Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans.

abstract：:We previously identified a transcriptional regulatory element, which we call NRE(DIT), that is required for repression of the sporulation-specific genes, DIT1 and DIT2, during vegetative growth of Saccharomyces cerevisiae. Repression through this element is dependent on the Ssn6-Tup1 corepressor. In this study, we sho...

journal_title：Genetics

authors： Friesen H,Tanny JC,Segall J

更新日期：1998-09-01 00:00:00

abstract：:As hamster scrapie cannot infect mice, due to sequence differences in their PrP proteins, we find "species barriers" to transmission of the [URE3] prion in Saccharomyces cerevisiae among Ure2 proteins of S. cerevisiae, paradoxus, bayanus, cariocanus, and mikatae on the basis of differences among their Ure2p prion doma...

journal_title：Genetics

authors： Edskes HK,McCann LM,Hebert AM,Wickner RB

更新日期：2009-03-01 00:00:00

abstract：:Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...

journal_title：Genetics

authors： Seier T,Padgett DR,Zilberberg G,Sutera VA Jr,Toha N,Lovett ST

更新日期：2011-06-01 00:00:00

abstract：:Levels of genetic variation and linkage disequilibrium (LD) are critical factors in association mapping methods as well as in identification of loci that have been targets of selection. Maize, an outcrosser, has a high level of sequence variation and a limited extent of LD. Sorghum, a closely related but largely self-...

journal_title：Genetics

authors： Hamblin MT,Mitchell SE,White GM,Gallego J,Kukatla R,Wing RA,Paterson AH,Kresovich S

更新日期：2004-05-01 00:00:00

abstract：:Statistical associations between phenotypic traits often result from shared developmental processes and include both covariation between the trait values and more complex associations between higher moments of the joint distribution of traits. In this article, an analytical technique for calculating the covariance bet...

journal_title：Genetics

authors： Rice SH

更新日期：2004-01-01 00:00:00

abstract：:Twelve mutations affecting nuclear migration, a major developmental phase in Schizophyllum commune, display a complex pattern of complementation and recombination. They are expressed only when a genetic factor controlling this phase of development, the B incompatibility factor, is operative. All twelve mutations are l...

journal_title：Genetics

authors： Dubovoy C

更新日期：1976-03-01 00:00:00

abstract：:Initial events in double-strand break repair by homologous recombination in vivo involve homology searching, 3' strand invasion, and new DNA synthesis. While studies in yeast have contributed much to our knowledge of these processes, in comparison, little is known of the early events in the integrated mammalian system...

journal_title：Genetics

authors： Si W,Mundia MM,Magwood AC,Mark AL,McCulloch RD,Baker MD

更新日期：2010-06-01 00:00:00

abstract：:Following the advent of a gene targeting technique in Drosophila, different methods have been developed to modify the Drosophila genome. The initial demonstration of gene targeting in flies used an ends-in method, which generates a duplication of the target locus. The duplicated locus can then be efficiently reduced t...

journal_title：Genetics

authors： Xie HB,Golic KG

更新日期：2004-11-01 00:00:00

abstract：:The consequences of asymmetric dispersion on the maintenance of an allele in a one-dimensional environmental pocket are examined. The diffusion model of migration and selection is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is further supposed that ...

journal_title：Genetics

authors： Nagylaki T

更新日期：1978-04-01 00:00:00

abstract：:In Caenorhabditis elegans embryos, specification of the germ lineage depends on PIE-1, a maternal protein that blocks mRNA transcription in germline blastomeres. Studies in mammalian cell culture have suggested that PIE-1 inhibits P-TEFb, a kinase that phosphorylates serine 2 in the carboxyl-terminal domain (CTD) repe...

journal_title：Genetics

authors： Ghosh D,Seydoux G

更新日期：2008-01-01 00:00:00

abstract：:Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a populatio...

journal_title：Genetics

authors： Huang K,Mi R,Dunn DW,Wang T,Li B

更新日期：2018-12-01 00:00:00

abstract：:Conspicuous differences in floral morphology are partly responsible for reproductive isolation between two sympatric species of monkeyflower because of their effect on visitation of the flowers by different pollinators. Mimulus lewisii flowers are visited primarily by bumblebees, whereas M. cardinalis flowers are visi...

journal_title：Genetics

authors： Bradshaw HD Jr,Otto KG,Frewen BE,McKay JK,Schemske DW

更新日期：1998-05-01 00:00:00

abstract：:We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of approximately 300 genes encoding seven-pass G-protein-coupled receptors. Almost one-third of the genes in each family are annotated as pseudogenes because of apparent functional defects...

journal_title：Genetics

authors： Stewart MK,Clark NL,Merrihew G,Galloway EM,Thomas JH

更新日期：2005-04-01 00:00:00

abstract：:Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. Ubiquitin E3 ligases confer substrate specificity in this pathway, and SCF-type ligases comprise a major class of E3s. SCF ligases have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate rec...

journal_title：Genetics

authors： Gilkerson J,Hu J,Brown J,Jones A,Sun TP,Callis J

更新日期：2009-03-01 00:00:00

abstract：:Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms. Likewise 1-naphthylamine and 2-naphthylamine are also nonmutagenic but the N-hydroxy derivatives are mutagenic in microorganisms. Apparently these compounds require metabolism to breakdown produ...

