Regulation of phosphate metabolism in Neurospora crassa: isolation of mutants deficient in ther repressible alkaline phosphatase.

abstract：:In the present study, we investigated intrachromosomal homologous recombination in a murine hybridoma in which the recipient for recombination, the haploid, endogenous chromosomal immunoglobulin mu-gene bearing a mutation in the constant (Cmu) region, was separated from the integrated single copy wild-type donor Cmu r...

journal_title：Genetics

authors： Baker MD,Read LR,Ng P,Beatty BG

更新日期：1999-06-01 00:00:00

abstract：:Genetic screens in Drosophila melanogaster and other organisms have been pursued to filter the genome for genetic functions important for memory formation. Such screens have employed primarily chemical or transposon-mediated mutagenesis and have identified numerous mutants including classical memory mutants, dunce and...

journal_title：Genetics

authors： Walkinshaw E,Gai Y,Farkas C,Richter D,Nicholas E,Keleman K,Davis RL

更新日期：2015-04-01 00:00:00

abstract：:The plant mitochondrial genome is composed of a set of molecules of various sizes that generate each other through recombination between repeated sequences. Molecular observations indicate that these different molecules are present in an equilibrium state. Different compositions of molecules have been observed within ...

journal_title：Genetics

authors： Albert B,Godelle B,Atlan A,De Paepe R,Gouyon PH

更新日期：1996-09-01 00:00:00

abstract：:Genetic analyses of nine traits associated with stem water-soluble carbohydrate (SWSC) accumulation and remobilization at grain-filling period under drought stress (DS) and well-watered (WW) conditions were undertaken using doubled haploid lines (DHLs) derived from two Chinese common wheat cultivars. Some significantl...

journal_title：Genetics

authors： Yang DL,Jing RL,Chang XP,Li W

更新日期：2007-05-01 00:00:00

abstract：:The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of two C(2)H(2)'s and a C(2)HC motif that a...

journal_title：Genetics

authors： Kim HR,Chae KS,Han KH,Han DM

更新日期：2009-07-01 00:00:00

abstract：:Microtubules are dynamic structures that must elongate, disassemble, and be cleaved into smaller pieces for proper neuronal development and function. The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance between long, stable filaments and shorter fragments that seed exte...

journal_title：Genetics

authors： Ozdowski EF,Gayle S,Bao H,Zhang B,Sherwood NT

更新日期：2011-09-01 00:00:00

abstract：:Combined with a system for identifying each of the chromosomes in a genome, visualizing the location of individual genetic loci by fluorescence in situ hybridization (FISH) would aid in assembling physical and genetic maps. Previously, large genomic clones have been successfully used as FISH probes onto somatic chromo...

journal_title：Genetics

authors： Lamb JC,Danilova T,Bauer MJ,Meyer JM,Holland JJ,Jensen MD,Birchler JA

更新日期：2007-03-01 00:00:00

abstract：:In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...

journal_title：Genetics

authors： Sarot E,Payen-Groschêne G,Bucheton A,Pélisson A

更新日期：2004-03-01 00:00:00

abstract：:We describe here a new variant of transposon Tn10 especially adapted for transposon analysis of cloned yeast genes; it can equally well be used for analysis of prokaryotic genes. We have applied this element to analysis of the LEU2, RAD50, and CDC48 genes of Saccharomyces cerevisiae. This transposon, nicknamed mini-Tn...

journal_title：Genetics

authors： Huisman O,Raymond W,Froehlich KU,Errada P,Kleckner N,Botstein D,Hoyt MA

更新日期：1987-06-01 00:00:00

abstract：:Small regulatory RNAs, such as small interfering RNAs (siRNAs) and PIWI-interacting RNAs, regulate splicing, transcription, and genome integrity in many eukaryotes. In Caenorhabditis elegans, siRNAs bind nuclear Argonautes (AGOs), which interact with homologous premessenger RNAs to recruit downstream silencing effecto...

journal_title：Genetics

authors： Wan G,Yan J,Fei Y,Pagano DJ,Kennedy S

更新日期：2020-12-01 00:00:00

abstract：:The size of the genome in the opportunistic fungus Candida albicans is 15.6 Mb. Whole-genome shotgun sequencing was carried out at Stanford University where the sequences were assembled into 412 contigs. C. albicans is a diploid basically, and analysis of the sequence is complicated due to repeated sequences and to se...

journal_title：Genetics

authors： Chibana H,Oka N,Nakayama H,Aoyama T,Magee BB,Magee PT,Mikami Y

更新日期：2005-08-01 00:00:00

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:Satellite DNA is an enigmatic component of genomic DNA with unclear function that has been regarded as "junk." Yet, persistence of these tandem highly repetitive sequences in heterochromatic regions of most eukaryotic chromosomes attests to their importance in the genome. We explored the Anopheles gambiae genome for t...

journal_title：Genetics

authors： Krzywinski J,Sangaré D,Besansky NJ

更新日期：2005-01-01 00:00:00

abstract：:Mutations in the SPT10 and SPT21 genes were originally isolated as suppressors of Ty and LTR (delta) insertion mutations in Saccharomyces cerevisiae, and the genes were shown to be required for normal transcription at a number of loci in yeast. Now we have cloned, sequenced, mapped and mutagenized SPT10 and SPT21. Sin...

journal_title：Genetics

authors： Natsoulis G,Winston F,Boeke JD

更新日期：1994-01-01 00:00:00

abstract：:Host mutations in Escherichia coli K12 selected for the temperature-sensitive replication of the bacterial plasmid colicinogenic factor E(1) (ColE(1)) exhibit a pleiotropic effect with respect to the effect of the mutation on other extra-chromosomal elements. The mutations also vary with respect to the time of incubat...

