Terminal synthesis of xanthommatin in Drosophila melanogaster. 3. Mutational pleiotropy and pigment granule association of phenoxazinone synthetase.

abstract：:This paper draws attention to the formal parallelism that exists between chromosomal-loss mosaicism and mutagenically induced mosaicism in Drosophila and suggests that, although the underlying processes by which these two types of genetic mosaics are generated are very different, the more refined methodology employed ...

journal_title：Genetics

authors： Nissani M

更新日期：1977-08-01 00:00:00

abstract：:We propose a new method for calculating probabilities for pedigree genetic data that incorporates crossover interference using the chi-square models. Applications include relationship inference, genetic map construction, and linkage analysis. The method is based on importance sampling of unobserved inheritance pattern...

journal_title：Genetics

authors： Browning S

更新日期：2003-08-01 00:00:00

abstract：:We recently described a yeast assay suitable for genetic screening in which simple religation nonhomologous end-joining (NHEJ) and single-strand annealing (SSA) compete for repair of an I-SceI-created double-strand break. Here, the required allele has been introduced into an array of 4781 MATa deletion mutants and eac...

journal_title：Genetics

authors： Wilson TE

更新日期：2002-10-01 00:00:00

abstract：:To understand long terminal repeat (LTR)-retrotransposon copy number dynamics, Ty1 elements were reintroduced into a "Ty-less" Saccharomyces strain where elements had been lost by LTR-LTR recombination. Repopulated strains exhibited alterations in chromosome size that were associated with Ty1 insertions, but did not b...

journal_title：Genetics

authors： Garfinkel DJ,Nyswaner KM,Stefanisko KM,Chang C,Moore SP

更新日期：2005-04-01 00:00:00

abstract：:Multilocus surveys of sequence variation can be used to identify targets of directional selection, which are expected to have reduced levels of variation. Following a population bottleneck, the signal of directional selection may be hard to detect because many loci may have low variation by chance and the frequency sp...

journal_title：Genetics

authors： Hamblin MT,Casa AM,Sun H,Murray SC,Paterson AH,Aquadro CF,Kresovich S

更新日期：2006-06-01 00:00:00

abstract：:In lytic cycle crosses with Red-Gam-lambda phage, particles were examined that had undergone an Int-mediated exchange. It was assumed that this exchange dimerized the circular lambda, making it packageable. Among these Int-mediated recombinants, particles were identified that had, in addition, enjoyed a close double e...

journal_title：Genetics

authors： Stahl FW,Lieb M,Stahl MM

更新日期：1984-12-01 00:00:00

abstract：:To understand the in vivo function of the unique and conserved carboxy-terminal repeat domain (CTD) of RNA polymerase II largest subunit (RpII215), we have studied RNA polymerase II biosynthesis, activity and genetic function in Drosophila RpII215 mutants that possessed all (C4), half (W81) or none (IIt) of the CTD re...

journal_title：Genetics

authors： Brickey WJ,Greenleaf AL

更新日期：1995-06-01 00:00:00

abstract：:Rapid and high wing-beat frequencies achieved during insect flight are powered by the indirect flight muscles, the largest group of muscles present in the thorax. Any anomaly during the assembly and/or structural impairment of the indirect flight muscles gives rise to a flightless phenotype. Multiple mutagenesis scree...

journal_title：Genetics

authors： Firdaus H,Mohan J,Naz S,Arathi P,Ramesh SR,Nongthomba U

更新日期：2015-05-01 00:00:00

abstract：:Chromatin is organized and compacted in the nucleus through the association of histones and other proteins, which together control genomic activity. Two broad types of chromatin can be distinguished: euchromatin, which is generally transcriptionally active, and heterochromatin, which is repressed. Here we examine the ...

journal_title：Genetics

authors： Ahringer J,Gasser SM

更新日期：2018-02-01 00:00:00

abstract：:Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...

journal_title：Genetics

authors： Shcherbakov VP,Plugina LA

更新日期：1991-08-01 00:00:00

abstract：:Genetic study of the reproductive barriers between related species plays an essential role in understanding the process of speciation. We developed a new method for mapping all possible factors causing deviations from expected Mendelian segregation ratios in F(2) progeny, which substantially contribute to reproductive...

journal_title：Genetics

authors： Harushima Y,Nakagahra M,Yano M,Sasaki T,Kurata N

更新日期：2001-10-01 00:00:00

abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...

journal_title：Genetics

authors： Schreck N,Piepho HP,Schlather M

更新日期：2019-10-01 00:00:00

abstract：:In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked ...

journal_title：Genetics

authors： Weissman DB,Hallatschek O

更新日期：2014-04-01 00:00:00

abstract：:The bristle worm Platynereis dumerilii displays many interesting biological characteristics. These include its reproductive timing, which is synchronized to the moon phase, its regenerative capacity that is hormonally controlled, and a slow rate of evolution, which permits analyses of ancestral genes and cell types. A...

journal_title：Genetics

authors： Zantke J,Bannister S,Rajan VB,Raible F,Tessmar-Raible K

更新日期：2014-05-01 00:00:00

abstract：:We have cloned and disrupted in vivo, by repeat-induced point mutations, the nuclear gene coding for an iron sulfur subunit of complex I from Neurospora crassa, homologue of the mammalian TYKY protein. Analysis of the obtained mutant nuo21.3c revealed that complex I fails to assemble. The peripheral arm of the enzyme ...

