The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae.

abstract：:The long-term population genetics of multigene families is influenced by several biased and unbiased mechanisms of nonreciprocal exchanges (gene conversion, unequal exchanges, transposition) between member genes, often distributed on several chromosomes. These mechanisms cause fluctuations in the copy number of varian...

journal_title：Genetics

authors： Ohta T,Dover GA

更新日期：1984-10-01 00:00:00

abstract：:Genetic control over chromosome stability in the interspecific hybrid embryos of Hordeum vulgare and H. bulbosum has been hypothesized to reside on specific chromosomes. In this study, crosses between the primary trisomic lines for the seven different H. vulgare chromosomes and tetraploid H. bulbosum revealed that bot...

journal_title：Genetics

authors： Ho KM,Kasha KJ

更新日期：1975-10-01 00:00:00

abstract：:The challenges of breeding autotetraploid potato (Solanum tuberosum) have motivated the development of alternative breeding strategies. A common approach is to obtain uniparental dihaploids from a tetraploid of interest through pollination with S. tuberosum Andigenum Group (formerly S. phureja) cultivars. The mechanis...

journal_title：Genetics

authors： Amundson KR,Ordoñez B,Santayana M,Tan EH,Henry IM,Mihovilovich E,Bonierbale M,Comai L

更新日期：2020-02-01 00:00:00

abstract：:Microsatellites are tandemly repeated short DNA sequences that are favored as molecular-genetic markers due to their high polymorphism index. Plant genomes characterized to date exhibit taxon-specific differences in frequency, genomic location, and motif structure of microsatellites, indicating that extant microsatell...

journal_title：Genetics

authors： Mun JH,Kim DJ,Choi HK,Gish J,Debellé F,Mudge J,Denny R,Endré G,Saurat O,Dudez AM,Kiss GB,Roe B,Young ND,Cook DR

更新日期：2006-04-01 00:00:00

abstract：:High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...

journal_title：Genetics

authors： Bates KL,Higley M,Letsou A

更新日期：2008-04-01 00:00:00

abstract：:Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), includi...

journal_title：Genetics

authors： Phillips JP,Forrest HS,Kulkarni AD

更新日期：1973-01-01 00:00:00

abstract：:Regulatory networks provide control over complex cell behavior in all kingdoms of life. Here we describe a statistical model, based on representing proteins as collections of domains or motifs, which predicts unknown molecular interactions within these biological networks. Using known protein-protein interactions of S...

journal_title：Genetics

authors： Gomez SM,Lo SH,Rzhetsky A

更新日期：2001-11-01 00:00:00

abstract：:Dis3 encodes a conserved RNase that degrades or processes all RNA species via an N-terminal PilT N terminus (PIN) domain and C-terminal RNB domain that harbor, respectively, endonuclease activity and 3'-5' exonuclease activity. In Schizosaccharomyces pombe, dis3 mutations cause chromosome missegregation and failure in...

journal_title：Genetics

authors： Snee MJ,Wilson WC,Zhu Y,Chen SY,Wilson BA,Kseib C,O'Neal J,Mahajan N,Tomasson MH,Arur S,Skeath JB

更新日期：2016-06-01 00:00:00

abstract：:No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed. ...

journal_title：Genetics

authors： Chen JJ,Duan T,Single R,Mather K,Thomson G

更新日期：2005-07-01 00:00:00

abstract：:Previous work showed that C. elegans gon-14 is required for gonadogenesis. Here we report that gon-14 encodes a protein with similarity to LIN-15B, a class B synMuv protein. An extensive region of GON-14 contains blocks of sequence similarity to transposases of the hAT superfamily, but key residues are not conserved, ...

journal_title：Genetics

authors： Chesney MA,Kidd AR 3rd,Kimble J

更新日期：2006-02-01 00:00:00

abstract：:137Cs-gamma irradiation of bacteriophage T4 induces large deletions plus a variety of types of point mutations. All mutations arise with single-hit kinetics, and all by a misrepair process. The estimated point mutation rate is 1.5 X 10(-9) per locus per rad. ...

