Abstract：
:A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibited rates of crossover considerably higher than those of individuals with no copies. Further, recombinant sperm from heterozygous individuals showed a preferential tendency to carry the G allele. We consider the effects of these phenomena on patterns of linkage disequilibrium and find them to be more subtle than might have been expected. In particular, our analysis suggests that, perhaps surprisingly, patterns of LD among chromosomes carrying the "hot" allele (in this case, A) will typically be similar to those among chromosomes carrying the "cold" allele (G).
journal_name
Geneticsjournal_title
Geneticsauthors
Hellenthal G,Pritchard JK,Stephens Mdoi
10.1534/genetics.104.039271keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
2001-5issue
3eissn
0016-6731issn
1943-2631pii
genetics.104.039271journal_volume
172pub_type
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