A genomics approach to the detection of positive selection in cattle: adaptive evolution of the T-cell and natural killer cell-surface protein CD2.

abstract：:The Saccharomyces cerevisiae nuclear membrane is part of a complex nuclear envelope environment also containing chromatin, integral and peripheral membrane proteins, and large structures such as nuclear pore complexes (NPCs) and the spindle pole body. To study how properties of the nuclear membrane affect nuclear enve...

journal_title：Genetics

authors： Witkin KL,Friederichs JM,Cohen-Fix O,Jaspersen SL

更新日期：2010-11-01 00:00:00

abstract：:We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX). In addition we show that recessive...

journal_title：Genetics

authors： Meneely PM,Wood WB

更新日期：1987-09-01 00:00:00

abstract：:The fixation probability is determined when population size and selection change over time and differs from Kimura's result, with long-term implications for a population. It is found that changes in population size are not equivalent to the corresponding changes in selection and can result in less drift than anticipat...

journal_title：Genetics

authors： Waxman D

更新日期：2011-08-01 00:00:00

abstract：:In(2LR)PL is a large pericentric inversion polymorphic in populations of Drosophila melanogaster on two Indian Ocean islands. This polymorphism is puzzling: because crossing over in female heterokaryotypes produces inviable zygotes, such inversions are thought to be underdominant and should be quickly eliminated from ...

journal_title：Genetics

authors： Coyne JA,Aulard S,Berry A

更新日期：1991-11-01 00:00:00

abstract：:The S-M checkpoint ensures that entry into mitosis is dependent on completion of DNA replication. In the fission yeast Schizosaccharomyces pombe, the SM checkpoint mutant cdc2-3w is thought to be defective in receiving the checkpoint signal. To isolate genes that function in the checkpoint pathway, we screened an S. p...

journal_title：Genetics

authors： Humphrey T,Enoch T

更新日期：1998-04-01 00:00:00

abstract：:In Drosophila melanogaster, heterochromatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insights into the properties of heterochromatin. Class I modifiers suppress PEV, and class II modifiers enhance PEV when the modifier gene is present in fewer than two doses. We have exami...

journal_title：Genetics

authors： Sass GL,Henikoff S

更新日期：1998-02-01 00:00:00

abstract：:In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss...

journal_title：Genetics

authors： Schüpbach T

更新日期：1985-03-01 00:00:00

abstract：:Biological robustness, the ability of an organism to maintain a steady-state output as genetic or environmental inputs change, is critical for proper development. MicroRNAs have been implicated in biological robustness mechanisms through their post-transcriptional regulation of genes and gene networks. Previous resear...

journal_title：Genetics

authors： Burke SL,Hammell M,Ambros V

更新日期：2015-08-01 00:00:00

abstract：:To analyze the phenotype of cells lacking the vacuolar ATPase, we inactivated the vma-1 gene, which encodes the catalytic subunit of the enzyme. Because preliminary experiments suggested the vma-1 gene was essential, we developed a method of simultaneously inactivating the gene and complementing it with a functional c...

journal_title：Genetics

authors： Ferea TL,Bowman BJ

更新日期：1996-05-01 00:00:00

abstract：:Retroviruses and their relatives, the long terminal repeat (LTR) retrotransposons, carry out complex life cycles within the cells of their hosts. We have exploited a collection of gene deletion mutants developed by the Saccharomyces Genome Deletion Project to perform a functional genomics screen for host factors that ...

journal_title：Genetics

authors： Griffith JL,Coleman LE,Raymond AS,Goodson SG,Pittard WS,Tsui C,Devine SE

更新日期：2003-07-01 00:00:00

abstract：:The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variation and the evolutionary fate of small populations. Properties of the DFE can be inferred by comparing the distributions of the frequencies of segregating nuc...

journal_title：Genetics

authors： Keightley PD,Eyre-Walker A

更新日期：2007-12-01 00:00:00

abstract：:Four species of the Hawaiian Drosophila planitibia subgroup which are homosequential in their polytene chromosomes are resident on the islands of Molokai, Maui and Hawaii. Comparisons of DNA sequence divergence in these four have been made by hybridization of total single-copy radiolabeled tracer DNA from each of the ...

journal_title：Genetics

authors： Hunt JA,Carson HL

更新日期：1983-06-01 00:00:00

abstract：:The Collaborative Cross (CC) was designed to facilitate rapid gene mapping and consists of hundreds of recombinant inbred lines descended from eight diverse inbred founder strains. A decade in production, it can now be applied to mapping projects. Here, we provide a proof of principle for rapid identification of major...

journal_title：Genetics

authors： Ram R,Mehta M,Balmer L,Gatti DM,Morahan G

更新日期：2014-09-01 00:00:00

abstract：:Strong deviation of allele frequencies from Mendelian inheritance favoring Mus spretus-derived alleles has been described previously for X-linked loci in four mouse interspecific crosses. We reanalyzed data for three of these crosses focusing on the location of the gene(s) controlling deviation on the X chromosome and...

journal_title：Genetics

authors： Montagutelli X,Turner R,Nadeau JH

更新日期：1996-08-01 00:00:00

abstract：:Dosage compensation in Drosophila has been studied at the steady state RNA level for several single-copy genes; however, an important point is addressed by analyzing a repetitive, transposable element for dosage compensation. The two issues of gene-specific cis control and genomic position can be studied by determinin...