journal_title：Genetics

authors： Conkling MA,Grunau JA,Drake JW

更新日期：1976-04-01 00:00:00

abstract：:The extent of conservation of synteny and gene order in the Lepidoptera has been investigated previously only by comparing a small subset of linkage groups between the moth Bombyx mori and the butterfly Heliconius melpomene. Here we report the mapping of 64 additional conserved genes in H. melpomene, which contributed...

journal_title：Genetics

authors： Pringle EG,Baxter SW,Webster CL,Papanicolaou A,Lee SF,Jiggins CD

更新日期：2007-09-01 00:00:00

abstract：:Evolution through natural selection suggests unnecessary genes are lost. We observed that the yeast Candida glabrata lost the gene encoding a phosphate-repressible acid phosphatase (PHO5) present in many yeasts including Saccharomyces cerevisiae. However, C. glabrata still had phosphate starvation-inducible phosphatas...

journal_title：Genetics

authors： Orkwis BR,Davies DL,Kerwin CL,Sanglard D,Wykoff DD

更新日期：2010-11-01 00:00:00

abstract：:Two parental strains of laboratory mice, NZB and CBA/H, were chosen for their differences in attack behavior. NZB have higher scores than CBA/H. An effect of the Y chromosome on attack behavior was determined for two maternal environments. Each male was tested once in a dyadic encounter with an A/J male as a standard ...

journal_title：Genetics

authors： Carlier M,Roubertoux PL,Pastoret C

更新日期：1991-09-01 00:00:00

abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

journal_title：Genetics

authors： Wagner M,Briza P,Pierce M,Winter E

更新日期：1999-04-01 00:00:00

abstract：:A unique aspect of meiosis is the segregation of homologous chromosomes at the meiosis I division. The pairing of homologous chromosomes is a critical aspect of meiotic prophase I that aids proper disjunction at anaphase I. We have used a site-specific recombination assay in Saccharomyces cerevisiae to examine allelic...

journal_title：Genetics

authors： Lui DY,Peoples-Holst TL,Mell JC,Wu HY,Dean EW,Burgess SM

更新日期：2006-07-01 00:00:00

abstract：:Male Drosophila heterozygous for an SD-bearing second chromosome and a normal homolog preferentially transmit the SD chromosome to their offspring. The distorted transmission involves the induced dysfunction of the sperm that receive the SD+ chromosome. The loci on the SD chromosome responsible for causing distortion ...

journal_title：Genetics

authors： Brittnacher JG,Ganetzky B

更新日期：1989-04-01 00:00:00

abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...

journal_title：Genetics

authors： Beckwith EJ,Hernando CE,Polcowñuk S,Bertolin AP,Mancini E,Ceriani MF,Yanovsky MJ

更新日期：2017-10-01 00:00:00

abstract：:To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cre-drivers) that restrict expression to specific cell types. To addres...

journal_title：Genetics

authors： Korecki AJ,Hickmott JW,Lam SL,Dreolini L,Mathelier A,Baker O,Kuehne C,Bonaguro RJ,Smith J,Tan CV,Zhou M,Goldowitz D,Deussing JM,Stewart AF,Wasserman WW,Holt RA,Simpson EM

更新日期：2019-04-01 00:00:00

abstract：:Paramutation generates heritable changes affecting regulation of specific alleles found at several Zea mays (maize) loci that encode transcriptional regulators of anthocyanin biosynthetic genes. Although the direction and extent of paramutation is influenced by poorly understood allelic interactions occurring in diplo...

journal_title：Genetics

authors： Hollick JB,Kermicle JL,Parkinson SE

更新日期：2005-10-01 00:00:00

abstract：:We tested the hypothesis that the time course of the evolution of antifungal drug resistance depends on the ploidy of the fungus. The experiments were designed to measure the initial response to the selection imposed by the antifungal drug fluconazole up to and including the fixation of the first resistance mutation i...

