Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.

abstract：:The spindle assembly checkpoint-mediated mitotic arrest depends on proteins that signal the presence of one or more unattached kinetochores and prevents the onset of anaphase in the presence of kinetochore or spindle damage. In the presence of either damage, bub2 cells initiate a preanaphase delay but do not maintain ...

journal_title：Genetics

authors： Krishnan R,Pangilinan F,Lee C,Spencer F

更新日期：2000-10-01 00:00:00

abstract：:The three-dimensional organization of polytene chromosomes within nuclei containing rearranged X chromosomes was examined in male Drosophila melanogaster. Salivary glands of third instar larvae containing either an inverted X chromosome (YSX.YL, In(1)EN/O) or a ring X chromosome (R(1) 2/BSYy+) were fixed, embedded, an...

journal_title：Genetics

authors： Mathog D,Sedat JW

更新日期：1989-02-01 00:00:00

abstract：:Recombination in mammalian cells is thought to involve both reciprocal and nonreciprocal modes of exchange, although rigorous proof is lacking due to the inability to recover all products of an exchange. To investigate further the relationship between these modes of exchange, we have analyzed intrachromosomal recombin...

journal_title：Genetics

authors： Bollag RJ,Liskay RM

更新日期：1988-05-01 00:00:00

abstract：:Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the sam...

journal_title：Genetics

authors： Lewontin RC

更新日期：1988-11-01 00:00:00

abstract：:In experiments with directional selection on a quantitative character a "reversed response" to selection is occasionally observed, when selection of individuals for a higher (lower) value of the character results in a lower (higher) value of the character among their offspring. A sudden change in environments or rando...

journal_title：Genetics

authors： Gimelfarb A

更新日期：1986-09-01 00:00:00

abstract：:The neutral rate of allelic substitution is analyzed for a class-structured population subject to a stationary stochastic demographic process. The substitution rate is shown to be generally equal to the effective mutation rate, and under overlapping generations it can be expressed as the effective mutation rate in new...

journal_title：Genetics

authors： Lehmann L

更新日期：2014-05-01 00:00:00

abstract：:Knowledge of the rate and fitness effects of mutations is essential for understanding the process of evolution. Mutations are inherently difficult to study because they are rare and are frequently eliminated by natural selection. In the ciliate Tetrahymena thermophila, mutations can accumulate in the germline genome w...

journal_title：Genetics

authors： Long HA,Paixão T,Azevedo RB,Zufall RA

更新日期：2013-10-01 00:00:00

abstract：:The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologic...

journal_title：Genetics

authors： Molnar M,Bähler J,Sipiczki M,Kohli J

更新日期：1995-09-01 00:00:00

abstract：:Synthetics play an important role in quantitative genetic research and plant breeding, but few studies have investigated the application of genomic prediction (GP) to these populations. Synthetics are generated by intermating a small number of parents ([Formula: see text] and thereby possess unique genetic properties,...

journal_title：Genetics

authors： Schopp P,Müller D,Technow F,Melchinger AE

更新日期：2017-01-01 00:00:00

abstract：:A point connecting a pair of homologous regions of DNA duplexes moves along the homology in a reaction intermediate of the homologous recombination. Formulating this movement as a random walk, we were previously successful at explaining the dependence of the recombination frequency on the homology length. Recently, th...

journal_title：Genetics

authors： Fujitani Y,Kobayashi I

更新日期：1999-12-01 00:00:00

abstract：:The decrease of meiotic exchanges (crossing over and conversion) in two mutants of Sordaria macrospora correlated strongly with a reduction of chiasmata and of both types of "recombination nodules." Serial section reconstruction electron microscopy was used to compare the synapsis pattern of meiotic prophase I in wild...

journal_title：Genetics

authors： Zickler D,Moreau PJ,Huynh AD,Slezec AM

更新日期：1992-09-01 00:00:00

abstract：:We showed that sufficient overexpression of the wild-type recF gene interfered with three normal cell functions: (1) UV induction of transcription from the LexA-protein-repressed sulA promoter, (2) UV resistance and (3) cell viability at 42 degrees. To show this, we altered a low-level overexpressing recF+ plasmid wit...

journal_title：Genetics

authors： Sandler SJ,Clark AJ

更新日期：1993-11-01 00:00:00

abstract：:The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by monitoring their relative abundance across time points in a si...

journal_title：Genetics

authors： Matuszewski S,Hildebrandt ME,Ghenu AH,Jensen JD,Bank C

更新日期：2016-09-01 00:00:00

abstract：:Plant endo-beta-1,3-glucanases (EGases) degrade the cell wall polysaccharides of attacking pathogens and release elicitors of additional plant defenses. Isozymes EGaseA and EGaseB of soybean differ in susceptibility to a glucanase inhibitor protein (GIP1) produced by Phytophthora sojae, a major soybean pathogen. EGase...

journal_title：Genetics

authors： Bishop JG,Ripoll DR,Bashir S,Damasceno CM,Seeds JD,Rose JK

更新日期：2005-02-01 00:00:00

abstract：:USING A NEWLY DEVELOPED PLATING SYSTEM, WE HAVE MEASURED CELL SURVIVAL AND THE FREQUENCIES OF VARIATION IN AN INHERITED TRAIT AFTER TREATMENT OF SOYBEAN CELL SUSPENSIONS WITH DIFFERENT MUTAGENS: ethyl methanesulfonate (EMS), methyl methanesulfonate (MMS), N-Methyl-N'-nitro-N-nitroso-guanidine (MNNG), hycanthone (1-{[2...

