Rates of R1 and R2 retrotransposition and elimination from the rDNA locus of Drosophila melanogaster.

abstract：:In eukaryotic cells, checkpoint pathways arrest cell-cycle progression if a particular event has failed to complete appropriately or if an important intracellular structure is defective or damaged. Saccharomyces cerevisiae strains that lack the SFP1 gene fail to arrest at the G2 DNA-damage checkpoint in response to ge...

journal_title：Genetics

authors： Xu Z,Norris D

更新日期：1998-12-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...

journal_title：Genetics

authors： Malavazi I,Lima JF,de Castro PA,Savoldi M,de Souza Goldman MH,Goldman GH

更新日期：2008-02-01 00:00:00

abstract：:Properties of identity relation between genes are discussed, and a derivation of recurrent equations of identity coefficients in a random mating, diploid dioecious population is presented. Computations are run by repeated matrix multiplication. Results show that for effective population size (Ne) larger than 16 and no...

journal_title：Genetics

authors： Chevalet C,Gillois M,Nassar RF

更新日期：1977-07-01 00:00:00

abstract：:Hotspots regulate the position and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicidal and are somehow resurrected elsewhere in the genome. After the DNA sequence-dependent activation of hotspots was discovered in fission yeast, nearly two decades elapsed before the key real...

journal_title：Genetics

authors： Wahls WP,Davidson MK

更新日期：2011-11-01 00:00:00

abstract：:Circadian ( approximately 24 hr) rhythms of behavior and physiology are driven by molecular clocks that are endogenous to most organisms. The mechanisms underlying these clocks are remarkably conserved across evolution and typically consist of auto-regulatory loops in which specific proteins (clock proteins) rhythmica...

journal_title：Genetics

authors： Zheng X,Sehgal A

更新日期：2008-03-01 00:00:00

abstract：:The long-term population genetics of multigene families is influenced by several biased and unbiased mechanisms of nonreciprocal exchanges (gene conversion, unequal exchanges, transposition) between member genes, often distributed on several chromosomes. These mechanisms cause fluctuations in the copy number of varian...

journal_title：Genetics

authors： Ohta T,Dover GA

更新日期：1984-10-01 00:00:00

abstract：:The process designated RIP (repeat-induced point mutation) alters duplicated DNA sequences in the sexual cycle of Neurospora crassa. We tested whether non-Neurospora sequences are susceptible to RIP, explored the basis for the observed immunity to this process of a diverged tandem duplication that probably arose by a ...

journal_title：Genetics

authors： Foss EJ,Garrett PW,Kinsey JA,Selker EU

更新日期：1991-04-01 00:00:00

abstract：:Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers. An important but usually implicit assumption is that the presence of any nonadditive genetic effect in...

journal_title：Genetics

authors： Kruijer W

更新日期：2016-01-01 00:00:00

abstract：:High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...

journal_title：Genetics

authors： Bates KL,Higley M,Letsou A

更新日期：2008-04-01 00:00:00

abstract：:The heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we pe...

journal_title：Genetics

authors： Coleman B,Topalidou I,Ailion M

更新日期：2018-06-01 00:00:00

abstract：:This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the...

journal_title：Genetics

authors： Miller CJ,Carlson JR

更新日期：2010-09-01 00:00:00

abstract：:Age-specific effects of spontaneous mutations on mortality rates in Drosophila are inferred from three large demographic experiments. Data were collected from inbred lines that were allowed to accumulate spontaneous mutations for 10, 19, and 47 generations. Estimates of age-specific mutational variance for mortality w...

journal_title：Genetics

authors： Pletcher SD,Houle D,Curtsinger JW

更新日期：1999-10-01 00:00:00

abstract：:In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements ...

journal_title：Genetics

authors： Golic MM,Golic KG

更新日期：1996-05-01 00:00:00

abstract：:To further understand how the nematode Caenorhabditis elegans defends itself against pathogen attack, we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility and pat...

journal_title：Genetics

authors： Miyata S,Begun J,Troemel ER,Ausubel FM

更新日期：2008-02-01 00:00:00

abstract：:The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved ...

journal_title：Genetics

authors： Tsuda M,Peyre JB,Asano T,Aigaki T

更新日期：2015-08-01 00:00:00

abstract：:An inbreeding matrix is defined for populations with overlapping generations. In the short term it can be expressed in terms of a matrix specifying the passage of genes between the different age groups (and sexes) and a diagonal matrix whose elements depend on the number of individuals in each age group. Formulae for ...

journal_title：Genetics

authors： Johnson DL

更新日期：1977-11-01 00:00:00

abstract：:The distribution of fitness effects (DFE) encompasses the fraction of deleterious, neutral, and beneficial mutations. It conditions the evolutionary trajectory of populations, as well as the rate of adaptive molecular evolution (α). Inferring DFE and α from patterns of polymorphism, as given through the site frequency...

