Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation.

abstract：:As hamster scrapie cannot infect mice, due to sequence differences in their PrP proteins, we find "species barriers" to transmission of the [URE3] prion in Saccharomyces cerevisiae among Ure2 proteins of S. cerevisiae, paradoxus, bayanus, cariocanus, and mikatae on the basis of differences among their Ure2p prion doma...

journal_title：Genetics

authors： Edskes HK,McCann LM,Hebert AM,Wickner RB

更新日期：2009-03-01 00:00:00

abstract：:Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...

journal_title：Genetics

authors： Hann BJ,Hebert PD

更新日期：1982-09-01 00:00:00

abstract：:To identify genomic regions required for establishment and patterning of the epidermis, we screened 58 deficiencies that collectively delete at least approximately 67% of the Caenorhabditis elegans genome. The epidermal pattern of deficiency homozygous embryos was analyzed by examining expression of a marker specific ...

journal_title：Genetics

authors： Terns RM,Kroll-Conner P,Zhu J,Chung S,Rothman JH

更新日期：1997-05-01 00:00:00

abstract：:An article by Singh and colleagues in this issue of GENETICS quantifies variation in recombination rate across a small region of the Drosophila melanogaster genome, providing an opportunity for instructors of genetics to introduce or reinforce important concepts such as recombination and recombination rate variation, ...

journal_title：Genetics

authors： Heil CS,Noor MA

更新日期：2013-06-01 00:00:00

abstract：:Previously isolated meiotic recombination (rec) mutants of Schizosaccharomyces pombe define 16 complementation groups. The rec genes cloned and sequenced to date reveal little amino acid sequence identity to other reported proteins. We examined the rec mutants for alterations in meiotic events other than recombination...

journal_title：Genetics

authors： Li YF,Smith GR

更新日期：1997-05-01 00:00:00

abstract：:Genotype by environment interactions (GEI) play a major part in shaping the genetic architecture of quantitative traits and are confounding factors in genetic studies, for example, in attempts to associate genetic variation with disease susceptibility. It is generally not known what proportion of phenotypic variation ...

journal_title：Genetics

authors： Sambandan D,Carbone MA,Anholt RR,Mackay TF

更新日期：2008-06-01 00:00:00

abstract：:Restriction map variation in two 5-6-kb chloroplast DNA regions of five diploid Aegilops species in the section Sitopsis and two wild tetraploid wheats, Triticum dicoccoides and Triticum araraticum, was investigated with a battery of four-cutter restriction enzymes. A single accession each of Triticum durum, Triticum ...

journal_title：Genetics

authors： Miyashita NT,Mori N,Tsunewaki K

更新日期：1994-07-01 00:00:00

abstract：:The resistance of rice to its bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo) has both qualitative and quantitative components that were investigated using three near-isogenic line sets for four resistance (R) genes (Xa4, xa5, xa13, and Xa21) and 12 Xoo races. Our results indicate that these two resistan...

journal_title：Genetics

authors： Li ZK,Sanchez A,Angeles E,Singh S,Domingo J,Huang N,Khush GS

更新日期：2001-10-01 00:00:00

abstract：:The gilthead sea bream (Sparus aurata L.) is a marine fish of great importance for fisheries and aquaculture. It has also a peculiar sex-determination system, being a protandrous hermaphrodite. Here we report the construction of a first-generation genetic linkage map for S. aurata, based on 204 microsatellite markers....

journal_title：Genetics

authors： Franch R,Louro B,Tsalavouta M,Chatziplis D,Tsigenopoulos CS,Sarropoulou E,Antonello J,Magoulas A,Mylonas CC,Babbucci M,Patarnello T,Power DM,Kotoulas G,Bargelloni L

更新日期：2006-10-01 00:00:00

abstract：:Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...

journal_title：Genetics

authors： Allen AT,Maher KN,Wani KA,Betts KE,Chase DL

更新日期：2011-07-01 00:00:00

abstract：:R1 and R2 elements are non-LTR retrotransposons that insert specifically into the 28S rRNA genes of arthropods. The process of concerted evolution of the rDNA locus should give rise to rapid turnover of these mobile elements compared to elements that insert at sites throughout a genome. To estimate the rate of R1 and ...

journal_title：Genetics

authors： Pérez-González CE,Eickbush TH

更新日期：2002-10-01 00:00:00

abstract：:We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutat...

journal_title：Genetics

authors： Tax FE,Thomas JH,Ferguson EL,Horvitz HR

更新日期：1997-12-01 00:00:00

abstract：:Seven hundred and three second chromosomes were extracted from a Raleigh, North Carolina population of Drosophila melanogaster in 1970. Additionally, four hundred and eighty-nine third chromosomes were extracted from a large cage population founded from the flies in the 1970 Raleigh collection. The alpha glycerol-3-ph...

journal_title：Genetics

authors： Muki T,Watanabe TK,Yamaguchi O

更新日期：1974-08-01 00:00:00

abstract：:Trichome development in Arabidopsis thaliana is a well-characterized model for the study of plant cell differentiation. Two genes that play an essential role in the initiation of trichome development are GL1 and TTG. Mutations in either gene prevent the initiation of most trichomes. The GL1 gene encodes a myb-related ...

