Phenotypes of mutations in the 5'-UTR of a limiting transcription factor in Aspergillus nidulans can be accounted for by translational inhibition and leaky scanning.

abstract：:The Genetics Society of America's George W. Beadle Award honors individuals who have made outstanding contributions to the community of genetics researchers and who exemplify the qualities of its namesake as a respected academic, administrator, and public servant. The 2015 recipient is John Postlethwait. He has made g...

journal_title：Genetics

authors： Postlethwait JH

更新日期：2015-07-01 00:00:00

abstract：:Segregation distorter (SD) chromosomes are preferentially transmitted to offspring from heterozygous SD/SD(+) males owing to the induced dysfunction of the SD(+)-bearing sperm. This phenomenon involves at least two major loci: the Sd locus whose presence is necessary for distortion to occur and the Rsp locus which act...

journal_title：Genetics

authors： Brittnacher JG,Ganetzky B

更新日期：1983-04-01 00:00:00

abstract：:When a polygenic character is exposed to natural selection in which the curve giving fitness as a function of phenotype is a mixture of two Gaussian (normal) curves, the population may respond either by evolving to a specialized phenotype near one of the two optimum phenotypes, or by evolving to a generalized phenotyp...

journal_title：Genetics

authors： Felsenstein J

更新日期：1979-11-01 00:00:00

abstract：:An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters containing 4607 genes, over one-fifth of all genes in C. elegans. Cluster genes are distributed unevenly in the genome, with t...

journal_title：Genetics

authors： Thomas JH

更新日期：2006-01-01 00:00:00

abstract：:We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood ...

journal_title：Genetics

authors： Durrant C,Mott R

更新日期：2010-03-01 00:00:00

abstract：:A continuing study of mortality rates among children born to survivors of the atomic bombings and a suitable group of controls has been updated; the average interval between birth and verification of death or survival is 17 years. The mortality experience is now based on 18,946 children liveborn to parents one or both...

journal_title：Genetics

authors： Neel JV,Kato H,Schull WJ

更新日期：1974-02-01 00:00:00

abstract：:Thirty-four independent nonviable c-locus mutations (types cal, albino lethal and cas, albino subvital), derived from radiation experiments, were tested for involvement of nearby markers tp, Mod-2, sh-1, and Hbb: 10, 22, and 2 involved, respectively, none of these markers, Mod-2 alone, and Mod-2 plus sh-1. When classi...

journal_title：Genetics

authors： Russell LB,Montgomery CS,Raymer GD

更新日期：1982-03-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. While many AMD susceptibility variants have been identified, their influence on AMD progression has not been elucidated. Using data from two large clinical trials, Age-Related Eye Disease Study (AREDS) and AREDS2, we evaluat...

journal_title：Genetics

authors： Ding Y,Liu Y,Yan Q,Fritsche LG,Cook RJ,Clemons T,Ratnapriya R,Klein ML,Abecasis GR,Swaroop A,Chew EY,Weeks DE,Chen W,AREDS2 Research Group.

更新日期：2017-05-01 00:00:00

abstract：:Resident gut bacteria are constantly influencing the immune system, yet the role of the immune system in shaping microbiota composition during an organism's life span has remained unclear. Experiments in mice have been inconclusive due to differences in husbandry schemes that led to conflicting results. We used Drosop...

journal_title：Genetics

authors： Mistry R,Kounatidis I,Ligoxygakis P

更新日期：2017-06-01 00:00:00

abstract：:We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX). In addition we show that recessive...

journal_title：Genetics

authors： Meneely PM,Wood WB

更新日期：1987-09-01 00:00:00

abstract：:Genes with unstable transcripts often encode proteins that play important regulatory roles. ATL2 is a member of a multigene family coding highly related RING-H2 zinc-finger proteins that may function as E3 ubiquitin ligases. ATL2 mRNA accumulation occurs rapidly and transiently after incubation with elicitors of patho...

journal_title：Genetics

authors： Serrano M,Guzmán P

更新日期：2004-06-01 00:00:00

abstract：:Vegetative incompatibility in fungi has long been known to reduce the transmission of viruses between individuals, but the barrier to transmission is incomplete. In replicated laboratory assays, we showed conclusively that the transmission of viruses between individuals of the chestnut blight fungus Cryphonectria para...

journal_title：Genetics

authors： Cortesi P,McCulloch CE,Song H,Lin H,Milgroom MG

更新日期：2001-09-01 00:00:00

abstract：:Distributive disjunction is defined as the first division meiotic segregation of either nonhomologous chromosomes that lack homologs or homologous chromosomes that have not recombined. To determine if chromosomes from the yeast Saccharomyces cerevisiae were capable of distributive disjunction, we constructed a strain ...

journal_title：Genetics

authors： Guacci V,Kaback DB

更新日期：1991-03-01 00:00:00

abstract：:The genetic etiology of many complex diseases is highly heterogeneous. A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci. Although these disease-susceptibility mutations can be collectively common in the population, they are often individu...

journal_title：Genetics

authors： Li M,He Z,Tong X,Witte JS,Lu Q

更新日期：2018-10-01 00:00:00

abstract：:The murine dilute suppressor gene (dsu) suppresses the coat-color phenotype of three pigment mutations, dilute (d), ashen (ash) and leaden (ln), that each produce adendritic melanocytes. Suppression is due to the ability of dsu to partially restore (ash and ln), or almost completely restore (d), normal melanocyte morp...

