Spatial autocorrelation of genotypes under directional selection.

Abstract:

:The spatial distributions of genetic variation under selection-mutation equilibrium within populations that have limited dispersal are investigated. The results show that directional selection with moderate strength rapidly reduces the amount of genetic structure and spatial autocorrelations far below that predicted for selectively neutral loci. For the latter, homozygotes are spatially clustered into separate areas or patches, each consisting of several hundred homozygotes. When selection is added the patches of the deleterious homozygotes are much smaller, in the range of 25 to 50 individuals. Selection also reduces temporal correlations. Also investigated are the effects of random replacement processes, such as mutation, immigration, and long-distance migration, on spatial and temporal correlations. The detection of natural selection through spatial pattern analysis is discussed, and applied to data from populations of the morning glory, Ipomoea purpurea.

journal_name

Genetics

journal_title

Genetics

authors

Epperson BK

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

757-71

issue

3

eissn

0016-6731

issn

1943-2631

journal_volume

124

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Assessing the Relationship of Ancient and Modern Populations.

    abstract::Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.117.300448

    authors: Schraiber JG

    更新日期:2018-01-01 00:00:00

  • Rhythmic Behavior Is Controlled by the SRm160 Splicing Factor in Drosophila melanogaster.

    abstract::Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.117.300139

    authors: Beckwith EJ,Hernando CE,Polcowñuk S,Bertolin AP,Mancini E,Ceriani MF,Yanovsky MJ

    更新日期:2017-10-01 00:00:00

  • MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae.

    abstract::Magnesium (Mg) is an essential enzyme cofactor and a key structural component of biological molecules, but relatively little is known about the molecular components required for Mg homeostasis in eukaryotic cells. The yeast genome encodes four characterized members of the CorA Mg transporter superfamily located in the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.109.106419

    authors: Pisat NP,Pandey A,Macdiarmid CW

    更新日期:2009-11-01 00:00:00

  • The Drosophila wispy gene is required for RNA localization and other microtubule-based events of meiosis and early embryogenesis.

    abstract::RNAs are localized by microtubule-based pathways to both the anterior and posterior poles of the developing Drosophila oocyte. We describe a new gene, wispy, required for localization of mRNAs to both poles of the egg. Embryos from wispy mothers arrest development after abnormal oocyte meiosis and failure of pronuclei...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Brent AE,MacQueen A,Hazelrigg T

    更新日期:2000-04-01 00:00:00

  • Evidence for complex genic interactions between conspecific chromosomes underlying hybrid female sterility in the Drosophila simulans clade.

    abstract::F1 hybrid females between the sibling species Drosophila simulans, Drosophila mauritiana and Drosophila sechellia are completely fertile. However, we have found that female sterility can be observed in F2 backcross females who are homozygous for D. simulans X chromosomes and homozygous for autosomal regions from eithe...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Davis AW,Noonburg EG,Wu CI

    更新日期:1994-05-01 00:00:00

  • Patterns of recombination and MLH1 foci density along mouse chromosomes: modeling effects of interference and obligate chiasma.

    abstract::Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.070235

    authors: Falque M,Mercier R,Mézard C,de Vienne D,Martin OC

    更新日期:2007-07-01 00:00:00

  • Flanking duplications and deletions associated with P-induced male recombination in Drosophila.

    abstract::We studied P element-induced recombination in germline mitotic cells by examining the structure of the recombinant chromosomes. We found that most recombinants retain a mobile P element at the site of the recombination, usually with either a deletion or a duplication immediately adjacent to the P end at which the cros...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Preston CR,Sved JA,Engels WR

    更新日期:1996-12-01 00:00:00

  • A Bayesian multilocus association method: allowing for higher-order interaction in association studies.

    abstract::For most common diseases with heritable components, not a single or a few single-nucleotide polymorphisms (SNPs) explain most of the variance for these disorders. Instead, much of the variance may be caused by interactions (epistasis) among multiple SNPs or interactions with environmental conditions. We present a new ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.071696

    authors: Albrechtsen A,Castella S,Andersen G,Hansen T,Pedersen O,Nielsen R

    更新日期:2007-06-01 00:00:00

  • Distinct steps in yeast spore morphogenesis require distinct SMK1 MAP kinase thresholds.

    abstract::The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Wagner M,Briza P,Pierce M,Winter E

    更新日期:1999-04-01 00:00:00

  • Role of testis-specific gene expression in sex-chromosome evolution of Anopheles gambiae.

