Abstract：
:We have analyzed two variants of Drosophila melanogaster (RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls. Both phenotypes show tight genetic linkage to the dopa decarboxylase, Ddc, and l(2)amd genes (i.e., less than 0.05 cM distant). We find that low (Oregon-R), medium (RS) and high (RE and Canton-S) levels of DDC activity seen at both pupariation and eclosion in these strains are completely accounted for by differences in accumulation of DDC protein as measured by immunoprecipitation. Genetic reconstruction experiments in which Ddc+ and amd+ gene doses are varied show that increasing DDC activity does not lead to a measurable increase in resistance to dietary alpha-methyldopa. This suggests that the increased resistance to dietary alpha-methyldopa is not the result of increased DDC activity but, rather, results from increased l(2)amd+ activity. Both cytogenetic and molecular analyses indicate that these overproduction variants are not the result of small duplications of the Ddc and amd genes, nor are they associated with small (greater than or equal to 100 bp) insertions or deletions. Measurements of DDC activity in wild-type strains of Drosophila reveal a unimodal distribution of activity levels with the Canton-S and RE strains at the high end of the scale, the Oregon-R control at the low end and RS near the modal value. We conclude that accumulated changes in a genetic element (or elements) in close proximity to the Ddc+ and amd+ genes lead to the coordinated changes in the expression of the Ddc and amd genes in these strains.
journal_name
Geneticsjournal_title
Geneticsauthors
Marsh JL,Wright TRsubject
Has Abstractpub_date
1986-02-01 00:00:00pages
249-65issue
2eissn
0016-6731issn
1943-2631journal_volume
112pub_type
杂志文章相关文献
GENETICS文献大全abstract：:The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase 4 and 6. In addition, they have been proposed to control the activity of various transcription factors without a partner kinase. Here we describe phenotypic con...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.027417
更新日期：2004-10-01 00:00:00
abstract：:Genetic studies of multidimensional phenotypes can potentially link genetic variation, gene expression, and physiological data to create multi-scale models of complex traits. The challenge of reducing these data to specific hypotheses has become increasingly acute with the advent of genome-scale data resources. Multi-...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.198051
更新日期：2017-06-01 00:00:00
abstract：:Dosage compensation refers to the equal expression of X-linked genes despite the difference in copy number between the two sexes. The male-specific lethal (MSL) complex is concentrated on the X chromosome in males. A gene expression assay for embryos was developed to examine the function of this complex. In mutant mal...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.036020
更新日期：2005-04-01 00:00:00
abstract：:Drosophila adult leg development provides an ideal model system for characterizing the molecular mechanisms of hormone-triggered morphogenesis. A pulse of the steroid hormone ecdysone at the onset of metamorphosis triggers the rapid transformation of a flat leg imaginal disc into an immature adult leg, largely through...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Seed component structures were grouped into maternal and offspring (embryo and endosperm) tissues to characterize a dormancy quantitative trait locus (QTL) for tissue-specific function using a marker-assisted genetic approach. The approach was devised to test if genotypic/allelic frequencies of a marker tightly linked...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.092007
更新日期：2008-08-01 00:00:00
abstract：:We consider the effect on the distribution of pairwise differences between mitochondrial DNA sequences of the incorporation into the underlying population genetics model of two particular effects that seem realistic for human populations. The first is that the population size was roughly constant before growing to its...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:The Sex-Ratio (SR) phenomenon is associated with the X chromosome of many species of Drosophila. Males carrying SR transmit predominantly sperm bearing the X chromosome. SR, therefore, has a very significant advantage in segregation. This paper provides an experimental analysis of the role of virility selection in pre...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:The parentals of the interspecific cross Cucurbita maxima xC. ecuadorensis had different isozyme phenotypes for 12 enzyme systems. Characterization of the systems demonstrated that the expression and intracellular distribution of the isozymes were similar to those in other plant taxa; however, a considerable number of...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
abstract：:Position effect variegation results from chromosome rearrangements which translocate euchromatic genes close to the heterochromatin. The euchromatin-heterochromatin association is responsible for the inactivation of these genes in some cell clones. In Drosophila melanogaster the Y chromosome, which is entirely heteroc...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuati...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
abstract：:A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was r...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.057034
更新日期：2006-07-01 00:00:00
abstract：:Whereas nonlinear relationships between genes are acknowledged, there exist only a few methods for estimating nonlinear gene coexpression networks or gene regulatory networks (GCNs/GRNs) with common deficiencies. These methods often consider only pairwise associations between genes, and are, therefore, poorly capable ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303186
更新日期：2020-07-01 00:00:00
abstract：:A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.144329
