Developmental defects in a Caenorhabditis elegans model for type III galactosemia.

abstract：:A new suppressor of +1 frameshift mutations has been isolated in Salmonella typhimurium. This suppressor, sufJ, maps at minute 89 on the Salmonella genetic map between the argH and rpo(rif) loci, closely linked to the gene for the ochre suppressor tyrU(supM). The suppressor mutation is dominant to its wild-type allele...

journal_title：Genetics

authors： Bossi L,Kohno T,Roth JR

更新日期：1983-01-01 00:00:00

abstract：:The standard approaches to estimation of quantitative genetic parameters and prediction of response to selection on quantitative traits are based on theory derived for populations undergoing random mating. Many studies demonstrate, however, that mating systems in natural populations often involve inbreeding in various...

journal_title：Genetics

authors： Shaw RG,Byers DL,Shaw FH

更新日期：1998-12-01 00:00:00

abstract：:The vacuolar hydrolase protease B in Saccharomyces cerevisiae is synthesized as an inactive precursor (Prb1p). The precursor undergoes post-translational modifications while transiting the secretory pathway. In addition to N- and O-linked glycosylations, four proteolytic cleavages occur during the maturation of Prb1p....

journal_title：Genetics

authors： Naik RR,Jones EW

更新日期：1998-07-01 00:00:00

abstract：:The impact of among-environment heteroscedasticity and genetic autocorrelation on the analysis of phenotypic plasticity is examined. Among-environment heteroscedasticity occurs when genotypic variances differ among environments. Genetic autocorrelation arises whenever the responses of a genotype to different environme...

journal_title：Genetics

authors： Dutilleul P,Potvin C

更新日期：1995-04-01 00:00:00

abstract：:We previously identified a transcriptional regulatory element, which we call NRE(DIT), that is required for repression of the sporulation-specific genes, DIT1 and DIT2, during vegetative growth of Saccharomyces cerevisiae. Repression through this element is dependent on the Ssn6-Tup1 corepressor. In this study, we sho...

journal_title：Genetics

authors： Friesen H,Tanny JC,Segall J

更新日期：1998-09-01 00:00:00

abstract：:We examined mutations that disrupt muscle activation in Caenorhabditis elegans. Fifteen of 17 of these genes were identified previously and we describe new mutations in three of them. We also describe mutations in two new genes, exp-3 and exp-4. We assessed the degree of defect in pharyngeal, body-wall, egg-laying, an...

journal_title：Genetics

authors： Reiner DJ,Weinshenker D,Thomas JH

更新日期：1995-11-01 00:00:00

abstract：:Previous work showed that C. elegans gon-14 is required for gonadogenesis. Here we report that gon-14 encodes a protein with similarity to LIN-15B, a class B synMuv protein. An extensive region of GON-14 contains blocks of sequence similarity to transposases of the hAT superfamily, but key residues are not conserved, ...

journal_title：Genetics

authors： Chesney MA,Kidd AR 3rd,Kimble J

更新日期：2006-02-01 00:00:00

abstract：:Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL under a mutation-s...

journal_title：Genetics

authors： Phillips PC,Johnson NA

更新日期：1998-09-01 00:00:00

abstract：:In most species, size homeostasis appears to be exerted in late G1 phase as cells commit to division, called Start in yeast and the Restriction Point in metazoans. This size threshold couples cell growth to division, and, thereby, establishes long-term size homeostasis. Our former investigations have shown that hundre...

journal_title：Genetics

authors： Chaillot J,Tebbji F,Mallick J,Sellam A

更新日期：2019-02-01 00:00:00

abstract：:We have isolated 15 spontaneous mutants resistant to one or several antibiotics like chloramphenicol, erythromycin and spiramycin. We have shown by several criteria that all of them result from mutations localized in the mitochondrial DNA. The mutations have been mapped by allelism tests and by two- and three-factor c...

journal_title：Genetics

authors： Netter P,Petrochilo E,Slonimski PP,Bolotin-Fukuhara M,Coen D,Deutsch J,Dujon B

更新日期：1974-12-01 00:00:00

abstract：:Thyroid hormone has pleiotropic effects on cochlear development, and genomic variation influences the severity of associated hearing deficits. DW/J-Pou1f1dw/dw mutant mice lack pituitary thyrotropin, which causes severe thyroid hormone deficiency and profound hearing impairment. To assess the genetic complexity of pro...

journal_title：Genetics

authors： Fang Q,Longo-Guess C,Gagnon LH,Mortensen AH,Dolan DF,Camper SA,Johnson KR

更新日期：2011-10-01 00:00:00

abstract：:Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown t...

journal_title：Genetics

authors： Hopper NA

更新日期：2006-05-01 00:00:00

abstract：:By using both numerical and analytical approaches, we have shown that heterosis alone is not a mechanism for maintaining many alleles segregating at a locus. Even when all heterozygous are more fit than all homozygotes, the proportion of fitness arrays that will lead to a stable, feasible equilibrium of more than 6 or...

journal_title：Genetics

authors： Lewontin RC,Ginzburg LR,Tuljapurkar SD

更新日期：1978-01-01 00:00:00

abstract：:Life-history traits or "fitness components"-such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span-are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding ...

journal_title：Genetics

authors： Flatt T

更新日期：2020-01-01 00:00:00

abstract：:We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...

journal_title：Genetics

authors： Spiliopoulou A,Colombo M,Orchard P,Agakov F,McKeigue P

更新日期：2017-05-01 00:00:00

abstract：:The Saccharomyces cerevisiae SEN1 gene codes for a nuclear-localized superfamily I helicase. SEN1 is an ortholog of human SETX (senataxin), which has been implicated in the neurological disorders ataxia-ocular apraxia type 2 and juvenile amyotrophic lateral sclerosis. Pleiotropic phenotypes conferred by sen1 mutations...