journal_title：Genetics

authors： Mayer VW

更新日期：1973-07-01 00:00:00

abstract：:Fifty-two wee mutants that undergo mitosis and cell division at a reduced size compared with wild type have been genetically analyzed. The mutants define two genes, wee1 and cdc2, which control the timing of mitosis. Fifty-one of the mutants map at the wee1 locus, which is unlinked to any known cdc gene. One of the we...

journal_title：Genetics

authors： Nurse P,Thuriaux P

更新日期：1980-11-01 00:00:00

abstract：:Two variations of the method of localized mutagenesis were used to introduce mutations into the 72 min region of the Escherichia coli chromosome. Twenty temperature-sensitive mutants, with linkage to markers in this region, have been examined. Each strain showed an inhibition of growth in liquid medium at 44 degrees, ...

journal_title：Genetics

authors： Champney WS

更新日期：1979-02-01 00:00:00

abstract：:Some populations of maize's closest relatives, the annual teosintes of Mexico, are unreceptive to maize pollen. When present in the pistil (silk and ovary) a number of maize genes discriminate against or exclude pollen not carrying the same allele. An analogous gene Tcb1-s was found in some teosinte populations but no...

journal_title：Genetics

authors： Kermicle JL

更新日期：2006-01-01 00:00:00

abstract：:Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genet...

journal_title：Genetics

authors： Chevin LM,Hospital F

更新日期：2006-07-01 00:00:00

abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...

journal_title：Genetics

authors： Beckwith EJ,Hernando CE,Polcowñuk S,Bertolin AP,Mancini E,Ceriani MF,Yanovsky MJ

更新日期：2017-10-01 00:00:00

abstract：:The polarized partitioning of proteins in cells underlies asymmetric cell division, which is an important driver of development and cellular diversity. The budding yeast Saccharomyces cerevisiae divides asymmetrically, like many other cells, to generate two distinct progeny cells. A well-known example of an asymmetric...

journal_title：Genetics

authors： Herrero E,Stinus S,Bellows E,Berry LK,Wood H,Thorpe PH

更新日期：2020-11-01 00:00:00

abstract：:The effect of nonhomologous DNA sequences at one or both sides of short genetic intervals on recombination within that interval was investigated, using an interplasmidic recombination system in Escherichia coli K-12. The recombining plasmids were derivatives of pBR322 and pACYC184, which share a 1330-nucleotide sequen...

journal_title：Genetics

authors： Laban A,Silberstein Z,Cohen A

更新日期：1984-09-01 00:00:00

abstract：:Obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. We hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. Comparisons of i...

journal_title：Genetics

authors： Kelkar YD,Ochman H

更新日期：2013-01-01 00:00:00

abstract：:Directional export of messenger RNA (mRNA) protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 are asymmetrically localized to the cytoplasmic face and have distinct functional domains: a phenylalanine-glycine (FG) re...

journal_title：Genetics

authors： Adams RL,Terry LJ,Wente SR

更新日期：2014-08-01 00:00:00

abstract：:The size of the genome in the opportunistic fungus Candida albicans is 15.6 Mb. Whole-genome shotgun sequencing was carried out at Stanford University where the sequences were assembled into 412 contigs. C. albicans is a diploid basically, and analysis of the sequence is complicated due to repeated sequences and to se...

journal_title：Genetics

authors： Chibana H,Oka N,Nakayama H,Aoyama T,Magee BB,Magee PT,Mikami Y

更新日期：2005-08-01 00:00:00

abstract：:Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segr...

journal_title：Genetics

authors： Gould KA,Tochacek M,Schaffer BS,Reindl TM,Murrin CR,Lachel CM,VanderWoude EA,Pennington KL,Flood LA,Bynote KK,Meza JL,Newton MA,Shull JD

更新日期：2004-12-01 00:00:00

abstract：:Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical of natural populations. Theoretical studies demonstrate that evolution of polygenic characters depends heavily on the genetic interdependence of the expression of traits in the differ...

journal_title：Genetics

authors： Shaw RG,Platenkamp GA,Shaw FH,Podolsky RH

更新日期：1995-01-01 00:00:00

abstract：:To identify genomic regions required for establishment and patterning of the epidermis, we screened 58 deficiencies that collectively delete at least approximately 67% of the Caenorhabditis elegans genome. The epidermal pattern of deficiency homozygous embryos was analyzed by examining expression of a marker specific ...

journal_title：Genetics

authors： Terns RM,Kroll-Conner P,Zhu J,Chung S,Rothman JH

更新日期：1997-05-01 00:00:00

abstract：:Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...

journal_title：Genetics

authors： Matsumoto S,Bandyopadhyay A,Kwiatkowski DJ,Maitra U,Matsumoto T

更新日期：2002-07-01 00:00:00

abstract：:The pattern of mutational covariance among traits plays a central, but largely untested, role in many theories in evolutionary genetics. Here we estimate the pattern of phenotypic, environmental, and mutational correlations for a set of life-history, behavioral, and morphological traits using 67 self-fertilizing lines...

journal_title：Genetics

authors： Estes S,Ajie BC,Lynch M,Phillips PC

更新日期：2005-06-01 00:00:00