更新日期：2013-01-01 00:00:00
abstract：:Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical of natural populations. Theoretical studies demonstrate that evolution of polygenic characters depends heavily on the genetic interdependence of the expression of traits in the differ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an impo...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.039040
更新日期：2005-07-01 00:00:00
abstract：:The r-X1 deficiency in maize induces nondisjunction at the second mitotic division during embryo sac formation. However, it was not known if this deficiency also induces nondisjunction during the microspore divisions. Microsporogenesis in plants lacking or containing this deficiency was compared using two approaches. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Genome-wide association mapping is a popular method for using natural variation within a species to generate a genotype-phenotype map. Statistical association between an allele at a locus and the trait in question is used as evidence that variation at the locus is responsible for variation of the trait. Indirect assoc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.121665
更新日期：2010-11-01 00:00:00
abstract：:LARK is an essential Drosophila RNA-binding protein of the RNA recognition motif (RRM) class that functions during embryonic development and for the circadian regulation of adult eclosion. LARK protein contains three consensus RNA-binding domains: two RRM domains and a retroviral-type zinc finger (RTZF). To show that ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:The Su(f) protein of Drosophila melanogaster shares extensive homologies with proteins from yeast (RNA14) and man (77 kD subunit of cleavage stimulation factor) that are required for 3' end processing of mRNA. These homologies suggest that su(f) is involved in mRNA 3' end formation and that some aspects of this proces...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:The trace element iron is crucial for living organisms, since it plays essential roles in numerous cellular functions. Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically a...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.186742
更新日期：2016-05-01 00:00:00
abstract：:Chromosome 1A(m) of Triticum monococcum is closely homeologous to T. aestivum chromosome 1A but recombines with it little in the presence of the wheat suppressor of homeologous chromosome pairing, Ph1. In the absence of Ph1, the two chromosomes recombine as if they were completely homologous. Chromosomes having either...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：:A sulfonamide-resistant mutant of pneumococcus, sulr-c, displays a genetic instability, regularly segregating to wild type. DNA extracts of derivatives of the strain possess transforming activities for both the mutant and wild-type alleles, establishing that the strain is a partial diploid. The linkage of sulr-c to st...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Some populations of maize's closest relatives, the annual teosintes of Mexico, are unreceptive to maize pollen. When present in the pistil (silk and ovary) a number of maize genes discriminate against or exclude pollen not carrying the same allele. An analogous gene Tcb1-s was found in some teosinte populations but no...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.048645
更新日期：2006-01-01 00:00:00
abstract：:The importance of quantifying and accounting for stochastic genotyping errors when analyzing microsatellite data is increasingly being recognized. This awareness is motivating the development of data analysis methods that not only take errors into consideration but also recognize the difference between two distinct cl...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.064618
更新日期：2007-02-01 00:00:00
abstract：:In Saccharomyces cerevisiae, silencers flanking the HML and HMR loci initiate the establishment of transcriptional silencing. We demonstrate that the activity of a silencer pertaining to its potency and directionality is dependent on its genomic position. The context of the HML-E silencer is more permissive to silence...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.055525
更新日期：2006-09-01 00:00:00
abstract：:The mutation process at microsatellite loci typically occurs at high rates and with stepwise changes in allele sizes, features that may introduce bias when using classical measures of population differentiation based on allele identity (e.g., F(ST), Nei's Ds genetic distance). Allele size-based measures of differentia...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：:The back-to-back geometry of sister kinetochores is essential in preventing loss or damage of chromosomes during mitosis. Kinetochore orientation is generated in part by a process of resolving kinetochores at the centromere (centromere resolution) prior to spindle interactions. Because few of the genes required for ce...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.075275
更新日期：2008-01-01 00:00:00
abstract：:Dis3 encodes a conserved RNase that degrades or processes all RNA species via an N-terminal PilT N terminus (PIN) domain and C-terminal RNB domain that harbor, respectively, endonuclease activity and 3'-5' exonuclease activity. In Schizosaccharomyces pombe, dis3 mutations cause chromosome missegregation and failure in...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.187930
更新日期：2016-06-01 00:00:00
abstract：:Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.156935
更新日期：2014-05-01 00:00:00
abstract：:A likelihood ratio test is presented for comparing rates of evolutionary change in the paths of descent leading to two species. The test is compared to previous relative rate tests based on variances of estimated numbers of base substitutions. The likelihood approach allows for different transversion and transition ra...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
