Antisense Transcription of Retrotransposons in Drosophila: An Origin of Endogenous Small Interfering RNA Precursors.

abstract：:Selective sweeps are typically associated with a local reduction of genetic diversity around the adaptive site. However, selective sweeps can also quickly carry neutral mutations to observable population frequencies if they arise early in a sweep and hitchhike with the adaptive allele. We show that the interplay betwe...

journal_title：Genetics

authors： Messer PW,Neher RA

更新日期：2012-06-01 00:00:00

abstract：:The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include ...

journal_title：Genetics

authors： Motro U,Thomson G

更新日期：1985-07-01 00:00:00

abstract：:Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation o...

journal_title：Genetics

authors： Hynes MJ,Murray SL,Khew GS,Davis MA

更新日期：2008-03-01 00:00:00

abstract：:Recessive lethal or semilethal alleles at the T/t locus in the mouse generate new t-variants, with characteristics different from the parent allele at a rate of about 10(-3). Almost invariably the variant chromosome carries marker genes derived from the opposite parental chromosome. New t-mutations obtained in this wa...

journal_title：Genetics

authors： Bennett D,Dunn LC,Artzt K

更新日期：1976-06-01 00:00:00

abstract：:To identify genes regulating the development of the six touch receptor neurons, we screened the F(2) progeny of mutated animals expressing an integrated mec-2::gfp transgene that is expressed mainly in these touch cells. From 2638 mutated haploid genomes, we obtained 11 mutations representing 11 genes that affected th...

journal_title：Genetics

authors： Du H,Chalfie M

更新日期：2001-05-01 00:00:00

abstract：:A genetic model with additive-dominance effects and genotype x environment interactions is presented for quantitative traits with time-dependent measures. The genetic model for phenotypic means at time t conditional on phenotypic means measured at previous time (t-1) is defined. Statistical methods are proposed for an...

journal_title：Genetics

authors： Zhu J

更新日期：1995-12-01 00:00:00

abstract：:Disease resistance to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) in the cultivated tomato, Lycopersicon esculentum, and the closely related L. pimpinellifolium is triggered by the physical interaction between plant disease resistance protein, Pto, and the pathogen avirulence protein, AvrPto. To inves...

journal_title：Genetics

authors： Rose LE,Langley CH,Bernal AJ,Michelmore RW

更新日期：2005-09-01 00:00:00

abstract：:Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase c...

journal_title：Genetics

authors： Wasserstrom L,Lengeler KB,Walther A,Wendland J

更新日期：2013-09-01 00:00:00

abstract：:Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are...

journal_title：Genetics

authors： Thomas PE,Hutton JJ,Taylor BA

更新日期：1973-08-01 00:00:00

abstract：:Trichome development in Arabidopsis thaliana is a well-characterized model for the study of plant cell differentiation. Two genes that play an essential role in the initiation of trichome development are GL1 and TTG. Mutations in either gene prevent the initiation of most trichomes. The GL1 gene encodes a myb-related ...

journal_title：Genetics

authors： Larkin JC,Walker JD,Bolognesi-Winfield AC,Gray JC,Walker AR

更新日期：1999-04-01 00:00:00

abstract：:Alteration of the subcellular distribution of Mod5p-I, a tRNA modification enzyme, member of the sorting isozyme family, affects tRNA-mediated nonsense suppression. Altered suppression efficiency was used to identify MDP genes, which, when mutant, change the mitochondrial/cytosolic distribution of Mod5p-I,KR6. MDP2 is...

journal_title：Genetics

authors： Zoladek T,Tobiasz A,Vaduva G,Boguta M,Martin NC,Hopper AK

更新日期：1997-03-01 00:00:00

abstract：:Gene targeting techniques have led to the phenotypic characterization of numerous genes; however, many genes show minimal to no phenotypic consequences when disrupted, despite many having highly conserved sequences. The standard explanation for these findings is functional redundancy. A competing hypothesis is that th...

journal_title：Genetics

authors： Ruff JS,Saffarini RB,Ramoz LL,Morrison LC,Baker S,Laverty SM,Tvrdik P,Potts WK

更新日期：2015-10-01 00:00:00

abstract：:Identifying loci under natural selection from genomic surveys is of great interest in different research areas. Commonly used methods to separate neutral effects from adaptive effects are based on locus-specific population differentiation coefficients to identify outliers. Here we extend such an approach to estimate d...

journal_title：Genetics

authors： Foll M,Gaggiotti O

更新日期：2008-10-01 00:00:00

abstract：:Although maize is naturally an outcrossing organism, modern breeding utilizes highly inbred lines in controlled crosses to produce hybrids. The U.S. Department of Agriculture's reciprocal recurrent selection experiment between the Iowa Stiff Stalk Synthetic (BSSS) and the Iowa Corn Borer Synthetic No. 1 (BSCB1) popula...

journal_title：Genetics

authors： Gerke JP,Edwards JW,Guill KE,Ross-Ibarra J,McMullen MD

更新日期：2015-11-01 00:00:00

abstract：:Samples of Rhynchosporium secalis were collected from two experimental barley populations known to carry a diverse array of alleles for resistance to this fungal pathogen. Classification of 163 isolates for four putative isozyme systems, a colony color dimorphism and 20 ribosomal DNA restriction fragment length varian...

