Abstract:
:An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, created through mating between divergent S. cerevisiae, yields mutator progeny that can rapidly but transiently adapt to an environmental stress. Here we analyzed the MLH1 and PMS1 genes across 1010 S. cerevisiae natural isolates spanning a wide range of ecological sources (tree exudates, Drosophila, fruits, and various fermentation and clinical isolates) and geographical sources (Europe, America, Africa, and Asia). We identified one homozygous clinical isolate and 18 heterozygous isolates containing the incompatible MMR genotype. The MLH1-PMS1 gene combination isolated from the homozygous clinical isolate conferred a mutator phenotype when expressed in the S288c laboratory background. Using a novel reporter to measure mutation rates, we showed that the overall mutation rate in the homozygous incompatible background was similar to that seen in compatible strains, indicating the presence of suppressor mutations in the clinical isolate that lowered its mutation rate. This observation and the identification of 18 heterozygous isolates, which can lead to MMR incompatible genotypes in the offspring, are consistent with an elevated mutation rate rapidly but transiently facilitating adaptation. To avoid long-term fitness costs, the incompatibility is apparently buffered by mating or by acquiring suppressors. These observations highlight effective strategies in eukaryotes to avoid long-term fitness costs associated with elevated mutation rates.
journal_name
Geneticsjournal_title
Geneticsauthors
Bui DT,Friedrich A,Al-Sweel N,Liti G,Schacherer J,Aquadro CF,Alani Edoi
10.1534/genetics.116.199513subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1459-1471issue
4eissn
0016-6731issn
1943-2631pii
genetics.116.199513journal_volume
205pub_type
杂志文章相关文献
GENETICS文献大全abstract::The conflicts between science and morals which still continue to arise despite the apparent hegemony of atheistic scientism over traditional Judeo-Christianity in the twentieth century reflect a basic contradiction in the metaphysical foundation of Western lives. As was set forth by Machiavelli, the contradiction inhe...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-09-01 00:00:00
abstract::Conversion between duplicated genes limits their independent evolution. Models in which conversion frequencies decrease as genes diverge are examined to determine conditions under which genes can "escape" further conversion and hence escape from a gene family. A review of results from various recombination systems sug...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract::To assess the reliability of genetic markers it is important to compare inferences that are based on them to a priori expectations. In this article we present an analysis of microsatellite variation within and among populations of island foxes (Urocyon littoralis) on California's Channel Islands. We first show that mi...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was r...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.057034
更新日期:2006-07-01 00:00:00
abstract::The net rate of mutation to deleterious but nonlethal alleles and the sizes of effects of these mutations are of great significance for many evolutionary questions. Here we describe three replicate experiments in which mutations have been accumulated on chromosome 3 of Drosophila melanogaster by means of single-male b...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.103.025262
更新日期:2004-06-01 00:00:00
abstract::Birds are characterized by female heterogamety; females carry the Z and W sex chromosomes, while males have two copies of the Z chromosome. We suggest here that full differentiation of the Z and W sex chromosomes of birds did not take place until after the split of major contemporary lineages, in the late Cretaceous. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::The availability of the complete DNA sequence of the Chlamydomonas reinhardtii genome and advanced computational biology tools has allowed elucidation and study of the small ubiquitin-like modifier (SUMO) system in this unicellular photosynthetic alga and model eukaryotic cell system. SUMO is a member of a ubiquitin-l...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.089128
更新日期:2008-05-01 00:00:00
abstract::PGM plays a central role in the glycolytic pathway at the branch point leading to glycogen metabolism and is highly polymorphic in allozyme studies of many species. We have characterized the nucleotide diversity across the Pgm gene in Drosophila melanogaster and D. simulans to investigate the role that protein polymor...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::We have isolated 15 spontaneous mutants resistant to one or several antibiotics like chloramphenicol, erythromycin and spiramycin. We have shown by several criteria that all of them result from mutations localized in the mitochondrial DNA. The mutations have been mapped by allelism tests and by two- and three-factor c...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-12-01 00:00:00
abstract::Dispersal is a crucial factor in natural evolution, since it determines the habitat experienced by any population and defines the spatial scale of interactions between individuals. There is compelling evidence for systematic differences in dispersal characteristics within the same population, i.e., genotype-dependent ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.193946
更新日期:2017-01-01 00:00:00
abstract::Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.084384
更新日期:2008-06-01 00:00:00
abstract::In Drosophila melanogaster, the female sexual development of the soma and the germline requires the activity of the gene Sxl. The somatic cells need the function of the gene fl(2)d to follow the female developmental pathway, due to its involvement in the female-specific splicing of Sxl RNA. Here we report the analysis...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly associated with stature in cattle (Bos taurus and Bos indicus). This suggests that these genes may contribute to control...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.123943
