abstract：BACKGROUND:Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis. The aim of our study was to determine the detailed role of mitochondrial fission in SW837 colorectal cancer cell viability, m...

journal_title：BMC cell biology

authors： Jieensinue S,Zhu H,Li G,Dong K,Liang M,Li Y

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature would be expected to cause endoplasmic reticulum (ER) localization. The aim of this study was to determine by which means the HIV...

journal_title：BMC cell biology

authors： Perrin J,Bary A,Vernay A,Cosson P

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinokitiol and DNA methylat...

journal_title：BMC cell biology

authors： Seo JS,Choi YH,Moon JW,Kim HS,Park SH

更新日期：2017-02-27 00:00:00

abstract：BACKGROUND:Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural proteins were upregulated when murine embryonic stem (ES) cells differentiated to primitive endoder...

journal_title：BMC cell biology

authors： Smith ER,Meng Y,Moore R,Tse JD,Xu AG,Xu XX

更新日期：2017-01-14 00:00:00

abstract：BACKGROUND:Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. In order to monitor the organisation of chromatin in live cells we have engineered fluorescent fusio...

journal_title：BMC cell biology

authors： Dickerson D,Gierliński M,Singh V,Kitamura E,Ball G,Tanaka TU,Owen-Hughes T

更新日期：2016-09-08 00:00:00

abstract：BACKGROUND:Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, increased membrane permeability and cell death. Despite the fact that the etiology of dysferlinopathie...

journal_title：BMC cell biology

authors： Cea LA,Bevilacqua JA,Arriagada C,Cárdenas AM,Bigot A,Mouly V,Sáez JC,Caviedes P

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a role for the nucleolus also in malignant transformation. We have recently demonstrated that under spe...

journal_title：BMC cell biology

authors： Ponti D,Bastianelli D,Rosa P,Pacini L,Ibrahim M,Rendina EA,Ragona G,Calogero A

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Endocytosis of activated EGF receptor (EGFR) to specific endocytic compartments is required to terminate EGF signaling. Trafficking of EGFR relies on microtubule tracks that transport the cargo vesicle to their intermediate and final destinations and can be modulated through posttranslational modification of...

journal_title：BMC cell biology

authors： Lee SJ,Li Z,Litan A,Yoo S,Langhans SA

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:Experimental models are inevitably a compromise between accurately reproducing a pathological situation and schematically simplifying it, which is intended to provide both relevance and conclusiveness. In-vivo models are very relevant, but multiple cell-types undergoing various changes may hinder the observa...

journal_title：BMC cell biology

authors： Legouis D,Bataille A,Hertig A,Vandermeersch S,Simon N,Rondeau E,Galichon P

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:There is evidence that several messenger RNAs (mRNAs) are bifunctional RNAs, i.e. RNA transcript carrying both protein-coding capacity and activity as functional non-coding RNA via 5' and 3' untranslated regions (UTRs). RESULTS:In this study, we identified a novel bifunctional RNA that is transcribed from i...

journal_title：BMC cell biology

authors： Nagano H,Yamagishi N,Tomida C,Yano C,Aibara K,Kohno S,Abe T,Ohno A,Hirasaka K,Okumura Y,Mills EM,Nikawa T,Teshima-Kondo S

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:Acacia honey (AH) has been proven to improve skin wound healing, but its therapeutic effects on corneal epithelium has not been elucidated to date. This study aimed to investigate the effects of AH on cultured corneal epithelial cells (CEC) on in vitro corneal abrasion wound healing model. Six New Zealand wh...

journal_title：BMC cell biology

authors： Ker-Woon C,Abd Ghafar N,Hui CK,Mohd Yusof YA,Wan Ngah WZ

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reported to operate through calcium flux, phosphoinoisitide 3 kinase (PI3K) and mitogen-activated protein k...

journal_title：BMC cell biology

authors： Leclair HM,Dubois SM,Azzi S,Dwyer J,Bidère N,Gavard J

更新日期：2014-10-22 00:00:00

abstract：BACKGROUND:Clathrin-mediated vesicular trafficking, the mechanism by which proteins and lipids are transported between membrane-bound organelles, accounts for a large proportion of import from the plasma membrane (endocytosis) and transport from the trans-Golgi network towards the endosomal system. Clathrin-mediated ev...

journal_title：BMC cell biology

authors： Kalb LC,Frederico YC,Batista CM,Eger I,Fragoso SP,Soares MJ

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Fetal mesenchymal stem/stromal cells (MSC) represent a developmentally-advantageous cell type with translational potential.To enhance adult MSC migration, studies have focussed on the role of the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12), but more recent work implicates an intricate system of CX...

journal_title：BMC cell biology

authors： Pelekanos RA,Ting MJ,Sardesai VS,Ryan JM,Lim YC,Chan JK,Fisk NM

更新日期：2014-05-16 00:00:00

abstract：BACKGROUND:Acrosomal proteins play crucial roles in the physiology of fertilization. Identification of proteins localizing to the acrosome is fundamental to the understanding of its contribution to fertilization. Novel proteins are still being reported from acrosome. In order to capture yet unreported proteins localizi...