journal_title：Genetics

authors： Hiebert JC,Birchler JA

更新日期：1992-03-01 00:00:00

abstract：:A combination of nuclear and chloroplast simple sequence repeats (SSRs) have been used to investigate the levels and pattern of variability detected in Glycine max and G. soja genotypes. Based on the analysis of 700 soybean genotypes with 115 restriction fragment length polymorphism (RFLP) probes, 12 accessions were i...

journal_title：Genetics

authors： Powell W,Morgante M,Doyle JJ,McNicol JW,Tingey SV,Rafalski AJ

更新日期：1996-10-01 00:00:00

abstract：:In budding yeast, at least 10 proteins are required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Spo11 is the enzyme responsible for cleaving DNA and is found in a complex that also contains Ski8, Rec102, and Rec104. The Mre11/Rad50/Xrs2 complex is required for both DSB formati...

journal_title：Genetics

authors： Li J,Hooker GW,Roeder GS

更新日期：2006-08-01 00:00:00

abstract：:We examined the inheritance of allelic variation at an isozyme locus, MDH-B, duplicated by ancestral polyploidy in salmonid fishes. We detected only disomic segregation in females. Segregation ratios in males were best explained by a mixture of disomic and tetrasomic inheritance. We propose a two-stage model of pairin...

journal_title：Genetics

authors： Allendorf FW,Danzmann RG

更新日期：1997-04-01 00:00:00

abstract：:The process designated RIP (repeat-induced point mutation) alters duplicated DNA sequences in the sexual cycle of Neurospora crassa. We tested whether non-Neurospora sequences are susceptible to RIP, explored the basis for the observed immunity to this process of a diverged tandem duplication that probably arose by a ...

journal_title：Genetics

authors： Foss EJ,Garrett PW,Kinsey JA,Selker EU

更新日期：1991-04-01 00:00:00

abstract：:Mapping markers from linkage data continues to be a task performed in many genetic epidemiological studies. Data collected in a study may be used to refine published map estimates and a study may use markers that do not appear in any published map. Furthermore, inaccuracies in meiotic maps can seriously bias linkage f...

journal_title：Genetics

authors： George AW

更新日期：2005-10-01 00:00:00

abstract：:Bacteriophages are the most abundant biological entities in our biosphere, characterized by their hyperplasticity, mosaic composition, and the many unknown functions (ORFans) encoded by their immense genetic repertoire. These genes are potentially maintained by the bacteriophage to allow efficient propagation on hosts...

journal_title：Genetics

authors： Ang D,Georgopoulos C

更新日期：2012-03-01 00:00:00

abstract：:The nuclear envelope in Saccharomyces cerevisiae harbors two essential macromolecular protein assemblies: the nuclear pore complexes (NPCs) that enable nucleocytoplasmic transport, and the spindle pole bodies (SPBs) that mediate chromosome segregation. Previously, based on metazoan and budding yeast studies, we report...

journal_title：Genetics

authors： Casey AK,Dawson TR,Chen J,Friederichs JM,Jaspersen SL,Wente SR

更新日期：2012-10-01 00:00:00

abstract：:A radiation-induced translocation, T(IIR----IIIL), has been shown to be nonreciprocal and to have most of IIR, including its terminus, attached uninverted to the terminus of IIIL.--Progeny with the IIR segment in duplicate, obtained from crosses of T(IIR----IIIL) to strains with a standard genome, were unstable at mit...

journal_title：Genetics

authors： Daud F,Ortori GS,Roper JA

更新日期：1985-06-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00

abstract：:Chromosome 1A(m) of Triticum monococcum is closely homeologous to T. aestivum chromosome 1A but recombines with it little in the presence of the wheat suppressor of homeologous chromosome pairing, Ph1. In the absence of Ph1, the two chromosomes recombine as if they were completely homologous. Chromosomes having either...

journal_title：Genetics

authors： Luo MC,Dubcovsky J,Dvorák J

更新日期：1996-11-01 00:00:00

abstract：:Candida albicans, which is diploid, possesses a single mating-type (MTL) locus on chromosome 5, which is normally heterozygous (a/alpha). To mate, C. albicans must undergo MTL homozygosis to a/a or alpha/alpha. Three possible mechanisms may be used in this process, mitotic recombination, gene conversion, or loss of on...

journal_title：Genetics

authors： Wu W,Pujol C,Lockhart SR,Soll DR

更新日期：2005-03-01 00:00:00

abstract：:Due to issues of practicality and confidentiality of genomic data sharing on a large scale, typically only meta- or mega-analyzed genome-wide association study (GWAS) summary data, not individual-level data, are publicly available. Reanalyses of such GWAS summary data for a wide range of applications have become more ...

journal_title：Genetics

authors： Deng Y,Pan W

更新日期：2018-06-01 00:00:00

abstract：:Changes in genome structure and gene expression have been documented in both resynthesized and natural allopolyploids that contain two or more divergent genomes. The underlying mechanisms for rapid and stochastic changes in gene expression are unknown. Arabidopsis suecica is a natural allotetraploid derived from the e...

journal_title：Genetics

authors： Chen M,Ha M,Lackey E,Wang J,Chen ZJ

更新日期：2008-04-01 00:00:00

abstract：:In Saccharomyces cerevisiae, genes located at the telomeres and the HM loci are subject to transcriptional silencing. Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing when targeted to a silencer-defective HMR locus. ...

journal_title：Genetics

authors： Andrulis ED,Zappulla DC,Alexieva-Botcheva K,Evangelista C,Sternglanz R

更新日期：2004-01-01 00:00:00

abstract：:A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...

journal_title：Genetics

authors： Birkner M,Blath J,Eldon B

更新日期：2013-01-01 00:00:00