Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis.

abstract：:A multi-locus model for complete positive assortative mating is discussed. For a two-locus model, if the gene frequencies for the two loci are different, as they are likely to be, it is shown that in equilibrium the population is not composed of only two homozygous types, as is usually thought. The limiting distributi...

journal_title：Genetics

authors： Ghai GL

更新日期：1973-12-01 00:00:00

abstract：:The nuclear envelope in Saccharomyces cerevisiae harbors two essential macromolecular protein assemblies: the nuclear pore complexes (NPCs) that enable nucleocytoplasmic transport, and the spindle pole bodies (SPBs) that mediate chromosome segregation. Previously, based on metazoan and budding yeast studies, we report...

journal_title：Genetics

authors： Casey AK,Dawson TR,Chen J,Friederichs JM,Jaspersen SL,Wente SR

更新日期：2012-10-01 00:00:00

abstract：:In California, Drosophila simulans females from some populations (type W) produce relatively few adult progeny when crossed to males from some other populations (type R), but the productivity of the reciprocal cross is comparable to within-population controls. These two incompatibility types are widespread in North Am...

journal_title：Genetics

authors： Hoffmann AA,Turelli M

更新日期：1988-06-01 00:00:00

abstract：:Evolutionary models appropriate for analyzing nucleotide sequences that are subject to constraints on secondary structure are developed. The models consider the evolution of pairs of nucleotides, and they incorporate the effects of base-pairing constraints on nucleotide substitution rates by introducing a new paramete...

journal_title：Genetics

authors： Muse SV

更新日期：1995-03-01 00:00:00

abstract：:The allozymic variation at at the esterase-6 locus examined in fourteen samples of natural populations of Drosophila simulans collected in two different localities. The samples were collected from different species of fruits in the two localities and from banana baits located some meters apart from the fruits. The ana...

journal_title：Genetics

authors： de Albuquerque CM,Napp M

更新日期：1981-06-01 00:00:00

abstract：:The Drosophila melanogaster ovo gene is required for survival and differentiation of female germline cells, apparently playing a role in germline sex determination. We recovered 60 kb of genomic DNA from its genetic location at 4E1,2 on the X chromosome. A transcription unit coding for an apparently female-specific ge...

journal_title：Genetics

authors： Garfinkel MD,Lohe AR,Mahowald AP

更新日期：1992-04-01 00:00:00

abstract：:Much of the material taken into cells by endocytosis is rapidly returned to the plasma membrane by the endocytic recycling pathway. Although recycling is vital for the correct localization of cell membrane receptors and lipids, the molecular mechanisms that regulate recycling are only partially understood. Here we sho...

journal_title：Genetics

authors： Nilsson L,Conradt B,Ruaud AF,Chen CC,Hatzold J,Bessereau JL,Grant BD,Tuck S

更新日期：2008-05-01 00:00:00

abstract：:The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume composition...

journal_title：Genetics

authors： Lercher MJ,Smith NG,Eyre-Walker A,Hurst LD

更新日期：2002-12-01 00:00:00

abstract：:The contribution of epigenetic alterations to natural variation for gene transcription levels remains unclear. In this study, we investigated the functional targets of the maize chromomethylase ZMET2 in multiple inbred lines to determine whether epigenetic changes conditioned by this chromomethylase are conserved or v...

journal_title：Genetics

authors： Makarevitch I,Stupar RM,Iniguez AL,Haun WJ,Barbazuk WB,Kaeppler SM,Springer NM

更新日期：2007-10-01 00:00:00

abstract：:The formation and stability of epigenetically regulated chromatin is influenced by DNA replication and factors that modulate post-translational modifications on histones. Here we describe evidence that PCNA can affect silencing in Saccharomyces cerevisiae by facilitating deposition of H3 K56ac onto chromosomes. We pro...

