Human fertility increases with marital radius.

Abstract:

:We report a positive association between marital radius (distance between mates' birthplaces) and fertility detected in a large population. Spurious association due to socioeconomic factors is discarded by a conditional analysis involving income, education, and urbanicity. Strong evidence of consanguinity's deleterious effects affecting an entire human population is provided.

journal_name

Genetics

journal_title

Genetics

authors

Labouriau R,Amorim A

doi

10.1534/genetics.107.072454

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

601-3

issue

1

eissn

0016-6731

issn

1943-2631

pii

178/1/601

journal_volume

178

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Linkage disequilibrium in natural populations of Drosophila melanogaster.

    abstract::Two large, stable populations (Texas and Japan) of Drosophila melanogaster were surveyed at 21 allozyme loci on the second and third chromosomes and for chromosomal gene arrangements on those two chromosomes. Over 220 independent gametes were sampled from each population. The types and frequencies of the surveyed gene...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Langley CH,Tobari YN,Kojima KI

    更新日期:1974-11-01 00:00:00

  • A Bayesian Approach to Inferring Rates of Selfing and Locus-Specific Mutation.

    abstract::We present a Bayesian method for characterizing the mating system of populations reproducing through a mixture of self-fertilization and random outcrossing. Our method uses patterns of genetic variation across the genome as a basis for inference about reproduction under pure hermaphroditism, gynodioecy, and a model de...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.115.179093

    authors: Redelings BD,Kumagai S,Tatarenkov A,Wang L,Sakai AK,Weller SG,Culley TM,Avise JC,Uyenoyama MK

    更新日期:2015-11-01 00:00:00

  • Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.

    abstract::The noncanonical Frizzled/planar cell polarity (PCP) pathway regulates establishment of polarity within the plane of an epithelium to generate diversity of cell fates, asymmetric, but highly aligned structures, or to orchestrate the directional migration of cells during convergent extension during vertebrate gastrulat...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.115.181438

    authors: Dollar G,Gombos R,Barnett AA,Sanchez Hernandez D,Maung SM,Mihály J,Jenny A

    更新日期:2016-03-01 00:00:00

  • Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae.

    abstract::HO endonuclease-induced double-strand breaks (DSBs) within a direct duplication of Escherichia coli lacZ genes are repaired either by gene conversion or by single-strand annealing (SSA), with > 80% being SSA. Previously it was demonstrated that the RAD52 gene is required for DSB-induced SSA. In the present study, the ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ivanov EL,Sugawara N,Fishman-Lobell J,Haber JE

    更新日期:1996-03-01 00:00:00

  • Estimating Linear and Nonlinear Gene Coexpression Networks by Semiparametric Neighborhood Selection.

    abstract::Whereas nonlinear relationships between genes are acknowledged, there exist only a few methods for estimating nonlinear gene coexpression networks or gene regulatory networks (GCNs/GRNs) with common deficiencies. These methods often consider only pairwise associations between genes, and are, therefore, poorly capable ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.120.303186

    authors: Kontio JAJ,Rinta-Aho MJ,Sillanpää MJ

    更新日期:2020-07-01 00:00:00

  • An integrated genetic map of the African human malaria vector mosquito, Anopheles gambiae.

    abstract::We present a genetic map based on microsatellite polymorphisms for the African human malaria vector, Anopheles gambiae. Polymorphisms in laboratory strains were detected for 89% of the tested microsatellite markers. Genotyping was performed for individual mosquitos from 13 backcross families that included 679 progeny....

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Zheng L,Benedict MQ,Cornel AJ,Collins FH,Kafatos FC

    更新日期:1996-06-01 00:00:00

  • Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.

    abstract::Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is ...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.119.302661

    authors: Smith KN,Miller SC,Varani G,Calabrese JM,Magnuson T

    更新日期:2019-12-01 00:00:00

  • Coalescent theory for a partially selfing population.

    abstract::A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals....

