Haldane's rule is linked to extraordinary sex ratios and sperm length in stalk-eyed flies.

abstract：:Previous association analyses showed that variation at major regulatory genes contributes to standing variation for complex traits in Balsas teosinte, the progenitor of maize. This study expands our previous association mapping effort in teosinte by testing 123 markers in 52 candidate genes for association with 31 tra...

journal_title：Genetics

authors： Weber AL,Briggs WH,Rucker J,Baltazar BM,de Jesús Sánchez-Gonzalez J,Feng P,Buckler ES,Doebley J

更新日期：2008-10-01 00:00:00

abstract：:Great interest was aroused by reports, based on microsatellite markers, of high levels of statistically significant long-range and nonsyntenic linkage disequilibrium (LD) in livestock. Simulation studies showed that this could result from population family structure. In contrast, recent SNP-based studies of livestock ...

journal_title：Genetics

authors： Lipkin E,Straus K,Stein RT,Bagnato A,Schiavini F,Fontanesi L,Russo V,Medugorac I,Foerster M,Sölkner J,Dolezal M,Medrano JF,Friedmann A,Soller M

更新日期：2009-02-01 00:00:00

abstract：:Our understanding of the cellular mechanisms by which animals regulate their response to starvation is limited, despite the strong relevance of the problem to major human health issues. The L1 diapause of Caenorhabditis elegans, where first-stage larvae arrest in response to a food-less environment, is an excellent sy...

journal_title：Genetics

authors： Cui M,Wang Y,Cavaleri J,Kelson T,Teng Y,Han M

更新日期：2017-02-01 00:00:00

abstract：:Inactivation of the maternal or paternal X chromosome in a mammalian embryonic XX cell is believed to involve random choice between the two X's. We propose two alternative models. One suggests that choice is not random, while the other is consistent with random choice, but not one between two X's. ...

journal_title：Genetics

authors： Williams BR,Wu CT

更新日期：2004-07-01 00:00:00

abstract：:Mutations affecting the self-incompatibility response of Nicotiana alata were generated by irradiation. Mutants in the M1 generation were selected on the basis of pollen tube growth through an otherwise incompatible pistil. Twelve of the 18 M1 plants obtained from the mutagenesis screen were self-compatible. Eleven se...

journal_title：Genetics

authors： Golz JF,Su V,Clarke AE,Newbigin E

更新日期：1999-07-01 00:00:00

abstract：:The maize ligule is an adaxial membranous structure on the leaf that develops at the boundary of the sheath and blade. The ligule and the associated auricle are dispensable structures, amenable to genetic manipulation. We present here a genetic analysis of liguleless1 (lg1) and liguleless2 (lg2), the two genes known t...

journal_title：Genetics

authors： Harper L,Freeling M

更新日期：1996-12-01 00:00:00

abstract：:The transcription factors Adr1 and Cat8 act in concert to regulate the expression of numerous yeast genes after the diauxic shift. Their activities are regulated by Snf1, the yeast homolog of the AMP-activated protein kinase of higher eukaryotes. Cat8 is regulated directly by Snf1, but how Snf1 regulates Adr1 is unkno...

journal_title：Genetics

authors： Ratnakumar S,Kacherovsky N,Arms E,Young ET

更新日期：2009-07-01 00:00:00

abstract：:Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...

journal_title：Genetics

authors： Malavazi I,Lima JF,de Castro PA,Savoldi M,de Souza Goldman MH,Goldman GH

更新日期：2008-02-01 00:00:00

abstract：:A flight test box was developed and used in the isolation and initial characterization of Drosophila melanogaster mutants defective in flight behavior. Forty-eight mutants were isolated from F(1) progeny of ethyl methanesulfonate-treated males. Genetic mapping and complementation tests show that the mutations reside a...

journal_title：Genetics

authors： Homyk T,Sheppard DE

更新日期：1977-09-01 00:00:00

abstract：:A canon of population genetics concerns the properties of FST, a descriptor of spatial genetic structure. Interest for FST arose from Wright's early insights linking FST to dispersal parameters as well as to his concept of effective population size (e.g., Wright 1938, 1951). Although there is continued interest in thi...

journal_title：Genetics

authors： Rousset F

更新日期：2013-07-01 00:00:00

abstract：:Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...

journal_title：Genetics

authors： Alcazar RM,Lin R,Fire AZ

更新日期：2008-11-01 00:00:00

abstract：:The supramolecular striatin-interacting phosphatases and kinases (STRIPAK) complex is conserved from yeast to human, and regulates a variety of key biological processes. In animals, this complex consists of the scaffold protein striatin, the protein phosphatase 2A, and kinases, such as germinal center kinase (GCK) III...

journal_title：Genetics

authors： Radchenko D,Teichert I,Pöggeler S,Kück U

更新日期：2018-09-01 00:00:00

abstract：:We present theoretical explanations and show through simulation that the individual admixture proportion estimates obtained by using ancestry informative markers should be seen as an error-contaminated measurement of the underlying individual ancestry proportion. These estimates can be used in structured association t...

journal_title：Genetics

authors： Divers J,Vaughan LK,Padilla MA,Fernandez JR,Allison DB,Redden DT

更新日期：2007-07-01 00:00:00

abstract：:The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chrom...

journal_title：Genetics

authors： Conley EJ,Nduati V,Gonzalez-Hernandez JL,Mesfin A,Trudeau-Spanjers M,Chao S,Lazo GR,Hummel DD,Anderson OD,Qi LL,Gill BS,Echalier B,Linkiewicz AM,Dubcovsky J,Akhunov ED,Dvorák J,Peng JH,Lapitan NL,Pathan MS,Nguyen HT