journal_title：Genetics

authors： Miller A,Yang B,Foster T,Kirchmaier AL

更新日期：2008-06-01 00:00:00

abstract：:Significant correlations between allelic frequencies and environmental variables in a number of insect species have been demonstrated by multivariate techniques. Since many environmental variables show a strong relationship to geographic location and since gene flow between populations can also produce patterns of gen...

journal_title：Genetics

authors： Schaffer HE,Johnson FM

更新日期：1974-05-01 00:00:00

abstract：:fl(2)d, the Drosophila homolog of Wilms'-tumor-1-associated protein (WTAP), regulates the alternative splicing of Sex-lethal (Sxl), transformer (tra), and Ultrabithorax (Ubx). Although WTAP has been found in functional human spliceosomes, exactly how it contributes to the splicing process remains unknown. Here we atte...

journal_title：Genetics

authors： Penn JK,Graham P,Deshpande G,Calhoun G,Chaouki AS,Salz HK,Schedl P

更新日期：2008-02-01 00:00:00

abstract：:The standard slipped-strand mispairing (SSM) model for the formation of variable number tandem repeats (VNTRs) proposes that a few tandem repeats, produced by chance mutations, provide the "raw material" for VNTR expansion. However, this model is unlikely to explain the formation of VNTRs with long motifs (e.g., minis...

journal_title：Genetics

authors： Taylor JS,Breden F

更新日期：2000-07-01 00:00:00

abstract：:We have studied the natural variation at microsatellite loci in two African and five non-African populations of Drosophila melanogaster. Ten dinucleotide simple sequence loci were cloned from chromosomally mapped P1 clones and typed for single individuals from isofemale lines of the respective populations. We find tha...

journal_title：Genetics

authors： Schlötterer C,Vogl C,Tautz D

更新日期：1997-05-01 00:00:00

abstract：:Meiotically driven sex chromosomes can quickly spread to fixation and cause population extinction unless balanced by selection or suppressed by genetic modifiers. We report results of genetic analyses that demonstrate that extreme female-biased sex ratios in two sister species of stalk-eyed flies, Cyrtodiopsis dalmann...

journal_title：Genetics

authors： Presgraves DC,Severance E,Wilkinson GS

更新日期：1997-11-01 00:00:00

abstract：:A sample of 16 Minutes, representing 12 loci distributed over all the chromosome arms and including 3 pairs of alleles and 4 deficiencies, has been studied with respect to several developmental and recombinational parameters. Cell marker mutants located in most of the chromosome arms were used to assess (1) spontaneou...

journal_title：Genetics

authors： Ferrus A

更新日期：1975-04-01 00:00:00

abstract：:I describe a method for simulating samples from gene families of size two under a neutral coalescent process, for the case where the duplicate gene either has fixed recently in the population or is still segregating. When a duplicate locus has recently fixed by genetic drift, diversity in the new gene is expected to b...

journal_title：Genetics

authors： Thornton KR

更新日期：2007-10-01 00:00:00

abstract：:LARK is an essential Drosophila RNA-binding protein of the RNA recognition motif (RRM) class that functions during embryonic development and for the circadian regulation of adult eclosion. LARK protein contains three consensus RNA-binding domains: two RRM domains and a retroviral-type zinc finger (RTZF). To show that ...

journal_title：Genetics

authors： McNeil GP,Schroeder AJ,Roberts MA,Jackson FR

更新日期：2001-09-01 00:00:00

abstract：:The rate of microsatellite mutation is dependent upon both the allele length and the repeat motif, but the exact nature of this relationship is still unknown. We analyzed data on the inheritance of human Y-chromosomal microsatellites in father-son duos, taken from 24 published reports and comprising 15,285 directly ob...

journal_title：Genetics

authors： Jochens A,Caliebe A,Rösler U,Krawczak M

更新日期：2011-12-01 00:00:00

abstract：:The transmission of transposed Ac elements in progeny derived by self-pollination of ten transformed tomato plants has been examined by Southern hybridization analysis. We show that six of these primary transformants have transmitted a transposed Ac to at least one progeny. One of the families was segregating for at l...