journal_title：Genetics

authors： Duarte M,Videira A

更新日期：2000-10-01 00:00:00

abstract：:This Perspectives article recounts the isolation and sequencing of the first human histocompatibility gene (HLA) in 1980-1981. At the time, general knowledge of the molecules of the immune system was already fairly extensive, and gene rearrangements in the immunoglobulin complex (discovered in 1976) had generated much...

journal_title：Genetics

authors： Jordan BR

更新日期：2010-04-01 00:00:00

abstract：:Evolutionary rescue describes a situation where adaptive evolution prevents the extinction of a population facing a stressing environment. Models of evolutionary rescue could in principle be used to predict the level of stress beyond which extinction becomes likely for species of conservation concern, or, conversely, ...

journal_title：Genetics

authors： Anciaux Y,Chevin LM,Ronce O,Martin G

更新日期：2018-05-01 00:00:00

abstract：:Variable numbers of tandem repeats (VNTRs) are a class of highly informative and widely dispersed genetic markers. Despite their wide application in biological science, little is known about their mutational mechanisms or population dynamics. The objective of this work was to investigate four summary measures of VNTR ...

journal_title：Genetics

authors： Shriver MD,Jin L,Chakraborty R,Boerwinkle E

更新日期：1993-07-01 00:00:00

abstract：:The genetic structure of green turtle (Chelonia mydas) rookeries located around the Australian coast was assessed by (1) comparing the structure found within and among geographic regions, (2) comparing microsatellite loci vs. restriction fragment length polymorphism analyses of anonymous single copy nuclear DNA (ascnD...

journal_title：Genetics

authors： FitzSimmons NN,Moritz C,Limpus CJ,Pope L,Prince R

更新日期：1997-12-01 00:00:00

abstract：:Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...

journal_title：Genetics

authors： Hann BJ,Hebert PD

更新日期：1982-09-01 00:00:00

abstract：:We show how to incorporate fluctuations of the recombination rate along the chromosome into standard gene-genealogical models for the decorrelation of gene histories. This enables us to determine how small-scale fluctuations (Poissonian hot-spot model) and large-scale variations (Kong et al. 2002) of the recombination...

journal_title：Genetics

authors： Eriksson A,Mehlig B

更新日期：2005-02-01 00:00:00

abstract：:Rp1 is a complex rust resistance locus of maize. The HRp1-D haplotype is composed of Rp1-D and eight paralogues, seven of which also code for predicted nucleotide binding site-leucine rich repeat (NBS-LRR) proteins similar to the Rp1-D gene. The paralogues are polymorphic (DNA identities 91-97%), especially in the C-t...

journal_title：Genetics

authors： Sun Q,Collins NC,Ayliffe M,Smith SM,Drake J,Pryor T,Hulbert SH

更新日期：2001-05-01 00:00:00

abstract：:Clustering individuals to subpopulations based on genetic data has become commonplace in many genetic studies. Inference about population structure is most often done by applying model-based approaches, aided by visualization using distance-based approaches such as multidimensional scaling. While existing distance-bas...

journal_title：Genetics

authors： Greenbaum G,Templeton AR,Bar-David S

更新日期：2016-04-01 00:00:00

abstract：:A sample of 16 Minutes, representing 12 loci distributed over all the chromosome arms and including 3 pairs of alleles and 4 deficiencies, has been studied with respect to several developmental and recombinational parameters. Cell marker mutants located in most of the chromosome arms were used to assess (1) spontaneou...

journal_title：Genetics

authors： Ferrus A

更新日期：1975-04-01 00:00:00

abstract：:Frequent nonhomologous recombination has been previously postulated to explain the 1045-bp insertion in one mitochondrial sperm-transmitted haplotype of Mytilus galloprovincialis. Such recombination would lead to the disruption of gene order and so the existence of a specific mechanism for maintaining the same gene or...

journal_title：Genetics

authors： Burzyński A

更新日期：2007-02-01 00:00:00

abstract：:Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of breast tumors are associated with significant differences in prognosis and survival. Assuming that the differences are attributed to subtype-specific pathways, we then...

journal_title：Genetics

authors： Li R,Campos J,Iida J

更新日期：2015-12-01 00:00:00

abstract：:In the absence of a vg+ gene, extensive cell death occurs in third instar imaginal discs, which results in a complete loss of adult wing margin structures. Essentially all molecularly characterized vg alleles are associated with deletions or insertions of DNA into the vg locus. These alterations reduce or eliminate a ...

journal_title：Genetics

authors： Williams JA,Scott IM,Atkin AL,Brook WJ,Russell MA,Bell JB

更新日期：1990-08-01 00:00:00

abstract：:The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster....

journal_title：Genetics

authors： Travaglini EC,Schultz J

更新日期：1972-11-01 00:00:00

abstract：:Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...

journal_title：Genetics

authors： Bueno Filho JS,Gilmour SG,Rosa GJ

更新日期：2006-10-01 00:00:00

abstract：:Next generation sequencing (NGS) is about to revolutionize genetic analysis. Currently NGS techniques are mainly used to sequence individual genomes. Due to the high sequence coverage required, the costs for population-scale analyses are still too high to allow an extension to nonmodel organisms. Here, we show that NG...

journal_title：Genetics

authors： Futschik A,Schlötterer C

更新日期：2010-09-01 00:00:00