Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.

abstract：:The genotypes of three color mutants in goldfish: a depigmentation character of larval melanophores, albinism and a recessive-transparent character, were analyzed by crossing experiments. The depigmentation character in the common goldfish is controlled by two dominant multiple genes, Dp1 and Dp2, and only fish with d...

journal_title：Genetics

authors： Kajishima T

更新日期：1977-05-01 00:00:00

abstract：:The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chrom...

journal_title：Genetics

authors： Conley EJ,Nduati V,Gonzalez-Hernandez JL,Mesfin A,Trudeau-Spanjers M,Chao S,Lazo GR,Hummel DD,Anderson OD,Qi LL,Gill BS,Echalier B,Linkiewicz AM,Dubcovsky J,Akhunov ED,Dvorák J,Peng JH,Lapitan NL,Pathan MS,Nguyen HT

更新日期：2004-10-01 00:00:00

abstract：:Sensory cues regulate several aspects of behavior and development in Caenorhabditis elegans, including entry into and exit from an alternative developmental stage called the dauer larva. Three parallel pathways, including a TGF-beta-like pathway, regulate dauer formation. The mechanisms by which the activities of thes...

journal_title：Genetics

authors： Daniels SA,Ailion M,Thomas JH,Sengupta P

更新日期：2000-09-01 00:00:00

abstract：:TE146 is a giant transposon of Drosophila melanogaster. It carries two copies of the white and roughest genes, normally found on the X chromosome. The structure of this transposon has been studied at the molecular level. TE146 may transpose to new chromosome positions, excise and be lost from the genome or undergo int...

journal_title：Genetics

authors： Lovering R,Harden N,Ashburner M

更新日期：1991-06-01 00:00:00

abstract：:Mutants arising spontaneously from sporulated cultures of certain strains of yeast, Saccharomyces cerevisiae, contained deletions of the CYC1 gene which controls the primary structure of iso-1-cytochrome c. At least 60 different kinds of deletions were uncovered among the 104 deletions examined and these ranged in len...

journal_title：Genetics

authors： Sherman F,Jackson M,Liebman SW,Schweingruber AM,Stewart JW

更新日期：1975-09-01 00:00:00

abstract：:By using both numerical and analytical approaches, we have shown that heterosis alone is not a mechanism for maintaining many alleles segregating at a locus. Even when all heterozygous are more fit than all homozygotes, the proportion of fitness arrays that will lead to a stable, feasible equilibrium of more than 6 or...

journal_title：Genetics

authors： Lewontin RC,Ginzburg LR,Tuljapurkar SD

更新日期：1978-01-01 00:00:00

abstract：:The nuclear envelope in Saccharomyces cerevisiae harbors two essential macromolecular protein assemblies: the nuclear pore complexes (NPCs) that enable nucleocytoplasmic transport, and the spindle pole bodies (SPBs) that mediate chromosome segregation. Previously, based on metazoan and budding yeast studies, we report...

journal_title：Genetics

authors： Casey AK,Dawson TR,Chen J,Friederichs JM,Jaspersen SL,Wente SR

更新日期：2012-10-01 00:00:00

abstract：:Two alternative hypotheses attribute different benefits to codon-anticodon adaptation. The first assumes that protein production is rate limited by both initiation and elongation and that codon-anticodon adaptation would result in higher elongation efficiency and more efficient and accurate protein production, especia...

journal_title：Genetics

authors： Xia X

更新日期：2015-02-01 00:00:00

abstract：:The yellow fever mosquito Aedes aegypti has been the subject of extensive genetic research due to its medical importance and the ease with which it can be manipulated in the laboratory. A molecular genetic linkage map was constructed using 148 amplified fragment length polymorphism (AFLP) and six single-strand conform...

journal_title：Genetics

authors： Zhong D,Menge DM,Temu EA,Chen H,Yan G

更新日期：2006-07-01 00:00:00

abstract：:Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...