journal_title：Genetics

authors： Larkin JC,Walker JD,Bolognesi-Winfield AC,Gray JC,Walker AR

更新日期：1999-04-01 00:00:00

abstract：:Regulation of transcription can be a complex process in which many cis- and trans-interactions determine the final pattern of expression. Among these interactions are trans-interactions mediated by the pairing of homologous chromosomes. These trans-effects are wide ranging, affecting gene regulation in many species an...

journal_title：Genetics

authors： Lum TE,Merritt TJ

更新日期：2011-11-01 00:00:00

abstract：:The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex of Saccharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate transcription by distinct mechanisms. Previous results have shown that the Spt3 and Spt8 components of SAGA regulate initiation of transcription of particular genes by ...

journal_title：Genetics

authors： Laprade L,Rose D,Winston F

更新日期：2007-12-01 00:00:00

abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...

journal_title：Genetics

authors： Cutter AD,Agrawal AF

更新日期：2010-06-01 00:00:00

abstract：:The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume composition...

journal_title：Genetics

authors： Lercher MJ,Smith NG,Eyre-Walker A,Hurst LD

更新日期：2002-12-01 00:00:00

abstract：:Evolution through natural selection suggests unnecessary genes are lost. We observed that the yeast Candida glabrata lost the gene encoding a phosphate-repressible acid phosphatase (PHO5) present in many yeasts including Saccharomyces cerevisiae. However, C. glabrata still had phosphate starvation-inducible phosphatas...

journal_title：Genetics

authors： Orkwis BR,Davies DL,Kerwin CL,Sanglard D,Wykoff DD

更新日期：2010-11-01 00:00:00

abstract：:In order to examine the operation of diversifying selection as the maintenance mechanism of excessive additive genetic variance for viability in southern populations in comparison with northern populations of Drosophila melanogaster, two sets of experiments were conducted using second chromosomes extracted from the Og...

journal_title：Genetics

authors： Takano T,Kusakabe S,Mukai T

更新日期：1987-10-01 00:00:00

abstract：:The mitochondrial genotype of all F(1) female offspring (426 individuals) of a single Drosophila mauritiana female, heteroplasmic for two types of mtDNA (a short and a long genome), was established. All descendants were heteroplasmic. The earliest eggs laid by this female show the cytoplasmic genetic structure of ovar...

journal_title：Genetics

authors： Solignac M,Génermont J,Monnerot M,Mounolou JC

更新日期：1987-12-01 00:00:00

abstract：:The r-X1 deficiency in maize induces nondisjunction at the second mitotic division during embryo sac formation. However, it was not known if this deficiency also induces nondisjunction during the microspore divisions. Microsporogenesis in plants lacking or containing this deficiency was compared using two approaches. ...

journal_title：Genetics

authors： Zhao ZY,Weber DF

更新日期：1988-08-01 00:00:00

abstract：:In a genetic screen for mutants showing modified splicing of an alternatively spliced GFP reporter gene in Arabidopsis thaliana, we identified mutations in genes encoding the putative U1 small nuclear ribonucleoprotein (snRNP) factors RBM25 and PRP39a. The latter has not yet been studied for its role in pre-messenger ...

journal_title：Genetics

authors： Kanno T,Lin WD,Fu JL,Chang CL,Matzke AJM,Matzke M

更新日期：2017-12-01 00:00:00

abstract：:We consider a population that adapts to a gradually changing environment. Our aim is to describe how ecological and genetic factors combine to determine the genetic basis of adaptation. Specifically, we consider the evolution of a polygenic trait that is under stabilizing selection with a moving optimum. The ecologica...

journal_title：Genetics

authors： Kopp M,Hermisson J

更新日期：2009-12-01 00:00:00

abstract：:Knowledge of the rate and fitness effects of mutations is essential for understanding the process of evolution. Mutations are inherently difficult to study because they are rare and are frequently eliminated by natural selection. In the ciliate Tetrahymena thermophila, mutations can accumulate in the germline genome w...

journal_title：Genetics

authors： Long HA,Paixão T,Azevedo RB,Zufall RA

更新日期：2013-10-01 00:00:00

abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

journal_title：Genetics

authors： Wagner M,Briza P,Pierce M,Winter E

更新日期：1999-04-01 00:00:00

abstract：:In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...

journal_title：Genetics

authors： Mafessoni F,Lachmann M

更新日期：2015-12-01 00:00:00

abstract：:The prion-like behavior of Sup35p, the eRF3 homolog in the yeast Saccharomyces cerevisiae, mediates the activity of the cytoplasmic nonsense suppressor known as [PSI(+)]. Sup35p is divided into three regions of distinct function. The N-terminal and middle (M) regions are required for the induction and propagation of [...

journal_title：Genetics

authors： Jensen MA,True HL,Chernoff YO,Lindquist S

更新日期：2001-10-01 00:00:00

abstract：:Restriction fragment length polymorphisms in mitochondrial DNA (mtDNA) were used to reconstruct evolutionary relationships of conspecific populations in four species of freshwater fish-Amia calva, Lepomis punctatus, L. gulosus, and L. microlophus. A suite of 14-17 endonucleases was employed to assay mtDNAs from 305 sp...

journal_title：Genetics

authors： Bermingham E,Avise JC

更新日期：1986-08-01 00:00:00

abstract：:Previous models suggested that regulation of telomere length in Saccharomyces cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here, we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathwa...

journal_title：Genetics

authors： Keener R,Connelly CJ,Greider CW

更新日期：2019-12-01 00:00:00