Abstract：
:To further understand how the nematode Caenorhabditis elegans defends itself against pathogen attack, we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility and pathogen resistance are highly correlated and that resistance in both epr and sterile mutants is dependent on DAF-16 activity. Our data indicate that a DAF-16-dependent signaling pathway distinct from previously described pathways is involved in the activation of genes that confer resistance to bacterial pathogens. The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of embryonic development in wild-type animals, suggesting that signals from developing embryos normally downregulate the immune response.
journal_name
Geneticsjournal_title
Geneticsauthors
Miyata S,Begun J,Troemel ER,Ausubel FMdoi
10.1534/genetics.107.083923subject
Has Abstractpub_date
2008-02-01 00:00:00pages
903-18issue
2eissn
0016-6731issn
1943-2631pii
genetics.107.083923journal_volume
178pub_type
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