journal_title：BMC cell biology

authors： Bhattacharya R,Devi MS,Dhople VM,Jesudasan RA

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Multilineage differentiation, immunomodulation and secretion of trophic factors render mesenchymal stromal cells (MSC) highly attractive for clinical application. Human platelet derivatives such as pooled human platelet lysate (pHPL) and thrombin-activated platelet releasate in plasma (tPRP) have been introd...

journal_title：BMC cell biology

authors： Kinzebach S,Dietz L,Klüter H,Thierse HJ,Bieback K

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type available for use in studies of FTSEC biology and malignant transformation. In vitro three-dimensi...

journal_title：BMC cell biology

authors： Lawrenson K,Notaridou M,Lee N,Benjamin E,Jacobs IJ,Jones C,Gayther SA

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of streptozotocin-induced diabetes on the bone marrow-mesenchymal stem cell (MSC) function, and examined...

journal_title：BMC cell biology

authors： Kim YS,Kwon JS,Hong MH,Kang WS,Jeong HY,Kang HJ,Jeong Mh,Ahn Y

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. RESULTS:MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50...

journal_title：BMC cell biology

authors： Barteneva NS,Fasler-Kan E,Bernimoulin M,Stern JN,Ponomarev ED,Duckett L,Vorobjev IA

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats. RESULTS:Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced u...

journal_title：BMC cell biology

authors： Guo JQ,Gao X,Lin ZJ,Wu WZ,Huang LH,Dong HY,Chen J,Lu J,Fu YF,Wang J,Ma YJ,Chen XW,Wu ZX,He FQ,Yang SL,Liao LM,Zheng F,Tan JM

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding "cargo" proteins. However, it is unknown whether these "cargo" proteins influence th...

journal_title：BMC cell biology

authors： Satake T,Otsuki K,Banba Y,Suenaga J,Hirano H,Yamanaka Y,Ohno S,Hirai S

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis. RESULTS:In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet as...

journal_title：BMC cell biology

authors： Liu R,Fu A,Hoffman AE,Zheng T,Zhu Y

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Induced pluripotent stem cells (iPSC) are generated by reprogramming somatic cells into embryonic like state (ESC) using defined factors. There is great interest in these cells because of their potential for application in regenerative medicine. RESULTS:iPSC reprogrammed from murine tail tip fibroblasts wer...

journal_title：BMC cell biology

authors： Li F,Niyibizi C

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:One of the problems associated with osteosarcoma is the frequent formation of micrometastases in the lung prior to diagnosis because the development of metastatic lesions often causes a fatal outcome. Therefore, the prevention of pulmonary metastases during the early stage of tumor development is critical fo...

journal_title：BMC cell biology

authors： Nakamura A,Aizawa J,Sakayama K,Kidani T,Takata T,Norimatsu Y,Miura H,Masuno H

更新日期：2012-09-26 00:00:00

abstract：BACKGROUND:In interferon-γ-stimulated cells, the dimeric transcription factor STAT1 (signal transducer and activator of transcription 1) recognizes semi-palindromic motifs in the promoter regions of cytokine-driven target genes termed GAS (gamma-activated sites). However, the molecular steps that facilitate GAS binding...

journal_title：BMC cell biology

authors： Koch V,Staab J,Ruppert V,Meyer T

更新日期：2012-08-24 00:00:00

abstract：BACKGROUND:The mammalian inner ear contains the organ of Corti which is responsible for the conversion of sound into neuronal signals. This specialised epithelial tissue is the product of a complex developmental process where a common precursor cell type differentiates into the sound transducing hair cells and the non-...

journal_title：BMC cell biology

authors： Brunetta I,Casalotti SO,Hart IR,Forge A,Reynolds LE

更新日期：2012-03-17 00:00:00

abstract：BACKGROUND:The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therapeutic applications and limitations of hMSCs derived from human umbilical cords, the effects of hypoxi...

journal_title：BMC cell biology

authors： Zeng HL,Zhong Q,Qin YL,Bu QQ,Han XA,Jia HT,Liu HW

更新日期：2011-08-09 00:00:00

abstract：BACKGROUND:Cellular senescence plays important roles in the aging process of complex organisms, in tumor suppression and in response to stress. Several markers can be used to identify senescent cells, of which the most widely used is the senescence-associated β-galactosidase (SABG) activity. The main advantage of SABG ...

journal_title：BMC cell biology

authors： Shlush LI,Itzkovitz S,Cohen A,Rutenberg A,Berkovitz R,Yehezkel S,Shahar H,Selig S,Skorecki K