journal_title：Genetics

authors： Weber G,Lark KG

更新日期：1980-09-01 00:00:00

abstract：:We present here a molecular analysis of the region surrounding the structural gene encoding alcohol dehydrogenase (Adh) in 47 lines of Drosophila melanogaster that have each accumulated mutations for 300 generations. While these lines show a significant increase in variation of alcohol dehydrogenase enzyme activity co...

journal_title：Genetics

authors： Aquadro CF,Tachida H,Langley CH,Harada K,Mukai T

更新日期：1990-12-01 00:00:00

abstract：:Candida albicans, which is diploid, possesses a single mating-type (MTL) locus on chromosome 5, which is normally heterozygous (a/alpha). To mate, C. albicans must undergo MTL homozygosis to a/a or alpha/alpha. Three possible mechanisms may be used in this process, mitotic recombination, gene conversion, or loss of on...

journal_title：Genetics

authors： Wu W,Pujol C,Lockhart SR,Soll DR

更新日期：2005-03-01 00:00:00

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:A correlation between diversity levels and rates of recombination is predicted both by models of positive selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models of purifying selection against strongly deleterious mutations (commonly referred to as "background selecti...

journal_title：Genetics

authors： Andolfatto P,Przeworski M

更新日期：2001-06-01 00:00:00

abstract：:In this article we investigate multiplicative effects between genes in relation to heterosis. The extensive literature on heterosis due to multiplicative effects between characters is reviewed, as is earlier work on the genetic description of heterosis. A two-locus diallelic model of arbitrary gene action is used to d...

journal_title：Genetics

authors： Schnell FW,Cockerham CC

更新日期：1992-06-01 00:00:00

abstract：:A genetic model with additive-dominance effects and genotype x environment interactions is presented for quantitative traits with time-dependent measures. The genetic model for phenotypic means at time t conditional on phenotypic means measured at previous time (t-1) is defined. Statistical methods are proposed for an...

journal_title：Genetics

authors： Zhu J

更新日期：1995-12-01 00:00:00

abstract：:The cut gene in Drosophila is necessary in at least one cell type, the external sensory organs, for proper cell type specification and morphogenesis. It is also expressed in a variety of other tissues, where its function is less well characterized. Previous work has demonstrated that mutations affecting all the tissue...

journal_title：Genetics

authors： Liu S,McLeod E,Jack J

更新日期：1991-01-01 00:00:00

abstract：:The DNA-binding protein encoded by the zeste gene of Drosophila activates transcription and mediates interchromosomal interactions such as transvection. The mutant protein encoded by the zeste1 (z1) allele retains the ability to support transvection, but represses white. Similar to transvection, repression requires Ze...

journal_title：Genetics

authors： Rosen C,Dorsett D,Jack J

更新日期：1998-04-01 00:00:00

abstract：:The Saccharomyces cerevisiae PHO85 gene encodes a nonessential cyclin-dependent kinase that associates with 10 cyclin subunits. To survey the functions provided by Pho85, we identified mutants that require PHO85 for viability. We identified mutations that define seven Pho Eighty-Five Requiring or Efr loci, six of whic...

journal_title：Genetics

authors： Lenburg ME,O'Shea EK

更新日期：2001-01-01 00:00:00

abstract：:The polarized partitioning of proteins in cells underlies asymmetric cell division, which is an important driver of development and cellular diversity. The budding yeast Saccharomyces cerevisiae divides asymmetrically, like many other cells, to generate two distinct progeny cells. A well-known example of an asymmetric...

journal_title：Genetics

authors： Herrero E,Stinus S,Bellows E,Berry LK,Wood H,Thorpe PH

更新日期：2020-11-01 00:00:00

abstract：:We have examined the stability of the tandemly repeated genes that encode the ribosomal RNA in Coprinus cinereus. These genes are contained within two linked HindIII fragments in a 3.0-Mb chromosome. We monitored the size of these fragments in both mitotic and meiotic segregants using the contour-clamped homogeneous e...

journal_title：Genetics

authors： Pukkila PJ,Skrzynia C

更新日期：1993-02-01 00:00:00

abstract：:Seed component structures were grouped into maternal and offspring (embryo and endosperm) tissues to characterize a dormancy quantitative trait locus (QTL) for tissue-specific function using a marker-assisted genetic approach. The approach was devised to test if genotypic/allelic frequencies of a marker tightly linked...

journal_title：Genetics

authors： Gu XY,Turnipseed EB,Foley ME

更新日期：2008-08-01 00:00:00

abstract：:Drosophila melanogaster males dosage compensate by twofold upregulation of the expression of genes on their single X chromosome. This process requires at least five proteins and two noncoding RNAs, roX1 and roX2, which paint the male X chromosome. We used a deletion analysis to search for functional RNA domains within...

journal_title：Genetics

authors： Stuckenholz C,Meller VH,Kuroda MI

更新日期：2003-07-01 00:00:00

abstract：:Plants with mutations in one of three maize genes, mop1, rmr1, and rmr2, are defective in paramutation, an allele-specific interaction that leads to meiotically heritable chromatin changes. Experiments reported here demonstrate that these genes are required to maintain the transcriptional silencing of two different tr...

journal_title：Genetics

authors： McGinnis KM,Springer C,Lin Y,Carey CC,Chandler V

更新日期：2006-07-01 00:00:00

abstract：:Several multilocus models that incorporate both preferential mating and viability selection are studied. Specifically, a class of symmetric heterozygosity models are considered that assign individuals to phenotypic classes according to which loci are in heterozygous state regardless of the actual allelic content. Othe...

journal_title：Genetics

authors： Karlin S,Raper J

更新日期：1982-01-01 00:00:00