journal_title：Genetics

authors： McDermott JM,McDonald BA,Allard RW,Webster RK

更新日期：1989-07-01 00:00:00

abstract：:The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation may play in diverse cellular functions, aside from ribosome production, hig...

journal_title：Genetics

authors： Sanchez JC,Ollodart A,Large CRL,Clough C,Alvino GM,Tsuchiya M,Crane M,Kwan EX,Kaeberlein M,Dunham MJ,Raghuraman MK,Brewer BJ

更新日期：2019-09-01 00:00:00

abstract：:Forty-eight new mutations at the am locus of Neurospora crassa have been characterized. Nineteen mutations were induced by UV; of these, eight were missense, two were frameshifts, two were nonsense, three were deletions and four were unidentified. Twenty-nine mutations were induced with nitrous acid; of these, twenty-...

journal_title：Genetics

authors： Kinsey JA,Hung BS

更新日期：1981-11-01 00:00:00

abstract：:Genomic imprinting is well known as a regulatory property of a few specific chromosomal regions and leads to differential behavior of maternally and paternally inherited alleles. We surveyed the activity of two reporter genes in 23 independent P-element insertions on the heterochromatic Y chromosome of Drosophila mela...

journal_title：Genetics

authors： Maggert KA,Golic KG

更新日期：2002-11-01 00:00:00

abstract：:Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spe...

journal_title：Genetics

authors： Ono BI,Fujimoto R,Ohno Y,Maeda N,Tsuchiya Y,Usui T,Ishino-Arao Y

更新日期：1988-01-01 00:00:00

abstract：:Zymograms were analyzed of a number of Triticum aestivum derivatives which incorporated a segment of the Aegilops umbellulata chromosome bearing resistance to leaf rust. Evidence has been presented which suggests that genes involved in the production of two peroxidases and a single peptidase are located on the short a...

journal_title：Genetics

authors： Macdonald T,Smith HH

更新日期：1972-09-01 00:00:00

abstract：:The opportunistic human pathogen Penicillium marneffei exhibits a temperature-dependent dimorphic switch. At 25 degrees, multinucleate, septate hyphae that can undergo differentiation to produce asexual spores (conidia) are produced. At 37 degrees hyphae undergo arthroconidiation to produce uninucleate yeast cells tha...

journal_title：Genetics

authors： Zuber S,Hynes MJ,Andrianopoulos A

更新日期：2003-06-01 00:00:00

abstract：:The Saccharomyces cerevisiae PHO85 gene encodes a nonessential cyclin-dependent kinase that associates with 10 cyclin subunits. To survey the functions provided by Pho85, we identified mutants that require PHO85 for viability. We identified mutations that define seven Pho Eighty-Five Requiring or Efr loci, six of whic...

journal_title：Genetics

authors： Lenburg ME,O'Shea EK

更新日期：2001-01-01 00:00:00

abstract：:Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is ...

journal_title：Genetics

authors： Smith KN,Miller SC,Varani G,Calabrese JM,Magnuson T

更新日期：2019-12-01 00:00:00

abstract：:Intron sizes show an asymmetrical distribution in a number of organisms, with a large number of "short" introns clustered around a minimal intron length and a much broader distribution of longer introns. In Drosophila melanogaster, the short intron class is centered around 61 bp. The narrow length distribution suggest...

journal_title：Genetics

authors： Parsch J

更新日期：2003-12-01 00:00:00

abstract：:In experiments with directional selection on a quantitative character a "reversed response" to selection is occasionally observed, when selection of individuals for a higher (lower) value of the character results in a lower (higher) value of the character among their offspring. A sudden change in environments or rando...

journal_title：Genetics

authors： Gimelfarb A

更新日期：1986-09-01 00:00:00

abstract：:Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...

journal_title：Genetics

authors： Bradford BR,Briand NE,Fassnacht N,Gervasio ED,Nowakowski AM,FitzGibbon TC,Maurina S,Benjamin AV,Kelly M,Checchi PM

更新日期：2020-12-01 00:00:00

abstract：:Clf1p is an essential, highly conserved protein in S. cerevisiae that has been implicated in pre-mRNA splicing. Clf1p's ortholog in Drosophila, Crn, is required for normal cell proliferation. Cells depleted of Clf1p arrest primarily with large buds, a single nucleus, a 2C DNA content, and a short, intact mitotic spind...

journal_title：Genetics

authors： Zhu W,Rainville IR,Ding M,Bolus M,Heintz NH,Pederson DS

更新日期：2002-04-01 00:00:00

abstract：:In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...

journal_title：Genetics

authors： Engels WR

更新日期：1981-07-01 00:00:00

abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...

journal_title：Genetics

authors： Rhee Y,Sekhon RS,Chopra S,Kaeppler S

更新日期：2010-11-01 00:00:00

abstract：:Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...

journal_title：Genetics

authors： Goldstein B,Nance J

更新日期：2020-02-01 00:00:00