Abstract:
:To study the evolutionary role played by differential male and female fertility (sexual asymmetry) both between individuals and over the life span within single individuals, the terms "intrinsic male fertility" and "intrinsic female fertility" are introduced. With the help of these terms, the concept of sexual asymmetry can be made precise and its effect on the establishment and maintenance of genetic polymorphisms can be analyzed. The main conclusions are: (1) any mutant causing a modification of the male fertility parameters which result in an increased intrinsic male fertility becomes established; (2) a corollary of this is that age-specific sexual asymmetry, as results from alternating degrees of female and male flowering in successive reproduction cycles, for example, has only secondary effects on the initial growth rate; (3) under the biologically reasonable premise that modifications of life histories result from reallocation of fixed net reproduction resources (defined as constant total female and male net reproduction output), a shift of net reproduction (whether female, male, or both in arbitrary proportions) to earlier ages is evolutionarily successful in growing but not in declining populations; shifts of net reproduction to later ages have opposite consequences.
journal_name
Geneticsjournal_title
Geneticsauthors
Gregorius HRsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
949-56issue
3eissn
0016-6731issn
1943-2631journal_volume
129pub_type
杂志文章相关文献
GENETICS文献大全abstract::In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::F1 hybrids between mouse inbred strains PWD and C57BL/6 represent the most thoroughly genetically defined model of hybrid sterility in vertebrates. Hybrid male sterility can be fully reconstituted from three components of this model, the Prdm9 gene, intersubspecific homeology of Mus musculus musculus and Mus musculus ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302554
更新日期:2019-11-01 00:00:00
abstract::Mismatch repair of palindromic loops in the presence or absence of single-base mismatches was investigated in wild-type and mismatch-binding defective mutant Chinese hamster ovary cells. Recombination intermediates with a maximum heteroduplex DNA (hDNA) region of 697 bp contained a centrally located, phenotypically si...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::The cosQ site of bacteriophage lambda is required for DNA packaging termination. Previous studies have shown that cosQ mutations can be suppressed in three ways: by a local suppressor within cosQ, an increase in the length of the lambda chromosome, and missense mutations affecting the prohead's portal protein, gpB. In...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::We describe here a family of P elements that we refer to as type I repressors. These elements are identified by their repressor functions and their lack of any deletion within the first two-thirds of the canonical P sequence. Elements belonging to this repressor class were isolated from P strains and were made in vitr...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::The fine-scale pattern of correlated paternity was characterized within a population of the narrow-endemic model plant species, Centaurea corymbosa, using microsatellites and natural progeny arrays. We used classical approaches to assess correlated mating within sibships and developed a new method based on pairwise ki...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.027714
更新日期:2004-11-01 00:00:00
abstract::We studied the control of pharyngeal excitation in Caenorhabditis elegans. By laser ablating subsets of the pharyngeal nervous system, we found that the MC neuron type is necessary and probably sufficient for rapid pharyngeal pumping. Electropharyngeograms showed that MC transmits excitatory postsynaptic potentials, s...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::We have studied the deletion of inverted repeats cloned into the EcoRI site within the CAT gene of plasmid pBR325. A cloned inverted repeat constitutes a palindrome that includes both EcoRI sites flanking the insert. In addition, the two EcoRI sites represent direct repeats flanking a region of palindromic symmetry. A...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::Host mutations in Escherichia coli K12 selected for the temperature-sensitive replication of the bacterial plasmid colicinogenic factor E(1) (ColE(1)) exhibit a pleiotropic effect with respect to the effect of the mutation on other extra-chromosomal elements. The mutations also vary with respect to the time of incubat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-05-01 00:00:00
abstract::The evolution of domesticated maize from its wild ancestor teosinte is a dramatic example of the effect of human selection on agricultural crops. Maize has one dominant axis of growth, whereas teosinte is highly branched. The axillary branches in maize are short and feminized whereas the axillary branches of teosinte ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::The rate of adaptive evolution of a population ultimately depends on the rate of incorporation of beneficial mutations. Even beneficial mutations may, however, be lost from a population since mutant individuals may, by chance, fail to reproduce. In this paper, we calculate the probability of fixation of beneficial mut...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract::The Mus101 family of chromosomal proteins, identified initially in Drosophila, is widely conserved and has been shown to function in a variety of DNA metabolic processes. Such functions include DNA replication, DNA damage repair, postreplication repair, damage checkpoint activation, chromosome stability, and chromosom...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.036137
更新日期:2005-03-01 00:00:00
abstract::Divergent phenotypes are often detected in domesticated plants despite the existence of invariant phenotypes in their wild forms. One such example in rice is the occurrence of varying degrees of apiculus coloration due to anthocyanin pigmentation, which was previously reported to be caused by a series of alleles at th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.103.018390
