Clines with asymmetric migration.

Abstract:

:The consequences of asymmetric dispersion on the maintenance of an allele in a one-dimensional environmental pocket are examined. The diffusion model of migration and selection is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is further supposed that migration is homogeneous and independent of genotype, the population density is constant and uniform, and Hardy-Weinberg proportions obtain locally. If dispersion is preferentially out of an environmental pocket at the end of a very long habitat, the condition for maintaining the allele favored in the pocket becomes less stringent than for symmetric migration; dispersion preferentially into the pocket increases the severity of the condition for polymorphism. If an allele is harmful in large regions on both sides of an environmental pocket, the probability for polymorphism is decreased by asymmetric migration. The criterion for the existence of a cline is independent of the sense of the asymmetry; the cline itself is not. These phenomena are studied both analytically and numerically.-It is shown for symmetric migration and variable population density that the more densely populated parts of the habitat are more influential in determining gene frequency than the others. Thus, the higher the population density in an environmental pocket, the more easily an allele beneficial in the pocket will be maintained in the population.

journal_name

Genetics

journal_title

Genetics

authors

Nagylaki T

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

813-27

issue

4

eissn

0016-6731

issn

1943-2631

journal_volume

88

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Empirical evaluation reveals best fit of a logistic mutation model for human Y-chromosomal microsatellites.

    abstract::The rate of microsatellite mutation is dependent upon both the allele length and the repeat motif, but the exact nature of this relationship is still unknown. We analyzed data on the inheritance of human Y-chromosomal microsatellites in father-son duos, taken from 24 published reports and comprising 15,285 directly ob...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.132308

    authors: Jochens A,Caliebe A,Rösler U,Krawczak M

    更新日期:2011-12-01 00:00:00

  • Aspects of the ultraviolet photobiology of some T-even bacteriophages.

    abstract::Bacteriophage T4 DNA metabolism is largely insulated from that of its host, although some host functions assist in the repair of T4 DNA damage. Environmental factors sometimes affect survival and mutagenesis after ultraviolet (UV) irradiation of T4, and can affect mutagenesis in many organisms. We therefore tested the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Smith LA,Drake JW

    更新日期:1998-04-01 00:00:00

  • Improving quantitative trait loci mapping resolution in experimental crosses by the use of genotypically selected samples.

    abstract::One of the key factors contributing to the success of a quantitative trait locus (QTL) mapping experiment is the precision with which QTL positions can be estimated. We show, using simulations, that QTL mapping precision for an experimental cross can be increased by the use of a genotypically selected sample of indivi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.033746

    authors: Xu Z,Zou F,Vision TJ

    更新日期:2005-05-01 00:00:00

  • Kin selection is implicated in partial sib-mating populations with constant viability differences before mating.

    abstract::The change in the frequency of a rare mutant allele under constant sex-differentiated viability selection in an infinite, partial full-sib mating population is studied. The diplo-diploid and haplo-diploid polygynous models are considered with a Poisson distribution for the number of offspring produced by every mated f...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.039024

    authors: Lessard S

    更新日期:2005-09-01 00:00:00

  • The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.

    abstract::Cryptococcus neoformans is a fungal pathogen that causes meningitis in immunocompromised hosts. The organism has a known sexual cycle, and strains of the MATalpha mating type are more virulent than isogenic MATa strains in mice, and they are more common in the environment and infected hosts. A C. neoformans homolog of...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Yue C,Cavallo LM,Alspaugh JA,Wang P,Cox GM,Perfect JR,Heitman J

    更新日期:1999-12-01 00:00:00

  • The colinearity of the Sh2/A1 orthologous region in rice, sorghum and maize is interrupted and accompanied by genome expansion in the triticeae.

    abstract::The Sh2/A1 orthologous region of maize, rice, and sorghum contains five genes in the order Sh2, X1, X2, and two A1 homologs in tandem duplication. The Sh2 and A1 homologs are separated by approximately 20 kb in rice and sorghum and by approximately 140 kb in maize. We analyzed the fate of the Sh2/A1 region in large-ge...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Li W,Gill BS

    更新日期:2002-03-01 00:00:00

  • Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

    abstract::A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was r...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.057034

    authors: Shiina T,Ota M,Shimizu S,Katsuyama Y,Hashimoto N,Takasu M,Anzai T,Kulski JK,Kikkawa E,Naruse T,Kimura N,Yanagiya K,Watanabe A,Hosomichi K,Kohara S,Iwamoto C,Umehara Y,Meyer A,Wanner V,Sano K,Macquin C,Ikeo K,T

    更新日期:2006-07-01 00:00:00

  • Genetic analysis of salt-tolerant mutants in Arabidopsis thaliana.

    abstract::Stress caused by the increased salinity of irrigated fields impairs plant growth and is one of the major constraints that limits crop productivity in many important agricultural areas. As a contribution to solving such agronomic problems, we have carried out a large-scale screening for Arabidopsis thaliana mutants ind...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Quesada V,Ponce MR,Micol JL