journal_title：Genetics

authors： Belzile F,Lassner MW,Tong Y,Khush R,Yoder JI

更新日期：1989-09-01 00:00:00

abstract：:Since the publication of the first comprehensive linkage map for the laboratory mouse, the architecture of recombination as a basic biological process has become amenable to investigation in mammalian model organisms. Here we take advantage of high-density genotyping and the unique pedigree structure of the incipient ...

journal_title：Genetics

authors： Liu EY,Morgan AP,Chesler EJ,Wang W,Churchill GA,Pardo-Manuel de Villena F

更新日期：2014-05-01 00:00:00

abstract：:The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation may play in diverse cellular functions, aside from ribosome production, hig...

journal_title：Genetics

authors： Sanchez JC,Ollodart A,Large CRL,Clough C,Alvino GM,Tsuchiya M,Crane M,Kwan EX,Kaeberlein M,Dunham MJ,Raghuraman MK,Brewer BJ

更新日期：2019-09-01 00:00:00

abstract：:In contrast to our growing understanding of patterns of additive genetic variance in single- and multi-trait combinations, the relative contribution of nonadditive genetic variance, particularly dominance variance, to multivariate phenotypes is largely unknown. While mechanisms for the evolution of dominance genetic v...

journal_title：Genetics

authors： Sztepanacz JL,Blows MW

更新日期：2015-05-01 00:00:00

abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

journal_title：Genetics

authors： Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

更新日期：2008-06-01 00:00:00

abstract：:The larval body wall muscles of Drosophila melanogaster arise by fusion of founder myoblasts (FMs) and fusion-competent myoblasts (FCMs). Sticks-and-Stones (SNS) is expressed on the surface of all FCMs and mediates adhesion with FMs and developing syncytia. Intracellular components essential for myoblast fusion are th...

journal_title：Genetics

authors： Kocherlakota KS,Wu JM,McDermott J,Abmayr SM

更新日期：2008-03-01 00:00:00

abstract：:The breeding systems of many organisms are cryptic and difficult to investigate with observational data, yet they have profound effects on a species' ecology, evolution, and genome organization. Genomic approaches offer a novel, indirect way to investigate breeding systems, specifically by studying the transmission of...

journal_title：Genetics

authors： Svendsen N,Reisser CM,Dukić M,Thuillier V,Ségard A,Liautard-Haag C,Fasel D,Hürlimann E,Lenormand T,Galimov Y,Haag CR

更新日期：2015-11-01 00:00:00

abstract：:The race-specific resistance gene Pi-ta has been effectively used to control blast disease, one of the most destructive plant diseases worldwide. A single amino acid change at the 918 position of the Pi-ta protein was known to determine resistance specificity. To understand the evolutionary dynamics present, we examin...

journal_title：Genetics

authors： Lee S,Costanzo S,Jia Y,Olsen KM,Caicedo AL

更新日期：2009-12-01 00:00:00

abstract：:Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown t...

journal_title：Genetics

authors： Hopper NA

更新日期：2006-05-01 00:00:00

abstract：:The POL3 encoded catalytic subunit of DNA polymerase delta possesses a highly conserved C-terminal cysteine-rich domain in Saccharomyces cerevisiae. Mutations in some of its cysteine codons display a lethal phenotype, which demonstrates an essential function of this domain. The thermosensitive mutant pol3-13, in which...

journal_title：Genetics

authors： Giot L,Chanet R,Simon M,Facca C,Faye G

更新日期：1997-08-01 00:00:00

abstract：:Inverted DNA repeats are an at-risk motif for genetic instability that can induce both deletions and recombination in yeast. We investigated the role of the length of inverted repeats and size of the DNA separating the repeats for deletion and recombination. Stimulation of both deletion and recombination was directly ...

journal_title：Genetics

authors： Lobachev KS,Shor BM,Tran HT,Taylor W,Keen JD,Resnick MA,Gordenin DA

更新日期：1998-04-01 00:00:00