更新日期:2004-10-01 00:00:00
abstract::There is an increasing awareness that selection affecting linked neutral sites strongly influences on how diversity is distributed across the genome. In particular, linked selection is likely involved in the formation of heterogenous landscapes of genetic diversity, including genomic regions with locally reduced effec...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.301991
更新日期:2019-05-01 00:00:00
abstract::The protein phosphatase calcineurin is central to Ca2+ signaling pathways from yeast to humans. Full activation of calcineurin requires Ca2+ binding to the regulatory subunit CNB, comprised of four Ca2+-binding EF hand domains, and recruitment of Ca2+-calmodulin. Here we report the consequences of disrupting Ca2+ bind...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.118.300911
更新日期:2018-07-01 00:00:00
abstract::Critically shortened telomeres can be subjected to DNA repair events that generate end-to-end chromosome fusions. The resulting dicentric chromosomes can enter breakage-fusion-bridge cycles, thereby impeding elucidation of the structures of the initial fusion events and a mechanistic understanding of their genesis. Cu...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.089920
更新日期:2008-10-01 00:00:00
abstract::Our previous work suggests that the Nhp6 HMGB protein stimulates RNA polymerase II transcription via the TATA-binding protein TBP and that Nhp6 functions in the same functional pathway as the Gcn5 histone acetyltransferase. In this report we examine the genetic relationship between Nhp6 and Gcn5 with the Mot1 and Ccr4...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.050245
更新日期:2006-02-01 00:00:00
abstract::Simple meiotic gene conversion tracts produced in wild-type females were compared with those from two meiotic mutants, mei-9 and mei-218. The positions and lengths of conversion tracts were determined by denaturing gradient gels and DNA sequencing. Conversion tracts in wild type averaged 885 base pairs in length, were...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical of natural populations. Theoretical studies demonstrate that evolution of polygenic characters depends heavily on the genetic interdependence of the expression of traits in the differ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.135590
更新日期:2012-02-01 00:00:00
abstract::Mapping markers from linkage data continues to be a task performed in many genetic epidemiological studies. Data collected in a study may be used to refine published map estimates and a study may use markers that do not appear in any published map. Furthermore, inaccuracies in meiotic maps can seriously bias linkage f...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.042705
更新日期:2005-10-01 00:00:00
abstract::Cell diversity in multicellular organisms relies on coordination between cell proliferation and the acquisition of cell identity. The equilibrium between these two processes is essential to assure the correct number of determined cells at a given time at a given place. Using genetic approaches and correlative microsco...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302234
更新日期:2019-07-01 00:00:00
abstract::Primary cilia have essential roles in transducing signals in eukaryotes. At their core is the ciliary axoneme, a microtubule-based structure that defines cilium morphology and provides a substrate for intraflagellar transport. However, the extent to which axonemal microtubules are specialized for sensory cilium functi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.116996
更新日期:2010-07-01 00:00:00
abstract::A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibite...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.039271
更新日期:2006-03-01 00:00:00
abstract::Mutations in maternally transmitted symbionts can affect host fitness. In this study we investigate a mutation in an obligate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid hosts (Acyrthosiphon pisum). The heat-sensitive allele arises through a single base deletion in a ho...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.117440
更新日期:2010-09-01 00:00:00
abstract::Ten mutations are described that transform genotypic hermaphrodites of the nematode Caenorhabditis elegans into phenotypic males. These fall into three autosomal complementation groups, termed tra-1, tra-2, and tra-3. Two alleles of tra-1 produce almost complete transformation, to a fertile male phenotype; such transf...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::The past century has seen substantial theoretical and empirical progress on the genetic basis of adaptation. Over this same period, a pressing need to prevent the evolution of drug resistance has uncovered much about the potential genetic basis of persistence in declining populations. However, we have little theory to...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302890
更新日期:2020-02-01 00:00:00
abstract::We have analyzed the requirements for the multi sex combs (mxc) gene during development to gain further insight into the mechanisms and developmental processes that depend on the important trans-regulators forming the Polycomb group (PcG) in Drosophila melanogaster. mxc is allelic with the tumor suppressor locus letha...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Predicting the chromosomal location of mapped markers has been difficult because linkage maps do not reveal differences in crossover frequencies along the physical structure of chromosomes. Here we combine a physical crossover map based on the distribution of recombination nodules (RNs) on Solanum lycopersicum (tomato...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.074138
更新日期:2007-08-01 00:00:00
abstract::Polycomb group response elements (PREs) play an essential role in gene regulation by the Polycomb group (PcG) repressor proteins in Drosophila. PREs are required for the recruitment and maintenance of repression by the PcG proteins. PREs are made up of binding sites for multiple DNA-binding proteins, but it is still u...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.153247
更新日期:2013-10-01 00:00:00