    更新日期:2000-01-01 00:00:00

  • Mutations in the second-largest subunit of Drosophila RNA polymerase II interact with Ubx.

    abstract::Specific mutations in the gene encoding the largest subunit of RNA polymerase II (RpII215) cause a partial transformation of a structure of the third thoracic segment, the capitellum, into the analogous structure of the second thoracic segment, the wing. This mutant phenotype is also caused by genetically reducing the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Mortin MA,Zuerner R,Berger S,Hamilton BJ

    更新日期:1992-08-01 00:00:00

  • Assessing probability of ancestry using simple sequence repeat profiles: applications to maize inbred lines and soybean varieties.

    abstract::Determining parentage is a fundamental problem in biology and in applications such as identifying pedigrees. Difficulties inferring parentage derive from extensive inbreeding within the population, whether natural or planned; using an insufficient number of hypervariable loci; and from allele mismatches caused by muta...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Berry DA,Seltzer JD,Xie C,Wright DL,Jones ES,Sebastian S,Smith JS

    更新日期:2003-09-01 00:00:00

  • Loss of Hsp70 in Drosophila is pleiotropic, with effects on thermotolerance, recovery from heat shock and neurodegeneration.

    abstract::The heat-shock response is a programmed change in gene expression carried out by cells in response to environmental stress, such as heat. This response is universal and is characterized by the synthesis of a small group of conserved protein chaperones. In Drosophila melanogaster the Hsp70 chaperone dominates the profi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.048793

    authors: Gong WJ,Golic KG

    更新日期:2006-01-01 00:00:00

  • The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure.

    abstract::Drosophila melanogaster heterochromatin protein 2 (HP2) interacts with heterochromatin protein 1 (HP1). In polytene chromosomes, HP2 and HP1 colocalize at the chromocenter, telomeres, and the small fourth chromosome. We show here that HP2 is present in the arms as well as the centromeric regions of mitotic chromosomes...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.057604

    authors: Shaffer CD,Cenci G,Thompson B,Stephens GE,Slawson EE,Adu-Wusu K,Gatti M,Elgin SC

    更新日期:2006-11-01 00:00:00

  • A novel Markov chain monte carlo approach for constructing accurate meiotic maps.

    abstract::Mapping markers from linkage data continues to be a task performed in many genetic epidemiological studies. Data collected in a study may be used to refine published map estimates and a study may use markers that do not appear in any published map. Furthermore, inaccuracies in meiotic maps can seriously bias linkage f...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.042705

    authors: George AW

    更新日期:2005-10-01 00:00:00

  • Drosophila signal peptide peptidase is an essential protease for larval development.

    abstract::We identified the Drosophila melanogaster Signal peptide peptidase gene (Spp) that encodes a multipass transmembrane aspartyl protease. Drosophila SPP is homologous to the human signal peptide peptidase (SPP) and is distantly related to the presenilins. We show that, like human SPP, Drosophila SPP can proteolyze a mod...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.039933

    authors: Casso DJ,Tanda S,Biehs B,Martoglio B,Kornberg TB

    更新日期:2005-05-01 00:00:00

  • Bayesian mapping of multiple quantitative trait loci from incomplete inbred line cross data.

    abstract::A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosome...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Sillanpää MJ,Arjas E

    更新日期:1998-03-01 00:00:00

  • The Utilization during Mitotic Cell Division of Loci Controlling Meiotic Recombination and Disjunction in DROSOPHILA MELANOGASTER.

    abstract::To inquire whether the loci identified by recombination-defective and disjunction-defective meiotic mutants in Drosophila are also utilized during mitotic cell division, the effects of 18 meiotic mutants (representing 13 loci) on mitotic chromosome stability have been examined genetically. To do this, meiotic-mutant-b...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Baker BS,Carpenter AT,Ripoll P

    更新日期:1978-11-01 00:00:00

  • A Novel Role for α-Importins and Akirin in Establishment of Meiotic Sister Chromatid Cohesion in Caenorhabditis elegans.

    abstract::During meiotic prophase I, sister chromatid cohesion is established in a way that supports the assembly of the synaptonemal complex (SC). The SC connects homologous chromosomes, directing meiotic recombination to create crossovers. In this paper, we identify two proteins that cooperate to import and load meiotic cohes...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.301458

    authors: Bowman R,Balukof N,Ford T,Smolikove S

    更新日期:2019-02-01 00:00:00

  • Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization.

    abstract::Insulin-like growth factors (IGFs) control cell and organism growth through evolutionarily conserved signaling pathways. The mammalian acid-labile subunit (ALS) is a secreted protein that complexes with IGFs to modulate their activity. Recent work has shown that a Drosophila homolog of ALS, dALS, can also complex with...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.099531

    authors: Swanson LE,Yu M,Nelson KS,Laprise P,Tepass U,Beitel GJ

    更新日期:2009-04-01 00:00:00

  • DNA sequence-mediated, evolutionarily rapid redistribution of meiotic recombination hotspots.