journal_title：Genetics

authors： Tataru P,Mollion M,Glémin S,Bataillon T

更新日期：2017-11-01 00:00:00

abstract：:During meiosis, the stable pairing of the homologous chromosomes is mediated by the assembly of the synaptonemal complex (SC). Its tripartite structure is well conserved in Metazoa and consists of two lateral elements (LEs) and a central region (CR) that in turn is formed by several transverse filaments (TFs) and a ce...

journal_title：Genetics

authors： Fraune J,Brochier-Armanet C,Alsheimer M,Benavente R

更新日期：2013-11-01 00:00:00

abstract：:In this article, we utilize stochastic search variable selection methodology to develop a Bayesian method for identifying multiple quantitative trait loci (QTL) for complex traits in experimental designs. The proposed procedure entails embedding multiple regression in a hierarchical normal mixture model, where latent ...

journal_title：Genetics

authors： Yi N,George V,Allison DB

更新日期：2003-07-01 00:00:00

abstract：:OrthoList, a compendium of Caenorhabditis elegans genes with human orthologs compiled in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for identifying conserved genes for research into biological and disease mechanisms. However, the efficacy of orthology prediction depends on th...

journal_title：Genetics

authors： Kim W,Underwood RS,Greenwald I,Shaye DD

更新日期：2018-10-01 00:00:00

abstract：:Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), includi...

journal_title：Genetics

authors： Phillips JP,Forrest HS,Kulkarni AD

更新日期：1973-01-01 00:00:00

abstract：:Restriction map variation in two 5-6-kb chloroplast DNA regions of five diploid Aegilops species in the section Sitopsis and two wild tetraploid wheats, Triticum dicoccoides and Triticum araraticum, was investigated with a battery of four-cutter restriction enzymes. A single accession each of Triticum durum, Triticum ...

journal_title：Genetics

authors： Miyashita NT,Mori N,Tsunewaki K

更新日期：1994-07-01 00:00:00

abstract：:Genetically marked P elements inserted into the subtelomeric satellites of Drosophila show repression and variegation of the reporter gene. One such white+ reporter, inserted between the subtelomeric satellite and the terminal HeT-A array in the left arm of chromosome 2 (2L), is sensitive to its context; changes in th...

journal_title：Genetics

authors： Golubovsky MD,Konev AY,Walter MF,Biessmann H,Mason JM

更新日期：2001-07-01 00:00:00

abstract：:Drosophila melanogaster, an ancestrally African species, has recently spread throughout the world, associated with human activity. The species has served as the focus of many studies investigating local adaptation relating to latitudinal variation in non-African populations, especially those from the United States and...

journal_title：Genetics

authors： Reinhardt JA,Kolaczkowski B,Jones CD,Begun DJ,Kern AD

更新日期：2014-05-01 00:00:00

abstract：:In paramutation two alleles of a gene interact so that one of the alleles is epigenetically silenced. The silenced state is then genetically transmissible for many generations. The large (220 kbp) multigenic complex R-r is paramutable: its level of expression is changed during paramutation. R-r was found to exhibit in...

journal_title：Genetics

authors： Walker EL

更新日期：1998-04-01 00:00:00

abstract：:The agouti locus on mouse chromosome 2 encodes a secreted cysteine-rich protein of 131 amino acids that acts as a molecular switch to instruct the melanocyte to make either yellow pigment (phaeomelanin) or black pigment (eumelanin). Mutations that up-regulate agouti expression are dominant to those causing decreased e...

journal_title：Genetics

authors： Hustad CM,Perry WL,Siracusa LD,Rasberry C,Cobb L,Cattanach BM,Kovatch R,Copeland NG,Jenkins NA

更新日期：1995-05-01 00:00:00

abstract：:The glp-1 gene product mediates cell-cell interactions required for cell fate specification during development in Caenorhabditis elegans. To identify genes that interact with glp-1, we screened for dominant suppressors of two temperature-sensitive glp-1 alleles and recovered 18 mutations that suppress both germline an...

journal_title：Genetics

authors： Lissemore JL,Currie PD,Turk CM,Maine EM

更新日期：1993-12-01 00:00:00

abstract：:Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. Ubiquitin E3 ligases confer substrate specificity in this pathway, and SCF-type ligases comprise a major class of E3s. SCF ligases have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate rec...

journal_title：Genetics

authors： Gilkerson J,Hu J,Brown J,Jones A,Sun TP,Callis J

更新日期：2009-03-01 00:00:00

abstract：:Previous models suggested that regulation of telomere length in Saccharomyces cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here, we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathwa...

journal_title：Genetics

authors： Keener R,Connelly CJ,Greider CW

更新日期：2019-12-01 00:00:00

abstract：:Transposable elements are often considered as selfish DNA sequences able to invade the genome of their host species. Their evolutive dynamics are complex, due to the interaction between their intrinsic amplification capacity, selection at the host level, transposition regulation, and genetic drift. Here, we propose mo...

journal_title：Genetics

authors： Le Rouzic A,Capy P

更新日期：2005-02-01 00:00:00