Specificity of repeat-induced point mutation (RIP) in Neurospora: sensitivity of non-Neurospora sequences, a natural diverged tandem duplication, and unique DNA adjacent to a duplicated region.

abstract：:Genes at the SerH locus of the ciliated protist Tetrahymena thermophila specify the major (H) surface protein on cells grown at 20-36 degrees. Alternative proteins L, T, S and I are expressed under different conditions of temperature and culture media. Mutants unable to express SerH genes were examined for expression ...

journal_title：Genetics

authors： Smith DL,Doerder FP

更新日期：1992-01-01 00:00:00

abstract：:The Aspergillus nidulans rcoADelta mutant exhibits growth and developmental defects. We show that the rcoADelta mutant lacks cleistothecia and is self-sterile. In crosses with wild-type strains, rcoADelta nuclei do not contribute to the cleistothecial walls. Furthermore, sexual development resulting from veA overexpre...

journal_title：Genetics

authors： Todd RB,Hynes MJ,Andrianopoulos A

更新日期：2006-11-01 00:00:00

abstract：:Genes with unstable transcripts often encode proteins that play important regulatory roles. ATL2 is a member of a multigene family coding highly related RING-H2 zinc-finger proteins that may function as E3 ubiquitin ligases. ATL2 mRNA accumulation occurs rapidly and transiently after incubation with elicitors of patho...

journal_title：Genetics

authors： Serrano M,Guzmán P

更新日期：2004-06-01 00:00:00

abstract：:The importance of quantifying and accounting for stochastic genotyping errors when analyzing microsatellite data is increasingly being recognized. This awareness is motivating the development of data analysis methods that not only take errors into consideration but also recognize the difference between two distinct cl...

journal_title：Genetics

authors： Johnson PC,Haydon DT

更新日期：2007-02-01 00:00:00

abstract：:The Drosophila melanogaster Gld gene has multiple and diverse developmental and physiological functions. We report herein that interactions among proximal promoter elements and a cluster of intronically located enhancers and silencers specify the complex regulation of Gld that underlies its diverse functions. Gld expr...

journal_title：Genetics

authors： Keplinger BL,Guo X,Quine J,Feng Y,Cavener DR

更新日期：2001-02-01 00:00:00

abstract：:A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals....

journal_title：Genetics

authors： Fu YX

更新日期：1997-08-01 00:00:00

abstract：:Gene silencing by heterochromatin is a well-known phenomenon that, in Drosophila, is called position effect variegation (PEV). The long-held hypothesis that this gene silencing is associated with an altered chromatin structure received direct support only recently. Another gene-silencing phenomenon in Drosophila, alth...

journal_title：Genetics

authors： Boivin A,Dura JM

更新日期：1998-12-01 00:00:00

abstract：:When a polygenic character is exposed to natural selection in which the curve giving fitness as a function of phenotype is a mixture of two Gaussian (normal) curves, the population may respond either by evolving to a specialized phenotype near one of the two optimum phenotypes, or by evolving to a generalized phenotyp...

journal_title：Genetics

authors： Felsenstein J

更新日期：1979-11-01 00:00:00

abstract：:Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network. Two MAP kinase (MAPK) pathways are essential for communicat...

journal_title：Genetics

authors： Fischer MS,Wu VW,Lee JE,O'Malley RC,Glass NL

更新日期：2018-06-01 00:00:00

abstract：:Synthetics play an important role in quantitative genetic research and plant breeding, but few studies have investigated the application of genomic prediction (GP) to these populations. Synthetics are generated by intermating a small number of parents ([Formula: see text] and thereby possess unique genetic properties,...

journal_title：Genetics

authors： Schopp P,Müller D,Technow F,Melchinger AE

更新日期：2017-01-01 00:00:00

abstract：:An extending axon growth cone is subjected to attractant and repellent cues. It is not clear how these growth cones discriminate the two opposing forces and select their projection paths. Here, we report that in the Drosophila nerve cord the growth cones of longitudinal tracts are subjected to attraction by the Netrin...

journal_title：Genetics

authors： Bhat KM

更新日期：2005-05-01 00:00:00

abstract：:Acrylamide gel electrophoresis was performed on the enzyme xanthine dehydrogenase in sixty isochromosomal lines of Drosophila persimilis from three geographic populations. Sequential electrophoretic analysis using varied gel concentrations and buffers revealed twenty-three alleles in this species where only five had b...

journal_title：Genetics

authors： Coyne JA

更新日期：1976-11-01 00:00:00

abstract：:The micronutrient boron is essential in maintaining the structure of plant cell walls and is critical for high yields in crop species. Boron can move into plants by diffusion or by active and facilitated transport mechanisms. We recently showed that mutations in the maize boron efflux transporter ROTTEN EAR (RTE) caus...

journal_title：Genetics

authors： Chatterjee M,Liu Q,Menello C,Galli M,Gallavotti A

更新日期：2017-08-01 00:00:00

abstract：:Gene targeting techniques have led to the phenotypic characterization of numerous genes; however, many genes show minimal to no phenotypic consequences when disrupted, despite many having highly conserved sequences. The standard explanation for these findings is functional redundancy. A competing hypothesis is that th...

journal_title：Genetics

authors： Ruff JS,Saffarini RB,Ramoz LL,Morrison LC,Baker S,Laverty SM,Tvrdik P,Potts WK