    abstract::Gene expression in Anopheles gambiae shows a deficiency of testis-expressed genes on the X chromosome associated with an excessive movement of retrogene duplication. We suggest that the degeneration of sex chromosomes in this monandrous species is likely the result of pressures from X inactivation, dosage compensation...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.133157

    authors: Baker DA,Russell S

    更新日期:2011-11-01 00:00:00

  • Uncovering Cryptic Asexuality in Daphnia magna by RAD Sequencing.

    abstract::The breeding systems of many organisms are cryptic and difficult to investigate with observational data, yet they have profound effects on a species' ecology, evolution, and genome organization. Genomic approaches offer a novel, indirect way to investigate breeding systems, specifically by studying the transmission of...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.115.179879

    authors: Svendsen N,Reisser CM,Dukić M,Thuillier V,Ségard A,Liautard-Haag C,Fasel D,Hürlimann E,Lenormand T,Galimov Y,Haag CR

    更新日期:2015-11-01 00:00:00

  • Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing.

    abstract::Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.084384

    authors: Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

    更新日期:2008-06-01 00:00:00

  • A novel Markov chain monte carlo approach for constructing accurate meiotic maps.

    abstract::Mapping markers from linkage data continues to be a task performed in many genetic epidemiological studies. Data collected in a study may be used to refine published map estimates and a study may use markers that do not appear in any published map. Furthermore, inaccuracies in meiotic maps can seriously bias linkage f...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.042705

    authors: George AW

    更新日期:2005-10-01 00:00:00

  • Isozyme allelic frequencies related to selection and gene-flow hypotheses.

    abstract::Significant correlations between allelic frequencies and environmental variables in a number of insect species have been demonstrated by multivariate techniques. Since many environmental variables show a strong relationship to geographic location and since gene flow between populations can also produce patterns of gen...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Schaffer HE,Johnson FM

    更新日期:1974-05-01 00:00:00

  • Improving quantitative trait loci mapping resolution in experimental crosses by the use of genotypically selected samples.

    abstract::One of the key factors contributing to the success of a quantitative trait locus (QTL) mapping experiment is the precision with which QTL positions can be estimated. We show, using simulations, that QTL mapping precision for an experimental cross can be increased by the use of a genotypically selected sample of indivi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.033746

    authors: Xu Z,Zou F,Vision TJ

    更新日期:2005-05-01 00:00:00

  • Inseparability of X-Heterochromatic Functions Responsible for X:Y Pairing, Meiotic Drive, and Male Fertility in Drosophila melanogaster.

    abstract::Deficiencies encompassing part or all of the X heterochromatin of Drosophila melanogaster have been linked to three abnormalities in male meiosis and spermatogenesis: X-Y nondisjunction, skewed sperm recovery ratios favoring sperm with reduced chromatin content, and sterility in males carrying either a Y-autosome tran...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: McKee B,Lindsley DL

    更新日期:1987-07-01 00:00:00

  • Linkage disequilibrium in related breeding lines of chickens.

    abstract::High-density genotyping of single-nucleotide polymorphisms (SNPs) enables detection of quantitative trait loci (QTL) by linkage disequilibrium (LD) mapping using LD between markers and QTL and the subsequent use of this information for marker-assisted selection (MAS). The success of LD mapping and MAS depends on the e...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.082206

    authors: Andreescu C,Avendano S,Brown SR,Hassen A,Lamont SJ,Dekkers JC

    更新日期:2007-12-01 00:00:00

  • The Genetics of Mating Song Evolution Underlying Rapid Speciation: Linking Quantitative Variation to Candidate Genes for Behavioral Isolation.

    abstract::Differences in mating behaviors evolve early during speciation, eventually contributing to reproductive barriers between species. Knowledge of the genetic and genomic basis of these behaviors is therefore integral to a causal understanding of speciation. Acoustic behaviors are often part of the mating ritual in animal...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.301706

    authors: Xu M,Shaw KL

    更新日期:2019-03-01 00:00:00

  • Improved confidence intervals in quantitative trait loci mapping by permutation bootstrapping.

    abstract::The nonparametric bootstrap approach is known to be suitable for calculating central confidence intervals for the locations of quantitative trait loci (QTL). However, the distribution of the bootstrap QTL position estimates along the chromosome is peaked at the positions of the markers and is not tailed equally. This ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bennewitz J,Reinsch N,Kalm E

    更新日期:2002-04-01 00:00:00

  • Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.

