Abstract:
:We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associated with this gene. The cacS mutant, which exhibits defects in the patterning of courtship lovesong and a newly revealed but subtle abnormality in visual physiology, is mutated such that a highly conserved phenylalanine (in one of the quasi-homologous intrapolypeptide regions called IIIS6) is replaced by isoleucine. The cacH18 mutant exhibits defects in visual physiology (including complete unresponsiveness to light in certain genetic combinations) and visually mediated behaviors; this mutant (originally nbAH18) has a stop codon in an alternative exon (within the cac ORF), which is differentially expressed in the eye. Analysis of the various courtship and visual phenotypes associated with this array of cac mutants demonstrates that Dmca1A calcium channels mediate multiple, separable biological functions; these correlate in part with transcript diversity generated via alternative splicing.
journal_name
Geneticsjournal_title
Geneticsauthors
Smith LA,Peixoto AA,Kramer EM,Villella A,Hall JCsubject
Has Abstractpub_date
1998-07-01 00:00:00pages
1407-26issue
3eissn
0016-6731issn
1943-2631journal_volume
149pub_type
杂志文章相关文献
GENETICS文献大全abstract::We have examined the in vivo requirement of two recently identified nonessential components of the budding yeast anaphase-promoting complex, Swm1p and Mnd2p, as well as that of the previously identified subunit Apc9p. swm1Delta mutants exhibit synthetic lethality or conditional synthetic lethality with other APC/C sub...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.040105
更新日期:2005-07-01 00:00:00
abstract::In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination often leads to loss of heterozygosity (LOH). Most previous studies of mitotic recombination in Saccharomyces cerevisiae have focused on a single chromosome or a single region of one chromosome at which LOH events can be selected. I...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.137927
更新日期:2012-04-01 00:00:00
abstract::We report a positive association between marital radius (distance between mates' birthplaces) and fertility detected in a large population. Spurious association due to socioeconomic factors is discarded by a conditional analysis involving income, education, and urbanicity. Strong evidence of consanguinity's deleteriou...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.072454
更新日期:2008-01-01 00:00:00
abstract::We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Repeated elements are remarkably important for male meiosis and spermiogenesis in Drosophila melanogaster. Pairing of the X and Y chromosomes is mediated by the ribosomal RNA genes of the Y chromosome and X chromosome heterochromatin, spermiogenesis depends on the fertility factors of the Y chromosome. Intriguingly, a...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Genomic integrity is threatened by multiple sources of DNA damage. DNA double-strand breaks (DSBs) are among the most dangerous types of DNA lesions and can be generated by endogenous or exogenous agents, but they can arise also during DNA replication. Sister chromatid recombination (SCR) is a key mechanism for the re...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101899
更新日期:2009-06-01 00:00:00
abstract::Candida albicans, which is diploid, possesses a single mating-type (MTL) locus on chromosome 5, which is normally heterozygous (a/alpha). To mate, C. albicans must undergo MTL homozygosis to a/a or alpha/alpha. Three possible mechanisms may be used in this process, mitotic recombination, gene conversion, or loss of on...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.033167
更新日期:2005-03-01 00:00:00
abstract::The Acp26Aa and Acp26Ab genes that code for male accessory gland proteins are tandemly arranged in the species of the Drosophila melanogaster complex. An approximately 1.6-kb region encompassing both genes has been sequenced in 10, 24, and 18 lines from Spain, Ivory Coast, and Malawi, respectively; the previously stud...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::A semi-lethal, sterile allele of the smooth locus (2-91.5), sm3, was discovered in an artificial selection line for low abdominal bristle number that had been started from a P-M dysgenic cross. The fitness effects and extremely low bristle number phenotype of the allele could not be separated by recombination from a P...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract::Telomere position effects on transcription (TPE, or telomeric silencing) are nucleated by association of nonhistone silencing factors with the telomere and propagated in subtelomeric regions through association of silencing factors with the specifically modified histones H3 and H4. However, the function of histone H2A...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Automated image acquisition, a custom analysis algorithm, and a distributed computing resource were used to add time as a third dimension to a quantitative trait locus (QTL) map for plant root gravitropism, a model growth response to an environmental cue. Digital images of Arabidopsis thaliana seedling roots from two ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.153346
更新日期:2013-11-01 00:00:00
abstract::Age-specific effects of spontaneous mutations on mortality rates in Drosophila are inferred from three large demographic experiments. Data were collected from inbred lines that were allowed to accumulate spontaneous mutations for 10, 19, and 47 generations. Estimates of age-specific mutational variance for mortality w...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::The effect of full-sib inbreeding on competitive male-mating ability (CImale symbol) in Drosophila melanogaster was investigated in two experiments. In the first, five inbred lines (with reserves) were assessed up to 18 generations. Linear inbreeding depression, of 5.9% per 10% increase in homozygosity, was observed. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract::We subjected the genes encoding the 19.3-, 21.3c-, and 51-kDa iron-sulfur subunits of respiratory chain complex I from Neurospora crassa to site-directed mutagenesis to mimic mutations in human complex I subunits associated with mitochondrial diseases. The V135M substitution was introduced into the 19.3-kDa cDNA, the ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.041517
