A two-locus model is used to analyze the effectiveness of a mixture of insecticides in delaying resistance, compared to the use of the insecticides singly. The effects of factors such as recombination, effective dominance, initial value of allele frequencies and initial value of linkage disequilibrium are considered. ...

journal_title：Genetics

authors： Mani GS

更新日期：1985-04-01 00:00:00

abstract：:An SSR-based linkage map was constructed in Brassica rapa. It includes 113 SSR, 87 RFLP, and 62 RAPD markers. It consists of 10 linkage groups with a total distance of 1005.5 cM and an average distance of 3.7 cM. SSRs are distributed throughout the linkage groups at an average of 8.7 cM. Synteny between B. rapa and a ...

journal_title：Genetics

authors： Suwabe K,Tsukazaki H,Iketani H,Hatakeyama K,Kondo M,Fujimura M,Nunome T,Fukuoka H,Hirai M,Matsumoto S

更新日期：2006-05-01 00:00:00

abstract：:The three-dimensional organization of polytene chromosomes within nuclei containing rearranged X chromosomes was examined in male Drosophila melanogaster. Salivary glands of third instar larvae containing either an inverted X chromosome (YSX.YL, In(1)EN/O) or a ring X chromosome (R(1) 2/BSYy+) were fixed, embedded, an...

journal_title：Genetics

authors： Mathog D,Sedat JW

更新日期：1989-02-01 00:00:00

abstract：:Dosage compensation in Drosophila has been studied at the steady state RNA level for several single-copy genes; however, an important point is addressed by analyzing a repetitive, transposable element for dosage compensation. The two issues of gene-specific cis control and genomic position can be studied by determinin...

journal_title：Genetics

authors： Hiebert JC,Birchler JA

更新日期：1992-03-01 00:00:00

abstract：:Quantitative trait loci (QTL) affecting milk production and health of dairy cattle were mapped in a very large Holstein granddaughter design. The analysis included 1794 sons of 14 sires and 206 genetic markers distributed across all 29 autosomes and flanking an estimated 2497 autosomal cM using Kosambi's mapping funct...

journal_title：Genetics

authors： Zhang Q,Boichard D,Hoeschele I,Ernst C,Eggen A,Murkve B,Pfister-Genskow M,Witte LA,Grignola FE,Uimari P,Thaller G,Bishop MD

更新日期：1998-08-01 00:00:00

abstract：:I factors in Drosophila melanogaster are non-LTR retrotransposons that transpose at very high frequencies in the germ line of females resulting from crosses between reactive females (devoid of active I factors) and inducer males (containing active I factors). Constructs containing I factor ORF1 under the control of th...

journal_title：Genetics

authors： Malinsky S,Bucheton A,Busseau I

更新日期：2000-11-01 00:00:00

abstract：:We have investigated the order of the four genes cyc1, rad7, SUP4, and cdc8 which form a tightly linked cluster on the right arm of chromosome X in the yeast Saccharomyces cerevisiae. Crossing over and coconversion data from tetrad analysis established the gene order to be centromere-cyc1-rad7-SUP4. Also cdc8 appeared...

journal_title：Genetics

authors： Lawrence CW,Sherman F,Jackson M,Gilmore RA

更新日期：1975-12-01 00:00:00

abstract：:We study the mechanisms that guide the formation and maintenance of the highly ordered actin-myosin cytoskeleton in striated muscle. The UNC-82 kinase of Caenorhabditis elegans is orthologous to mammalian kinases ARK5/NUAK1 and SNARK/NUAK2. UNC-82 localizes to the M-line, and is required for proper organization of thi...

journal_title：Genetics

authors： Schiller NR,Duchesneau CD,Lane LS,Reedy AR,Manzon ER,Hoppe PE

更新日期：2017-03-01 00:00:00

abstract：:The formation and stability of epigenetically regulated chromatin is influenced by DNA replication and factors that modulate post-translational modifications on histones. Here we describe evidence that PCNA can affect silencing in Saccharomyces cerevisiae by facilitating deposition of H3 K56ac onto chromosomes. We pro...

journal_title：Genetics

authors： Miller A,Yang B,Foster T,Kirchmaier AL

更新日期：2008-06-01 00:00:00