journal_title：Genetics

authors： Anderson JB,Sirjusingh C,Ricker N

更新日期：2004-12-01 00:00:00

abstract：:Genetically marked P elements inserted into the subtelomeric satellites of Drosophila show repression and variegation of the reporter gene. One such white+ reporter, inserted between the subtelomeric satellite and the terminal HeT-A array in the left arm of chromosome 2 (2L), is sensitive to its context; changes in th...

journal_title：Genetics

authors： Golubovsky MD,Konev AY,Walter MF,Biessmann H,Mason JM

更新日期：2001-07-01 00:00:00

abstract：:In fission yeast, regulation of p34cdc2 plays an important role in the checkpoint coupling mitosis to completion of DNA replication. The cdc2 mutations cdc2-3w (C67Y) and cdc2-4w (C67F) abolish checkpoint control without seriously affecting normal cell proliferation. However the molecular basis of this phenotype is no...

journal_title：Genetics

authors： Basi G,Enoch T

更新日期：1996-12-01 00:00:00

abstract：:Natural selection favors alleles that increase the number of offspring produced by their carriers. But in a world that is inherently uncertain within generations, selection also favors alleles that reduce the variance in the number of offspring produced. If previous studies have established this principle, they have l...

journal_title：Genetics

authors： Mullon C,Reuter M,Lehmann L

更新日期：2014-01-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are secreted signaling molecules that control important developmental events in many different organisms. Previous studies have shown that BMPs are expressed at the earliest stages of skeletal development, and are required for formation of specific skeletal features, strongly suggest...

journal_title：Genetics

authors： DiLeone RJ,Russell LB,Kingsley DM

更新日期：1998-01-01 00:00:00

abstract：:Wolbachia-induced cytoplasmic incompatibility (CI) is expressed when infected males are crossed with either uninfected females or females infected with Wolbachia of different CI specificity. In diploid insects, CI results in embryonic mortality, apparently due to the the loss of the paternal set of chromosomes, usuall...

journal_title：Genetics

authors： Zabalou S,Apostolaki A,Pattas S,Veneti Z,Paraskevopoulos C,Livadaras I,Markakis G,Brissac T,Merçot H,Bourtzis K

更新日期：2008-04-01 00:00:00

abstract：:The fission yeast Schizosaccharomyces pombe has never been found to give rise to viable cells totally lacking mitochondrial DNA (rho(o)). This paper describes the isolation of rho(o) strains of S. pombe by very long term incubation of cells in liquid medium containing glucose, potassium acetate and ethidium bromide. O...

journal_title：Genetics

authors： Haffter P,Fox TD

更新日期：1992-06-01 00:00:00

abstract：:Mathematical models are presented for the evolution of postmating and premating reproductive isolation. In the case of postmating isolation it is assumed that hybrid sterility or inviability is caused by incompatibility of alleles at one or two loci, and evolution of reproductive isolation occurs by random fixation of...

journal_title：Genetics

authors： Nei M,Maruyama T,Wu CI

更新日期：1983-03-01 00:00:00

abstract：:The complete nucleotide sequence of the 14,771-bp-long mitochondrial (mt) DNA of a urochordate (Chordata)-the ascidian Halocynthia roretzi-was determined. All the Halocynthia mt-genes were found to be located on a single strand, which is rich in T and G rather than in A and C. Like nematode and Mytilus edulis mtDNAs, ...

journal_title：Genetics

authors： Yokobori Si,Ueda T,Feldmaier-Fuchs G,Pääbo S,Ueshima R,Kondow A,Nishikawa K,Watanabe K

更新日期：1999-12-01 00:00:00

abstract：:One of the key factors contributing to the success of a quantitative trait locus (QTL) mapping experiment is the precision with which QTL positions can be estimated. We show, using simulations, that QTL mapping precision for an experimental cross can be increased by the use of a genotypically selected sample of indivi...

journal_title：Genetics

authors： Xu Z,Zou F,Vision TJ

更新日期：2005-05-01 00:00:00