journal_title：Genetics

authors： Bueno Filho JS,Gilmour SG,Rosa GJ

更新日期：2006-10-01 00:00:00

abstract：:The bristle worm Platynereis dumerilii displays many interesting biological characteristics. These include its reproductive timing, which is synchronized to the moon phase, its regenerative capacity that is hormonally controlled, and a slow rate of evolution, which permits analyses of ancestral genes and cell types. A...

journal_title：Genetics

authors： Zantke J,Bannister S,Rajan VB,Raible F,Tessmar-Raible K

更新日期：2014-05-01 00:00:00

abstract：:Salient features of recombination at ARG4 of Saccharomyces provoke a variation of the double-strand-break repair (DSBR) model that has the following features: (1) Holliday junction cutting is biased in favor of strands upon which DNA synthesis occurred during formation of the joint molecule (this bias ensures that cut...

journal_title：Genetics

authors： Foss HM,Hillers KJ,Stahl FW

更新日期：1999-10-01 00:00:00

abstract：:The phenomenon of heterosis describes the increased agronomic performance of heterozygous F(1) plants compared to their homozygous parental inbred plants. Heterosis is manifested during the early stages of root development in maize. The goal of this study was to identify nonadditive gene expression in primary roots of...

journal_title：Genetics

authors： Hoecker N,Keller B,Muthreich N,Chollet D,Descombes P,Piepho HP,Hochholdinger F

更新日期：2008-07-01 00:00:00

abstract：:RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) in Drosophila cells are currently being performed and emphasize the strengths and weaknesses of the...

journal_title：Genetics

authors： Perrimon N,Mathey-Prevot B

更新日期：2007-01-01 00:00:00

abstract：:An approximately 135-bp sequence called the A1/A2 repeat was isolated from the transcribed region of the 26-18S rDNA intergenic spacer (IGS) of Nicotiana tomentosiformis. Fluorescence in situ hybridization (FISH) and Southern blot analysis revealed its occurrence as an independent satellite (termed an A1/A2 satellite)...

journal_title：Genetics

authors： Lim KY,Skalicka K,Koukalova B,Volkov RA,Matyasek R,Hemleben V,Leitch AR,Kovarik A

更新日期：2004-04-01 00:00:00

abstract：:Dosage compensation in Drosophila has been studied at the steady state RNA level for several single-copy genes; however, an important point is addressed by analyzing a repetitive, transposable element for dosage compensation. The two issues of gene-specific cis control and genomic position can be studied by determinin...

journal_title：Genetics

authors： Hiebert JC,Birchler JA

更新日期：1992-03-01 00:00:00

abstract：:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, ...

journal_title：Genetics

authors： Hales KG,Korey CA,Larracuente AM,Roberts DM

更新日期：2015-11-01 00:00:00

abstract：:We have identified two Saccharomyces cerevisiae genes that, in high copy, confer resistance to Kluyveromyces lactis zymocin, an inhibitor that blocks cells in the G(1) phase of the cell cycle prior to budding and DNA replication. One gene (GRX3) encodes a glutaredoxin and is likely to act at the level of zymocin entry...

journal_title：Genetics

authors： Jablonowski D,Butler AR,Fichtner L,Gardiner D,Schaffrath R,Stark MJ

更新日期：2001-12-01 00:00:00

abstract：:mod(mdg4), also known as E(var)3-93D, is involved in a variety of processes, such as gene silencing in position effect variegation (PEV), the control of gypsy insulator sequences, regulation of homeotic gene expression, and programmed cell death. We have isolated a large number of mod(mdg4) cDNAs, representing 21 diff...

journal_title：Genetics

authors： Büchner K,Roth P,Schotta G,Krauss V,Saumweber H,Reuter G,Dorn R

更新日期：2000-05-01 00:00:00

abstract：:In yeast, 17 histidine-requiring mutants derived from and interallelically complementary to his1-7 were analyzed. The genetic basis of the complementation response was elucidated by mitotic and meiotic gene conversion. Each allele probably carries an unaltered 7-site mutation and a unique second-site alteration. The s...