    abstract::To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cre-drivers) that restrict expression to specific cell types. To addres...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.119.301984

    authors: Korecki AJ,Hickmott JW,Lam SL,Dreolini L,Mathelier A,Baker O,Kuehne C,Bonaguro RJ,Smith J,Tan CV,Zhou M,Goldowitz D,Deussing JM,Stewart AF,Wasserman WW,Holt RA,Simpson EM

    更新日期:2019-04-01 00:00:00

  • Linkage disequilibrium for two X-linked genes in Sardinia and its bearing on the statistical mapping of the human X chromosome.

    abstract::The distribution of four X-linked mutants (G6PD, Deutan, Protan and Xg) among lowland and once highly malarial populations of Sardinia discloses a clear-cut example of linkage disequiligrium between two of them (G6PD and Protan). In the same populations the distribution of G6PD-deficiency versus colorblindness of the ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Filippi G,Rinaldi A,Palmarino R,Seravalli E,Siniscalco M

    更新日期:1977-05-01 00:00:00

  • RNA sequence evolution with secondary structure constraints: comparison of substitution rate models using maximum-likelihood methods.

    abstract::We test models for the evolution of helical regions of RNA sequences, where the base pairing constraint leads to correlated compensatory substitutions occurring on either side of the pair. These models are of three types: 6-state models include only the four Watson-Crick pairs plus GU and UG; 7-state models include a ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Savill NJ,Hoyle DC,Higgs PG

    更新日期:2001-01-01 00:00:00

  • Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.

    abstract::Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous re...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.031492

    authors: Singer JB,Hill AE,Nadeau JH,Lander ES

    更新日期:2005-02-01 00:00:00

  • Evolution of MHC class II E beta diversity within the genus Peromyscus.

    abstract::Progress in understanding the evolution of variation at the MHC has been slowed by an inability to assess the relative roles of mutation vs. intragenic recombination in contributing to observed polymorphism. Recent theoretical advances now permit a quantitative treatment of the problem, with the result that the amount...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Richman AD,Herrera LG,Nash D

    更新日期:2003-05-01 00:00:00

  • Raw mediates antagonism of AP-1 activity in Drosophila.

    abstract::High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.086298

    authors: Bates KL,Higley M,Letsou A

    更新日期:2008-04-01 00:00:00

  • Life-History Evolution and the Genetics of Fitness Components in Drosophila melanogaster.

    abstract::Life-history traits or "fitness components"-such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span-are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding ...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.119.300160

    authors: Flatt T

    更新日期:2020-01-01 00:00:00

  • New Map Location of ilvO in ESCHERICHIA COLI.

    abstract::Mutations in ilvO, the operator site for operon A of the ilv region of E. coli K-12, are reported to cause a cis dominant derepression of the operon A gene products and to map between ilvC and ilvA. Studies reported here demonstrate that the F25 episome which does not carry the region between ilvC and ilvA but only il...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cohen BM,Jones EW

    更新日期:1976-06-01 00:00:00

  • The expanding genetic toolbox of the wasp Nasonia vitripennis and its relatives.

    abstract::The parasitoid wasp Nasonia represents a genus of four species that is emerging as a powerful genetic model system that has made and will continue to make important contributions to our understanding of evolutionary biology, development, ecology, and behavior. Particularly powerful are the haplodiploid genetics of the...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.112.147512

    authors: Lynch JA

    更新日期:2015-04-01 00:00:00

  • The Paf1 Complex Broadly Impacts the Transcriptome of Saccharomyces cerevisiae.

    abstract::The Polymerase Associated Factor 1 complex (Paf1C) is a multifunctional regulator of eukaryotic gene expression important for the coordination of transcription with chromatin modification and post-transcriptional processes. In this study, we investigated the extent to which the functions of Paf1C combine to regulate t...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.119.302262

    authors: Ellison MA,Lederer AR,Warner MH,Mavrich TN,Raupach EA,Heisler LE,Nislow C,Lee MT,Arndt KM

    更新日期:2019-07-01 00:00:00

  • Functional redundancy within roX1, a noncoding RNA involved in dosage compensation in Drosophila melanogaster.

    abstract::Drosophila melanogaster males dosage compensate by twofold upregulation of the expression of genes on their single X chromosome. This process requires at least five proteins and two noncoding RNAs, roX1 and roX2, which paint the male X chromosome. We used a deletion analysis to search for functional RNA domains within...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Stuckenholz C,Meller VH,Kuroda MI

    更新日期:2003-07-01 00:00:00