Abstract：
:Notch is a receptor that mediates cell-cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the elucidation of the unusual mechanism of signal transduction a little over a decade ago. As an essay for the GENETICS Perspectives series, it is my personal and critical commentary as well as an historical account of discovery.
journal_name
Geneticsjournal_title
Geneticsauthors
Greenwald Idoi
10.1534/genetics.112.141812subject
Has Abstractpub_date
2012-07-01 00:00:00pages
655-69issue
3eissn
0016-6731issn
1943-2631pii
191/3/655journal_volume
191pub_type
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