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:The transcription factor STAT3 (signal transducer and activator of transcription 3) is frequently activated in tumor cells. Activated STAT3 forms homodimers, or heterodimers with other TFs such as NF-κB, which becomes activated. Cytoplasmic STAT3 dimers are activated by tyrosine phosphorylation; they interac...

journal_title：BMC cell biology

authors： Souissi I,Najjar I,Ah-Koon L,Schischmanoff PO,Lesage D,Le Coquil S,Roger C,Dusanter-Fourt I,Varin-Blank N,Cao A,Metelev V,Baran-Marszak F,Fagard R

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:In the bone marrow, hematopietic and mesenchymal stem cells form a unique niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell fate, self renewal and multipotency. However, whereas most studies addressed the effect of transient in vitro exposure of MSC to hypoxia, perman...

journal_title：BMC cell biology

authors： Basciano L,Nemos C,Foliguet B,de Isla N,de Carvalho M,Tran N,Dalloul A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Chromatin insulators or boundary elements are a class of functional elements in the eukaryotic genome. They regulate gene transcription by interfering with promoter-enhancer communication. The Cp190 protein of Drosophila melanogaster is essential to the function of at least three-types of chromatin insulator...

journal_title：BMC cell biology

authors： Oliver D,Sheehan B,South H,Akbari O,Pai CY

更新日期：2010-12-31 00:00:00

abstract：BACKGROUND:In cancer cells the three-dimensional (3D) telomere organization of interphase nuclei into a telomeric disk is heavily distorted and aggregates are found. In Hodgkin's lymphoma quantitative FISH (3D Q-FISH) reveals a major impact of nuclear telomere dynamics during the transition form mononuclear Hodgkin (H)...

journal_title：BMC cell biology

authors： Knecht H,Brüderlein S,Wegener S,Lichtensztejn D,Lichtensztejn Z,Lemieux B,Möller P,Mai S

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:The estrogen receptor alpha (ERα) is found predominately in the nucleus, both in hormone stimulated and untreated cells. Intracellular distribution of the ERα changes in the presence of agonists but the impact of different antiestrogens on the fate of ERα is a matter of debate. RESULTS:A MCF-7 cell line sta...

journal_title：BMC cell biology

authors： Kocanova S,Mazaheri M,Caze-Subra S,Bystricky K

更新日期：2010-12-10 00:00:00

abstract：BACKGROUND:Lipid droplets are a class of eukaryotic cell organelles for storage of neutral fat such as triacylglycerol (TAG) and cholesterol ester (CE). We and others have recently reported that lysosome-related organelles (LROs) are not fat storage structures in the nematode C. elegans. We also reported the formation ...

journal_title：BMC cell biology

authors： Zhang SO,Trimble R,Guo F,Mak HY

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:Adipose-Derived Stromal Cells have been shown to have multiple lineage differentiation properties and to be suitable for tissues regeneration in many degenerative processes. Their use has been proposed for the therapy of joint diseases and tendon injuries in the horse. In the present report the genetic manip...

journal_title：BMC cell biology

authors： Donofrio G,Capocefalo A,Franceschi V,Morini G,Del Bue M,Conti V,Cavirani S,Grolli S

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C. elegans have demonstrated that Unc-45 facilitates the process of myosin folding and assembly in body wall muscles. Loss or overexpression of Unc-45 in C. elegans results in...

journal_title：BMC cell biology

authors： Bernick EP,Zhang PJ,Du S

更新日期：2010-09-17 00:00:00

abstract：BACKGROUND:Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on the microenvironment of the specific vascular bed and on interact...

journal_title：BMC cell biology

authors： Beese M,Wyss K,Haubitz M,Kirsch T

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:We have previously obtained a clonal population of cells from human foreskin that is able to differentiate into mesodermal, ectodermal and endodermal progenies. It is of great interest to know whether these cells could be further differentiated into functional insulin-producing cells. RESULTS:Sixty-one sing...

journal_title：BMC cell biology

authors： Bi D,Chen FG,Zhang WJ,Zhou GD,Cui L,Liu W,Cao Y

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:In cytokinesis, when the cleavage furrow has been formed, the two centrioles in each daughter cell separate. It has been suggested that the centrioles facilitate and regulate cytokinesis to some extent. It has been postulated that termination of cytokinesis (abscission) depends on the migration of a centriol...

journal_title：BMC cell biology

authors： Jonsdottir AB,Dirks RW,Vrolijk J,Ogmundsdottir HM,Tanke HJ,Eyfjörd JE,Szuhai K

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Dental pulp stem cells (DPSCs) can be driven into odontoblast, osteoblast, and chondrocyte lineages in different inductive media. However, the differentiation potential of naive DPSCs after serial passaging in the routine culture system has not been fully elucidated. RESULTS:DPSCs were isolated from human/r...

journal_title：BMC cell biology

authors： Yu J,He H,Tang C,Zhang G,Li Y,Wang R,Shi J,Jin Y

更新日期：2010-05-08 00:00:00