更新日期:2005-09-01 00:00:00
abstract::The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.177550
更新日期:2015-08-01 00:00:00
abstract::Although most living organisms reproduce sexually, some have developed a uniparental reproduction where the embryo usually derives from the female parent. A unique case of paternal apomixis in plants has been recently reported in Cupressus dupreziana, an endangered Mediterranean conifer. This species produces unreduce...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.080572
更新日期:2008-01-01 00:00:00
abstract::Mutants of Paramecium caudatum with abnormal swimming behavior or responses to cations were obtained by mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Some of the mutants, like pawn in P. tetraurelia, cannot swim backward and are called CNR. Seven independently obtained CNR mutants belonged to three complement...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract::The infinite-sites model with no recombination is extended to include mutations that affect electrophoretic mobility. The model allows the effect of a single-site mutation to have a continuous effect on mobility. Formulae are obtained for the variance of electrophoretic mobility of alleles after an arbitrary lenght of...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract::In most eukaryotes, crossovers are not independently distributed along the length of a chromosome. Instead, they appear to avoid close proximity to one another--a phenomenon known as crossover interference. Previously, for three of the five Arabidopsis chromosomes, we measured the strength of interference and suggeste...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.040055
更新日期:2005-06-01 00:00:00
abstract::The uaY gene encodes the transcriptional activator of purine catabolism genes in Aspergillus nidulans. uaY12 results in strongly defective growth on purines as nitrogen sources and in strongly diminished transcription of UaY-regulated genes. This mutation introduces an ATG codon 64 bp upstream of the uaY ATG, generati...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.099515
更新日期:2009-04-01 00:00:00
abstract::High-density genotyping of single-nucleotide polymorphisms (SNPs) enables detection of quantitative trait loci (QTL) by linkage disequilibrium (LD) mapping using LD between markers and QTL and the subsequent use of this information for marker-assisted selection (MAS). The success of LD mapping and MAS depends on the e...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.082206
更新日期:2007-12-01 00:00:00
abstract::Genetic drift is an important evolutionary force of strength inversely proportional to Ne , the effective population size. The impact of drift on genome diversity and evolution is known to vary among species, but quantifying this effect is a difficult task. Here we assess the magnitude of variation in drift power amon...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303622
更新日期:2020-10-01 00:00:00
abstract::We have studied the deletion of inverted repeats cloned into the EcoRI site within the CAT gene of plasmid pBR325. A cloned inverted repeat constitutes a palindrome that includes both EcoRI sites flanking the insert. In addition, the two EcoRI sites represent direct repeats flanking a region of palindromic symmetry. A...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::In plants, many major regulatory genes that control plant growth and development have been identified and characterized. Despite a detailed knowledge of the function of these genes little is known about how they contribute to the natural variation for complex traits. To determine whether major regulatory genes of maiz...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.080424
更新日期:2007-12-01 00:00:00
abstract::Escherichia coli K12 does not metabolize beta-glucosides such as arbutin and salicin because of lack of expression of the bglBSRC operon, which contains structural genes for transport (bglC) and hydrolysis (bglB) of phospho-beta-glucosides. Mutants carrying lesions in the cis-acting regulatory site bglR metabolize bet...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Meiosis and spore formation in the yeast Saccharomyces cerevisiae are associated with increased expression of sporulation-specific genes. One of these genes, IME2, encodes a putative protein kinase that is a positive regulator of other sporulation-specific genes. We have isolated mutations that cause reduced expressio...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this "Compact" phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this li...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Specialized insect mouthparts, such as those of Drosophila, are derived from an ancestral mandibulate state, but little is known about the developmental genetics of mandibulate mouthparts. Here, we study the metamorphic patterning of mandibulate mouthparts of the beetle Tribolium castaneum, using RNA interference to d...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.134296
更新日期:2012-02-01 00:00:00
abstract::The consequences of asymmetric dispersion on the maintenance of an allele in a one-dimensional environmental pocket are examined. The diffusion model of migration and selection is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is further supposed that ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract::Mitotic interconversion of the mating-type locus (mat1) of the fission yeast Schizosaccharomyces pombe is initiated by a double-strand break at mat1. The mat2 and mat3 loci act as nonrandom donors of genetic information for mat1 switching such that switches occur primarily (or only) to the opposite mat1 allele. Locati...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00