journal_title：Genetics

authors： Finkel JS,Chinchilla K,Ursic D,Culbertson MR

更新日期：2010-01-01 00:00:00

abstract：:The T-box genes comprise an ancient family of putative transcription factors conserved across species as divergent as Mus musculus and Caenorhabditis elegans. All T-box gene products are characterized by a novel 174-186-amino acid DNA binding domain called the T-box that was first discovered in the polypeptide product...

journal_title：Genetics

authors： Agulnik SI,Garvey N,Hancock S,Ruvinsky I,Chapman DL,Agulnik I,Bollag R,Papaioannou V,Silver LM

更新日期：1996-09-01 00:00:00

abstract：:Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stre...

journal_title：Genetics

authors： Dapa T,Fleurier S,Bredeche MF,Matic I

更新日期：2017-07-01 00:00:00

abstract：:Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than conventional metaanalysis based on within-study estimates. However, conducting analyses with pooled genetic data, in particular, is a daunting task that raises importan...

journal_title：Genetics

authors： Heo M,Leibel RL,Boyer BB,Chung WK,Koulu M,Karvonen MK,Pesonen U,Rissanen A,Laakso M,Uusitupa MI,Chagnon Y,Bouchard C,Donohoue PA,Burns TL,Shuldiner AR,Silver K,Andersen RE,Pedersen O,Echwald S,Sørensen TI,Behn P,

更新日期：2001-11-01 00:00:00

abstract：:No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed. ...

journal_title：Genetics

authors： Chen JJ,Duan T,Single R,Mather K,Thomson G

更新日期：2005-07-01 00:00:00

abstract：:A long-standing prediction in evolutionary biology is that organisms experience a so-called "cost of complexity" manifested as a decreasing rate of adaptation in populations as organisms or selective environments become increasingly complex. This theory assumes the ubiquity of antagonistic pleiotropy, or trade-offs in...

journal_title：Genetics

authors： Sackman AM,Rokyta DR

更新日期：2019-05-01 00:00:00

abstract：:Heteroduplexes with single base pair mismatches of known sequence were prepared by annealing separated strands of bacteriophage lambda DNA and used to transfect Escherichia coli. A series of transition (G:T and A:C) and transversion (G:A and C:T) mismatches located throughout most of the bacteriophage lambda cI gene h...

journal_title：Genetics

authors： Jones M,Wagner R,Radman M

更新日期：1987-04-01 00:00:00

abstract：:The polarized partitioning of proteins in cells underlies asymmetric cell division, which is an important driver of development and cellular diversity. The budding yeast Saccharomyces cerevisiae divides asymmetrically, like many other cells, to generate two distinct progeny cells. A well-known example of an asymmetric...

journal_title：Genetics

authors： Herrero E,Stinus S,Bellows E,Berry LK,Wood H,Thorpe PH

更新日期：2020-11-01 00:00:00

abstract：:All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...

journal_title：Genetics

authors： Cyert MS,Philpott CC

更新日期：2013-03-01 00:00:00

abstract：:The genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reporte...

journal_title：Genetics

authors： Daetwyler HD,Calus MP,Pong-Wong R,de Los Campos G,Hickey JM

更新日期：2013-02-01 00:00:00

abstract：:Boundaries (insulators) in the Drosophila bithorax complex (BX-C) delimit autonomous regulatory domains that orchestrate the parasegment (PS)-specific expression of the BX-C homeotic genes. The Fab-7 boundary separates the iab-6 and iab-7 regulatory domains, which control Abd-B expression in PS11 and PS12, respectivel...

journal_title：Genetics

authors： Fedotova A,Aoki T,Rossier M,Mishra RK,Clendinen C,Kyrchanova O,Wolle D,Bonchuk A,Maeda RK,Mutero A,Cleard F,Mogila V,Karch F,Georgiev P,Schedl P

更新日期：2018-10-01 00:00:00

abstract：:Interactions between Drosophila C virus (DCV) and its natural host, Drosophila melanogaster, were investigated using 15 geographical population samples infected by intraabdominal inoculation. These strains derived from natural populations of D. melanogaster differed in susceptibility to the DCVc. One strain was "parti...

journal_title：Genetics

authors： Thomas-Orillard M,Jeune B,Cusset G

更新日期：1995-08-01 00:00:00

abstract：:We have created a resource to rapidly map genetic traits to specific chromosomes in yeast. This mapping is done using a set of 16 yeast strains each containing a different chromosome with a conditionally functional centromere. Conditional centromere function is achieved by integration of a GAL1 promoter in cis to cent...

journal_title：Genetics

authors： Reid RJ,Sunjevaric I,Voth WP,Ciccone S,Du W,Olsen AE,Stillman DJ,Rothstein R

更新日期：2008-12-01 00:00:00

abstract：:As hamster scrapie cannot infect mice, due to sequence differences in their PrP proteins, we find "species barriers" to transmission of the [URE3] prion in Saccharomyces cerevisiae among Ure2 proteins of S. cerevisiae, paradoxus, bayanus, cariocanus, and mikatae on the basis of differences among their Ure2p prion doma...

journal_title：Genetics

authors： Edskes HK,McCann LM,Hebert AM,Wickner RB

更新日期：2009-03-01 00:00:00

abstract：:Sphingolipid signaling plays an important role in the regulation of central cellular processes, including cell growth, survival, and differentiation. Many of the essential pathways responsible for sphingolipid biogenesis, and key cellular responses to changes in sphingolipid balance, are conserved between mammalian an...

journal_title：Genetics

authors： Brace JL,Lester RL,Dickson RC,Rudin CM

更新日期：2007-01-01 00:00:00