Abstract：
:The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include families with more than two affected sibs in the sib-pair analysis. This paper presents appropriate weighting schemes. A procedure for estimating the frequency of the disease allele in the general population, under the assumptions of single-allele recessive, additive, dominant and intermediate models, with negligible recombination (theta = 0) between the disease-predisposing gene and the HLA region, and no selective disadvantage of the trait, is also given. Cluster-sampling techniques are used in the analysis.
journal_name
Geneticsjournal_title
Geneticsauthors
Motro U,Thomson Gsubject
Has Abstractpub_date
1985-07-01 00:00:00pages
525-38issue
3eissn
0016-6731issn
1943-2631journal_volume
110pub_type
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