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Fu YX

    更新日期:1997-08-01 00:00:00

  • Population dynamics of HIV-1 inferred from gene sequences.

    abstract::A method for the estimation of population dynamic history from sequence data is described and used to investigate the past population dynamics of HIV-1 subtypes A and B. Using both gag and env gene alignments the effective population size of each subtype is estimated and found to be surprisingly small. This may be a r...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Grassly NC,Harvey PH,Holmes EC

    更新日期:1999-02-01 00:00:00

  • Interaction between Ustilago maydis REC2 and RAD51 genes in DNA repair and mitotic recombination.

    abstract::A gene encoding a Ustilago maydis Rad51 orthologue has been isolated, rad51-1, a mutant constructed by disrupting the gene, was as sensitive to killing by ultraviolet light and gamma radiation as the rec2-1 mutant and slightly more sensitive to killing by methyl methanesulfonate. There was no suppression of killing by...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ferguson DO,Rice MC,Rendi MH,Kotani H,Kmiec EB,Holloman WK

    更新日期:1997-02-01 00:00:00

  • The cohesive population genetics of molecular drive.

    abstract::The long-term population genetics of multigene families is influenced by several biased and unbiased mechanisms of nonreciprocal exchanges (gene conversion, unequal exchanges, transposition) between member genes, often distributed on several chromosomes. These mechanisms cause fluctuations in the copy number of varian...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ohta T,Dover GA

    更新日期:1984-10-01 00:00:00

  • Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.

    abstract::To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Smit M,Segers K,Carrascosa LG,Shay T,Baraldi F,Gyapay G,Snowder G,Georges M,Cockett N,Charlier C

    更新日期:2003-01-01 00:00:00

  • Feedback regulation of SIN by Etd1 and Rho1 in fission yeast.

    abstract::In fission yeast, the septation initiation network (SIN) is thought to promote cytokinesis by downstream activation of Rho1, a conserved GTPase that controls cell growth and division. Here we show that Etd1 and PP2A-Pab1, antagonistic regulators of SIN, are Rho1 regulators. Our genetic and biochemical studies indicate...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.113.155218

    authors: Alcaide-Gavilán M,Lahoz A,Daga RR,Jimenez J

    更新日期:2014-02-01 00:00:00

  • Gamma-ray mutagenesis in bacteriophage T4.

    abstract::137Cs-gamma irradiation of bacteriophage T4 induces large deletions plus a variety of types of point mutations. All mutations arise with single-hit kinetics, and all by a misrepair process. The estimated point mutation rate is 1.5 X 10(-9) per locus per rad. ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Conkling MA,Grunau JA,Drake JW

    更新日期:1976-04-01 00:00:00

  • Euploid derivatives of duplications from a translocation in neurospora.

    abstract::Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Turner BC

    更新日期:1977-03-01 00:00:00

  • Comparative effects of pollen and seed migration on the cytonuclear structure of plant populations. I. Maternal cytoplasmic inheritance.

    abstract::We explicitly solve and analyze a series of deterministic continent-island models to delimit the effects of pollen and seed migration on cytonuclear frequencies and disequilibria in random-mating, mixed-mating and self-fertilized populations. Given the critical assumption of maternal cytoplasmic inheritance, five majo...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Asmussen MA,Schnabel A

    更新日期:1991-07-01 00:00:00

  • Logjam encodes a predicted EMP24/GP25 protein that is required for Drosophila oviposition behavior.

    abstract::A newly characterized Drosophila melanogaster gene, logjam (loj), functions in female reproduction by modulating oviposition behavior. The locus encodes at least six overlapping transcripts with unique 5' ends. P-element mutants that express very low levels of loj transcripts are unable to oviposit mature eggs. This p...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Carney GE,Taylor BJ

    更新日期:2003-05-01 00:00:00

  • Maintenance of Heterochromatin by the Large Subunit of the CAF-1 Replication-Coupled Histone Chaperone Requires Its Interaction with HP1a Through a Conserved Motif.

    abstract::In eukaryotic cells, the organization of genomic DNA into chromatin regulates many biological processes, from the control of gene expression to the regulation of chromosome segregation. The proper maintenance of this structure upon cell division is therefore of prime importance during development for the maintenance o...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.190785

    authors: Roelens B,Clémot M,Leroux-Coyau M,Klapholz B,Dostatni N

    更新日期:2017-01-01 00:00:00

  • Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans.

    abstract::Ten mutations are described that transform genotypic hermaphrodites of the nematode Caenorhabditis elegans into phenotypic males. These fall into three autosomal complementation groups, termed tra-1, tra-2, and tra-3. Two alleles of tra-1 produce almost complete transformation, to a fertile male phenotype; such transf...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hodgkin JA,Brenner S

    更新日期:1977-06-01 00:00:00

  • Genic Heterozygosity and Variation in Permanent Translocation Heterozygotes of the OENOTHERA BIENNIS Complex.

