Abstract：
:By using both numerical and analytical approaches, we have shown that heterosis alone is not a mechanism for maintaining many alleles segregating at a locus. Even when all heterozygous are more fit than all homozygotes, the proportion of fitness arrays that will lead to a stable, feasible equilibrium of more than 6 or 7 alleles is vanishingly small. More alleles can be maintained if, in addition to heterosis, it is assumed that there is very little variation in fitness from heterozygote to heterozygote, with the ratio of mean heterosis to standard deviation of fitness among heterozygotes in the neighborhood of 10. When such conditions hold, the allelic frequency distribution and equilibrium will be very uniform, with all alleles very close to equal frequency (see PDF). It is much more likely that stable equilibria for multiple alleles will be best explained by multiple niche selection.
journal_name
Geneticsjournal_title
Geneticsauthors
Lewontin RC,Ginzburg LR,Tuljapurkar SDsubject
Has Abstractpub_date
1978-01-01 00:00:00pages
149-69issue
1eissn
0016-6731issn
1943-2631journal_volume
88pub_type
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