Abstract：
:We examined the effect of a single variant repeat on the stability of a 51-base pair (bp) microsatellite (poly GT). We found that the insertion stabilizes the microsatellite about fivefold in wild-type strains. The stabilizing effect of the variant base was also observed in strains with mutations in the DNA mismatch repair genes pms1, msh2 and msh3, indicating that this effect does not require a functional DNA mismatch repair system. Most of the microsatellite alterations in the pms1, msh2 and msh3 strains were additions or deletions of single GT repeats, but about half of the alterations in the wild-type and msh6 strains were large (> 8 bp) deletions or additions.
journal_name
Geneticsjournal_title
Geneticsauthors
Petes TD,Greenwell PW,Dominska Msubject
Has Abstractpub_date
1997-06-01 00:00:00pages
491-8issue
2eissn
0016-6731issn
1943-2631journal_volume
146pub_type
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