更新日期：2004-10-01 00:00:00

abstract：:Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and encode small secreted proteins of unknown function. For both families in three Caenorhabditis species, concerted groups of ge...

journal_title：Genetics

authors： Thomas JH

更新日期：2006-04-01 00:00:00

abstract：:In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...

journal_title：Genetics

authors： Sarot E,Payen-Groschêne G,Bucheton A,Pélisson A

更新日期：2004-03-01 00:00:00

abstract：:As an ancient segmental tetraploid, the maize (Zea mays L.) genome contains large numbers of paralogs that are expected to have diverged by a minimum of 10% over time. Nearly identical paralogs (NIPs) are defined as paralogous genes that exhibit > or = 98% identity. Sequence analyses of the "gene space" of the maize i...

journal_title：Genetics

authors： Emrich SJ,Li L,Wen TJ,Yandeau-Nelson MD,Fu Y,Guo L,Chou HH,Aluru S,Ashlock DA,Schnable PS

更新日期：2007-01-01 00:00:00

abstract：:We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretation...

journal_title：Genetics

authors： Housworth EA,Stahl FW

更新日期：2009-09-01 00:00:00

abstract：:We study levels of X-linked vs. autosomal diversity using a model developed to analyze the hitchhiking effect. Repeated bouts of hitchhiking are thought to lower X-linked diversity for two reasons: first, because sojourn times of beneficial mutations are shorter on the X, and second, because adaptive substitutions may...

journal_title：Genetics

authors： Betancourt AJ,Kim Y,Orr HA

更新日期：2004-12-01 00:00:00

abstract：:Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...

journal_title：Genetics

authors： Shcherbakov VP,Plugina LA

更新日期：1991-08-01 00:00:00

abstract：:Brassica carinata, an allotetraploid with B and C genomes, has a number of traits that would be valuable to introgress into B. napus. Interspecific hybrids were created between B. carinata (BBCC) and B. napus (AACC), using an advanced backcross approach to identify and introgress traits of agronomic interest from the ...

journal_title：Genetics

authors： Navabi ZK,Stead KE,Pires JC,Xiong Z,Sharpe AG,Parkin IA,Rahman MH,Good AG

更新日期：2011-03-01 00:00:00

abstract：:Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, results in phenotypes characteristic of premature aging. Mutation of SRS2, another DNA helicase, c...

journal_title：Genetics

authors： McVey M,Kaeberlein M,Tissenbaum HA,Guarente L

更新日期：2001-04-01 00:00:00

abstract：:Arabidopsis seedlings repair UV-induced DNA damage via light-dependent and independent pathways. The mechanism of the "dark repair" pathway is still unknown. To determine the number of genes required for dark repair and to investigate the substrate-specificity of this process we isolated mutants with enhanced sensitiv...

journal_title：Genetics

authors： Jiang CZ,Yen CN,Cronin K,Mitchell D,Britt AB

更新日期：1997-11-01 00:00:00

abstract：:The possibility that fitness relationships associated with an inversion polymorphism in D. paulistorum were frequency dependent was investigated. Using allozymes of tetrazolium oxidase to mark inversions, the effects of genotype frequency, larval density, and culture conditions on fitness were assessed. The proportion...

journal_title：Genetics

authors： Gromko MH,Richmond RC

更新日期：1978-02-01 00:00:00

abstract：:Four species of the Hawaiian Drosophila planitibia subgroup which are homosequential in their polytene chromosomes are resident on the islands of Molokai, Maui and Hawaii. Comparisons of DNA sequence divergence in these four have been made by hybridization of total single-copy radiolabeled tracer DNA from each of the ...

journal_title：Genetics

authors： Hunt JA,Carson HL

更新日期：1983-06-01 00:00:00

abstract：:Bonus, a Drosophila TIF1 homolog, is a nuclear receptor cofactor required for viability, molting, and numerous morphological events. Here we establish a role for Bonus in the modulation of chromatin structure. We show that weak loss-of-function alleles of bonus have a more deleterious effect on males than on females. ...

journal_title：Genetics

authors： Beckstead RB,Ner SS,Hales KG,Grigliatti TA,Baker BS,Bellen HJ

更新日期：2005-02-01 00:00:00

abstract：:Pigmentation is a rapidly evolving trait that can play important roles in mimicry, sexual selection, thermoregulation, and other adaptive processes in many groups of animals. In Drosophila, pigmentation can differ dramatically among closely related taxa, presenting a good opportunity to dissect the genetic changes und...

journal_title：Genetics

authors： Ng CS,Hamilton AM,Frank A,Barmina O,Kopp A

更新日期：2008-09-01 00:00:00

abstract：:Mutant alleles of two genetic regulatory elements, which underlie a three- to sixfold reduction in beta-glucuronidase (GUS) activity levels, distinguish mice of the H haplotype from those of the other two common GUS haplotypes, A and B. Both elements are tightly linked to the GUS structural gene over which they exert ...

journal_title：Genetics

authors： Wawrzyniak CJ,Meredith SA,Ganschow RE

更新日期：1989-01-01 00:00:00

abstract：:Genome-wide association studies have identified thousands of variants implicated in dozens of complex diseases. Most studies collect individuals with and without disease and search for variants with different frequencies between the groups. For many of these studies, additional disease traits are also collected. Joint...

journal_title：Genetics

authors： Bilow M,Crespo F,Pan Z,Eskin E,Eyheramendy S

更新日期：2017-03-01 00:00:00

abstract：:A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals....

journal_title：Genetics

authors： Fu YX

更新日期：1997-08-01 00:00:00