    abstract::Hotspots regulate the position and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicidal and are somehow resurrected elsewhere in the genome. After the DNA sequence-dependent activation of hotspots was discovered in fission yeast, nearly two decades elapsed before the key real...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.134130

    authors: Wahls WP,Davidson MK

    更新日期:2011-11-01 00:00:00

  • Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction.

    abstract::Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.166.2.807

    authors: Myster SH,Wang F,Cavallo R,Christian W,Bhotika S,Anderson CT,Peifer M

    更新日期:2004-02-01 00:00:00

  • Simultaneous Modeling of Disease Status and Clinical Phenotypes To Increase Power in Genome-Wide Association Studies.

    abstract::Genome-wide association studies have identified thousands of variants implicated in dozens of complex diseases. Most studies collect individuals with and without disease and search for variants with different frequencies between the groups. For many of these studies, additional disease traits are also collected. Joint...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.198473

    authors: Bilow M,Crespo F,Pan Z,Eskin E,Eyheramendy S

    更新日期:2017-03-01 00:00:00

  • Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.

    abstract::To identify hypothesized missing components of the synaptic G alpha(o)-G alpha(q) signaling network, which tightly regulates neurotransmitter release, we undertook two large forward genetic screens in the model organism C. elegans and focused first on mutations that strongly rescue the paralysis of ric-8(md303) reduct...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.032334

    authors: Schade MA,Reynolds NK,Dollins CM,Miller KG

    更新日期:2005-02-01 00:00:00

  • Bayesian quantitative trait locus mapping using inferred haplotypes.

    abstract::We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.109.113183

    authors: Durrant C,Mott R

    更新日期:2010-03-01 00:00:00

  • Noncell- and cell-autonomous G-protein-signaling converges with Ca2+/mitogen-activated protein kinase signaling to regulate str-2 receptor gene expression in Caenorhabditis elegans.

    abstract::In the sensory system of C. elegans, the candidate odorant receptor gene str-2 is strongly expressed in one of the two AWC neurons and weakly in both ASI neurons. Asymmetric AWC expression results from suppression of str-2 expression by a Ca2+/MAPK signaling pathway in one of the AWC neurons early in development. Here...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.058750

    authors: Lans H,Jansen G

    更新日期:2006-07-01 00:00:00

  • Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri.

    abstract::The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which make N. furzeri a uniqu...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.109.108670

    authors: Valenzano DR,Kirschner J,Kamber RA,Zhang E,Weber D,Cellerino A,Englert C,Platzer M,Reichwald K,Brunet A

    更新日期:2009-12-01 00:00:00

  • Developmental defects in a Caenorhabditis elegans model for type III galactosemia.

    abstract::Type III galactosemia is a metabolic disorder caused by reduced activity of UDP-galactose-4-epimerase, which participates in galactose metabolism and the generation of various UDP-sugar species. We characterized gale-1 in Caenorhabditis elegans and found that a complete loss-of-function mutation is lethal, as has been...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.114.170084

    authors: Brokate-Llanos AM,Monje JM,Murdoch Pdel S,Muñoz MJ

    更新日期:2014-12-01 00:00:00

  • A conserved long noncoding RNA affects sleep behavior in Drosophila.

    abstract::Metazoan genomes encode an abundant collection of mRNA-like, long noncoding (lnc)RNAs. Although lncRNAs greatly expand the transcriptional repertoire, we have a limited understanding of how these RNAs contribute to developmental regulation. Here, we investigate the function of the Drosophila lncRNA called yellow-achae...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.131706

    authors: Soshnev AA,Ishimoto H,McAllister BF,Li X,Wehling MD,Kitamoto T,Geyer PK

    更新日期:2011-10-01 00:00:00

  • The genetic structure of a tribal population, the Yanomama Indians. XIV. Clines and their interpretation.

    abstract::The Yanomama Indians are a South American tribe distributed over an irregular area approximately 200 X 300 miles. The gene frequencies observed at 12 loci in 47 villages within this area have been analyzed for the occurrence of clines. Apparently significant clines are observed for alleles of the Rh, MNSs, Kidd, Gm, I...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ward RH,Neel JV

    更新日期:1976-01-01 00:00:00

  • Misrepair mutagenesis in bacteriophage T4.

    abstract::The T4 mutations px, y and 1206 inactivate an error-prone recombination-like repair system, reducing or abolishing mutagenesis by UV irradiation, MMS, and white light irradiation in the presence of the photosensitizer 8MOP. Both px and y increase some spontaneous mutation rates and slightly enhance proflavin mutagenes...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Green RR,Drake JW

    更新日期:1974-09-01 00:00:00

  • An Investigation of the Genetics of "Male Sex-Ratio" Phenotype in DROSOPHILA PSEUDOOBSCURA.

    abstract::A laboratory strain of Drosophila pseudoobscura (L116) is studied that, when crossed to sex-ratio homozygous females, produces sons that exhibit varying levels of the male sex-ratio (msr) phenotype. The msr phenotype occurs only in sex-ratio males and is due to the production of a high frequency of nullo-XY sperm. The...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cobbs G

    更新日期:1986-06-01 00:00:00