Dating the primigenial C4-CYP21 duplication in primates.

abstract：:G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate stimulus-dependent activation of cognate heterotrimeric G-proteins, triggering ensuing downstream cellular responses. Tight regulation of GPCR-evoked pathways is required because prolonged stimulation can be detrimental to an organism. St...

journal_title：Genetics

authors： Alvaro CG,Aindow A,Thorner J

更新日期：2016-05-01 00:00:00

abstract：:At least six nuclear loci are responsible for the genetic control of malate dehydrogenase (L-malate: NAD oxidoreductase; EC 1.1.1.37; MDH) in coleoptiles of maize. Three independently segregating loci (Mdh1, Mdh2, Mdh3) govern the production of MDH isozymes resistant to inactivation by ascorbic acid and found largely ...

journal_title：Genetics

authors： Goodman MM,Stuber CW,Lee CN,Johnson FM

更新日期：1980-01-01 00:00:00

abstract：:We subjected the genes encoding the 19.3-, 21.3c-, and 51-kDa iron-sulfur subunits of respiratory chain complex I from Neurospora crassa to site-directed mutagenesis to mimic mutations in human complex I subunits associated with mitochondrial diseases. The V135M substitution was introduced into the 19.3-kDa cDNA, the ...

journal_title：Genetics

authors： Duarte M,Schulte U,Ushakova AV,Videira A

更新日期：2005-09-01 00:00:00

abstract：:A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these th...

journal_title：Genetics

authors： Rebaï A,Goffinet B,Mangin B

更新日期：1994-09-01 00:00:00

abstract：:Biosynthesis of most peptide hormones and neuropeptides requires proteolytic excision of the active peptide from inactive proprotein precursors, an activity carried out by subtilisin-like proprotein convertases (SPCs) in constitutive or regulated secretory pathways. The Drosophila amontillado (amon) gene encodes a hom...

journal_title：Genetics

authors： Rayburn LY,Gooding HC,Choksi SP,Maloney D,Kidd AR 3rd,Siekhaus DE,Bender M

更新日期：2003-01-01 00:00:00

abstract：:The translation elongation factor EF-Tu is a GTPase that delivers amino-acylated tRNAs to the ribosome during the elongation step of translation. EF-Tu/GDP is recycled by the guanine nucleotide exchange factor EF-Ts. Whereas EF-Ts is lacking in S. cerevisiae, both translation factors are found in S. pombe and H. sapie...

journal_title：Genetics

authors： Chiron S,Suleau A,Bonnefoy N

更新日期：2005-04-01 00:00:00

abstract：:The Arabidopsis SECRET AGENT (SEC) and SPINDLY (SPY) proteins are similar to animal O-linked N-acetylglucosamine transferases (OGTs). OGTs catalyze the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to Ser/Thr residues of proteins. In animals, O-GlcNAcylation has been shown to affect protein activity, stabil...

journal_title：Genetics

authors： Hartweck LM,Scott CL,Olszewski NE

更新日期：2002-07-01 00:00:00

abstract：:The gilthead sea bream (Sparus aurata L.) is a marine fish of great importance for fisheries and aquaculture. It has also a peculiar sex-determination system, being a protandrous hermaphrodite. Here we report the construction of a first-generation genetic linkage map for S. aurata, based on 204 microsatellite markers....

journal_title：Genetics

authors： Franch R,Louro B,Tsalavouta M,Chatziplis D,Tsigenopoulos CS,Sarropoulou E,Antonello J,Magoulas A,Mylonas CC,Babbucci M,Patarnello T,Power DM,Kotoulas G,Bargelloni L

更新日期：2006-10-01 00:00:00

abstract：:Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations in the Drosophila Khc gene are known to cause distal paralysis and lethality preceded by the o...

journal_title：Genetics

authors： Djagaeva I,Rose DJ,Lim A,Venter CE,Brendza KM,Moua P,Saxton WM

更新日期：2012-09-01 00:00:00

abstract：:Frequent nonhomologous recombination has been previously postulated to explain the 1045-bp insertion in one mitochondrial sperm-transmitted haplotype of Mytilus galloprovincialis. Such recombination would lead to the disruption of gene order and so the existence of a specific mechanism for maintaining the same gene or...

journal_title：Genetics

authors： Burzyński A

更新日期：2007-02-01 00:00:00

abstract：:A key quantity in the analysis of structured populations is the parameter K, which describes the number of subpopulations that make up the total population. Inference of K ideally proceeds via the model evidence, which is equivalent to the likelihood of the model. However, the evidence in favor of a particular value o...

journal_title：Genetics

authors： Verity R,Nichols RA

更新日期：2016-08-01 00:00:00

abstract：:We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. mela...

journal_title：Genetics

authors： Balakirev ES,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:The small subunit ribosomal RNA gene (srDNA) has been used extensively for phylogenetic analyses. One common assumption in these analyses is that substitution rates are biased toward transitions. We have developed a simple method for estimating relative rates of base change that does not assume rate constancy and take...

journal_title：Genetics

authors： Vawter L,Brown WM

更新日期：1993-06-01 00:00:00

abstract：:Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the ...

journal_title：Genetics

authors： Yi N,Banerjee S,Pomp D,Yandell BS

更新日期：2007-07-01 00:00:00

abstract：:Synthetics play an important role in quantitative genetic research and plant breeding, but few studies have investigated the application of genomic prediction (GP) to these populations. Synthetics are generated by intermating a small number of parents ([Formula: see text] and thereby possess unique genetic properties,...

journal_title：Genetics

authors： Schopp P,Müller D,Technow F,Melchinger AE

更新日期：2017-01-01 00:00:00

abstract：:Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed...