journal_title：Genetics

authors： Moore KJ,Swing DA,Copeland NG,Jenkins NA

更新日期：1994-10-01 00:00:00

abstract：:The X and Y chromosomes of Drosophila melanogaster each contain a cluster of several hundred ribosomal RNA genes (rDNA). A nontranscribed spacer region separates adjacent rRNA genes and contains tandem copies of 240 bp repeats that include the initiation site for RNA polymerase I transcription. We show here that Droso...

journal_title：Genetics

authors： Lohe AR,Roberts PA

更新日期：1990-06-01 00:00:00

abstract：:Selection of Gl-Sb coupling heterozygotes was carried out for more than one hundred generations commencing with six independent lines drawn from a common base population. Population sizes were eight, sixteen and forty-eight parents per generation. The effect of natural selection on recombination value was measured by ...

journal_title：Genetics

authors： Kidwell MG

更新日期：1972-03-01 00:00:00

abstract：:Aimed at investigating the recovery of a specific mutant allele of the mating type locus (MAT) by switching a defective MAT allele, these experiments provide information bearing on several models proposed for MAT interconversion in bakers yeast, Saccharomyces cerevisiae. Hybrids between heterothallic (ho) cells carryi...

journal_title：Genetics

authors： Klar AJ,Fogel S,Radin DN

更新日期：1979-07-01 00:00:00

abstract：:Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...

journal_title：Genetics

authors： Hodgkin J

更新日期：1983-01-01 00:00:00

abstract：:One crossover point between a pair of homologous chromosomes in meiosis appears to interfere with occurrence of another in the neighborhood. It has been revealed that Drosophila and Neurospora, in spite of their large difference in the frequency of crossover points, show very similar plots of coincidence-a measure of ...

journal_title：Genetics

authors： Fujitani Y,Mori S,Kobayashi I

更新日期：2002-05-01 00:00:00

abstract：:The effect of genetic hitchhiking on neutral variation is analyzed in subdivided populations with differentiated demes. After fixation of a favorable mutation, the consequences on particular subpopulations can be radically different. In the subpopulation where the mutation first appeared by mutation, variation at link...

journal_title：Genetics

authors： Santiago E,Caballero A

更新日期：2005-01-01 00:00:00

abstract：:Various management strategies aim at maintaining pesticide resistance frequency under a threshold value by taking advantage of the benefit of the fitness penalty (the cost) expressed by the resistance allele outside the treated area or during the pesticide selection "off years." One method to estimate a fitness cost i...

journal_title：Genetics

authors： Roux F,Giancola S,Durand S,Reboud X

更新日期：2006-06-01 00:00:00

abstract：:We use three allopatric populations of the stalk-eyed fly Teleopsis dalmanni from Southeast Asia to test two predictions made by the sex chromosome drive hypothesis for Haldane's rule. The first is that modifiers that suppress or enhance drive should evolve rapidly and independently in isolated populations. The second...

journal_title：Genetics

authors： Wilkinson GS,Christianson SJ,Brand CL,Ru G,Shell W

更新日期：2014-11-01 00:00:00

abstract：:The Mus101 family of chromosomal proteins, identified initially in Drosophila, is widely conserved and has been shown to function in a variety of DNA metabolic processes. Such functions include DNA replication, DNA damage repair, postreplication repair, damage checkpoint activation, chromosome stability, and chromosom...

journal_title：Genetics

authors： Holway AH,Hung C,Michael WM

更新日期：2005-03-01 00:00:00

abstract：:We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of approximately 300 genes encoding seven-pass G-protein-coupled receptors. Almost one-third of the genes in each family are annotated as pseudogenes because of apparent functional defects...

journal_title：Genetics

authors： Stewart MK,Clark NL,Merrihew G,Galloway EM,Thomas JH

更新日期：2005-04-01 00:00:00

abstract：:To understand long terminal repeat (LTR)-retrotransposon copy number dynamics, Ty1 elements were reintroduced into a "Ty-less" Saccharomyces strain where elements had been lost by LTR-LTR recombination. Repopulated strains exhibited alterations in chromosome size that were associated with Ty1 insertions, but did not b...

journal_title：Genetics

authors： Garfinkel DJ,Nyswaner KM,Stefanisko KM,Chang C,Moore SP

更新日期：2005-04-01 00:00:00

abstract：:Gene mapping studies to determine the order of alpha- and beta-interferon (Ifa, Ifb), aminolevulinate dehydratase (Lv), and alpha-1 acid glycoprotein-1 and -2 (Orm-1, Orm-2) relative to each other and to the reference genes brown (b), B-cell maturation factor responsiveness (Bmfr-1), and major urinary protein-1 (Mup-1...

journal_title：Genetics

authors： Nadeau JH,Berger FG,Kelley KA,Pitha PM,Sidman CL,Worrall N

更新日期：1986-12-01 00:00:00

abstract：:Homolog recombination and unequal sister chromatid recombination were monitored in rad1-1/rad1-1 diploid yeast cells deficient for excision repair, and in control cells, RAD1/rad1-1, after exposure to UV irradiation. In a rad1-1/rad1-1 diploid, UV irradiation stimulated much more sister chromatid recombination relativ...

journal_title：Genetics

authors： Kadyk LC,Hartwell LH

更新日期：1993-03-01 00:00:00

abstract：:The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved ...

journal_title：Genetics

authors： Tsuda M,Peyre JB,Asano T,Aigaki T

更新日期：2015-08-01 00:00:00

abstract：:Circadian ( approximately 24 hr) rhythms of behavior and physiology are driven by molecular clocks that are endogenous to most organisms. The mechanisms underlying these clocks are remarkably conserved across evolution and typically consist of auto-regulatory loops in which specific proteins (clock proteins) rhythmica...

journal_title：Genetics

authors： Zheng X,Sehgal A

更新日期：2008-03-01 00:00:00