journal_title：Genetics

authors： Kingsbury DT,Sieckmann DG,Helinski DR

更新日期：1973-05-01 00:00:00

abstract：:We have analyzed donor and target sites of the mobile element Activator (Ac) that are altered as a result of somatic transposition from the P locus in maize. Previous genetic analysis has indicated that the two mitotic daughter lineages which result from Ac transposition from P differ in their Ac constitution at the P...

journal_title：Genetics

authors： Chen J,Greenblatt IM,Dellaporta SL

更新日期：1987-09-01 00:00:00

abstract：:RNA polymerase II (RNAPII) in eukaryotic cells drives transcription of most messenger RNAs. RNAPII core enzyme is composed of 12 polypeptides where Rpb1 is the largest subunit. To further understand the mechanisms of RNAPII transcription, we isolated and characterized novel point mutants of RPB1 that are sensitive to ...

journal_title：Genetics

authors： Malagon F,Kireeva ML,Shafer BK,Lubkowska L,Kashlev M,Strathern JN

更新日期：2006-04-01 00:00:00

abstract：:Selection during evolution, whether natural or artificial, acts through the phenotype. For multifaceted phenotypes such as plant and inflorescence architecture, the underlying genetic architecture is comprised of a complex network of interacting genes rather than single genes that act independently to determine the tr...

journal_title：Genetics

authors： Studer AJ,Wang H,Doebley JF

更新日期：2017-10-01 00:00:00

abstract：:All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...

journal_title：Genetics

authors： Cyert MS,Philpott CC

更新日期：2013-03-01 00:00:00

abstract：:In yeast meiotic recombination, alleles used as genetic markers fall into two classes as regards their fate when incorporated into heteroduplex DNA. Normal alleles are those that form heteroduplexes that are nearly always recognized and corrected by the mismatch repair system operating in meiosis. High PMS (postmeioti...

journal_title：Genetics

authors： Manivasakam P,Rosenberg SM,Hastings PJ

更新日期：1996-02-01 00:00:00

abstract：:An inbreeding matrix is defined for populations with overlapping generations. In the short term it can be expressed in terms of a matrix specifying the passage of genes between the different age groups (and sexes) and a diagonal matrix whose elements depend on the number of individuals in each age group. Formulae for ...

journal_title：Genetics

authors： Johnson DL

更新日期：1977-11-01 00:00:00

abstract：:RecQ helicases function in the maintenance of genome stability in many organisms. The filamentous fungus Neurospora crassa has two RecQ homologs, QDE3 and RECQ2. We found that the qde-3 recQ2 double mutant showed a severe growth defect. The growth defect was alleviated by mutation in mei-3, the homolog of yeast RAD51,...

journal_title：Genetics

authors： Kato A,Inoue H

更新日期：2006-01-01 00:00:00

abstract：:Drosophila melanogaster, an ancestrally African species, has recently spread throughout the world, associated with human activity. The species has served as the focus of many studies investigating local adaptation relating to latitudinal variation in non-African populations, especially those from the United States and...

journal_title：Genetics

authors： Reinhardt JA,Kolaczkowski B,Jones CD,Begun DJ,Kern AD

更新日期：2014-05-01 00:00:00

abstract：:The meiotic properties of paracentric inversion heterozygotes have been well studied in insects and plants, but not in mammalian species. In essence, a single meiotic recombination event within the inverted region results in the formation of a dicentric chromatid, which usually breaks or is stretched between the two d...

journal_title：Genetics

authors： Koehler KE,Millie EA,Cherry JP,Burgoyne PS,Evans EP,Hunt PA,Hassold TJ

更新日期：2002-11-01 00:00:00

abstract：:Genomic resources for hundreds of species of evolutionary, agricultural, economic, and medical importance are unavailable due to the expense of well-assembled genome sequences and difficulties with multigenerational studies. Teleost fish provide many models for human disease but possess anciently duplicated genomes th...

journal_title：Genetics

authors： Amores A,Catchen J,Ferrara A,Fontenot Q,Postlethwait JH

更新日期：2011-08-01 00:00:00

abstract：:The larval body wall muscles of Drosophila melanogaster arise by fusion of founder myoblasts (FMs) and fusion-competent myoblasts (FCMs). Sticks-and-Stones (SNS) is expressed on the surface of all FCMs and mediates adhesion with FMs and developing syncytia. Intracellular components essential for myoblast fusion are th...

journal_title：Genetics

authors： Kocherlakota KS,Wu JM,McDermott J,Abmayr SM

更新日期：2008-03-01 00:00:00

abstract：:We have analyzed the requirements for the multi sex combs (mxc) gene during development to gain further insight into the mechanisms and developmental processes that depend on the important trans-regulators forming the Polycomb group (PcG) in Drosophila melanogaster. mxc is allelic with the tumor suppressor locus letha...

journal_title：Genetics

authors： Saget O,Forquignon F,Santamaria P,Randsholt NB

更新日期：1998-08-01 00:00:00

abstract：:A Plasmodium-refractory strain of Anopheles gambiae melanotically encapsulates many species of Plasmodium, whereas wild-type mosquitoes are usually susceptible. This encapsulation trait can also be observed by studying the response of refractory and susceptible strains to intrathoracically injected CM-Sephadex beads. ...

journal_title：Genetics

authors： Gorman MJ,Severson DW,Cornel AJ,Collins FH,Paskewitz SM

更新日期：1997-07-01 00:00:00

abstract：:We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood ...

journal_title：Genetics

authors： Durrant C,Mott R

更新日期：2010-03-01 00:00:00

abstract：:Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...

journal_title：Genetics

authors： Falque M,Mercier R,Mézard C,de Vienne D,Martin OC

更新日期：2007-07-01 00:00:00