journal_title：Genetics

authors： Proulx SR

更新日期：2012-02-01 00:00:00

abstract：:In most eukaryotes, crossovers are not independently distributed along the length of a chromosome. Instead, they appear to avoid close proximity to one another--a phenomenon known as crossover interference. Previously, for three of the five Arabidopsis chromosomes, we measured the strength of interference and suggeste...

journal_title：Genetics

authors： Lam SY,Horn SR,Radford SJ,Housworth EA,Stahl FW,Copenhaver GP

更新日期：2005-06-01 00:00:00

abstract：:Research on the genetics of natural populations was revolutionized in the 1990s by methods for genotyping noninvasively collected samples. However, these methods have remained largely unchanged for the past 20 years and lag far behind the genomics era. To close this gap, here we report an optimized laboratory protocol...

journal_title：Genetics

authors： Snyder-Mackler N,Majoros WH,Yuan ML,Shaver AO,Gordon JB,Kopp GH,Schlebusch SA,Wall JD,Alberts SC,Mukherjee S,Zhou X,Tung J

更新日期：2016-06-01 00:00:00

abstract：:Whole-mount fluorescence in situ hybridization (FISH) was applied to Arabidopsis thaliana seedlings to determine the three-dimensional (3D) interphase chromosome territory (CT) arrangement and heterochromatin location within the positional context of entire tissues or in particular cell types of morphologically well-p...

journal_title：Genetics

authors： Berr A,Schubert I

更新日期：2007-06-01 00:00:00

abstract：:Levels of genetic variation and linkage disequilibrium (LD) are critical factors in association mapping methods as well as in identification of loci that have been targets of selection. Maize, an outcrosser, has a high level of sequence variation and a limited extent of LD. Sorghum, a closely related but largely self-...

journal_title：Genetics

authors： Hamblin MT,Mitchell SE,White GM,Gallego J,Kukatla R,Wing RA,Paterson AH,Kresovich S

更新日期：2004-05-01 00:00:00

abstract：:The initiation of growth cessation and dormancy represents a critical ecological and evolutionary trade-off between survival and growth in most forest trees. The most important environmental cue regulating the initiation of dormancy is a shortening of the photoperiod and phytochrome genes have been implicated in short...

journal_title：Genetics

authors： Ingvarsson PK,García MV,Hall D,Luquez V,Jansson S

更新日期：2006-03-01 00:00:00

abstract：:An article by Singh and colleagues in this issue of GENETICS quantifies variation in recombination rate across a small region of the Drosophila melanogaster genome, providing an opportunity for instructors of genetics to introduce or reinforce important concepts such as recombination and recombination rate variation, ...

journal_title：Genetics

authors： Heil CS,Noor MA

更新日期：2013-06-01 00:00:00

abstract：:Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are ...

journal_title：Genetics

authors： Fu BX,Wainberg M,Kundaje A,Fire AZ

更新日期：2017-08-01 00:00:00

abstract：:Studies of genetic variation at allozyme loci, assumed to be selectively neutral, have provided valuable insights into the genetic structure of numerous populations. The degree to which population structure of allozyme variation reflects that of quantitative traits, however, is not well resolved. Here, we compare esti...

journal_title：Genetics

authors： Podolsky RH,Holtsford TP

更新日期：1995-06-01 00:00:00

abstract：:Retrotransposons are mobile genetic elements that colonize eukaryotic genomes by replicating through an RNA intermediate. As retrotransposons can move within the host genome, defense mechanisms have evolved to repress their potential mutagenic activities. In the fission yeast Schizosaccharomyces pombe, the mRNA of Tf2...

journal_title：Genetics

authors： Mallet PL,Larochelle M,Bachand F

更新日期：2017-02-01 00:00:00

abstract：:We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associa...

journal_title：Genetics

authors： Smith LA,Peixoto AA,Kramer EM,Villella A,Hall JC

更新日期：1998-07-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are an important family of signaling molecules with the unusual property that they are able to transduce their signals using the same downstream pathways. This has led to an unresolved debate as to whether individual receptors are interchangeable, or if each receptor can mediate specif...

journal_title：Genetics

authors： Leatherbarrow JR,Halfon MS

更新日期：2009-04-01 00:00:00

abstract：:Numerous loci in host organisms are involved in parasite recognition, such as major histocompatibility complex (MHC) genes in vertebrates or genes involved in gene-for-gene (GFG) relationships in plants. Diversity is commonly observed at such loci and at corresponding loci encoding antigenic molecules in parasites. Mu...

journal_title：Genetics

authors： Tellier A,Brown JK

更新日期：2007-11-01 00:00:00

abstract：:We estimated DNA sequence variation in a 5.7-kb fragment of the furrowed (fw) gene region within and between four populations of Drosophila ananassae; fw is located in a chromosomal region of very low recombination. We analyzed gene flow between these four populations along a latitudinal transect on the Indian subcont...

journal_title：Genetics

authors： Chen Y,Marsh BJ,Stephan W

更新日期：2000-07-01 00:00:00

abstract：:USING A NEWLY DEVELOPED PLATING SYSTEM, WE HAVE MEASURED CELL SURVIVAL AND THE FREQUENCIES OF VARIATION IN AN INHERITED TRAIT AFTER TREATMENT OF SOYBEAN CELL SUSPENSIONS WITH DIFFERENT MUTAGENS: ethyl methanesulfonate (EMS), methyl methanesulfonate (MMS), N-Methyl-N'-nitro-N-nitroso-guanidine (MNNG), hycanthone (1-{[2...

journal_title：Genetics

authors： Weber G,Lark KG

更新日期：1980-09-01 00:00:00