    abstract::Genic heterozygosity and variation were studied in the permanent translocation heterozygotes Oenothera biennis I, Oe. biennis II, Oe. biennis III, Oe. strigosa, Oe. parviflora I, Oe. parviflora II, and in the related bivalent formers Oe. argillicola and Oe. hookeri. From variation at 20 enzyme loci, we find that trans...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Levy M,Levin DA

    更新日期:1975-03-01 00:00:00

  • P element-mediated in vivo deletion analysis of white-apricot: deletions between direct repeats are strongly favored.

    abstract::We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kurkulos M,Weinberg JM,Roy D,Mount SM

    更新日期:1994-03-01 00:00:00

  • Restructuring of Holocentric Centromeres During Meiosis in the Plant Rhynchospora pubera.

    abstract::Centromeres are responsible for the correct segregation of chromosomes during mitosis and meiosis. Holocentric chromosomes, characterized by multiple centromere units along each chromatid, have particular adaptations to ensure regular disjunction during meiosis. Here we show by detecting CENH3, CENP-C, tubulin, and ce...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.191213

    authors: Marques A,Schubert V,Houben A,Pedrosa-Harand A

    更新日期:2016-10-01 00:00:00

  • Detecting structure of haplotypes and local ancestry.

    abstract::We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.113.160697

    authors: Guan Y

    更新日期:2014-03-01 00:00:00

  • Behavioral Mutants of DROSOPHILA MELANOGASTER. I. Isolation and Mapping of Mutations Which Decrease Flight Ability.

    abstract::A flight test box was developed and used in the isolation and initial characterization of Drosophila melanogaster mutants defective in flight behavior. Forty-eight mutants were isolated from F(1) progeny of ethyl methanesulfonate-treated males. Genetic mapping and complementation tests show that the mutations reside a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Homyk T,Sheppard DE

    更新日期:1977-09-01 00:00:00

  • Proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growth.

    abstract::In the yeast Saccharomyces cerevisiae, rim1, 8, 9, or 13 mutations cause four phenotypes: poor growth at low temperature, altered colony morphology, inefficient sporulation due to reduced expression of the meiotic activator IME1, and, as shown here, defective invasive growth. In this report, we have determined the rel...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Li W,Mitchell AP

    更新日期:1997-01-01 00:00:00

  • A quantitative measure of the mitotic pairing of alleles in Drosophila melanogaster and the influence of structural heterozygosity.

    abstract::In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Golic MM,Golic KG

    更新日期:1996-05-01 00:00:00

  • Sequence-dependent gene conversion: can duplicated genes diverge fast enough to escape conversion?

    abstract::Conversion between duplicated genes limits their independent evolution. Models in which conversion frequencies decrease as genes diverge are examined to determine conditions under which genes can "escape" further conversion and hence escape from a gene family. A review of results from various recombination systems sug...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Walsh JB

    更新日期:1987-11-01 00:00:00

  • Selective genotyping and phenotyping strategies in a complex trait context.

    abstract::Selective genotyping and phenotyping strategies are used to lower the cost of quantitative trait locus studies. Their efficiency has been studied primarily in simplified contexts--when a single locus contributes to the phenotype, and when the residual error (phenotype conditional on the genotype) is normally distribut...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.094607

    authors: Sen S,Johannes F,Broman KW

    更新日期:2009-04-01 00:00:00

  • Genetic Variance Partitioning and Genome-Wide Prediction with Allele Dosage Information in Autotetraploid Potato.

    abstract::As one of the world's most important food crops, the potato (Solanum tuberosum L.) has spurred innovation in autotetraploid genetics, including in the use of SNP arrays to determine allele dosage at thousands of markers. By combining genotype and pedigree information with phenotype data for economically important trai...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.300685

    authors: Endelman JB,Carley CAS,Bethke PC,Coombs JJ,Clough ME,da Silva WL,De Jong WS,Douches DS,Frederick CM,Haynes KG,Holm DG,Miller JC,Muñoz PR,Navarro FM,Novy RG,Palta JP,Porter GA,Rak KT,Sathuvalli VR,Thompson AL,Yench

    更新日期:2018-05-01 00:00:00

  • Context dependence of meiotic recombination hotspots in yeast: the relationship between recombination activity of a reporter construct and base composition.

    abstract::Borde and colleagues reported that a reporter plasmid inserted at different genomic locations in Saccharomyces cerevisiae had different levels of meiotic recombination activity. We show that the level of recombination activity is very significantly correlated with the GC content of DNA sequences flanking the insertion...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Petes TD,Merker JD

    更新日期:2002-12-01 00:00:00