更新日期:2011-03-01 00:00:00
abstract::A large number of arginine-requiring mutants of Neurospora was isolated, using a strain already partially impaired in an enzyme of the pathway. Among the mutants, all previously described loci, except one, were represented, and several new loci were defined and mapped. Four groups of mutants were of particular interes...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract::Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::The robustness of parametric linkage mapping against model misspecification is considered in experimental breeding designs, with a focus on localization of the gene. By examining the expected LOD across the genome, it is shown that single-gene models are quite robust, even for polygenic traits. However, when the marke...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Centromere H3 proteins (CenH3's) are variants of histone H3 specialized for packaging centromere DNA. Unlike canonical H3, which is among the most conserved of eukaryotic proteins, CenH3's are rapidly evolving, raising questions about orthology and conservation of function across species. To gain insight on CenH3 evol...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.062794
更新日期:2006-11-01 00:00:00
abstract::The initiation of growth cessation and dormancy represents a critical ecological and evolutionary trade-off between survival and growth in most forest trees. The most important environmental cue regulating the initiation of dormancy is a shortening of the photoperiod and phytochrome genes have been implicated in short...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.047522
更新日期:2006-03-01 00:00:00
abstract::Phylogenetic analyses of non-LTR retrotransposons suggest that all elements can be divided into 11 lineages. The 3 oldest lineages show target site specificity for unique locations in the genome and encode an endonuclease with an active site similar to certain restriction enzymes. The more "modern" non-LTR lineages po...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Bisphenol A (BPA) is an organic compound to which human populations are ubiquitously exposed. Epidemiological data suggest BPA exposure might be associated with higher rates of diabetes and reproductive anomalies. Health concerns also include transgenerational consequences, but these mechanisms are crudely defined. Si...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163170
更新日期:2014-05-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) are secreted signaling molecules that control important developmental events in many different organisms. Previous studies have shown that BMPs are expressed at the earliest stages of skeletal development, and are required for formation of specific skeletal features, strongly suggest...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::To test genetic recombination in the vicinity of insertions of the transposon Tn5, crosses were performed by transduction between M. xanthus strains carrying different insertions of Tn5. One member of each pair carried resistance to kanamycin (Tn5-Km); the other carried resistance to tetracycline (Tn5-Tc). The distanc...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::We recently described a yeast assay suitable for genetic screening in which simple religation nonhomologous end-joining (NHEJ) and single-strand annealing (SSA) compete for repair of an I-SceI-created double-strand break. Here, the required allele has been introduced into an array of 4781 MATa deletion mutants and eac...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Though much has been learned about the process of ovarian follicle maturation through studies of oogenesis in both vertebrate and invertebrate systems, less is known about how follicles form initially. In Drosophila, two somatic follicle stem cells (FSCs) in each ovariole give rise to all polar cells, stalk cells, and...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.109538
更新日期:2010-02-01 00:00:00
abstract::A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals....
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.178160
更新日期:2015-12-01 00:00:00
abstract::The Drosophila piwi gene is the founding member of the only known family of genes whose function in stem cell maintenance is highly conserved in both animal and plant kingdoms. piwi mutants fail to maintain germline stem cells in both male and female gonads. The identification of piwi-interacting genes is essential fo...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Selection during evolution, whether natural or artificial, acts through the phenotype. For multifaceted phenotypes such as plant and inflorescence architecture, the underlying genetic architecture is comprised of a complex network of interacting genes rather than single genes that act independently to determine the tr...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.300071
更新日期:2017-10-01 00:00:00
abstract::We define a new gene, SRD1, involved in the processing of pre-rRNA to mature rRNA. The SRD1 gene was identified by selecting for second-site suppressors of the previously described rrp1-1 mutation. The rrp1-1 mutation causes temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::Haploid Saccharomyces can change mating type through HO-endonuclease cleavage of an expressor locus, MAT, followed by gene conversion using one of two repository loci, HML or HMR, as donor. The mating type of a cell dictates which repository locus is used as donor, with a cells using HML and alpha cells using HMR. Thi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.166.3.1187
更新日期:2004-03-01 00:00:00