journal_title：Genetics

authors： Lax C,Fogel S

更新日期：1978-11-01 00:00:00

abstract：:We analyzed linkage and chromosomal positions of genes in A. lyrata ssp. petraea that are located near the centromere (CEN) regions of A. thaliana, using at least two genes from the short and long arms of each chromosome. In our map, genes from all 10 A. thaliana chromosome arms are also tightly linked in A. lyrata. G...

journal_title：Genetics

authors： Kawabe A,Hansson B,Hagenblad J,Forrest A,Charlesworth D

更新日期：2006-07-01 00:00:00

abstract：:Recessive lethan mutations in the 3A1 to 3C2 region of the X-chromosome of Drosophila melanogaster were detected in 113 of 33,544 sperm treated by feeding 5 mM methyl methanesulfonate in 1% sucrose for 22 hours. Seven of the 113 lethans were sterile, leaving 106 for analysis by complementation tests. With only one exc...

journal_title：Genetics

authors： Liu CP,Lim JK

更新日期：1975-04-01 00:00:00

abstract：:The gastrulation defective (gd) locus encodes a novel serine protease that is involved in specifying the dorsal-ventral axis during embryonic development. Mutant alleles of gd have been classified into three complementation groups, two of which exhibit strong interallelic (intragenic) complementation. To understand th...

journal_title：Genetics

authors： Ponomareff G,Giordano H,DeLotto Y,DeLotto R

更新日期：2001-10-01 00:00:00

abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...

journal_title：Genetics

authors： Desai MM,Plotkin JB

更新日期：2008-12-01 00:00:00

abstract：:Pairwise linkage disequilibrium values (D) were estimated for 14 allozyme loci in two natural populations of lodgepole pine (Pinus contorta ssp. latifolia). Maternal multilocus genotypes were inferred from samples of (haploid) megagametophytic seed-endosperms. Coupling/repulsion double heterozygotes were distinguished...

journal_title：Genetics

authors： Epperson BK,Allard RW

更新日期：1987-02-01 00:00:00

abstract：:We demonstrate that the previously described gene Androgen binding protein (Abp; Dlouhy and Karn, 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa). A study of recombinant inbred strains demonstrates that Abpa is located on chromosome 7 near Glucose phosphate isomerase...

journal_title：Genetics

authors： Dlouhy SR,Taylor BA,Karn RC

更新日期：1987-03-01 00:00:00

abstract：:A long-standing prediction in evolutionary biology is that organisms experience a so-called "cost of complexity" manifested as a decreasing rate of adaptation in populations as organisms or selective environments become increasingly complex. This theory assumes the ubiquity of antagonistic pleiotropy, or trade-offs in...

journal_title：Genetics

authors： Sackman AM,Rokyta DR

更新日期：2019-05-01 00:00:00

abstract：:A location of the structural gene(s) for dopa decarboxylase (EC 4.1.1.26) is proposed on the basis of enzyme determinations in a set of duplication-bearing aneuploids, which revealed only one dosage-sensitive region in the Drosophila genome. This region lies between 36EF and 37D on the left arm of chromosome 2. ...

journal_title：Genetics

authors： Hodgetts RB

更新日期：1975-01-01 00:00:00

abstract：:Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a populatio...

journal_title：Genetics

authors： Huang K,Mi R,Dunn DW,Wang T,Li B

更新日期：2018-12-01 00:00:00

abstract：:Two composite multiple regression-interval mapping analyses were performed to identify candidate quantitative trait loci (QTL) affecting components of wing shape in Drosophila melanogaster defined by eight relative warp-based measures. A recombinant inbred line design was used to map QTL for the shape of two intervein...

journal_title：Genetics

authors： Zimmerman E,Palsson A,Gibson G

更新日期：2000-06-01 00:00:00