Abstract:
:X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress and X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, although these two genes are located in a region of the X chromosome that is not duplicated. The effects do not depend on the region of the X chromosome duplicated and is stronger in strains with two doses of a duplication than in strains with one dose. This is evidence for a general elevation of X-linked gene expression in strains carrying X-chromosome duplications, consistent with the hypothesis that the duplications titrate a repressor acting on many X-linked genes.
journal_name
Geneticsjournal_title
Geneticsauthors
Meneely PM,Nordstrom KDsubject
Has Abstractpub_date
1988-06-01 00:00:00pages
365-75issue
2eissn
0016-6731issn
1943-2631journal_volume
119pub_type
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