更新日期：2015-10-01 00:00:00

abstract：:The yeast pheromone/filamentous growth MAPK pathway mediates both mating and invasive-growth responses. The interface between this MAPK module and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 ...

journal_title：Genetics

authors： Breitkreutz A,Boucher L,Breitkreutz BJ,Sultan M,Jurisica I,Tyers M

更新日期：2003-11-01 00:00:00

abstract：:The eight enzymes of the tricarboxylic acid (TCA) cycle are encoded by at least 15 different nuclear genes in Saccharomyces cerevisiae. We have constructed a set of yeast strains defective in these genes as part of a comprehensive analysis of the interactions among the TCA cycle proteins. The 15 major TCA cycle genes ...

journal_title：Genetics

authors： Przybyla-Zawislak B,Gadde DM,Ducharme K,McCammon MT

更新日期：1999-05-01 00:00:00

abstract：:The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon s...

journal_title：Genetics

authors： Petersen L,Enos-Berlage J,Downs DM

更新日期：1996-05-01 00:00:00

abstract：:In this work we study how mutations that change physical properties of cell proteins (stability) affect population survival and growth. We present a model in which the genotype is presented as a set folding free energies of cell proteins. Mutations occur upon replication, so stabilities of some proteins in daughter ce...

journal_title：Genetics

authors： Chen P,Shakhnovich EI

更新日期：2009-10-01 00:00:00

abstract：:The noncanonical Frizzled/planar cell polarity (PCP) pathway regulates establishment of polarity within the plane of an epithelium to generate diversity of cell fates, asymmetric, but highly aligned structures, or to orchestrate the directional migration of cells during convergent extension during vertebrate gastrulat...

journal_title：Genetics

authors： Dollar G,Gombos R,Barnett AA,Sanchez Hernandez D,Maung SM,Mihály J,Jenny A

更新日期：2016-03-01 00:00:00

abstract：:Expectations for the time scale and structure of allelic genealogies in finite populations are formed under three models of sporophytic self-incompatibility. The models differ in the dominance interactions among the alleles that determine the self-incompatibility phenotype: In the SSIcod model, alleles act codominantl...

journal_title：Genetics

authors： Schierup MH,Vekemans X,Christiansen FB

更新日期：1998-11-01 00:00:00

abstract：:As a genetic mutation is passed down across generations, it distinguishes those genomes that have inherited it from those that have not, providing a glimpse of the genealogical tree relating the genomes to each other at that site. Statistical summaries of genetic variation therefore also describe the underlying geneal...

journal_title：Genetics

authors： Ralph P,Thornton K,Kelleher J

更新日期：2020-07-01 00:00:00

abstract：:The evidence in support of two types of alternate disjunction in translocation heterozygotes from the German cockroach, Blattella germanica (L.), is reviewed. When unique cytomorphological features occur in the translocation figure, the two types of alternate disjunction are identifiable regardless of the angle of obs...

journal_title：Genetics

authors： Cochran DG

更新日期：1983-05-01 00:00:00

abstract：:Classical studies have established that, during meiosis, the X and Y chromosomes of the model dioecious plant Silene latifolia pair over a region at the ends of their q arms. We used fluorescence in situ hybridization of two molecular markers to demonstrate that this widely accepted model is incorrect. From these data...

journal_title：Genetics

authors： Lengerova M,Moore RC,Grant SR,Vyskot B

更新日期：2003-10-01 00:00:00

abstract：:A scheme for rapidly mapping chromosome rearrangements relative to the physical map of Caenorhabditis elegans is described that is based on hybridization patterns of cloned DNA on meiotic nuclei, as visualized by fluorescent in situ hybridization. From the nearly complete physical map, DNA clones, in yeast artificial ...

journal_title：Genetics

authors： Albertson DG

更新日期：1993-05-01 00:00:00

abstract：:The purpose of this study was to characterize two mutator stocks of yeast which were induced and selected on the basis of high spontaneous reversion rates of the suppressible "ochre" nonsense allele lys1-1. In the mutator stock VA-3, a single mutation, designated mut1-1, is responsible for the increase in the reversio...

journal_title：Genetics

authors： Gottlieb DJ,von Borstel RC

更新日期：1976-08-01 00:00:00

abstract：:Using a new model of isoalleles, extensive Monte Carlo experiments were performed to examine the pattern of allelic distribution in a finite population. In this model it was assumed that the set of allelic states is represented by discrete points on a one-dimensional lattice and that change of state by mutation occurs...

journal_title：Genetics

authors： Ohta T,Kimura M

更新日期：1974-03-01 00:00:00

abstract：:Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...

journal_title：Genetics

authors： Eustice M,Pillus L

更新日期：2014-04-01 00:00:00

abstract：:Genomic resources for hundreds of species of evolutionary, agricultural, economic, and medical importance are unavailable due to the expense of well-assembled genome sequences and difficulties with multigenerational studies. Teleost fish provide many models for human disease but possess anciently duplicated genomes th...

journal_title：Genetics

authors： Amores A,Catchen J,Ferrara A,Fontenot Q,Postlethwait JH

更新日期：2011-08-01 00:00:00

abstract：:The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient DNA polymerase γ mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, sug...

journal_title：Genetics

authors： Stumpf JD,Copeland WC

更新日期：2013-06-01 00:00:00

abstract：:Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

journal_title：Genetics

authors： Schraiber JG

更新日期：2018-01-01 00:00:00